LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AEJ2_LEIMA
TriTrypDb:
LmjF.35.0150 , LMJLV39_350006500 , LMJSD75_350006600 *
Length:
290

Annotations

LeishMANIAdb annotations

A conserved mitochondrial transporter, might be an ADP/ATP translocase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9AEJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEJ2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 288 290 PF00675 0.511
CLV_PCSK_KEX2_1 288 290 PF00082 0.511
CLV_PCSK_KEX2_1 48 50 PF00082 0.654
CLV_PCSK_PC1ET2_1 48 50 PF00082 0.662
CLV_PCSK_PC7_1 284 290 PF00082 0.584
CLV_PCSK_SKI1_1 238 242 PF00082 0.608
CLV_PCSK_SKI1_1 51 55 PF00082 0.638
DEG_APCC_DBOX_1 50 58 PF00400 0.410
DOC_CYCLIN_yCln2_LP_2 57 63 PF00134 0.397
DOC_MAPK_MEF2A_6 222 231 PF00069 0.397
DOC_PP2B_LxvP_1 186 189 PF13499 0.440
DOC_PP2B_LxvP_1 63 66 PF13499 0.393
DOC_USP7_MATH_1 10 14 PF00917 0.449
LIG_14-3-3_CanoR_1 191 195 PF00244 0.376
LIG_14-3-3_CanoR_1 246 250 PF00244 0.371
LIG_APCC_ABBA_1 21 26 PF00400 0.403
LIG_BIR_II_1 1 5 PF00653 0.591
LIG_BRCT_BRCA1_1 12 16 PF00533 0.485
LIG_BRCT_BRCA1_1 165 169 PF00533 0.444
LIG_BRCT_BRCA1_1 251 255 PF00533 0.324
LIG_BRCT_BRCA1_1 286 290 PF00533 0.730
LIG_deltaCOP1_diTrp_1 171 177 PF00928 0.351
LIG_EH1_1 176 184 PF00400 0.395
LIG_FHA_1 185 191 PF00498 0.344
LIG_FHA_1 256 262 PF00498 0.348
LIG_FHA_1 4 10 PF00498 0.365
LIG_LIR_Gen_1 13 24 PF02991 0.471
LIG_LIR_Gen_1 171 182 PF02991 0.351
LIG_LIR_Gen_1 258 265 PF02991 0.344
LIG_LIR_Nem_3 13 19 PF02991 0.420
LIG_LIR_Nem_3 171 177 PF02991 0.351
LIG_LIR_Nem_3 258 262 PF02991 0.344
LIG_NRBOX 85 91 PF00104 0.408
LIG_PCNA_PIPBox_1 133 142 PF02747 0.457
LIG_PCNA_yPIPBox_3 132 140 PF02747 0.457
LIG_Pex14_2 286 290 PF04695 0.730
LIG_Pex14_2 72 76 PF04695 0.485
LIG_SH2_CRK 112 116 PF00017 0.646
LIG_SH2_CRK 120 124 PF00017 0.573
LIG_SH2_CRK 134 138 PF00017 0.462
LIG_SH2_STAP1 165 169 PF00017 0.464
LIG_SH2_STAP1 93 97 PF00017 0.644
LIG_SH2_STAT5 213 216 PF00017 0.454
LIG_SH2_STAT5 45 48 PF00017 0.465
LIG_SH2_STAT5 71 74 PF00017 0.401
LIG_SH2_STAT5 93 96 PF00017 0.643
LIG_SUMO_SIM_anti_2 157 162 PF11976 0.363
LIG_UBA3_1 123 132 PF00899 0.605
LIG_WRC_WIRS_1 136 141 PF05994 0.401
LIG_WRC_WIRS_1 182 187 PF05994 0.358
MOD_CK1_1 14 20 PF00069 0.230
MOD_CK1_1 201 207 PF00069 0.448
MOD_CK1_1 3 9 PF00069 0.401
MOD_CK2_1 165 171 PF00069 0.469
MOD_GlcNHglycan 120 123 PF01048 0.475
MOD_GlcNHglycan 146 149 PF01048 0.376
MOD_GlcNHglycan 202 206 PF01048 0.630
MOD_GlcNHglycan 29 32 PF01048 0.624
MOD_GSK3_1 10 17 PF00069 0.414
MOD_GSK3_1 161 168 PF00069 0.459
MOD_GSK3_1 190 197 PF00069 0.401
MOD_GSK3_1 241 248 PF00069 0.368
MOD_GSK3_1 93 100 PF00069 0.587
MOD_N-GLC_1 241 246 PF02516 0.609
MOD_NEK2_1 110 115 PF00069 0.535
MOD_NEK2_1 144 149 PF00069 0.412
MOD_NEK2_1 161 166 PF00069 0.252
MOD_NEK2_1 194 199 PF00069 0.429
MOD_NEK2_1 241 246 PF00069 0.386
MOD_NEK2_1 249 254 PF00069 0.354
MOD_NEK2_1 255 260 PF00069 0.324
MOD_NEK2_1 53 58 PF00069 0.436
MOD_NEK2_1 91 96 PF00069 0.529
MOD_NEK2_1 97 102 PF00069 0.613
MOD_NEK2_2 11 16 PF00069 0.452
MOD_NEK2_2 135 140 PF00069 0.369
MOD_PIKK_1 55 61 PF00454 0.379
MOD_PKA_2 110 116 PF00069 0.700
MOD_PKA_2 190 196 PF00069 0.376
MOD_PKA_2 245 251 PF00069 0.374
MOD_Plk_4 11 17 PF00069 0.364
MOD_Plk_4 135 141 PF00069 0.392
MOD_Plk_4 181 187 PF00069 0.389
MOD_Plk_4 194 200 PF00069 0.432
MOD_Plk_4 93 99 PF00069 0.635
TRG_ENDOCYTIC_2 120 123 PF00928 0.576
TRG_ENDOCYTIC_2 134 137 PF00928 0.476
TRG_ENDOCYTIC_2 24 27 PF00928 0.356
TRG_ENDOCYTIC_2 259 262 PF00928 0.444
TRG_ENDOCYTIC_2 50 53 PF00928 0.363
TRG_ER_diArg_1 288 290 PF00400 0.689

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JQQ1 Bodo saltans 36% 98%
A0A1X0NJA4 Trypanosomatidae 46% 100%
A0A3S7X8R5 Leishmania donovani 95% 100%
A4HM54 Leishmania braziliensis 85% 100%
A4IAR6 Leishmania infantum 95% 100%
D0A2E6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9B5Q3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5BNB5 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS