ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

E9AEK8_LEIMA

TriTrypDb:

LmjF.35.0310 , LMJLV39_350008400 , LMJSD75_350008300

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEK8

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010941	regulation of cell death	4	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0042981	regulation of apoptotic process	6	2
GO:0043067	regulation of programmed cell death	5	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051090	regulation of DNA-binding transcription factor activity	3	2
GO:0051091	positive regulation of DNA-binding transcription factor activity	4	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.706
CLV_NRD_NRD_1	411	413	PF00675	0.693
CLV_NRD_NRD_1	78	80	PF00675	0.679
CLV_PCSK_KEX2_1	413	415	PF00082	0.661
CLV_PCSK_KEX2_1	58	60	PF00082	0.662
CLV_PCSK_KEX2_1	78	80	PF00082	0.679
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.661
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.662
CLV_PCSK_SKI1_1	190	194	PF00082	0.427
CLV_PCSK_SKI1_1	404	408	PF00082	0.655
CLV_PCSK_SKI1_1	423	427	PF00082	0.725
DEG_Nend_UBRbox_3	1	3	PF02207	0.722
DEG_SPOP_SBC_1	260	264	PF00917	0.281
DEG_SPOP_SBC_1	344	348	PF00917	0.805
DOC_AGCK_PIF_2	70	75	PF00069	0.686
DOC_MAPK_gen_1	138	147	PF00069	0.641
DOC_MAPK_gen_1	363	372	PF00069	0.586
DOC_MAPK_gen_1	58	67	PF00069	0.676
DOC_MAPK_gen_1	78	88	PF00069	0.678
DOC_MAPK_gen_1	99	107	PF00069	0.588
DOC_MAPK_MEF2A_6	138	147	PF00069	0.607
DOC_MAPK_MEF2A_6	82	90	PF00069	0.668
DOC_PP1_RVXF_1	366	373	PF00149	0.645
DOC_PP2B_LxvP_1	276	279	PF13499	0.566
DOC_USP7_MATH_1	148	152	PF00917	0.510
DOC_USP7_MATH_1	259	263	PF00917	0.413
DOC_USP7_MATH_1	286	290	PF00917	0.592
DOC_USP7_MATH_1	320	324	PF00917	0.716
DOC_USP7_MATH_1	344	348	PF00917	0.803
DOC_USP7_MATH_1	419	423	PF00917	0.665
DOC_USP7_MATH_1	69	73	PF00917	0.654
DOC_USP7_UBL2_3	117	121	PF12436	0.572
DOC_USP7_UBL2_3	337	341	PF12436	0.770
DOC_USP7_UBL2_3	58	62	PF12436	0.652
DOC_WW_Pin1_4	131	136	PF00397	0.743
DOC_WW_Pin1_4	205	210	PF00397	0.393
DOC_WW_Pin1_4	216	221	PF00397	0.261
DOC_WW_Pin1_4	249	254	PF00397	0.328
DOC_WW_Pin1_4	390	395	PF00397	0.696
DOC_WW_Pin1_4	46	51	PF00397	0.685
LIG_14-3-3_CanoR_1	387	396	PF00244	0.598
LIG_14-3-3_CanoR_1	412	418	PF00244	0.652
LIG_14-3-3_CanoR_1	82	87	PF00244	0.594
LIG_14-3-3_CterR_2	423	427	PF00244	0.740
LIG_AP2alpha_2	68	70	PF02296	0.677
LIG_BRCT_BRCA1_1	150	154	PF00533	0.578
LIG_BRCT_BRCA1_1	218	222	PF00533	0.376
LIG_deltaCOP1_diTrp_1	391	398	PF00928	0.697
LIG_EVH1_2	313	317	PF00568	0.710
LIG_FHA_1	172	178	PF00498	0.439
LIG_FHA_1	261	267	PF00498	0.383
LIG_FHA_1	41	47	PF00498	0.655
LIG_FHA_1	55	61	PF00498	0.456
LIG_FHA_2	331	337	PF00498	0.762
LIG_FHA_2	355	361	PF00498	0.540
LIG_LIR_Apic_2	297	301	PF02991	0.657
LIG_LIR_Apic_2	323	327	PF02991	0.728
LIG_LIR_Gen_1	118	123	PF02991	0.610
LIG_LIR_Gen_1	174	181	PF02991	0.410
LIG_LIR_Gen_1	219	230	PF02991	0.357
LIG_LIR_Nem_3	118	122	PF02991	0.599
LIG_LIR_Nem_3	174	178	PF02991	0.419
LIG_LIR_Nem_3	213	218	PF02991	0.369
LIG_LIR_Nem_3	219	225	PF02991	0.333
LIG_LIR_Nem_3	280	285	PF02991	0.593
LIG_LIR_Nem_3	293	298	PF02991	0.558
LIG_LIR_Nem_3	68	73	PF02991	0.673
LIG_LIR_Nem_3	93	98	PF02991	0.518
LIG_MLH1_MIPbox_1	150	154	PF16413	0.578
LIG_Pex14_2	149	153	PF04695	0.552
LIG_REV1ctd_RIR_1	151	158	PF16727	0.599
LIG_RPA_C_Fungi	165	177	PF08784	0.607
LIG_SH2_CRK	14	18	PF00017	0.620
LIG_SH2_CRK	218	222	PF00017	0.449
LIG_SH2_CRK	298	302	PF00017	0.651
LIG_SH2_GRB2like	5	8	PF00017	0.665
LIG_SH2_NCK_1	218	222	PF00017	0.449
LIG_SH2_NCK_1	5	9	PF00017	0.665
LIG_SH2_SRC	73	76	PF00017	0.620
LIG_SH2_STAT3	35	38	PF00017	0.655
LIG_SH2_STAT5	175	178	PF00017	0.498
LIG_SH2_STAT5	277	280	PF00017	0.599
LIG_SH2_STAT5	316	319	PF00017	0.648
LIG_SH2_STAT5	35	38	PF00017	0.628
LIG_SH2_STAT5	5	8	PF00017	0.665
LIG_SH3_3	142	148	PF00018	0.624
LIG_SH3_3	306	312	PF00018	0.656
LIG_SH3_3	63	69	PF00018	0.656
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.389
LIG_SUMO_SIM_par_1	176	182	PF11976	0.419
LIG_SUMO_SIM_par_1	301	307	PF11976	0.690
LIG_TRAF2_1	109	112	PF00917	0.564
LIG_TRAF2_1	304	307	PF00917	0.733
LIG_TRAF2_1	408	411	PF00917	0.687
LIG_UBA3_1	177	185	PF00899	0.448
LIG_UBA3_1	302	310	PF00899	0.727
LIG_UBA3_1	52	58	PF00899	0.623
LIG_WRC_WIRS_1	116	121	PF05994	0.604
LIG_WW_1	313	316	PF00397	0.711
MOD_CDK_SPxxK_3	131	138	PF00069	0.732
MOD_CK1_1	131	137	PF00069	0.639
MOD_CK1_1	164	170	PF00069	0.664
MOD_CK1_1	179	185	PF00069	0.276
MOD_CK1_1	262	268	PF00069	0.445
MOD_CK1_1	331	337	PF00069	0.798
MOD_CK1_1	348	354	PF00069	0.755
MOD_CK2_1	21	27	PF00069	0.596
MOD_CK2_1	330	336	PF00069	0.651
MOD_CK2_1	348	354	PF00069	0.789
MOD_GlcNHglycan	130	133	PF01048	0.631
MOD_GlcNHglycan	150	153	PF01048	0.540
MOD_GlcNHglycan	19	22	PF01048	0.682
MOD_GlcNHglycan	23	26	PF01048	0.668
MOD_GlcNHglycan	347	350	PF01048	0.762
MOD_GlcNHglycan	365	368	PF01048	0.435
MOD_GlcNHglycan	398	401	PF01048	0.565
MOD_GlcNHglycan	417	420	PF01048	0.611
MOD_GlcNHglycan	92	95	PF01048	0.546
MOD_GSK3_1	160	167	PF00069	0.675
MOD_GSK3_1	17	24	PF00069	0.575
MOD_GSK3_1	235	242	PF00069	0.413
MOD_GSK3_1	286	293	PF00069	0.633
MOD_GSK3_1	340	347	PF00069	0.758
MOD_GSK3_1	415	422	PF00069	0.561
MOD_LATS_1	80	86	PF00433	0.677
MOD_N-GLC_1	199	204	PF02516	0.385
MOD_N-GLC_1	396	401	PF02516	0.681
MOD_N-GLC_1	46	51	PF02516	0.668
MOD_N-GLC_1	82	87	PF02516	0.653
MOD_NEK2_1	161	166	PF00069	0.662
MOD_NEK2_1	17	22	PF00069	0.638
MOD_NEK2_1	176	181	PF00069	0.337
MOD_NEK2_1	235	240	PF00069	0.365
MOD_NEK2_1	34	39	PF00069	0.458
MOD_NEK2_1	84	89	PF00069	0.588
MOD_NEK2_2	239	244	PF00069	0.437
MOD_PIKK_1	290	296	PF00454	0.625
MOD_PIKK_1	34	40	PF00454	0.675
MOD_PK_1	141	147	PF00069	0.631
MOD_PKA_1	3	9	PF00069	0.682
MOD_PKA_1	340	346	PF00069	0.571
MOD_PKA_1	412	418	PF00069	0.705
MOD_PKA_2	328	334	PF00069	0.791
MOD_PKA_2	413	419	PF00069	0.700
MOD_PKA_2	54	60	PF00069	0.613
MOD_PKA_2	98	104	PF00069	0.622
MOD_PKB_1	385	393	PF00069	0.695
MOD_Plk_1	141	147	PF00069	0.631
MOD_Plk_1	199	205	PF00069	0.363
MOD_Plk_1	296	302	PF00069	0.615
MOD_Plk_1	396	402	PF00069	0.574
MOD_Plk_1	82	88	PF00069	0.681
MOD_Plk_4	161	167	PF00069	0.596
MOD_Plk_4	171	177	PF00069	0.398
MOD_Plk_4	199	205	PF00069	0.342
MOD_Plk_4	312	318	PF00069	0.666
MOD_ProDKin_1	131	137	PF00069	0.741
MOD_ProDKin_1	205	211	PF00069	0.393
MOD_ProDKin_1	216	222	PF00069	0.261
MOD_ProDKin_1	249	255	PF00069	0.328
MOD_ProDKin_1	390	396	PF00069	0.692
MOD_ProDKin_1	46	52	PF00069	0.678
MOD_SUMO_rev_2	126	131	PF00179	0.699
MOD_SUMO_rev_2	328	334	PF00179	0.752
MOD_SUMO_rev_2	351	359	PF00179	0.691
MOD_SUMO_rev_2	409	415	PF00179	0.694
TRG_DiLeu_BaEn_1	231	236	PF01217	0.364
TRG_ENDOCYTIC_2	14	17	PF00928	0.615
TRG_ENDOCYTIC_2	175	178	PF00928	0.498
TRG_ENDOCYTIC_2	218	221	PF00928	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M0	Leptomonas seymouri	76%	95%
A0A0S4JN35	Bodo saltans	42%	100%
A0A1X0NIX5	Trypanosomatidae	38%	100%
A0A3S5H7Y3	Leishmania donovani	96%	100%
A0A422NN82	Trypanosoma rangeli	36%	100%
A4HM70	Leishmania braziliensis	91%	100%
A4IAT2	Leishmania infantum	96%	100%
D0A2C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B5R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BNA7	Trypanosoma cruzi	37%	100%