Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEK7_LEIMA

TriTrypDb:

LmjF.35.0300 , LMJLV39_350008300 , LMJSD75_350008200

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AEK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEK7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.497
CLV_NRD_NRD_1	283	285	PF00675	0.612
CLV_NRD_NRD_1	328	330	PF00675	0.512
CLV_NRD_NRD_1	52	54	PF00675	0.594
CLV_PCSK_KEX2_1	282	284	PF00082	0.453
CLV_PCSK_KEX2_1	328	330	PF00082	0.512
CLV_PCSK_KEX2_1	54	56	PF00082	0.599
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.453
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.596
CLV_PCSK_SKI1_1	109	113	PF00082	0.447
CLV_PCSK_SKI1_1	127	131	PF00082	0.518
CLV_PCSK_SKI1_1	283	287	PF00082	0.440
DOC_CDC14_PxL_1	34	42	PF14671	0.383
DOC_MAPK_gen_1	151	160	PF00069	0.530
DOC_MAPK_MEF2A_6	35	42	PF00069	0.380
DOC_USP7_MATH_1	171	175	PF00917	0.757
DOC_USP7_MATH_1	190	194	PF00917	0.662
DOC_USP7_MATH_1	195	199	PF00917	0.723
DOC_USP7_MATH_1	239	243	PF00917	0.718
DOC_USP7_MATH_1	88	92	PF00917	0.578
DOC_USP7_UBL2_3	109	113	PF12436	0.444
DOC_USP7_UBL2_3	282	286	PF12436	0.434
DOC_WW_Pin1_4	160	165	PF00397	0.571
DOC_WW_Pin1_4	63	68	PF00397	0.505
LIG_14-3-3_CanoR_1	238	247	PF00244	0.677
LIG_14-3-3_CanoR_1	309	319	PF00244	0.522
LIG_BIR_III_4	128	132	PF00653	0.575
LIG_BRCT_BRCA1_1	107	111	PF00533	0.559
LIG_BRCT_BRCA1_1	30	34	PF00533	0.592
LIG_BRCT_BRCA1_1	65	69	PF00533	0.550
LIG_BRCT_BRCA1_2	107	113	PF00533	0.561
LIG_CaM_IQ_9	45	60	PF13499	0.481
LIG_FHA_1	2	8	PF00498	0.659
LIG_FHA_1	221	227	PF00498	0.665
LIG_FHA_1	25	31	PF00498	0.453
LIG_FHA_1	265	271	PF00498	0.599
LIG_FHA_2	123	129	PF00498	0.494
LIG_FHA_2	27	33	PF00498	0.555
LIG_FHA_2	270	276	PF00498	0.494
LIG_LIR_Nem_3	293	299	PF02991	0.547
LIG_LIR_Nem_3	31	37	PF02991	0.591
LIG_LIR_Nem_3	313	319	PF02991	0.423
LIG_LYPXL_S_1	36	40	PF13949	0.379
LIG_LYPXL_yS_3	37	40	PF13949	0.381
LIG_MAD2	156	164	PF02301	0.568
LIG_Pex14_2	292	296	PF04695	0.403
LIG_Rb_LxCxE_1	255	274	PF01857	0.395
LIG_SH2_CRK	299	303	PF00017	0.593
LIG_SH2_STAT3	136	139	PF00017	0.574
LIG_SH3_3	4	10	PF00018	0.544
LIG_SH3_3	91	97	PF00018	0.598
MOD_CK1_1	101	107	PF00069	0.601
MOD_CK1_1	193	199	PF00069	0.548
MOD_CK1_1	205	211	PF00069	0.743
MOD_CK1_1	271	277	PF00069	0.403
MOD_CK1_1	41	47	PF00069	0.470
MOD_CK2_1	269	275	PF00069	0.537
MOD_CK2_1	291	297	PF00069	0.429
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.573
MOD_GlcNHglycan	193	196	PF01048	0.707
MOD_GlcNHglycan	197	200	PF01048	0.674
MOD_GlcNHglycan	212	215	PF01048	0.668
MOD_GlcNHglycan	226	229	PF01048	0.600
MOD_GlcNHglycan	241	244	PF01048	0.587
MOD_GlcNHglycan	90	93	PF01048	0.585
MOD_GSK3_1	101	108	PF00069	0.560
MOD_GSK3_1	167	174	PF00069	0.684
MOD_GSK3_1	175	182	PF00069	0.606
MOD_GSK3_1	191	198	PF00069	0.736
MOD_GSK3_1	20	27	PF00069	0.394
MOD_GSK3_1	204	211	PF00069	0.676
MOD_GSK3_1	215	222	PF00069	0.637
MOD_GSK3_1	264	271	PF00069	0.565
MOD_GSK3_1	9	16	PF00069	0.498
MOD_NEK2_1	210	215	PF00069	0.757
MOD_NEK2_1	226	231	PF00069	0.545
MOD_NEK2_1	24	29	PF00069	0.470
MOD_NEK2_1	69	74	PF00069	0.435
MOD_NEK2_2	122	127	PF00069	0.521
MOD_PIKK_1	179	185	PF00454	0.622
MOD_PIKK_1	22	28	PF00454	0.388
MOD_PIKK_1	69	75	PF00454	0.529
MOD_PIKK_1	9	15	PF00454	0.518
MOD_PKA_2	101	107	PF00069	0.600
MOD_PKA_2	150	156	PF00069	0.459
MOD_PKA_2	208	214	PF00069	0.729
MOD_Plk_1	122	128	PF00069	0.530
MOD_Plk_1	171	177	PF00069	0.584
MOD_Plk_1	20	26	PF00069	0.542
MOD_Plk_1	205	211	PF00069	0.731
MOD_Plk_1	268	274	PF00069	0.571
MOD_Plk_1	56	62	PF00069	0.573
MOD_Plk_2-3	269	275	PF00069	0.457
MOD_Plk_4	2	8	PF00069	0.721
MOD_ProDKin_1	160	166	PF00069	0.576
MOD_ProDKin_1	63	69	PF00069	0.503
MOD_SUMO_for_1	322	325	PF00179	0.430
MOD_SUMO_rev_2	134	142	PF00179	0.558
TRG_ENDOCYTIC_2	299	302	PF00928	0.597
TRG_ENDOCYTIC_2	319	322	PF00928	0.411
TRG_ENDOCYTIC_2	37	40	PF00928	0.381
TRG_ER_diArg_1	283	285	PF00400	0.498
TRG_ER_diArg_1	53	56	PF00400	0.471
TRG_NES_CRM1_1	255	269	PF08389	0.605
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I316	Leptomonas seymouri	74%	100%
A0A0S4JRP8	Bodo saltans	34%	91%
A0A1X0NJS6	Trypanosomatidae	37%	82%
A0A3Q8IFZ2	Leishmania donovani	94%	100%
A0A3R7MJB6	Trypanosoma rangeli	38%	94%
A4HM69	Leishmania braziliensis	81%	100%
A4IAT1	Leishmania infantum	95%	100%
D0A2C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B5R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BSV2	Trypanosoma cruzi	36%	95%