Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEI6_LEIMA

TriTrypDb:

LmjF.35.0090 , LMJLV39_350005900 , LMJSD75_350006000

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.533
CLV_NRD_NRD_1	143	145	PF00675	0.546
CLV_NRD_NRD_1	202	204	PF00675	0.585
CLV_NRD_NRD_1	221	223	PF00675	0.542
CLV_NRD_NRD_1	69	71	PF00675	0.573
CLV_NRD_NRD_1	91	93	PF00675	0.560
CLV_PCSK_KEX2_1	141	143	PF00082	0.508
CLV_PCSK_KEX2_1	178	180	PF00082	0.593
CLV_PCSK_KEX2_1	202	204	PF00082	0.636
CLV_PCSK_KEX2_1	221	223	PF00082	0.542
CLV_PCSK_KEX2_1	252	254	PF00082	0.577
CLV_PCSK_KEX2_1	69	71	PF00082	0.594
CLV_PCSK_KEX2_1	76	78	PF00082	0.488
CLV_PCSK_KEX2_1	90	92	PF00082	0.453
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.566
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.542
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.540
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.524
CLV_PCSK_SKI1_1	118	122	PF00082	0.571
CLV_PCSK_SKI1_1	151	155	PF00082	0.635
CLV_PCSK_SKI1_1	210	214	PF00082	0.440
DOC_MAPK_gen_1	178	184	PF00069	0.535
DOC_MAPK_MEF2A_6	108	116	PF00069	0.565
DOC_PP1_RVXF_1	74	81	PF00149	0.389
DOC_USP7_MATH_1	4	8	PF00917	0.693
DOC_WW_Pin1_4	276	281	PF00397	0.728
LIG_14-3-3_CanoR_1	100	109	PF00244	0.524
LIG_14-3-3_CanoR_1	202	207	PF00244	0.521
LIG_14-3-3_CanoR_1	275	280	PF00244	0.769
LIG_14-3-3_CanoR_1	69	78	PF00244	0.511
LIG_deltaCOP1_diTrp_1	129	136	PF00928	0.559
LIG_DLG_GKlike_1	260	267	PF00625	0.697
LIG_FHA_1	104	110	PF00498	0.609
LIG_FHA_1	179	185	PF00498	0.571
LIG_FHA_2	246	252	PF00498	0.738
LIG_FHA_2	42	48	PF00498	0.406
LIG_LIR_Apic_2	257	262	PF02991	0.611
LIG_LIR_Nem_3	266	271	PF02991	0.543
LIG_Pex14_1	132	136	PF04695	0.653
LIG_RPA_C_Fungi	65	77	PF08784	0.553
LIG_SH2_CRK	259	263	PF00017	0.544
LIG_SH2_CRK	268	272	PF00017	0.538
LIG_SH2_NCK_1	21	25	PF00017	0.554
LIG_SH2_STAT5	157	160	PF00017	0.573
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.504
LIG_SUMO_SIM_par_1	180	185	PF11976	0.490
LIG_TRAF2_1	72	75	PF00917	0.612
LIG_TRAF2_1	93	96	PF00917	0.629
MOD_CK1_1	134	140	PF00069	0.403
MOD_CK1_1	160	166	PF00069	0.586
MOD_CK2_1	160	166	PF00069	0.520
MOD_CK2_1	245	251	PF00069	0.717
MOD_CK2_1	260	266	PF00069	0.479
MOD_CK2_1	41	47	PF00069	0.405
MOD_CK2_1	83	89	PF00069	0.553
MOD_GlcNHglycan	237	240	PF01048	0.673
MOD_GlcNHglycan	39	42	PF01048	0.517
MOD_GlcNHglycan	5	9	PF01048	0.712
MOD_GSK3_1	156	163	PF00069	0.506
MOD_GSK3_1	235	242	PF00069	0.678
MOD_GSK3_1	37	44	PF00069	0.526
MOD_NEK2_1	227	232	PF00069	0.704
MOD_NEK2_1	237	242	PF00069	0.611
MOD_NEK2_1	267	272	PF00069	0.712
MOD_NEK2_1	83	88	PF00069	0.609
MOD_NEK2_2	103	108	PF00069	0.533
MOD_PIKK_1	41	47	PF00454	0.405
MOD_PIKK_1	70	76	PF00454	0.543
MOD_PIKK_1	83	89	PF00454	0.377
MOD_PKA_1	178	184	PF00069	0.496
MOD_PKA_1	202	208	PF00069	0.430
MOD_PKA_2	134	140	PF00069	0.403
MOD_PKA_2	160	166	PF00069	0.574
MOD_PKA_2	167	173	PF00069	0.431
MOD_PKA_2	178	184	PF00069	0.464
MOD_PKA_2	202	208	PF00069	0.508
MOD_PKA_2	245	251	PF00069	0.605
MOD_PKA_2	274	280	PF00069	0.771
MOD_Plk_1	187	193	PF00069	0.528
MOD_Plk_4	160	166	PF00069	0.499
MOD_Plk_4	267	273	PF00069	0.620
MOD_ProDKin_1	276	282	PF00069	0.736
MOD_SUMO_for_1	177	180	PF00179	0.551
TRG_DiLeu_BaEn_1	61	66	PF01217	0.549
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.512
TRG_ENDOCYTIC_2	268	271	PF00928	0.555
TRG_ER_diArg_1	142	144	PF00400	0.569
TRG_ER_diArg_1	9	12	PF00400	0.552
TRG_ER_diArg_1	90	92	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q7	Leptomonas seymouri	39%	100%
A0A3Q8IFY1	Leishmania donovani	91%	100%
A4HM48	Leishmania braziliensis	72%	100%
A4IAR0	Leishmania infantum	90%	100%
E9B5P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%