DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEJ4_LEIMA

TriTrypDb:

LmjF.35.0170 , LMJLV39_350006700 , LMJSD75_350006800

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.400
CLV_NRD_NRD_1	262	264	PF00675	0.429
CLV_NRD_NRD_1	279	281	PF00675	0.423
CLV_NRD_NRD_1	288	290	PF00675	0.425
CLV_NRD_NRD_1	45	47	PF00675	0.453
CLV_NRD_NRD_1	72	74	PF00675	0.538
CLV_PCSK_KEX2_1	18	20	PF00082	0.569
CLV_PCSK_KEX2_1	25	27	PF00082	0.471
CLV_PCSK_KEX2_1	288	290	PF00082	0.425
CLV_PCSK_KEX2_1	74	76	PF00082	0.488
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.569
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.471
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.488
CLV_PCSK_SKI1_1	134	138	PF00082	0.553
CLV_PCSK_SKI1_1	174	178	PF00082	0.541
CLV_PCSK_SKI1_1	26	30	PF00082	0.413
CLV_PCSK_SKI1_1	280	284	PF00082	0.611
CLV_PCSK_SKI1_1	288	292	PF00082	0.407
DEG_APCC_DBOX_1	287	295	PF00400	0.354
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DOC_CDC14_PxL_1	320	328	PF14671	0.436
DOC_CYCLIN_RxL_1	128	138	PF00134	0.544
DOC_MAPK_gen_1	186	195	PF00069	0.513
DOC_MAPK_gen_1	261	268	PF00069	0.498
DOC_PP1_RVXF_1	45	52	PF00149	0.542
DOC_PP1_SILK_1	318	323	PF00149	0.491
DOC_PP2B_LxvP_1	321	324	PF13499	0.605
DOC_USP7_UBL2_3	25	29	PF12436	0.505
LIG_14-3-3_CanoR_1	156	162	PF00244	0.590
LIG_14-3-3_CanoR_1	215	219	PF00244	0.460
LIG_14-3-3_CanoR_1	26	32	PF00244	0.476
LIG_14-3-3_CanoR_1	289	295	PF00244	0.469
LIG_14-3-3_CanoR_1	86	92	PF00244	0.497
LIG_Actin_WH2_2	278	294	PF00022	0.446
LIG_BRCT_MDC1_1	328	332	PF00533	0.520
LIG_eIF4E_1	189	195	PF01652	0.382
LIG_FHA_1	161	167	PF00498	0.660
LIG_FHA_1	170	176	PF00498	0.532
LIG_FHA_1	185	191	PF00498	0.378
LIG_FHA_1	200	206	PF00498	0.360
LIG_FHA_1	225	231	PF00498	0.437
LIG_FHA_2	112	118	PF00498	0.577
LIG_FHA_2	39	45	PF00498	0.449
LIG_FHA_2	6	12	PF00498	0.481
LIG_GBD_Chelix_1	91	99	PF00786	0.501
LIG_LIR_Nem_3	300	304	PF02991	0.431
LIG_NRBOX	12	18	PF00104	0.495
LIG_PCNA_PIPBox_1	216	225	PF02747	0.406
LIG_PCNA_yPIPBox_3	215	223	PF02747	0.397
LIG_PCNA_yPIPBox_3	36	49	PF02747	0.549
LIG_SH2_NCK_1	273	277	PF00017	0.465
LIG_SH2_SRC	189	192	PF00017	0.392
LIG_SH2_SRC	273	276	PF00017	0.469
LIG_SH2_STAT5	157	160	PF00017	0.560
LIG_SH2_STAT5	189	192	PF00017	0.455
LIG_SH2_STAT5	20	23	PF00017	0.606
LIG_SH2_STAT5	48	51	PF00017	0.539
LIG_SUMO_SIM_par_1	309	314	PF11976	0.540
LIG_TRAF2_1	115	118	PF00917	0.507
LIG_TRAF2_1	30	33	PF00917	0.514
LIG_WRC_WIRS_1	127	132	PF05994	0.492
LIG_WRC_WIRS_1	219	224	PF05994	0.534
LIG_WRC_WIRS_1	298	303	PF05994	0.418
MOD_CK1_1	144	150	PF00069	0.599
MOD_CK1_1	155	161	PF00069	0.507
MOD_CK2_1	111	117	PF00069	0.580
MOD_CK2_1	158	164	PF00069	0.662
MOD_CK2_1	27	33	PF00069	0.466
MOD_CK2_1	38	44	PF00069	0.435
MOD_GlcNHglycan	301	304	PF01048	0.462
MOD_GSK3_1	126	133	PF00069	0.461
MOD_GSK3_1	214	221	PF00069	0.537
MOD_GSK3_1	322	329	PF00069	0.583
MOD_N-GLC_1	77	82	PF02516	0.382
MOD_NEK2_1	130	135	PF00069	0.475
MOD_NEK2_1	141	146	PF00069	0.597
MOD_NEK2_1	218	223	PF00069	0.540
MOD_PKA_2	155	161	PF00069	0.583
MOD_PKA_2	214	220	PF00069	0.485
MOD_Plk_1	158	164	PF00069	0.584
MOD_Plk_1	77	83	PF00069	0.410
MOD_Plk_4	214	220	PF00069	0.425
MOD_Plk_4	77	83	PF00069	0.444
MOD_SUMO_for_1	35	38	PF00179	0.513
MOD_SUMO_rev_2	120	130	PF00179	0.406
TRG_DiLeu_BaEn_1	12	17	PF01217	0.557
TRG_DiLeu_BaEn_1	214	219	PF01217	0.535
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.483
TRG_ENDOCYTIC_2	48	51	PF00928	0.539
TRG_ER_diArg_1	288	290	PF00400	0.425
TRG_ER_diArg_1	98	101	PF00400	0.476
TRG_NES_CRM1_1	257	271	PF08389	0.557
TRG_NES_CRM1_1	312	327	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M0	Leptomonas seymouri	38%	97%
A0A3Q8INY6	Leishmania donovani	87%	97%
A4HM56	Leishmania braziliensis	61%	98%
A4IAR8	Leishmania infantum	87%	97%
E9B5Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%