3-keto-dihydrosphingosine reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-keto-dihydrosphingosine reductase

Species:

Leishmania major

UniProt:

E9AEL0_LEIMA

TriTrypDb:

LmjF.35.0330 , LMJLV39_350008600 , LMJSD75_350008500

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	4
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

E9AEL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEL0

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0006643	membrane lipid metabolic process	4	10
GO:0006665	sphingolipid metabolic process	4	10
GO:0006666	3-keto-sphinganine metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	10
GO:0047560	3-dehydrosphinganine reductase activity	5	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.290
CLV_NRD_NRD_1	67	69	PF00675	0.224
CLV_PCSK_FUR_1	111	115	PF00082	0.191
CLV_PCSK_KEX2_1	113	115	PF00082	0.191
CLV_PCSK_KEX2_1	67	69	PF00082	0.264
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.191
CLV_PCSK_SKI1_1	173	177	PF00082	0.298
CLV_PCSK_SKI1_1	251	255	PF00082	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.310
DOC_CKS1_1	225	230	PF01111	0.453

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS4	Leptomonas seymouri	27%	100%
A0A0N1I1P8	Leptomonas seymouri	80%	99%
A0A0N1I6F8	Leptomonas seymouri	27%	100%
A0A0N1I7L3	Leptomonas seymouri	29%	100%
A0A0S4JMY7	Bodo saltans	50%	99%
A0A1X0NFB1	Trypanosomatidae	28%	100%
A0A1X0NKR7	Trypanosomatidae	46%	91%
A0A1X0NWL8	Trypanosomatidae	27%	100%
A0A3Q8GLE8	Nepeta racemosa	26%	100%
A0A3Q8IF11	Leishmania donovani	27%	100%

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