Myosin_tail_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEJ5_LEIMA

TriTrypDb:

LmjF.35.0180 , LMJLV39_350006800 , LMJSD75_350006900

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	432	436	PF00656	0.476
CLV_NRD_NRD_1	19	21	PF00675	0.439
CLV_NRD_NRD_1	190	192	PF00675	0.560
CLV_NRD_NRD_1	268	270	PF00675	0.570
CLV_NRD_NRD_1	524	526	PF00675	0.675
CLV_NRD_NRD_1	663	665	PF00675	0.657
CLV_NRD_NRD_1	707	709	PF00675	0.561
CLV_NRD_NRD_1	715	717	PF00675	0.568
CLV_NRD_NRD_1	738	740	PF00675	0.570
CLV_NRD_NRD_1	806	808	PF00675	0.569
CLV_NRD_NRD_1	834	836	PF00675	0.593
CLV_NRD_NRD_1	90	92	PF00675	0.537
CLV_PCSK_KEX2_1	268	270	PF00082	0.631
CLV_PCSK_KEX2_1	391	393	PF00082	0.477
CLV_PCSK_KEX2_1	662	664	PF00082	0.549
CLV_PCSK_KEX2_1	707	709	PF00082	0.562
CLV_PCSK_KEX2_1	715	717	PF00082	0.566
CLV_PCSK_KEX2_1	806	808	PF00082	0.638
CLV_PCSK_KEX2_1	818	820	PF00082	0.514
CLV_PCSK_KEX2_1	876	878	PF00082	0.635
CLV_PCSK_KEX2_1	90	92	PF00082	0.588
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.505
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.561
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.562
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.566
CLV_PCSK_PC1ET2_1	818	820	PF00082	0.591
CLV_PCSK_PC1ET2_1	876	878	PF00082	0.626
CLV_PCSK_PC7_1	872	878	PF00082	0.617
CLV_PCSK_SKI1_1	185	189	PF00082	0.565
CLV_PCSK_SKI1_1	232	236	PF00082	0.581
CLV_PCSK_SKI1_1	337	341	PF00082	0.538
CLV_PCSK_SKI1_1	415	419	PF00082	0.546
CLV_PCSK_SKI1_1	525	529	PF00082	0.604
CLV_PCSK_SKI1_1	68	72	PF00082	0.508
CLV_PCSK_SKI1_1	757	761	PF00082	0.462
CLV_PCSK_SKI1_1	775	779	PF00082	0.535
CLV_Separin_Metazoa	351	355	PF03568	0.503
CLV_Separin_Metazoa	669	673	PF03568	0.427
DEG_APCC_DBOX_1	524	532	PF00400	0.665
DEG_APCC_DBOX_1	566	574	PF00400	0.476
DEG_APCC_DBOX_1	756	764	PF00400	0.569
DEG_APCC_DBOX_1	89	97	PF00400	0.569
DEG_Nend_UBRbox_1	1	4	PF02207	0.444
DOC_CYCLIN_RxL_1	523	533	PF00134	0.567
DOC_CYCLIN_RxL_1	772	782	PF00134	0.522
DOC_MAPK_gen_1	662	670	PF00069	0.456
DOC_MAPK_gen_1	842	849	PF00069	0.537
DOC_MAPK_MEF2A_6	2	9	PF00069	0.431
DOC_MAPK_MEF2A_6	471	479	PF00069	0.599
DOC_MAPK_MEF2A_6	615	623	PF00069	0.545
DOC_MAPK_MEF2A_6	818	825	PF00069	0.578
DOC_MAPK_NFAT4_5	818	826	PF00069	0.578
DOC_USP7_MATH_1	158	162	PF00917	0.475
DOC_USP7_MATH_1	187	191	PF00917	0.568
DOC_USP7_MATH_1	284	288	PF00917	0.491
DOC_USP7_MATH_1	305	309	PF00917	0.705
DOC_USP7_MATH_1	400	404	PF00917	0.630
DOC_USP7_MATH_1	407	411	PF00917	0.495
DOC_USP7_MATH_1	675	679	PF00917	0.603
DOC_USP7_UBL2_3	68	72	PF12436	0.526
LIG_14-3-3_CanoR_1	202	206	PF00244	0.591
LIG_14-3-3_CanoR_1	268	278	PF00244	0.632
LIG_14-3-3_CanoR_1	392	398	PF00244	0.627
LIG_14-3-3_CanoR_1	513	521	PF00244	0.647
LIG_14-3-3_CanoR_1	525	531	PF00244	0.660
LIG_14-3-3_CanoR_1	615	623	PF00244	0.525
LIG_14-3-3_CanoR_1	766	774	PF00244	0.522
LIG_14-3-3_CanoR_1	835	845	PF00244	0.609
LIG_14-3-3_CanoR_1	863	871	PF00244	0.638
LIG_Actin_WH2_2	33	50	PF00022	0.601
LIG_Actin_WH2_2	827	844	PF00022	0.498
LIG_APCC_ABBA_1	845	850	PF00400	0.671
LIG_BRCT_BRCA1_1	656	660	PF00533	0.571
LIG_BRCT_BRCA1_2	656	662	PF00533	0.511
LIG_Clathr_ClatBox_1	384	388	PF01394	0.580
LIG_FHA_1	193	199	PF00498	0.522
LIG_FHA_1	256	262	PF00498	0.533
LIG_FHA_1	432	438	PF00498	0.576
LIG_FHA_1	632	638	PF00498	0.472
LIG_FHA_2	131	137	PF00498	0.508
LIG_FHA_2	313	319	PF00498	0.574
LIG_FHA_2	518	524	PF00498	0.689
LIG_FHA_2	638	644	PF00498	0.488
LIG_FHA_2	654	660	PF00498	0.501
LIG_FHA_2	671	677	PF00498	0.383
LIG_FHA_2	771	777	PF00498	0.530
LIG_GBD_Chelix_1	113	121	PF00786	0.432
LIG_GBD_Chelix_1	813	821	PF00786	0.588
LIG_LIR_Gen_1	12	22	PF02991	0.439
LIG_LIR_Gen_1	172	180	PF02991	0.549
LIG_LIR_Gen_1	371	381	PF02991	0.495
LIG_LIR_Gen_1	403	411	PF02991	0.534
LIG_LIR_Gen_1	424	433	PF02991	0.602
LIG_LIR_Gen_1	469	479	PF02991	0.472
LIG_LIR_Gen_1	73	84	PF02991	0.557
LIG_LIR_Nem_3	11	16	PF02991	0.437
LIG_LIR_Nem_3	172	176	PF02991	0.550
LIG_LIR_Nem_3	371	376	PF02991	0.495
LIG_LIR_Nem_3	403	408	PF02991	0.597
LIG_LIR_Nem_3	424	430	PF02991	0.413
LIG_LIR_Nem_3	469	475	PF02991	0.475
LIG_LIR_Nem_3	73	79	PF02991	0.559
LIG_LIR_Nem_3	800	805	PF02991	0.496
LIG_NRBOX	572	578	PF00104	0.551
LIG_NRBOX	773	779	PF00104	0.527
LIG_PCNA_yPIPBox_3	28	36	PF02747	0.626
LIG_Pex14_2	9	13	PF04695	0.433
LIG_SH2_CRK	795	799	PF00017	0.437
LIG_SH2_STAP1	173	177	PF00017	0.499
LIG_SH2_STAP1	380	384	PF00017	0.469
LIG_SH2_STAT3	131	134	PF00017	0.563
LIG_SH2_STAT5	131	134	PF00017	0.443
LIG_SH2_STAT5	721	724	PF00017	0.546
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.428
LIG_SUMO_SIM_anti_2	666	674	PF11976	0.459
LIG_SUMO_SIM_anti_2	697	706	PF11976	0.474
LIG_SUMO_SIM_par_1	328	336	PF11976	0.575
LIG_SUMO_SIM_par_1	475	481	PF11976	0.346
LIG_SUMO_SIM_par_1	634	641	PF11976	0.469
LIG_TRAF2_1	429	432	PF00917	0.476
LIG_TRAF2_1	64	67	PF00917	0.534
LIG_UBA3_1	384	391	PF00899	0.621
MOD_CK1_1	3	9	PF00069	0.428
MOD_CK1_1	379	385	PF00069	0.549
MOD_CK1_1	410	416	PF00069	0.485
MOD_CK1_1	452	458	PF00069	0.568
MOD_CK1_1	508	514	PF00069	0.709
MOD_CK1_1	517	523	PF00069	0.671
MOD_CK1_1	533	539	PF00069	0.492
MOD_CK1_1	695	701	PF00069	0.548
MOD_CK1_1	769	775	PF00069	0.552
MOD_CK1_1	826	832	PF00069	0.556
MOD_CK1_1	878	884	PF00069	0.733
MOD_CK2_1	130	136	PF00069	0.546
MOD_CK2_1	221	227	PF00069	0.635
MOD_CK2_1	282	288	PF00069	0.708
MOD_CK2_1	312	318	PF00069	0.619
MOD_CK2_1	426	432	PF00069	0.562
MOD_CK2_1	517	523	PF00069	0.626
MOD_CK2_1	526	532	PF00069	0.528
MOD_CK2_1	621	627	PF00069	0.494
MOD_CK2_1	637	643	PF00069	0.441
MOD_CK2_1	770	776	PF00069	0.509
MOD_CK2_1	878	884	PF00069	0.676
MOD_GlcNHglycan	165	168	PF01048	0.441
MOD_GlcNHglycan	2	5	PF01048	0.431
MOD_GlcNHglycan	251	254	PF01048	0.649
MOD_GlcNHglycan	278	281	PF01048	0.728
MOD_GlcNHglycan	307	310	PF01048	0.695
MOD_GlcNHglycan	424	427	PF01048	0.576
MOD_GlcNHglycan	507	510	PF01048	0.687
MOD_GlcNHglycan	55	58	PF01048	0.614
MOD_GlcNHglycan	743	746	PF01048	0.524
MOD_GlcNHglycan	757	760	PF01048	0.370
MOD_GlcNHglycan	82	85	PF01048	0.551
MOD_GlcNHglycan	850	853	PF01048	0.640
MOD_GlcNHglycan	99	102	PF01048	0.562
MOD_GSK3_1	152	159	PF00069	0.515
MOD_GSK3_1	422	429	PF00069	0.590
MOD_GSK3_1	513	520	PF00069	0.619
MOD_GSK3_1	526	533	PF00069	0.522
MOD_GSK3_1	621	628	PF00069	0.491
MOD_GSK3_1	633	640	PF00069	0.487
MOD_GSK3_1	654	661	PF00069	0.607
MOD_GSK3_1	698	705	PF00069	0.518
MOD_GSK3_1	762	769	PF00069	0.562
MOD_GSK3_1	80	87	PF00069	0.488
MOD_GSK3_1	826	833	PF00069	0.551
MOD_GSK3_1	837	844	PF00069	0.522
MOD_GSK3_1	875	882	PF00069	0.738
MOD_LATS_1	390	396	PF00433	0.495
MOD_LATS_1	873	879	PF00433	0.733
MOD_N-GLC_1	220	225	PF02516	0.661
MOD_N-GLC_1	239	244	PF02516	0.503
MOD_N-GLC_1	421	426	PF02516	0.585
MOD_N-GLC_1	594	599	PF02516	0.651
MOD_N-GLC_1	652	657	PF02516	0.599
MOD_N-GLC_1	837	842	PF02516	0.572
MOD_N-GLC_1	864	869	PF02516	0.646
MOD_N-GLC_2	512	514	PF02516	0.578
MOD_NEK2_1	152	157	PF00069	0.613
MOD_NEK2_1	163	168	PF00069	0.515
MOD_NEK2_1	201	206	PF00069	0.544
MOD_NEK2_1	310	315	PF00069	0.600
MOD_NEK2_1	359	364	PF00069	0.533
MOD_NEK2_1	530	535	PF00069	0.663
MOD_NEK2_1	576	581	PF00069	0.550
MOD_NEK2_1	614	619	PF00069	0.565
MOD_NEK2_1	658	663	PF00069	0.574
MOD_NEK2_1	841	846	PF00069	0.627
MOD_NEK2_1	848	853	PF00069	0.684
MOD_PIKK_1	130	136	PF00454	0.442
MOD_PIKK_1	310	316	PF00454	0.647
MOD_PIKK_1	360	366	PF00454	0.600
MOD_PIKK_1	530	536	PF00454	0.594
MOD_PIKK_1	692	698	PF00454	0.492
MOD_PIKK_1	823	829	PF00454	0.492
MOD_PKA_1	192	198	PF00069	0.522
MOD_PKA_1	20	26	PF00069	0.445
MOD_PKA_1	391	397	PF00069	0.585
MOD_PKA_1	708	714	PF00069	0.534
MOD_PKA_1	875	881	PF00069	0.738
MOD_PKA_2	201	207	PF00069	0.593
MOD_PKA_2	391	397	PF00069	0.585
MOD_PKA_2	452	458	PF00069	0.550
MOD_PKA_2	514	520	PF00069	0.646
MOD_PKA_2	548	554	PF00069	0.580
MOD_PKA_2	614	620	PF00069	0.550
MOD_PKA_2	876	882	PF00069	0.553
MOD_Plk_1	239	245	PF00069	0.659
MOD_Plk_1	337	343	PF00069	0.629
MOD_Plk_1	371	377	PF00069	0.571
MOD_Plk_1	517	523	PF00069	0.660
MOD_Plk_1	594	600	PF00069	0.655
MOD_Plk_1	769	775	PF00069	0.544
MOD_Plk_1	837	843	PF00069	0.577
MOD_Plk_2-3	770	776	PF00069	0.506
MOD_Plk_4	3	9	PF00069	0.428
MOD_Plk_4	452	458	PF00069	0.532
MOD_Plk_4	526	532	PF00069	0.649
MOD_Plk_4	698	704	PF00069	0.596
MOD_SUMO_for_1	117	120	PF00179	0.539
MOD_SUMO_for_1	178	181	PF00179	0.363
MOD_SUMO_for_1	236	239	PF00179	0.582
MOD_SUMO_for_1	71	74	PF00179	0.573
MOD_SUMO_for_1	854	857	PF00179	0.672
MOD_SUMO_rev_2	181	187	PF00179	0.367
MOD_SUMO_rev_2	62	71	PF00179	0.589
MOD_SUMO_rev_2	691	701	PF00179	0.481
MOD_SUMO_rev_2	729	738	PF00179	0.559
MOD_SUMO_rev_2	758	765	PF00179	0.572
MOD_SUMO_rev_2	811	820	PF00179	0.595
TRG_DiLeu_BaEn_1	572	577	PF01217	0.551
TRG_DiLeu_BaEn_1	780	785	PF01217	0.500
TRG_DiLeu_BaEn_3	65	71	PF01217	0.405
TRG_DiLeu_BaEn_4	238	244	PF01217	0.585
TRG_DiLeu_BaEn_4	586	592	PF01217	0.681
TRG_DiLeu_BaEn_4	66	72	PF01217	0.403
TRG_ENDOCYTIC_2	173	176	PF00928	0.500
TRG_ENDOCYTIC_2	795	798	PF00928	0.438
TRG_ER_diArg_1	107	110	PF00400	0.454
TRG_ER_diArg_1	805	807	PF00400	0.637
TRG_ER_diArg_1	89	91	PF00400	0.600
TRG_NES_CRM1_1	111	126	PF08389	0.492
TRG_NES_CRM1_1	815	828	PF08389	0.589
TRG_NLS_MonoExtN_4	872	879	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM4	Leptomonas seymouri	55%	100%
A0A1X0NIX3	Trypanosomatidae	30%	100%
A0A3Q8IHM9	Leishmania donovani	91%	100%
A0A422N7K6	Trypanosoma rangeli	31%	100%
A4HM57	Leishmania braziliensis	76%	100%
A4IAR9	Leishmania infantum	91%	100%
D0A2E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B5Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%