3-keto-dihydrosphingosine reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-keto-dihydrosphingosine reductase

Species:

Leishmania major

UniProt:

E9AEL0_LEIMA

TriTrypDb:

LmjF.35.0330 , LMJLV39_350008600 , LMJSD75_350008500

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	4
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AEL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEL0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0006643	membrane lipid metabolic process	4	10
GO:0006665	sphingolipid metabolic process	4	10
GO:0006666	3-keto-sphinganine metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030148	sphingolipid biosynthetic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0042180	cellular ketone metabolic process	3	10
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0046467	membrane lipid biosynthetic process	4	10
GO:0046519	sphingoid metabolic process	5	10
GO:0071704	organic substance metabolic process	2	10
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	10
GO:0047560	3-dehydrosphinganine reductase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.290
CLV_NRD_NRD_1	67	69	PF00675	0.224
CLV_PCSK_FUR_1	111	115	PF00082	0.191
CLV_PCSK_KEX2_1	113	115	PF00082	0.191
CLV_PCSK_KEX2_1	67	69	PF00082	0.264
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.191
CLV_PCSK_SKI1_1	173	177	PF00082	0.298
CLV_PCSK_SKI1_1	251	255	PF00082	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.310
DOC_CKS1_1	225	230	PF01111	0.453
DOC_MAPK_DCC_7	56	64	PF00069	0.535
DOC_MAPK_gen_1	56	64	PF00069	0.514
DOC_MAPK_JIP1_4	119	125	PF00069	0.539
DOC_MAPK_MEF2A_6	56	64	PF00069	0.535
DOC_MAPK_RevD_3	44	58	PF00069	0.502
DOC_PP4_FxxP_1	130	133	PF00568	0.453
DOC_USP7_MATH_1	243	247	PF00917	0.546
DOC_USP7_MATH_1	291	295	PF00917	0.526
DOC_WW_Pin1_4	218	223	PF00397	0.467
DOC_WW_Pin1_4	224	229	PF00397	0.447
DOC_WW_Pin1_4	235	240	PF00397	0.471
DOC_WW_Pin1_4	333	338	PF00397	0.670
LIG_14-3-3_CanoR_1	280	285	PF00244	0.564
LIG_14-3-3_CanoR_1	327	335	PF00244	0.606
LIG_14-3-3_CanoR_1	91	95	PF00244	0.546
LIG_Actin_WH2_2	296	311	PF00022	0.520
LIG_Actin_WH2_2	57	75	PF00022	0.494
LIG_DCNL_PONY_1	1	4	PF03556	0.310
LIG_FHA_1	104	110	PF00498	0.512
LIG_FHA_1	12	18	PF00498	0.436
LIG_FHA_1	34	40	PF00498	0.539
LIG_GBD_Chelix_1	8	16	PF00786	0.428
LIG_LIR_Gen_1	93	100	PF02991	0.514
LIG_PCNA_yPIPBox_3	301	309	PF02747	0.567
LIG_PTB_Apo_2	124	131	PF02174	0.464
LIG_SH2_CRK	320	324	PF00017	0.518
LIG_SH2_STAP1	269	273	PF00017	0.547
LIG_SH2_STAT5	152	155	PF00017	0.494
LIG_SH2_STAT5	94	97	PF00017	0.464
LIG_SH3_3	216	222	PF00018	0.453
LIG_SH3_3	233	239	PF00018	0.485
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.375
LIG_SUMO_SIM_par_1	33	40	PF11976	0.530
LIG_TYR_ITIM	318	323	PF00017	0.506
LIG_Vh1_VBS_1	5	23	PF01044	0.375
LIG_WRC_WIRS_1	244	249	PF05994	0.553
MOD_CDK_SPK_2	333	338	PF00069	0.660
MOD_CK1_1	139	145	PF00069	0.527
MOD_CK1_1	283	289	PF00069	0.530
MOD_CK1_1	329	335	PF00069	0.613
MOD_GlcNHglycan	138	141	PF01048	0.330
MOD_GlcNHglycan	192	195	PF01048	0.339
MOD_GlcNHglycan	285	288	PF01048	0.323
MOD_GlcNHglycan	332	335	PF01048	0.480
MOD_GSK3_1	267	274	PF00069	0.539
MOD_GSK3_1	326	333	PF00069	0.612
MOD_GSK3_1	33	40	PF00069	0.487
MOD_N-GLC_2	210	212	PF02516	0.261
MOD_NEK2_1	12	17	PF00069	0.412
MOD_NEK2_1	136	141	PF00069	0.467
MOD_NEK2_1	176	181	PF00069	0.458
MOD_NEK2_1	208	213	PF00069	0.478
MOD_NEK2_1	271	276	PF00069	0.508
MOD_NEK2_1	299	304	PF00069	0.574
MOD_PK_1	67	73	PF00069	0.502
MOD_PKA_1	67	73	PF00069	0.488
MOD_PKA_2	326	332	PF00069	0.564
MOD_PKA_2	67	73	PF00069	0.532
MOD_PKA_2	90	96	PF00069	0.539
MOD_Plk_1	101	107	PF00069	0.478
MOD_Plk_1	208	214	PF00069	0.494
MOD_Plk_1	267	273	PF00069	0.510
MOD_Plk_1	32	38	PF00069	0.587
MOD_Plk_4	12	18	PF00069	0.407
MOD_Plk_4	299	305	PF00069	0.557
MOD_Plk_4	33	39	PF00069	0.539
MOD_Plk_4	67	73	PF00069	0.545
MOD_Plk_4	90	96	PF00069	0.518
MOD_ProDKin_1	218	224	PF00069	0.467
MOD_ProDKin_1	235	241	PF00069	0.467
MOD_SUMO_rev_2	233	239	PF00179	0.571
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.565
TRG_ENDOCYTIC_2	320	323	PF00928	0.497
TRG_ENDOCYTIC_2	94	97	PF00928	0.464
TRG_NLS_MonoExtC_3	55	60	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS4	Leptomonas seymouri	27%	100%
A0A0N1I1P8	Leptomonas seymouri	80%	99%
A0A0N1I6F8	Leptomonas seymouri	27%	100%
A0A0N1I7L3	Leptomonas seymouri	29%	100%
A0A0S4JMY7	Bodo saltans	50%	99%
A0A1X0NFB1	Trypanosomatidae	28%	100%
A0A1X0NKR7	Trypanosomatidae	46%	91%
A0A1X0NWL8	Trypanosomatidae	27%	100%
A0A3Q8GLE8	Nepeta racemosa	26%	100%
A0A3Q8IF11	Leishmania donovani	27%	100%
A0A3Q8IHN8	Leishmania donovani	96%	100%
A0A3Q8IIU6	Leishmania donovani	30%	100%
A0A3S7X6T1	Leishmania donovani	28%	100%
A0A3S7XB64	Leishmania donovani	30%	100%
A0A422N9W5	Trypanosoma rangeli	28%	100%
A0A422NG64	Trypanosoma rangeli	28%	100%
A0A422NNE9	Trypanosoma rangeli	54%	100%
A4HLM0	Leishmania braziliensis	27%	100%
A4HM71	Leishmania braziliensis	88%	100%
A4HME4	Leishmania braziliensis	28%	100%
A4HPK8	Leishmania braziliensis	31%	100%
A4I111	Leishmania infantum	27%	100%
A4I931	Leishmania infantum	28%	100%
A4IAT4	Leishmania infantum	96%	100%
A4IB16	Leishmania infantum	30%	100%
A4ID56	Leishmania infantum	30%	100%
A5PJF6	Bos taurus	28%	100%
D0A2C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
D0A534	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D3U1D9	Klebsiella oxytoca	28%	100%
E9AEU5	Leishmania major	29%	100%
E9AX49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B3Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B601	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B602	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F4JZN6	Arabidopsis thaliana	33%	100%
O05730	Helicobacter pylori (strain ATCC 700392 / 26695)	25%	100%
O75452	Homo sapiens	28%	100%
O88451	Mus musculus	28%	100%
P0AFP4	Escherichia coli (strain K12)	28%	100%
P0AFP5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	28%	100%
P0CR36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	100%
P0CR37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	100%
P10528	Priestia megaterium	24%	100%
P12310	Bacillus subtilis (strain 168)	23%	100%
P25970	Myxococcus xanthus (strain DK1622)	32%	100%
P28845	Homo sapiens	28%	100%
P37694	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	27%	100%
P39482	Priestia megaterium	24%	100%
P39483	Priestia megaterium	23%	100%
P39484	Priestia megaterium	24%	100%
P39485	Priestia megaterium	24%	100%
P39577	Bacillus subtilis (strain 168)	27%	100%
P39831	Escherichia coli (strain K12)	25%	100%
P40288	Priestia megaterium	24%	100%
P40579	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P69935	Salmonella typhi	26%	100%
P69936	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
P80869	Bacillus subtilis (strain 168)	25%	100%
P9WGR4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WGR5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
Q06136	Homo sapiens	33%	100%
Q0WRJ2	Arabidopsis thaliana	29%	100%
Q13268	Homo sapiens	28%	100%
Q2KIJ5	Bos taurus	34%	100%
Q3T0R4	Bos taurus	28%	100%
Q3U0B3	Mus musculus	25%	100%
Q3ZBV9	Bos taurus	26%	100%
Q4L8Y1	Staphylococcus haemolyticus (strain JCSC1435)	27%	100%
Q4Q428	Leishmania major	28%	100%
Q4QAC7	Leishmania major	27%	100%
Q556J2	Dictyostelium discoideum	28%	100%
Q566S6	Danio rerio	27%	100%
Q59RQ2	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	100%
Q5BE65	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	92%
Q5FPE5	Gluconobacter oxydans (strain 621H)	30%	100%
Q5HLD8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q5R6U1	Pongo abelii	26%	100%
Q5RJY4	Rattus norvegicus	28%	100%
Q5XGF7	Xenopus tropicalis	26%	99%
Q5ZJG8	Gallus gallus	26%	100%
Q6CLN0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q6CVS4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	98%
Q6F7B8	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	30%	100%
Q6GV12	Mus musculus	32%	100%
Q6IAN0	Homo sapiens	26%	100%
Q6NRV4	Xenopus laevis	26%	99%
Q6UWP2	Homo sapiens	25%	100%
Q71R50	Gallus gallus	27%	100%
Q758B6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q7Q732	Anopheles gambiae	31%	100%
Q7RZR2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	93%
Q7T2D1	Danio rerio	28%	100%
Q7TQA3	Mus musculus	26%	100%
Q83RE8	Shigella flexneri	25%	100%
Q8CN40	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q8FHD2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	100%
Q8K9J5	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	100%
Q8N3Y7	Homo sapiens	26%	100%
Q8U8I2	Agrobacterium fabrum (strain C58 / ATCC 33970)	30%	100%
Q8WNV7	Sus scrofa	26%	100%
Q8X505	Escherichia coli O157:H7	25%	100%
Q99J47	Mus musculus	29%	100%
Q9FYL6	Arabidopsis thaliana	25%	100%
Q9KWN1	Rhizobium radiobacter	30%	100%
Q9NYR8	Homo sapiens	27%	100%
Q9P7B4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q9X248	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	28%	100%
Q9Y140	Drosophila melanogaster	28%	100%
Q9Y7P2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	68%
Q9ZKW1	Helicobacter pylori (strain J99 / ATCC 700824)	27%	100%
V5B376	Trypanosoma cruzi	51%	100%
V5BCN8	Trypanosoma cruzi	27%	100%
V5BS47	Trypanosoma cruzi	26%	100%