Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEK4_LEIMA

TriTrypDb:

LmjF.35.0270 , LMJLV39_350007700 , LMJSD75_350007800

Length:


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

E9AEK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEK4


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	75	77	PF00675	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DEG_SPOP_SBC_1	71	75	PF00917	0.605
DOC_USP7_MATH_1	45	49	PF00917	0.501
DOC_USP7_MATH_1	71	75	PF00917	0.652
LIG_Actin_WH2_2	49	67	PF00022	0.430
LIG_FHA_1	17	23	PF00498	0.355
LIG_LIR_Gen_1	19	28	PF02991	0.556
LIG_LIR_Nem_3	19	23	PF02991	0.355
LIG_LIR_Nem_3	4	10	PF02991	0.556
LIG_Pex14_2	7	11	PF04695	0.410
LIG_SH3_1	65	71	PF00018	0.621
LIG_SH3_3	65	71	PF00018	0.679
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.268
LIG_SUMO_SIM_par_1	27	33	PF11976	0.380
LIG_WRC_WIRS_1	17	22	PF05994	0.376
MOD_CK1_1	16	22	PF00069	0.430
MOD_GlcNHglycan	47	50	PF01048	0.501
MOD_NEK2_1	1	6	PF00069	0.689
MOD_NEK2_1	13	18	PF00069	0.430
MOD_Plk_4	16	22	PF00069	0.373
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.385


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P608	Leptomonas seymouri	67%	100%
A0A3Q8IIN9	Leishmania donovani	90%	100%
A4HM66	Leishmania braziliensis	82%	100%
A4IAS8	Leishmania infantum	90%	100%
D0A2D0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
E9B5R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%