FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

E9AEJ6_LEIMA

TriTrypDb:

LmjF.35.0190 , LMJLV39_350006900 , LMJSD75_350007000

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 41
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	9
GO:0016020	membrane	2	7

Expansion

Sequence features

E9AEJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEJ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004721	phosphoprotein phosphatase activity	3	5
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.343
CLV_NRD_NRD_1	130	132	PF00675	0.360
CLV_NRD_NRD_1	24	26	PF00675	0.685
CLV_PCSK_KEX2_1	205	207	PF00082	0.464
CLV_PCSK_KEX2_1	26	28	PF00082	0.646
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.501
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.685
CLV_PCSK_PC7_1	22	28	PF00082	0.748
CLV_PCSK_SKI1_1	50	54	PF00082	0.388
DEG_APCC_DBOX_1	130	138	PF00400	0.360
DEG_Nend_UBRbox_3	1	3	PF02207	0.745
DEG_ODPH_VHL_1	40	53	PF01847	0.449
DOC_MAPK_MEF2A_6	33	40	PF00069	0.561
DOC_MAPK_MEF2A_6	50	57	PF00069	0.309
DOC_MAPK_MEF2A_6	83	91	PF00069	0.330
DOC_MAPK_NFAT4_5	50	58	PF00069	0.351
DOC_PP4_FxxP_1	192	195	PF00568	0.320
DOC_USP7_MATH_1	102	106	PF00917	0.474
DOC_WW_Pin1_4	147	152	PF00397	0.325
LIG_eIF4E_1	178	184	PF01652	0.350
LIG_FHA_1	91	97	PF00498	0.319
LIG_GBD_Chelix_1	53	61	PF00786	0.329
LIG_LIR_Apic_2	189	195	PF02991	0.315
LIG_MAD2	143	151	PF02301	0.373
LIG_SH2_CRK	70	74	PF00017	0.358
LIG_SH2_GRB2like	216	219	PF00017	0.528
LIG_SH2_NCK_1	178	182	PF00017	0.459
LIG_SH2_NCK_1	70	74	PF00017	0.309
LIG_SH2_SRC	216	219	PF00017	0.496
LIG_SH2_STAP1	99	103	PF00017	0.330
LIG_SH2_STAT5	216	219	PF00017	0.435
LIG_SH2_STAT5	220	223	PF00017	0.404
LIG_SH3_1	70	76	PF00018	0.433
LIG_SH3_3	36	42	PF00018	0.560
LIG_SH3_3	70	76	PF00018	0.412
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.308
LIG_SUMO_SIM_anti_2	84	91	PF11976	0.337
LIG_SUMO_SIM_par_1	142	148	PF11976	0.346
LIG_SUMO_SIM_par_1	50	56	PF11976	0.329
MOD_CK1_1	190	196	PF00069	0.410
MOD_CK2_1	162	168	PF00069	0.425
MOD_GlcNHglycan	65	68	PF01048	0.402
MOD_GSK3_1	102	109	PF00069	0.399
MOD_GSK3_1	27	34	PF00069	0.664
MOD_N-GLC_1	190	195	PF02516	0.446
MOD_N-GLC_1	31	36	PF02516	0.620
MOD_NEK2_1	187	192	PF00069	0.365
MOD_NEK2_1	57	62	PF00069	0.307
MOD_NEK2_1	63	68	PF00069	0.307
MOD_PKB_1	25	33	PF00069	0.569
MOD_PKB_1	5	13	PF00069	0.538
MOD_Plk_1	173	179	PF00069	0.320
MOD_Plk_1	190	196	PF00069	0.444
MOD_Plk_1	57	63	PF00069	0.326
MOD_Plk_4	173	179	PF00069	0.366
MOD_Plk_4	57	63	PF00069	0.317
MOD_ProDKin_1	147	153	PF00069	0.325
MOD_SUMO_for_1	11	14	PF00179	0.453
MOD_SUMO_for_1	204	207	PF00179	0.525
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z9	Leptomonas seymouri	43%	82%
A0A0N1HTD7	Leptomonas seymouri	28%	83%
A0A0N1IKD3	Leptomonas seymouri	91%	98%
A0A0N1PG96	Leptomonas seymouri	27%	68%
A0A0S4IJH3	Bodo saltans	30%	83%
A0A0S4ILH7	Bodo saltans	30%	67%
A0A0S4IMS1	Bodo saltans	25%	71%
A0A0S4IUQ9	Bodo saltans	39%	66%
A0A0S4J5Z2	Bodo saltans	30%	75%
A0A0S4JCX0	Bodo saltans	31%	73%
A0A0S4JU61	Bodo saltans	46%	88%
A0A0S4JWE2	Bodo saltans	65%	90%
A0A1X0NJT2	Trypanosomatidae	66%	89%
A0A1X0NLU1	Trypanosomatidae	47%	95%
A0A1X0NR11	Trypanosomatidae	31%	71%
A0A1X0P5T3	Trypanosomatidae	37%	75%
A0A1X0PA23	Trypanosomatidae	43%	68%
A0A3Q8IHT4	Leishmania donovani	30%	84%
A0A3R7LAC9	Trypanosoma rangeli	42%	67%
A0A3R7NSE5	Trypanosoma rangeli	61%	89%
A0A3S7X8P8	Leishmania donovani	98%	100%
A0A3S7XCG7	Leishmania donovani	41%	82%
A0A422NVW2	Trypanosoma rangeli	48%	94%
A0A422P410	Trypanosoma rangeli	34%	66%
A4HEM1	Leishmania braziliensis	29%	83%
A4HFZ5	Leishmania braziliensis	31%	84%
A4HM58	Leishmania braziliensis	98%	100%
A4HQK0	Leishmania braziliensis	43%	82%
A4I314	Leishmania infantum	30%	84%
A4IAS0	Leishmania infantum	98%	100%
A4ICB8	Leishmania infantum	41%	82%
C9ZJI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	71%
C9ZZ90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	85%
D0A2E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	97%
D0A3Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	90%
E9ACT5	Leishmania major	31%	84%
E9AEA2	Leishmania major	38%	100%
E9ALI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	80%
E9AUB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	82%
E9AZC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	84%
E9B5Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O14595	Homo sapiens	30%	89%
O15194	Homo sapiens	27%	87%
O95476	Homo sapiens	25%	98%
P58465	Mus musculus	29%	87%
P58466	Mus musculus	29%	92%
Q09695	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	74%
Q1RMV9	Bos taurus	25%	98%
Q28HW9	Xenopus tropicalis	27%	98%
Q29I63	Drosophila pseudoobscura pseudoobscura	24%	99%
Q3B7T6	Rattus norvegicus	26%	98%
Q3TP92	Mus musculus	26%	98%
Q4Q077	Leishmania major	41%	82%
Q5U395	Danio rerio	26%	98%
Q5U3T3	Danio rerio	26%	98%
Q8BX07	Mus musculus	29%	89%
Q8JIL9	Xenopus laevis	27%	98%
Q9GZU7	Homo sapiens	29%	92%
Q9PTJ6	Gallus gallus	30%	87%
Q9VRG7	Drosophila melanogaster	24%	99%
V5AYU0	Trypanosoma cruzi	32%	70%
V5BAV0	Trypanosoma cruzi	36%	82%
V5BHN4	Trypanosoma cruzi	48%	94%
V5BSW0	Trypanosoma cruzi	63%	89%