Protein kish

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kish

Gene product:

Protein of unknown function (DUF1242), putative

Species:

Leishmania major

UniProt:

E9AEJ8_LEIMA

TriTrypDb:

LmjF.35.0210 , LMJLV39_350007100 , LMJSD75_350007200

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	8
GO:0016020	membrane	2	8
GO:0031090	organelle membrane	3	8
GO:0098588	bounding membrane of organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AEJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEJ8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0008104	protein localization	4	2
GO:0009306	protein secretion	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0032940	secretion by cell	3	2
GO:0033036	macromolecule localization	2	2
GO:0035592	establishment of protein localization to extracellular region	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046903	secretion	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071692	protein localization to extracellular region	5	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0140352	export from cell	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	41	45	PF00082	0.277
CLV_PCSK_SKI1_1	68	72	PF00082	0.455
DOC_MAPK_MEF2A_6	53	60	PF00069	0.515
DOC_PP1_RVXF_1	66	72	PF00149	0.389
DOC_USP7_MATH_1	56	60	PF00917	0.461
DOC_USP7_UBL2_3	42	46	PF12436	0.477
DOC_WW_Pin1_4	52	57	PF00397	0.515
LIG_BIR_II_1	1	5	PF00653	0.409
LIG_BRCT_BRCA1_1	1	5	PF00533	0.420
LIG_Clathr_ClatBox_1	4	8	PF01394	0.472
LIG_LIR_Gen_1	55	65	PF02991	0.389
LIG_LIR_Gen_1	6	15	PF02991	0.323
LIG_LIR_Nem_3	35	40	PF02991	0.554
LIG_LIR_Nem_3	55	60	PF02991	0.357
LIG_LIR_Nem_3	6	10	PF02991	0.369
LIG_NRBOX	10	16	PF00104	0.461
LIG_Pex14_2	67	71	PF04695	0.461
LIG_SH2_PTP2	12	15	PF00017	0.389
LIG_SH2_STAT3	23	26	PF00017	0.336
LIG_SH2_STAT5	12	15	PF00017	0.386
LIG_SH2_STAT5	23	26	PF00017	0.158
LIG_SUMO_SIM_par_1	14	20	PF11976	0.336
LIG_TYR_ITIM	10	15	PF00017	0.461
MOD_GlcNHglycan	1	4	PF01048	0.647
MOD_GSK3_1	52	59	PF00069	0.567
MOD_PKA_2	27	33	PF00069	0.515
MOD_Plk_4	19	25	PF00069	0.276
MOD_Plk_4	27	33	PF00069	0.477
MOD_Plk_4	45	51	PF00069	0.554
MOD_Plk_4	6	12	PF00069	0.302
MOD_ProDKin_1	52	58	PF00069	0.515
TRG_ENDOCYTIC_2	12	15	PF00928	0.389
TRG_ENDOCYTIC_2	40	43	PF00928	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JU30	Bodo saltans	71%	100%
A0A3Q8IHY3	Leishmania donovani	97%	100%
A2VDC5	Xenopus laevis	44%	100%
A4HM60	Leishmania braziliensis	95%	100%
A4IAS2	Leishmania infantum	97%	100%
B5G2S6	Taeniopygia guttata	44%	100%
D0A2D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9B5Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
G2TRS3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
Q148I3	Bos taurus	46%	100%
Q28FL7	Xenopus tropicalis	44%	100%
Q54HH9	Dictyostelium discoideum	40%	100%
Q5BJC2	Danio rerio	41%	100%
Q5RAL1	Pongo abelii	46%	100%
Q5ZII6	Gallus gallus	46%	100%
Q8TBQ9	Homo sapiens	46%	100%
Q8TGJ3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q9CR64	Mus musculus	43%	100%
Q9VWH8	Drosophila melanogaster	44%	100%