C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEK0_LEIMA

TriTrypDb:

LmjF.35.0230 , LMJLV39_350007300 , LMJSD75_350007400

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.697
CLV_NRD_NRD_1	128	130	PF00675	0.659
CLV_PCSK_KEX2_1	127	129	PF00082	0.702
CLV_PCSK_KEX2_1	174	176	PF00082	0.715
CLV_PCSK_KEX2_1	245	247	PF00082	0.482
CLV_PCSK_KEX2_1	335	337	PF00082	0.741
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.566
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.504
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.741
CLV_PCSK_SKI1_1	266	270	PF00082	0.436
DEG_SPOP_SBC_1	12	16	PF00917	0.662
DOC_ANK_TNKS_1	126	133	PF00023	0.780
DOC_MAPK_MEF2A_6	34	41	PF00069	0.415
DOC_PP2B_LxvP_1	221	224	PF13499	0.476
DOC_USP7_MATH_1	114	118	PF00917	0.546
DOC_USP7_MATH_1	209	213	PF00917	0.509
DOC_USP7_MATH_1	30	34	PF00917	0.575
DOC_USP7_MATH_1	48	52	PF00917	0.499
DOC_USP7_MATH_1	75	79	PF00917	0.447
DOC_USP7_MATH_1	86	90	PF00917	0.470
DOC_USP7_UBL2_3	241	245	PF12436	0.547
DOC_WW_Pin1_4	110	115	PF00397	0.679
DOC_WW_Pin1_4	16	21	PF00397	0.674
DOC_WW_Pin1_4	175	180	PF00397	0.601
DOC_WW_Pin1_4	304	309	PF00397	0.711
LIG_14-3-3_CanoR_1	122	131	PF00244	0.711
LIG_14-3-3_CanoR_1	149	155	PF00244	0.727
LIG_14-3-3_CanoR_1	175	179	PF00244	0.735
LIG_14-3-3_CanoR_1	341	347	PF00244	0.689
LIG_DCNL_PONY_1	1	4	PF03556	0.659
LIG_FHA_2	189	195	PF00498	0.623
LIG_FHA_2	214	220	PF00498	0.434
LIG_LIR_Gen_1	216	224	PF02991	0.429
LIG_LIR_LC3C_4	134	139	PF02991	0.748
LIG_LIR_Nem_3	108	112	PF02991	0.711
LIG_LIR_Nem_3	216	221	PF02991	0.411
LIG_PAM2_1	2	14	PF00658	0.673
LIG_PCNA_yPIPBox_3	266	278	PF02747	0.384
LIG_SH2_CRK	218	222	PF00017	0.435
LIG_SH2_GRB2like	42	45	PF00017	0.518
LIG_SH2_SRC	348	351	PF00017	0.560
LIG_SH2_SRC	42	45	PF00017	0.518
LIG_SH2_STAP1	218	222	PF00017	0.534
LIG_SH2_STAP1	278	282	PF00017	0.439
LIG_SH2_STAP1	348	352	PF00017	0.680
LIG_SH2_STAP1	7	11	PF00017	0.508
LIG_SH2_STAT3	278	281	PF00017	0.543
LIG_SH3_2	144	149	PF14604	0.529
LIG_SH3_2	283	288	PF14604	0.672
LIG_SH3_3	141	147	PF00018	0.757
LIG_SH3_3	184	190	PF00018	0.636
LIG_SH3_3	280	286	PF00018	0.628
LIG_SUMO_SIM_par_1	354	360	PF11976	0.650
MOD_CDK_SPxK_1	304	310	PF00069	0.737
MOD_CK1_1	14	20	PF00069	0.718
MOD_CK1_1	153	159	PF00069	0.667
MOD_CK1_1	161	167	PF00069	0.644
MOD_CK1_1	173	179	PF00069	0.565
MOD_CK1_1	303	309	PF00069	0.705
MOD_CK1_1	317	323	PF00069	0.565
MOD_CK1_1	342	348	PF00069	0.746
MOD_CK2_1	157	163	PF00069	0.691
MOD_CK2_1	48	54	PF00069	0.558
MOD_CK2_1	86	92	PF00069	0.580
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.551
MOD_GlcNHglycan	116	119	PF01048	0.584
MOD_GlcNHglycan	141	144	PF01048	0.597
MOD_GlcNHglycan	160	163	PF01048	0.767
MOD_GlcNHglycan	20	23	PF01048	0.706
MOD_GlcNHglycan	321	324	PF01048	0.613
MOD_GSK3_1	110	117	PF00069	0.608
MOD_GSK3_1	150	157	PF00069	0.651
MOD_GSK3_1	170	177	PF00069	0.727
MOD_GSK3_1	209	216	PF00069	0.507
MOD_GSK3_1	299	306	PF00069	0.667
MOD_GSK3_1	310	317	PF00069	0.630
MOD_GSK3_1	337	344	PF00069	0.637
MOD_GSK3_1	57	64	PF00069	0.533
MOD_GSK3_1	7	14	PF00069	0.611
MOD_LATS_1	339	345	PF00433	0.694
MOD_N-GLC_1	342	347	PF02516	0.748
MOD_NEK2_1	137	142	PF00069	0.636
MOD_NEK2_1	154	159	PF00069	0.485
MOD_NEK2_1	301	306	PF00069	0.749
MOD_NEK2_1	330	335	PF00069	0.703
MOD_NEK2_1	337	342	PF00069	0.718
MOD_NEK2_1	70	75	PF00069	0.509
MOD_NEK2_1	84	89	PF00069	0.462
MOD_PIKK_1	225	231	PF00454	0.503
MOD_PIKK_1	310	316	PF00454	0.754
MOD_PIKK_1	63	69	PF00454	0.452
MOD_PIKK_1	84	90	PF00454	0.499
MOD_PKA_1	174	180	PF00069	0.554
MOD_PKA_2	174	180	PF00069	0.737
MOD_PKA_2	57	63	PF00069	0.516
MOD_Plk_1	120	126	PF00069	0.734
MOD_Plk_1	342	348	PF00069	0.749
MOD_Plk_4	2	8	PF00069	0.604
MOD_Plk_4	213	219	PF00069	0.420
MOD_Plk_4	342	348	PF00069	0.697
MOD_ProDKin_1	110	116	PF00069	0.678
MOD_ProDKin_1	16	22	PF00069	0.678
MOD_ProDKin_1	175	181	PF00069	0.600
MOD_ProDKin_1	304	310	PF00069	0.714
TRG_ENDOCYTIC_2	109	112	PF00928	0.728
TRG_ENDOCYTIC_2	217	220	PF00928	0.405
TRG_ER_diArg_1	127	129	PF00400	0.757
TRG_ER_diArg_1	204	207	PF00400	0.508
TRG_NES_CRM1_1	67	77	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P9	Leptomonas seymouri	57%	99%
A0A1X0NKL5	Trypanosomatidae	43%	98%
A0A3Q8IV00	Leishmania donovani	92%	100%
A0A422NNF8	Trypanosoma rangeli	40%	99%
A4HM62	Leishmania braziliensis	73%	100%
A4IAS4	Leishmania infantum	92%	100%
E9B5R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNB0	Trypanosoma cruzi	39%	100%