Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEK2_LEIMA

TriTrypDb:

LmjF.35.0250 , LMJLV39_350007500 , LMJSD75_350007600

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	333	335	PF00675	0.713
CLV_NRD_NRD_1	386	388	PF00675	0.732
CLV_NRD_NRD_1	430	432	PF00675	0.611
CLV_NRD_NRD_1	6	8	PF00675	0.477
CLV_NRD_NRD_1	677	679	PF00675	0.584
CLV_NRD_NRD_1	688	690	PF00675	0.564
CLV_PCSK_KEX2_1	333	335	PF00082	0.713
CLV_PCSK_KEX2_1	386	388	PF00082	0.679
CLV_PCSK_KEX2_1	6	8	PF00082	0.477
CLV_PCSK_KEX2_1	687	689	PF00082	0.582
CLV_PCSK_KEX2_1	711	713	PF00082	0.660
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.535
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.660
CLV_PCSK_SKI1_1	140	144	PF00082	0.543
CLV_PCSK_SKI1_1	239	243	PF00082	0.541
CLV_PCSK_SKI1_1	334	338	PF00082	0.716
CLV_Separin_Metazoa	95	99	PF03568	0.543
DEG_APCC_DBOX_1	69	77	PF00400	0.605
DEG_SPOP_SBC_1	324	328	PF00917	0.420
DEG_SPOP_SBC_1	497	501	PF00917	0.716
DOC_CDC14_PxL_1	602	610	PF14671	0.541
DOC_CYCLIN_yClb3_PxF_3	132	140	PF00134	0.605
DOC_CYCLIN_yClb5_NLxxxL_5	349	358	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	608	614	PF00134	0.566
DOC_MAPK_MEF2A_6	615	623	PF00069	0.526
DOC_PP2B_LxvP_1	587	590	PF13499	0.602
DOC_PP2B_LxvP_1	608	611	PF13499	0.622
DOC_PP2B_LxvP_1	619	622	PF13499	0.461
DOC_PP4_FxxP_1	193	196	PF00568	0.596
DOC_USP7_MATH_1	155	159	PF00917	0.713
DOC_USP7_MATH_1	258	262	PF00917	0.505
DOC_USP7_MATH_1	406	410	PF00917	0.737
DOC_USP7_MATH_1	497	501	PF00917	0.724
DOC_WW_Pin1_4	128	133	PF00397	0.664
DOC_WW_Pin1_4	151	156	PF00397	0.742
DOC_WW_Pin1_4	192	197	PF00397	0.532
DOC_WW_Pin1_4	361	366	PF00397	0.780
DOC_WW_Pin1_4	556	561	PF00397	0.767
DOC_WW_Pin1_4	593	598	PF00397	0.642
DOC_WW_Pin1_4	634	639	PF00397	0.599
LIG_14-3-3_CanoR_1	101	109	PF00244	0.537
LIG_14-3-3_CanoR_1	120	128	PF00244	0.552
LIG_14-3-3_CanoR_1	147	155	PF00244	0.748
LIG_14-3-3_CanoR_1	180	187	PF00244	0.511
LIG_14-3-3_CanoR_1	323	330	PF00244	0.657
LIG_14-3-3_CanoR_1	333	337	PF00244	0.662
LIG_14-3-3_CanoR_1	377	385	PF00244	0.740
LIG_14-3-3_CanoR_1	545	552	PF00244	0.602
LIG_14-3-3_CanoR_1	6	11	PF00244	0.526
LIG_14-3-3_CanoR_1	615	619	PF00244	0.626
LIG_14-3-3_CanoR_1	678	686	PF00244	0.620
LIG_Actin_WH2_2	529	547	PF00022	0.584
LIG_Actin_WH2_2	82	100	PF00022	0.597
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_BRCT_BRCA1_1	421	425	PF00533	0.658
LIG_BRCT_BRCA1_1	595	599	PF00533	0.580
LIG_Clathr_ClatBox_1	460	464	PF01394	0.515
LIG_eIF4E_1	598	604	PF01652	0.600
LIG_FHA_1	101	107	PF00498	0.432
LIG_FHA_1	129	135	PF00498	0.610
LIG_FHA_1	261	267	PF00498	0.535
LIG_FHA_1	279	285	PF00498	0.552
LIG_FHA_1	286	292	PF00498	0.520
LIG_FHA_1	3	9	PF00498	0.497
LIG_FHA_1	349	355	PF00498	0.712
LIG_FHA_1	45	51	PF00498	0.554
LIG_FHA_1	506	512	PF00498	0.577
LIG_FHA_1	575	581	PF00498	0.445
LIG_FHA_1	615	621	PF00498	0.490
LIG_FHA_1	678	684	PF00498	0.600
LIG_FHA_1	85	91	PF00498	0.493
LIG_FHA_2	134	140	PF00498	0.583
LIG_FHA_2	207	213	PF00498	0.462
LIG_FHA_2	308	314	PF00498	0.637
LIG_FHA_2	557	563	PF00498	0.724
LIG_LIR_Gen_1	261	272	PF02991	0.532
LIG_LIR_Gen_1	288	295	PF02991	0.534
LIG_LIR_Gen_1	508	516	PF02991	0.552
LIG_LIR_Gen_1	637	647	PF02991	0.332
LIG_LIR_Nem_3	261	267	PF02991	0.535
LIG_LIR_Nem_3	288	293	PF02991	0.540
LIG_LIR_Nem_3	35	39	PF02991	0.461
LIG_LIR_Nem_3	422	428	PF02991	0.656
LIG_LIR_Nem_3	508	512	PF02991	0.534
LIG_LIR_Nem_3	596	602	PF02991	0.501
LIG_LIR_Nem_3	637	643	PF02991	0.339
LIG_LYPXL_S_1	604	608	PF13949	0.541
LIG_LYPXL_yS_3	605	608	PF13949	0.550
LIG_MLH1_MIPbox_1	595	599	PF16413	0.652
LIG_SH2_CRK	187	191	PF00017	0.402
LIG_SH2_CRK	456	460	PF00017	0.531
LIG_SH2_CRK	484	488	PF00017	0.518
LIG_SH2_CRK	655	659	PF00017	0.483
LIG_SH2_SRC	217	220	PF00017	0.477
LIG_SH2_STAP1	217	221	PF00017	0.480
LIG_SH2_STAP1	456	460	PF00017	0.531
LIG_SH2_STAP1	655	659	PF00017	0.430
LIG_SH2_STAT5	187	190	PF00017	0.431
LIG_SH2_STAT5	255	258	PF00017	0.535
LIG_SH2_STAT5	264	267	PF00017	0.511
LIG_SH2_STAT5	598	601	PF00017	0.506
LIG_SH3_3	129	135	PF00018	0.669
LIG_SH3_3	228	234	PF00018	0.540
LIG_SH3_3	362	368	PF00018	0.756
LIG_SH3_3	485	491	PF00018	0.465
LIG_SH3_3	594	600	PF00018	0.662
LIG_SH3_3	654	660	PF00018	0.464
LIG_SUMO_SIM_anti_2	617	622	PF11976	0.587
LIG_TRAF2_1	136	139	PF00917	0.585
LIG_TRAF2_1	162	165	PF00917	0.655
LIG_TRFH_1	602	606	PF08558	0.593
LIG_TYR_ITIM	603	608	PF00017	0.535
LIG_UBA3_1	424	432	PF00899	0.575
LIG_WRC_WIRS_1	134	139	PF05994	0.570
MOD_CK1_1	133	139	PF00069	0.552
MOD_CK1_1	148	154	PF00069	0.714
MOD_CK1_1	158	164	PF00069	0.631
MOD_CK1_1	2	8	PF00069	0.598
MOD_CK1_1	279	285	PF00069	0.573
MOD_CK1_1	328	334	PF00069	0.670
MOD_CK1_1	438	444	PF00069	0.534
MOD_CK1_1	529	535	PF00069	0.569
MOD_CK1_1	633	639	PF00069	0.501
MOD_CK1_1	9	15	PF00069	0.513
MOD_CK2_1	133	139	PF00069	0.643
MOD_CK2_1	167	173	PF00069	0.564
MOD_CK2_1	206	212	PF00069	0.456
MOD_CK2_1	307	313	PF00069	0.633
MOD_CK2_1	431	437	PF00069	0.766
MOD_CK2_1	438	444	PF00069	0.640
MOD_CK2_1	535	541	PF00069	0.556
MOD_CK2_1	89	95	PF00069	0.495
MOD_GlcNHglycan	148	151	PF01048	0.634
MOD_GlcNHglycan	169	172	PF01048	0.605
MOD_GlcNHglycan	175	179	PF01048	0.521
MOD_GlcNHglycan	25	28	PF01048	0.478
MOD_GlcNHglycan	273	276	PF01048	0.611
MOD_GlcNHglycan	303	306	PF01048	0.665
MOD_GlcNHglycan	327	330	PF01048	0.686
MOD_GlcNHglycan	373	376	PF01048	0.758
MOD_GlcNHglycan	410	413	PF01048	0.730
MOD_GlcNHglycan	433	436	PF01048	0.692
MOD_GlcNHglycan	441	444	PF01048	0.661
MOD_GlcNHglycan	528	531	PF01048	0.606
MOD_GlcNHglycan	58	61	PF01048	0.499
MOD_GlcNHglycan	91	94	PF01048	0.565
MOD_GSK3_1	120	127	PF00069	0.691
MOD_GSK3_1	146	153	PF00069	0.767
MOD_GSK3_1	154	161	PF00069	0.679
MOD_GSK3_1	2	9	PF00069	0.564
MOD_GSK3_1	279	286	PF00069	0.538
MOD_GSK3_1	303	310	PF00069	0.670
MOD_GSK3_1	324	331	PF00069	0.624
MOD_GSK3_1	341	348	PF00069	0.686
MOD_GSK3_1	431	438	PF00069	0.697
MOD_GSK3_1	566	573	PF00069	0.592
MOD_GSK3_1	610	617	PF00069	0.590
MOD_GSK3_1	621	628	PF00069	0.483
MOD_GSK3_1	629	636	PF00069	0.428
MOD_N-GLC_1	120	125	PF02516	0.704
MOD_N-GLC_1	394	399	PF02516	0.823
MOD_N-GLC_1	45	50	PF02516	0.560
MOD_NEK2_1	1	6	PF00069	0.616
MOD_NEK2_1	109	114	PF00069	0.630
MOD_NEK2_1	259	264	PF00069	0.513
MOD_NEK2_1	283	288	PF00069	0.532
MOD_NEK2_1	291	296	PF00069	0.590
MOD_NEK2_1	303	308	PF00069	0.355
MOD_NEK2_1	322	327	PF00069	0.502
MOD_NEK2_1	349	354	PF00069	0.679
MOD_NEK2_1	394	399	PF00069	0.643
MOD_NEK2_1	424	429	PF00069	0.653
MOD_NEK2_1	544	549	PF00069	0.643
MOD_NEK2_1	614	619	PF00069	0.543
MOD_NEK2_2	345	350	PF00069	0.707
MOD_NEK2_2	570	575	PF00069	0.388
MOD_PIKK_1	126	132	PF00454	0.758
MOD_PK_1	6	12	PF00069	0.528
MOD_PKA_1	386	392	PF00069	0.805
MOD_PKA_1	431	437	PF00069	0.685
MOD_PKA_1	6	12	PF00069	0.528
MOD_PKA_2	100	106	PF00069	0.560
MOD_PKA_2	119	125	PF00069	0.541
MOD_PKA_2	146	152	PF00069	0.692
MOD_PKA_2	179	185	PF00069	0.502
MOD_PKA_2	322	328	PF00069	0.636
MOD_PKA_2	332	338	PF00069	0.663
MOD_PKA_2	349	355	PF00069	0.712
MOD_PKA_2	376	382	PF00069	0.782
MOD_PKA_2	386	392	PF00069	0.749
MOD_PKA_2	430	436	PF00069	0.686
MOD_PKA_2	544	550	PF00069	0.607
MOD_PKA_2	6	12	PF00069	0.528
MOD_PKA_2	614	620	PF00069	0.615
MOD_PKA_2	677	683	PF00069	0.628
MOD_Plk_1	138	144	PF00069	0.595
MOD_Plk_1	174	180	PF00069	0.492
MOD_Plk_1	394	400	PF00069	0.733
MOD_Plk_1	45	51	PF00069	0.554
MOD_Plk_2-3	625	631	PF00069	0.649
MOD_Plk_4	138	144	PF00069	0.595
MOD_Plk_4	212	218	PF00069	0.590
MOD_Plk_4	279	285	PF00069	0.579
MOD_Plk_4	614	620	PF00069	0.543
MOD_ProDKin_1	128	134	PF00069	0.653
MOD_ProDKin_1	151	157	PF00069	0.740
MOD_ProDKin_1	192	198	PF00069	0.533
MOD_ProDKin_1	361	367	PF00069	0.782
MOD_ProDKin_1	556	562	PF00069	0.768
MOD_ProDKin_1	593	599	PF00069	0.632
MOD_ProDKin_1	634	640	PF00069	0.598
MOD_SUMO_rev_2	133	142	PF00179	0.596
TRG_DiLeu_BaEn_1	139	144	PF01217	0.600
TRG_DiLeu_BaEn_2	137	143	PF01217	0.593
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.533
TRG_ENDOCYTIC_2	187	190	PF00928	0.406
TRG_ENDOCYTIC_2	264	267	PF00928	0.511
TRG_ENDOCYTIC_2	31	34	PF00928	0.428
TRG_ENDOCYTIC_2	456	459	PF00928	0.536
TRG_ENDOCYTIC_2	605	608	PF00928	0.549
TRG_ENDOCYTIC_2	655	658	PF00928	0.435
TRG_ER_diArg_1	385	387	PF00400	0.728
TRG_ER_diArg_1	6	8	PF00400	0.477
TRG_ER_diArg_1	688	690	PF00400	0.566
TRG_ER_diArg_1	70	73	PF00400	0.651
TRG_NLS_MonoCore_2	710	715	PF00514	0.734
TRG_NLS_MonoExtC_3	710	716	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L9	Leptomonas seymouri	64%	98%
A0A3Q8IJ18	Leishmania donovani	94%	100%
A4HM64	Leishmania braziliensis	82%	100%
A4IAS6	Leishmania infantum	94%	100%
D0A2D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B5R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%