LMBR1 domain-containing protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania major

UniProt:

E9AEI9_LEIMA

TriTrypDb:

LmjF.35.0120 , LMJLV39_350006200 , LMJSD75_350006300

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005794	Golgi apparatus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AEI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.231
CLV_C14_Caspase3-7	32	36	PF00656	0.511
CLV_NRD_NRD_1	218	220	PF00675	0.272
CLV_NRD_NRD_1	241	243	PF00675	0.415
CLV_PCSK_KEX2_1	218	220	PF00082	0.289
CLV_PCSK_KEX2_1	241	243	PF00082	0.403
CLV_PCSK_SKI1_1	192	196	PF00082	0.258
CLV_PCSK_SKI1_1	236	240	PF00082	0.359
CLV_PCSK_SKI1_1	432	436	PF00082	0.420
CLV_PCSK_SKI1_1	77	81	PF00082	0.463
DEG_APCC_DBOX_1	112	120	PF00400	0.535
DEG_MDM2_SWIB_1	72	80	PF02201	0.214
DEG_Nend_Nbox_1	1	3	PF02207	0.382
DEG_SPOP_SBC_1	157	161	PF00917	0.274
DOC_CYCLIN_RxL_1	232	243	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.311
DOC_MAPK_gen_1	203	210	PF00069	0.535
DOC_MAPK_gen_1	232	240	PF00069	0.572
DOC_MAPK_MEF2A_6	113	120	PF00069	0.525
DOC_MAPK_MEF2A_6	40	49	PF00069	0.322
DOC_PP1_RVXF_1	234	241	PF00149	0.525
DOC_PP1_RVXF_1	301	308	PF00149	0.296
DOC_PP2B_LxvP_1	343	346	PF13499	0.662
DOC_PP2B_LxvP_1	422	425	PF13499	0.420
DOC_PP2B_LxvP_1	55	58	PF13499	0.311
DOC_PP4_FxxP_1	188	191	PF00568	0.431
DOC_USP7_MATH_1	103	107	PF00917	0.431
DOC_USP7_UBL2_3	232	236	PF12436	0.601
DOC_WW_Pin1_4	99	104	PF00397	0.535
LIG_Actin_WH2_2	167	184	PF00022	0.321
LIG_BRCT_BRCA1_1	68	72	PF00533	0.214
LIG_BRCT_BRCA1_1	84	88	PF00533	0.321
LIG_CaM_NSCaTE_8	76	83	PF13499	0.420
LIG_Clathr_ClatBox_1	56	60	PF01394	0.328
LIG_CSL_BTD_1	36	39	PF09270	0.507
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.312
LIG_eIF4E_1	322	328	PF01652	0.297
LIG_FHA_1	44	50	PF00498	0.397
LIG_FHA_2	193	199	PF00498	0.463
LIG_GBD_Chelix_1	11	19	PF00786	0.400
LIG_GBD_Chelix_1	408	416	PF00786	0.204
LIG_Integrin_RGD_1	64	66	PF01839	0.364
LIG_LIR_Gen_1	106	117	PF02991	0.488
LIG_LIR_Gen_1	162	172	PF02991	0.352
LIG_LIR_Gen_1	370	380	PF02991	0.360
LIG_LIR_Gen_1	423	434	PF02991	0.450
LIG_LIR_Nem_3	106	112	PF02991	0.462
LIG_LIR_Nem_3	162	168	PF02991	0.322
LIG_LIR_Nem_3	370	375	PF02991	0.331
LIG_LIR_Nem_3	381	385	PF02991	0.245
LIG_LIR_Nem_3	423	429	PF02991	0.349
LIG_LIR_Nem_3	73	79	PF02991	0.222
LIG_NRBOX	286	292	PF00104	0.454
LIG_NRBOX	356	362	PF00104	0.501
LIG_PCNA_PIPBox_1	301	310	PF02747	0.302
LIG_PCNA_yPIPBox_3	203	214	PF02747	0.525
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.368
LIG_Pex14_1	165	169	PF04695	0.311
LIG_Pex14_2	126	130	PF04695	0.357
LIG_Pex14_2	163	167	PF04695	0.449
LIG_Pex14_2	2	6	PF04695	0.334
LIG_Pex14_2	70	74	PF04695	0.261
LIG_Pex14_2	93	97	PF04695	0.371
LIG_Pex3_1	287	298	PF04882	0.334
LIG_REV1ctd_RIR_1	185	190	PF16727	0.527
LIG_SH2_CRK	414	418	PF00017	0.420
LIG_SH2_CRK	52	56	PF00017	0.362
LIG_SH2_CRK	84	88	PF00017	0.441
LIG_SH2_STAP1	320	324	PF00017	0.328
LIG_SH2_STAP1	414	418	PF00017	0.321
LIG_SH2_STAP1	84	88	PF00017	0.400
LIG_SH2_STAT3	407	410	PF00017	0.429
LIG_SH2_STAT5	155	158	PF00017	0.312
LIG_SH2_STAT5	22	25	PF00017	0.322
LIG_SH2_STAT5	264	267	PF00017	0.552
LIG_SH2_STAT5	322	325	PF00017	0.310
LIG_SH2_STAT5	326	329	PF00017	0.291
LIG_SH2_STAT5	407	410	PF00017	0.303
LIG_SH3_2	346	351	PF14604	0.538
LIG_SH3_3	343	349	PF00018	0.579
LIG_SH3_3	394	400	PF00018	0.301
LIG_SH3_3	86	92	PF00018	0.345
LIG_Sin3_3	13	20	PF02671	0.321
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.342
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.373
LIG_SUMO_SIM_par_1	364	370	PF11976	0.370
LIG_SUMO_SIM_par_1	40	46	PF11976	0.417
LIG_TRAF2_1	28	31	PF00917	0.508
LIG_TYR_ITIM	412	417	PF00017	0.290
LIG_WRC_WIRS_1	379	384	PF05994	0.432
MOD_CK1_1	107	113	PF00069	0.556
MOD_CK1_1	381	387	PF00069	0.308
MOD_CK2_1	192	198	PF00069	0.469
MOD_CK2_1	25	31	PF00069	0.508
MOD_Cter_Amidation	216	219	PF01082	0.307
MOD_GlcNHglycan	260	263	PF01048	0.405
MOD_GlcNHglycan	27	30	PF01048	0.317
MOD_GlcNHglycan	338	341	PF01048	0.394
MOD_GlcNHglycan	369	372	PF01048	0.399
MOD_GSK3_1	139	146	PF00069	0.298
MOD_GSK3_1	155	162	PF00069	0.398
MOD_GSK3_1	381	388	PF00069	0.317
MOD_GSK3_1	432	439	PF00069	0.675
MOD_GSK3_1	66	73	PF00069	0.349
MOD_GSK3_1	97	104	PF00069	0.560
MOD_N-GLC_1	253	258	PF02516	0.360
MOD_NEK2_1	156	161	PF00069	0.341
MOD_NEK2_1	314	319	PF00069	0.351
MOD_NEK2_1	328	333	PF00069	0.356
MOD_NEK2_1	361	366	PF00069	0.350
MOD_NEK2_1	367	372	PF00069	0.319
MOD_NEK2_1	395	400	PF00069	0.349
MOD_NEK2_1	420	425	PF00069	0.394
MOD_NEK2_1	70	75	PF00069	0.316
MOD_NEK2_1	97	102	PF00069	0.527
MOD_PIKK_1	101	107	PF00454	0.559
MOD_PKA_2	112	118	PF00069	0.464
MOD_PKA_2	248	254	PF00069	0.655
MOD_PKA_2	25	31	PF00069	0.535
MOD_PKA_2	352	358	PF00069	0.591
MOD_PKA_2	66	72	PF00069	0.264
MOD_PKB_1	190	198	PF00069	0.493
MOD_Plk_1	253	259	PF00069	0.504
MOD_Plk_1	70	76	PF00069	0.280
MOD_Plk_2-3	66	72	PF00069	0.356
MOD_Plk_4	104	110	PF00069	0.519
MOD_Plk_4	279	285	PF00069	0.365
MOD_Plk_4	314	320	PF00069	0.369
MOD_Plk_4	328	334	PF00069	0.321
MOD_Plk_4	352	358	PF00069	0.513
MOD_Plk_4	361	367	PF00069	0.285
MOD_Plk_4	386	392	PF00069	0.340
MOD_Plk_4	82	88	PF00069	0.411
MOD_ProDKin_1	99	105	PF00069	0.535
TRG_DiLeu_BaEn_1	209	214	PF01217	0.469
TRG_DiLeu_BaEn_2	442	448	PF01217	0.549
TRG_ENDOCYTIC_2	322	325	PF00928	0.305
TRG_ENDOCYTIC_2	414	417	PF00928	0.309
TRG_ENDOCYTIC_2	52	55	PF00928	0.381
TRG_ENDOCYTIC_2	84	87	PF00928	0.373
TRG_ER_diArg_1	190	193	PF00400	0.465
TRG_ER_diArg_1	218	220	PF00400	0.505
TRG_ER_diArg_1	240	242	PF00400	0.608
TRG_ER_diArg_1	350	353	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRR8	Leptomonas seymouri	26%	94%
A0A0N1I533	Leptomonas seymouri	66%	100%
A0A0S4IQ17	Bodo saltans	28%	93%
A0A0S4JTI8	Bodo saltans	34%	87%
A0A1X0NKT2	Trypanosomatidae	33%	100%
A0A1X0NM00	Trypanosomatidae	25%	96%
A0A3Q8IGK4	Leishmania donovani	23%	93%
A0A3S5H7Y2	Leishmania donovani	96%	100%
A0A422P212	Trypanosoma rangeli	27%	94%
A4HE60	Leishmania braziliensis	23%	93%
A4HM51	Leishmania braziliensis	85%	100%
A4I1F8	Leishmania infantum	23%	93%
A4IAR3	Leishmania infantum	96%	100%
C9ZK11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
D0A2E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	95%
E9AXJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	93%
E9B5Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q0VGV9	Xenopus tropicalis	21%	83%
Q4Q9X7	Leishmania major	24%	93%
Q658I5	Oryza sativa subsp. japonica	22%	88%
Q7SYR6	Xenopus laevis	21%	83%
Q9M028	Arabidopsis thaliana	24%	88%
Q9SR93	Arabidopsis thaliana	24%	88%