Putative GTP-ase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-ase activating protein, putative

Species:

Leishmania major

UniProt:

E9AEK3_LEIMA

TriTrypDb:

LmjF.35.0260 , LMJLV39_350007600 , LMJSD75_350007700

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEK3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005096	GTPase activator activity	4	10
GO:0005488	binding	1	10
GO:0005543	phospholipid binding	3	10
GO:0008047	enzyme activator activity	3	10
GO:0008289	lipid binding	2	10
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.751
CLV_NRD_NRD_1	242	244	PF00675	0.671
CLV_NRD_NRD_1	245	247	PF00675	0.674
CLV_NRD_NRD_1	28	30	PF00675	0.473
CLV_NRD_NRD_1	353	355	PF00675	0.439
CLV_NRD_NRD_1	438	440	PF00675	0.645
CLV_PCSK_FUR_1	243	247	PF00082	0.508
CLV_PCSK_KEX2_1	244	246	PF00082	0.656
CLV_PCSK_KEX2_1	28	30	PF00082	0.466
CLV_PCSK_KEX2_1	437	439	PF00082	0.485
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.656
CLV_PCSK_SKI1_1	138	142	PF00082	0.396
CLV_PCSK_SKI1_1	411	415	PF00082	0.408
CLV_PCSK_SKI1_1	460	464	PF00082	0.607
CLV_PCSK_SKI1_1	536	540	PF00082	0.625
CLV_PCSK_SKI1_1	76	80	PF00082	0.514
DEG_Nend_UBRbox_2	1	3	PF02207	0.654
DOC_ANK_TNKS_1	171	178	PF00023	0.666
DOC_CKS1_1	610	615	PF01111	0.631
DOC_MAPK_gen_1	150	158	PF00069	0.574
DOC_MAPK_gen_1	368	376	PF00069	0.412
DOC_MAPK_gen_1	427	435	PF00069	0.485
DOC_MAPK_gen_1	51	59	PF00069	0.490
DOC_MAPK_RevD_3	228	244	PF00069	0.574
DOC_PP1_RVXF_1	136	143	PF00149	0.424
DOC_PP1_RVXF_1	596	602	PF00149	0.579
DOC_PP1_RVXF_1	74	81	PF00149	0.503
DOC_PP2B_LxvP_1	228	231	PF13499	0.475
DOC_PP2B_LxvP_1	447	450	PF13499	0.594
DOC_PP4_FxxP_1	42	45	PF00568	0.475
DOC_USP7_MATH_1	115	119	PF00917	0.759
DOC_USP7_MATH_1	125	129	PF00917	0.599
DOC_USP7_MATH_1	187	191	PF00917	0.700
DOC_USP7_MATH_1	204	208	PF00917	0.750
DOC_USP7_MATH_1	210	214	PF00917	0.709
DOC_USP7_MATH_1	331	335	PF00917	0.444
DOC_USP7_MATH_1	396	400	PF00917	0.381
DOC_USP7_MATH_1	45	49	PF00917	0.506
DOC_USP7_MATH_1	589	593	PF00917	0.553
DOC_WW_Pin1_4	306	311	PF00397	0.457
DOC_WW_Pin1_4	609	614	PF00397	0.641
LIG_14-3-3_CanoR_1	117	125	PF00244	0.649
LIG_14-3-3_CanoR_1	183	187	PF00244	0.792
LIG_14-3-3_CanoR_1	22	28	PF00244	0.589
LIG_14-3-3_CanoR_1	301	307	PF00244	0.532
LIG_14-3-3_CanoR_1	485	491	PF00244	0.463
LIG_14-3-3_CanoR_1	542	551	PF00244	0.545
LIG_APCC_ABBA_1	156	161	PF00400	0.582
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.553
LIG_BRCT_BRCA1_1	398	402	PF00533	0.484
LIG_BRCT_BRCA1_1	591	595	PF00533	0.518
LIG_deltaCOP1_diTrp_1	367	376	PF00928	0.344
LIG_deltaCOP1_diTrp_1	579	587	PF00928	0.538
LIG_deltaCOP1_diTrp_1	615	621	PF00928	0.522
LIG_EVH1_1	447	451	PF00568	0.608
LIG_FHA_1	119	125	PF00498	0.717
LIG_FHA_1	22	28	PF00498	0.452
LIG_FHA_1	395	401	PF00498	0.456
LIG_FHA_1	404	410	PF00498	0.378
LIG_FHA_1	442	448	PF00498	0.652
LIG_FHA_1	466	472	PF00498	0.689
LIG_FHA_1	515	521	PF00498	0.443
LIG_FHA_1	6	12	PF00498	0.441
LIG_FHA_2	171	177	PF00498	0.667
LIG_FHA_2	270	276	PF00498	0.713
LIG_FHA_2	292	298	PF00498	0.646
LIG_FHA_2	543	549	PF00498	0.430
LIG_FHA_2	610	616	PF00498	0.664
LIG_IBAR_NPY_1	209	211	PF08397	0.665
LIG_KLC1_Yacidic_2	55	60	PF13176	0.548
LIG_LIR_Gen_1	152	160	PF02991	0.549
LIG_LIR_Gen_1	236	242	PF02991	0.679
LIG_LIR_Gen_1	334	343	PF02991	0.344
LIG_LIR_Gen_1	390	400	PF02991	0.444
LIG_LIR_Gen_1	524	534	PF02991	0.437
LIG_LIR_Gen_1	623	629	PF02991	0.538
LIG_LIR_Nem_3	152	158	PF02991	0.546
LIG_LIR_Nem_3	236	240	PF02991	0.607
LIG_LIR_Nem_3	334	338	PF02991	0.328
LIG_LIR_Nem_3	390	395	PF02991	0.333
LIG_LIR_Nem_3	524	530	PF02991	0.422
LIG_LIR_Nem_3	623	628	PF02991	0.427
LIG_LYPXL_SIV_4	69	77	PF13949	0.584
LIG_Pex14_1	617	621	PF04695	0.495
LIG_PTB_Apo_2	123	130	PF02174	0.596
LIG_PTB_Apo_2	80	87	PF02174	0.565
LIG_PTB_Phospho_1	123	129	PF10480	0.612
LIG_PTB_Phospho_1	80	86	PF10480	0.556
LIG_Rb_LxCxE_1	35	48	PF01857	0.536
LIG_REV1ctd_RIR_1	432	440	PF16727	0.408
LIG_SH2_CRK	237	241	PF00017	0.445
LIG_SH2_CRK	499	503	PF00017	0.509
LIG_SH2_CRK	564	568	PF00017	0.485
LIG_SH2_CRK	625	629	PF00017	0.557
LIG_SH2_NCK_1	70	74	PF00017	0.646
LIG_SH2_PTP2	392	395	PF00017	0.408
LIG_SH2_SRC	58	61	PF00017	0.552
LIG_SH2_STAP1	312	316	PF00017	0.519
LIG_SH2_STAP1	430	434	PF00017	0.444
LIG_SH2_STAP1	474	478	PF00017	0.712
LIG_SH2_STAP1	86	90	PF00017	0.611
LIG_SH2_STAT3	129	132	PF00017	0.524
LIG_SH2_STAT5	129	132	PF00017	0.445
LIG_SH2_STAT5	155	158	PF00017	0.640
LIG_SH2_STAT5	392	395	PF00017	0.373
LIG_SH2_STAT5	40	43	PF00017	0.403
LIG_SH2_STAT5	564	567	PF00017	0.390
LIG_SH2_STAT5	58	61	PF00017	0.509
LIG_SH2_STAT5	99	102	PF00017	0.607
LIG_SH3_1	445	451	PF00018	0.620
LIG_SH3_3	163	169	PF00018	0.538
LIG_SH3_3	183	189	PF00018	0.744
LIG_SH3_3	252	258	PF00018	0.719
LIG_SH3_3	390	396	PF00018	0.416
LIG_SH3_3	406	412	PF00018	0.225
LIG_SH3_3	443	449	PF00018	0.595
LIG_SH3_4	319	326	PF00018	0.444
LIG_SUMO_SIM_anti_2	215	224	PF11976	0.734
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.611
LIG_SUMO_SIM_par_1	29	35	PF11976	0.367
LIG_TRAF2_1	239	242	PF00917	0.677
LIG_UBA3_1	144	153	PF00899	0.561
LIG_UBA3_1	502	508	PF00899	0.544
LIG_UBA3_1	594	598	PF00899	0.454
LIG_WRC_WIRS_1	413	418	PF05994	0.444
LIG_WW_1	496	499	PF00397	0.458
MOD_CK1_1	118	124	PF00069	0.641
MOD_CK1_1	21	27	PF00069	0.639
MOD_CK1_1	217	223	PF00069	0.705
MOD_CK1_1	415	421	PF00069	0.444
MOD_CK1_1	476	482	PF00069	0.680
MOD_CK1_1	609	615	PF00069	0.660
MOD_CK2_1	210	216	PF00069	0.773
MOD_CK2_1	220	226	PF00069	0.675
MOD_CK2_1	291	297	PF00069	0.590
MOD_CK2_1	369	375	PF00069	0.477
MOD_CK2_1	414	420	PF00069	0.401
MOD_CK2_1	466	472	PF00069	0.667
MOD_CK2_1	609	615	PF00069	0.674
MOD_GlcNHglycan	189	192	PF01048	0.676
MOD_GlcNHglycan	206	209	PF01048	0.749
MOD_GlcNHglycan	216	219	PF01048	0.705
MOD_GlcNHglycan	362	365	PF01048	0.441
MOD_GlcNHglycan	417	420	PF01048	0.436
MOD_GlcNHglycan	475	478	PF01048	0.632
MOD_GSK3_1	113	120	PF00069	0.672
MOD_GSK3_1	210	217	PF00069	0.720
MOD_GSK3_1	23	30	PF00069	0.459
MOD_GSK3_1	293	300	PF00069	0.627
MOD_GSK3_1	302	309	PF00069	0.468
MOD_GSK3_1	456	463	PF00069	0.628
MOD_GSK3_1	5	12	PF00069	0.442
MOD_GSK3_1	617	624	PF00069	0.470
MOD_LATS_1	212	218	PF00433	0.747
MOD_LATS_1	353	359	PF00433	0.441
MOD_LATS_1	540	546	PF00433	0.575
MOD_N-GLC_1	125	130	PF02516	0.555
MOD_N-GLC_2	359	361	PF02516	0.444
MOD_NEK2_1	250	255	PF00069	0.674
MOD_NEK2_1	291	296	PF00069	0.679
MOD_NEK2_1	414	419	PF00069	0.500
MOD_NEK2_1	433	438	PF00069	0.245
MOD_NEK2_1	456	461	PF00069	0.573
MOD_NEK2_1	486	491	PF00069	0.479
MOD_NEK2_1	541	546	PF00069	0.561
MOD_NEK2_1	563	568	PF00069	0.527
MOD_NEK2_1	599	604	PF00069	0.508
MOD_NEK2_1	621	626	PF00069	0.401
MOD_NEK2_2	23	28	PF00069	0.561
MOD_NEK2_2	526	531	PF00069	0.532
MOD_PIKK_1	403	409	PF00454	0.439
MOD_PIKK_1	529	535	PF00454	0.548
MOD_PIKK_1	599	605	PF00454	0.553
MOD_PIKK_1	606	612	PF00454	0.640
MOD_PKA_1	606	612	PF00069	0.608
MOD_PKA_2	116	122	PF00069	0.636
MOD_PKA_2	149	155	PF00069	0.604
MOD_PKA_2	182	188	PF00069	0.782
MOD_PKA_2	21	27	PF00069	0.583
MOD_PKA_2	369	375	PF00069	0.252
MOD_PKA_2	421	427	PF00069	0.444
MOD_PKA_2	541	547	PF00069	0.553
MOD_PKB_1	437	445	PF00069	0.680
MOD_PKB_1	458	466	PF00069	0.644
MOD_Plk_1	125	131	PF00069	0.404
MOD_Plk_1	2	8	PF00069	0.466
MOD_Plk_1	456	462	PF00069	0.615
MOD_Plk_2-3	2	8	PF00069	0.576
MOD_Plk_4	125	131	PF00069	0.404
MOD_Plk_4	421	427	PF00069	0.444
MOD_Plk_4	486	492	PF00069	0.684
MOD_Plk_4	5	11	PF00069	0.448
MOD_Plk_4	563	569	PF00069	0.494
MOD_ProDKin_1	306	312	PF00069	0.454
MOD_ProDKin_1	609	615	PF00069	0.635
MOD_SUMO_for_1	258	261	PF00179	0.757
MOD_SUMO_rev_2	43	48	PF00179	0.560
TRG_DiLeu_BaEn_1	534	539	PF01217	0.639
TRG_DiLeu_BaEn_1	88	93	PF01217	0.612
TRG_DiLeu_BaEn_4	264	270	PF01217	0.590
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.485
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.613
TRG_ENDOCYTIC_2	155	158	PF00928	0.589
TRG_ENDOCYTIC_2	237	240	PF00928	0.597
TRG_ENDOCYTIC_2	392	395	PF00928	0.369
TRG_ENDOCYTIC_2	430	433	PF00928	0.485
TRG_ENDOCYTIC_2	499	502	PF00928	0.415
TRG_ENDOCYTIC_2	564	567	PF00928	0.410
TRG_ENDOCYTIC_2	625	628	PF00928	0.475
TRG_ER_diArg_1	243	246	PF00400	0.610
TRG_ER_diArg_1	27	29	PF00400	0.484
TRG_ER_diArg_1	437	439	PF00400	0.485
TRG_ER_diArg_1	458	461	PF00400	0.661
TRG_ER_diArg_1	568	571	PF00400	0.602
TRG_NLS_MonoExtN_4	243	248	PF00514	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE2	Leptomonas seymouri	58%	100%
A0A1X0NIZ1	Trypanosomatidae	33%	100%
A0A3S5IRI6	Trypanosoma rangeli	34%	100%
A0A3S7X8N7	Leishmania donovani	91%	100%
A4HM65	Leishmania braziliensis	79%	100%
A4IAS7	Leishmania infantum	91%	100%
E9B5R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B380	Trypanosoma cruzi	33%	100%