Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEJ3_LEIMA

TriTrypDb:

LmjF.35.0160 , LMJLV39_350006600 , LMJSD75_350006700

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.264
CLV_NRD_NRD_1	168	170	PF00675	0.554
CLV_PCSK_SKI1_1	170	174	PF00082	0.510
CLV_PCSK_SKI1_1	236	240	PF00082	0.497
CLV_PCSK_SKI1_1	66	70	PF00082	0.502
DOC_CYCLIN_RxL_1	208	218	PF00134	0.420
DOC_MAPK_gen_1	89	97	PF00069	0.515
DOC_PP2B_LxvP_1	254	257	PF13499	0.494
DOC_PP2B_LxvP_1	47	50	PF13499	0.447
DOC_PP4_FxxP_1	115	118	PF00568	0.279
DOC_PP4_FxxP_1	45	48	PF00568	0.380
DOC_USP7_MATH_1	171	175	PF00917	0.477
DOC_USP7_MATH_1	19	23	PF00917	0.406
DOC_USP7_MATH_1	48	52	PF00917	0.546
DOC_USP7_MATH_1	76	80	PF00917	0.364
DOC_WW_Pin1_4	114	119	PF00397	0.279
LIG_14-3-3_CanoR_1	236	241	PF00244	0.441
LIG_14-3-3_CanoR_1	263	267	PF00244	0.607
LIG_14-3-3_CanoR_1	34	42	PF00244	0.482
LIG_14-3-3_CanoR_1	44	48	PF00244	0.367
LIG_BIR_II_1	1	5	PF00653	0.371
LIG_BRCT_BRCA1_1	115	119	PF00533	0.417
LIG_BRCT_BRCA1_1	92	96	PF00533	0.644
LIG_Clathr_ClatBox_1	240	244	PF01394	0.528
LIG_deltaCOP1_diTrp_1	244	249	PF00928	0.646
LIG_EH_1	201	205	PF12763	0.412
LIG_FHA_1	145	151	PF00498	0.424
LIG_FHA_1	194	200	PF00498	0.496
LIG_FHA_1	44	50	PF00498	0.401
LIG_FHA_2	237	243	PF00498	0.546
LIG_FHA_2	33	39	PF00498	0.573
LIG_LIR_Apic_2	112	118	PF02991	0.283
LIG_LIR_Apic_2	43	48	PF02991	0.459
LIG_LIR_Gen_1	129	137	PF02991	0.612
LIG_LIR_Gen_1	244	254	PF02991	0.594
LIG_LIR_Nem_3	129	135	PF02991	0.544
LIG_LIR_Nem_3	244	249	PF02991	0.596
LIG_LIR_Nem_3	272	278	PF02991	0.689
LIG_PCNA_yPIPBox_3	20	28	PF02747	0.567
LIG_Pex14_2	115	119	PF04695	0.264
LIG_Pex14_2	27	31	PF04695	0.544
LIG_REV1ctd_RIR_1	66	74	PF16727	0.427
LIG_REV1ctd_RIR_1	94	103	PF16727	0.264
LIG_SH2_STAP1	15	19	PF00017	0.565
LIG_SH2_STAT3	14	17	PF00017	0.430
LIG_SH2_STAT5	132	135	PF00017	0.601
LIG_SH3_3	271	277	PF00018	0.656
LIG_SH3_3	82	88	PF00018	0.577
LIG_SUMO_SIM_par_1	142	147	PF11976	0.527
LIG_SUMO_SIM_par_1	239	244	PF11976	0.526
LIG_TRAF2_1	35	38	PF00917	0.665
LIG_TRAF2_1	98	101	PF00917	0.279
LIG_UBA3_1	3	9	PF00899	0.374
MOD_CK1_1	180	186	PF00069	0.419
MOD_CK2_1	236	242	PF00069	0.629
MOD_CK2_1	32	38	PF00069	0.626
MOD_GlcNHglycan	129	132	PF01048	0.595
MOD_GlcNHglycan	177	180	PF01048	0.655
MOD_GlcNHglycan	58	61	PF01048	0.486
MOD_GlcNHglycan	92	95	PF01048	0.684
MOD_GSK3_1	142	149	PF00069	0.549
MOD_GSK3_1	171	178	PF00069	0.621
MOD_GSK3_1	193	200	PF00069	0.425
MOD_N-GLC_1	20	25	PF02516	0.559
MOD_N-GLC_1	270	275	PF02516	0.680
MOD_NEK2_1	113	118	PF00069	0.440
MOD_NEK2_1	146	151	PF00069	0.463
MOD_NEK2_1	204	209	PF00069	0.475
MOD_NEK2_1	262	267	PF00069	0.674
MOD_NEK2_2	270	275	PF00069	0.705
MOD_PIKK_1	213	219	PF00454	0.389
MOD_PIKK_1	225	231	PF00454	0.427
MOD_PIKK_1	33	39	PF00454	0.652
MOD_PKA_2	225	231	PF00069	0.410
MOD_PKA_2	262	268	PF00069	0.568
MOD_PKA_2	33	39	PF00069	0.482
MOD_PKA_2	43	49	PF00069	0.369
MOD_Plk_1	20	26	PF00069	0.580
MOD_Plk_1	270	276	PF00069	0.579
MOD_Plk_1	76	82	PF00069	0.377
MOD_Plk_2-3	155	161	PF00069	0.440
MOD_Plk_4	146	152	PF00069	0.512
MOD_Plk_4	270	276	PF00069	0.554
MOD_ProDKin_1	114	120	PF00069	0.279
MOD_SUMO_rev_2	77	85	PF00179	0.439
TRG_ENDOCYTIC_2	132	135	PF00928	0.601
TRG_ENDOCYTIC_2	15	18	PF00928	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P611	Leptomonas seymouri	62%	85%
A0A0S4JHS2	Bodo saltans	33%	71%
A0A1X0NJ57	Trypanosomatidae	43%	90%
A0A3R7LQI0	Trypanosoma rangeli	47%	89%
A0A3S7X8M8	Leishmania donovani	93%	88%
A4HM55	Leishmania braziliensis	85%	100%
A4IAR7	Leishmania infantum	93%	88%
D0A2E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	90%
E9B5Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DJR0	Trypanosoma cruzi	49%	89%