Trk system potassium uptake protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trk system potassium uptake protein

Species:

Leishmania major

UniProt:

E9AEI5_LEIMA

TriTrypDb:

LmjF.35.0080 , LMJLV39_350005800 , LMJSD75_350005900

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AEI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEI5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006811	monoatomic ion transport	4	11
GO:0006812	monoatomic cation transport	5	11
GO:0006813	potassium ion transport	7	11
GO:0030001	metal ion transport	6	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.651
CLV_C14_Caspase3-7	338	342	PF00656	0.527
CLV_C14_Caspase3-7	518	522	PF00656	0.262
CLV_C14_Caspase3-7	563	567	PF00656	0.579
CLV_NRD_NRD_1	184	186	PF00675	0.371
CLV_NRD_NRD_1	284	286	PF00675	0.318
CLV_NRD_NRD_1	450	452	PF00675	0.379
CLV_PCSK_KEX2_1	179	181	PF00082	0.304
CLV_PCSK_KEX2_1	184	186	PF00082	0.311
CLV_PCSK_KEX2_1	284	286	PF00082	0.313
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.362
CLV_PCSK_PC7_1	180	186	PF00082	0.354
CLV_PCSK_SKI1_1	13	17	PF00082	0.470
CLV_PCSK_SKI1_1	131	135	PF00082	0.455
CLV_PCSK_SKI1_1	159	163	PF00082	0.389
CLV_PCSK_SKI1_1	284	288	PF00082	0.354
CLV_PCSK_SKI1_1	454	458	PF00082	0.383
CLV_PCSK_SKI1_1	463	467	PF00082	0.244
CLV_PCSK_SKI1_1	501	505	PF00082	0.442
DEG_SCF_FBW7_1	24	31	PF00400	0.671
DEG_SPOP_SBC_1	141	145	PF00917	0.410
DEG_SPOP_SBC_1	567	571	PF00917	0.602
DOC_CDC14_PxL_1	44	52	PF14671	0.586
DOC_CDC14_PxL_1	91	99	PF14671	0.381
DOC_CKS1_1	25	30	PF01111	0.673
DOC_CYCLIN_RxL_1	495	508	PF00134	0.260
DOC_MAPK_gen_1	546	554	PF00069	0.455
DOC_MAPK_MEF2A_6	362	371	PF00069	0.429
DOC_MAPK_MEF2A_6	546	554	PF00069	0.450
DOC_PP1_RVXF_1	466	472	PF00149	0.357
DOC_PP1_RVXF_1	60	67	PF00149	0.452
DOC_PP2B_LxvP_1	134	137	PF13499	0.355
DOC_PP2B_LxvP_1	323	326	PF13499	0.702
DOC_PP2B_LxvP_1	517	520	PF13499	0.263
DOC_PP4_FxxP_1	45	48	PF00568	0.648
DOC_SPAK_OSR1_1	495	499	PF12202	0.336
DOC_USP7_MATH_1	106	110	PF00917	0.249
DOC_USP7_MATH_1	190	194	PF00917	0.410
DOC_USP7_MATH_1	347	351	PF00917	0.561
DOC_USP7_MATH_1	415	419	PF00917	0.284
DOC_USP7_MATH_1	567	571	PF00917	0.680
DOC_WW_Pin1_4	166	171	PF00397	0.631
DOC_WW_Pin1_4	193	198	PF00397	0.297
DOC_WW_Pin1_4	24	29	PF00397	0.751
DOC_WW_Pin1_4	296	301	PF00397	0.663
LIG_14-3-3_CanoR_1	310	318	PF00244	0.759
LIG_14-3-3_CanoR_1	39	47	PF00244	0.567
LIG_14-3-3_CanoR_1	458	462	PF00244	0.451
LIG_14-3-3_CanoR_1	463	472	PF00244	0.432
LIG_14-3-3_CanoR_1	573	579	PF00244	0.690
LIG_APCC_ABBA_1	478	483	PF00400	0.360
LIG_BRCT_BRCA1_1	234	238	PF00533	0.318
LIG_BRCT_BRCA1_1	466	470	PF00533	0.279
LIG_deltaCOP1_diTrp_1	122	130	PF00928	0.328
LIG_deltaCOP1_diTrp_1	276	281	PF00928	0.493
LIG_FHA_1	194	200	PF00498	0.335
LIG_FHA_1	249	255	PF00498	0.362
LIG_FHA_1	285	291	PF00498	0.547
LIG_FHA_1	313	319	PF00498	0.699
LIG_FHA_1	364	370	PF00498	0.442
LIG_FHA_1	38	44	PF00498	0.641
LIG_FHA_1	457	463	PF00498	0.461
LIG_FHA_1	464	470	PF00498	0.307
LIG_FHA_1	472	478	PF00498	0.356
LIG_FHA_1	498	504	PF00498	0.249
LIG_FHA_1	79	85	PF00498	0.407
LIG_FHA_2	167	173	PF00498	0.624
LIG_FHA_2	500	506	PF00498	0.286
LIG_GBD_Chelix_1	461	469	PF00786	0.298
LIG_IRF3_LxIS_1	439	445	PF10401	0.362
LIG_LIR_Gen_1	101	110	PF02991	0.197
LIG_LIR_Gen_1	196	204	PF02991	0.360
LIG_LIR_Gen_1	221	231	PF02991	0.317
LIG_LIR_Gen_1	276	283	PF02991	0.585
LIG_LIR_Gen_1	330	337	PF02991	0.563
LIG_LIR_Gen_1	494	504	PF02991	0.255
LIG_LIR_Gen_1	530	541	PF02991	0.395
LIG_LIR_Gen_1	555	565	PF02991	0.519
LIG_LIR_Gen_1	81	90	PF02991	0.407
LIG_LIR_Nem_3	101	107	PF02991	0.248
LIG_LIR_Nem_3	128	133	PF02991	0.356
LIG_LIR_Nem_3	143	149	PF02991	0.262
LIG_LIR_Nem_3	196	201	PF02991	0.324
LIG_LIR_Nem_3	221	226	PF02991	0.336
LIG_LIR_Nem_3	263	268	PF02991	0.290
LIG_LIR_Nem_3	276	280	PF02991	0.475
LIG_LIR_Nem_3	330	334	PF02991	0.575
LIG_LIR_Nem_3	355	359	PF02991	0.563
LIG_LIR_Nem_3	365	371	PF02991	0.442
LIG_LIR_Nem_3	387	392	PF02991	0.329
LIG_LIR_Nem_3	397	403	PF02991	0.253
LIG_LIR_Nem_3	418	422	PF02991	0.373
LIG_LIR_Nem_3	467	473	PF02991	0.279
LIG_LIR_Nem_3	502	507	PF02991	0.255
LIG_LIR_Nem_3	530	536	PF02991	0.357
LIG_LIR_Nem_3	555	561	PF02991	0.516
LIG_LIR_Nem_3	81	85	PF02991	0.407
LIG_MYND_1	24	28	PF01753	0.667
LIG_MYND_1	48	52	PF01753	0.579
LIG_MYND_3	420	424	PF01753	0.372
LIG_NRBOX	207	213	PF00104	0.453
LIG_NRBOX	285	291	PF00104	0.466
LIG_Pex14_1	453	457	PF04695	0.611
LIG_Pex14_2	66	70	PF04695	0.527
LIG_PTAP_UEV_1	29	34	PF05743	0.653
LIG_REV1ctd_RIR_1	64	73	PF16727	0.557
LIG_SH2_CRK	188	192	PF00017	0.357
LIG_SH2_CRK	331	335	PF00017	0.524
LIG_SH2_GRB2like	425	428	PF00017	0.297
LIG_SH2_SRC	438	441	PF00017	0.410
LIG_SH2_STAP1	188	192	PF00017	0.295
LIG_SH2_STAP1	244	248	PF00017	0.366
LIG_SH2_STAT5	200	203	PF00017	0.302
LIG_SH2_STAT5	403	406	PF00017	0.338
LIG_SH2_STAT5	438	441	PF00017	0.414
LIG_SH2_STAT5	71	74	PF00017	0.279
LIG_SH2_STAT5	78	81	PF00017	0.279
LIG_SH3_3	158	164	PF00018	0.552
LIG_SH3_3	2	8	PF00018	0.764
LIG_SH3_3	22	28	PF00018	0.739
LIG_SH3_3	437	443	PF00018	0.279
LIG_SH3_3	46	52	PF00018	0.538
LIG_SH3_5	33	37	PF00018	0.637
LIG_TRAF2_1	169	172	PF00917	0.538
LIG_TRFH_1	133	137	PF08558	0.282
LIG_TYR_ITIM	186	191	PF00017	0.469
LIG_UBA3_1	60	69	PF00899	0.594
LIG_Vh1_VBS_1	279	297	PF01044	0.459
LIG_WRC_WIRS_1	230	235	PF05994	0.249
MOD_CK1_1	193	199	PF00069	0.410
MOD_CK1_1	218	224	PF00069	0.323
MOD_CK1_1	232	238	PF00069	0.290
MOD_CK1_1	327	333	PF00069	0.624
MOD_CK1_1	38	44	PF00069	0.618
MOD_CK1_1	522	528	PF00069	0.282
MOD_CK1_1	560	566	PF00069	0.680
MOD_CK2_1	166	172	PF00069	0.628
MOD_CK2_1	302	308	PF00069	0.697
MOD_CK2_1	310	316	PF00069	0.668
MOD_CK2_1	346	352	PF00069	0.647
MOD_CK2_1	499	505	PF00069	0.242
MOD_CK2_1	566	572	PF00069	0.631
MOD_GlcNHglycan	122	126	PF01048	0.627
MOD_GlcNHglycan	192	195	PF01048	0.349
MOD_GlcNHglycan	2	5	PF01048	0.461
MOD_GlcNHglycan	220	223	PF01048	0.540
MOD_GlcNHglycan	308	313	PF01048	0.471
MOD_GlcNHglycan	316	321	PF01048	0.509
MOD_GlcNHglycan	507	510	PF01048	0.451
MOD_GSK3_1	121	128	PF00069	0.328
MOD_GSK3_1	229	236	PF00069	0.249
MOD_GSK3_1	24	31	PF00069	0.705
MOD_GSK3_1	248	255	PF00069	0.396
MOD_GSK3_1	308	315	PF00069	0.755
MOD_GSK3_1	442	449	PF00069	0.526
MOD_GSK3_1	515	522	PF00069	0.269
MOD_GSK3_1	556	563	PF00069	0.622
MOD_GSK3_1	568	575	PF00069	0.731
MOD_N-GLC_1	215	220	PF02516	0.535
MOD_N-GLC_1	522	527	PF02516	0.528
MOD_NEK2_1	174	179	PF00069	0.478
MOD_NEK2_1	215	220	PF00069	0.302
MOD_NEK2_1	226	231	PF00069	0.233
MOD_NEK2_1	233	238	PF00069	0.256
MOD_NEK2_1	260	265	PF00069	0.302
MOD_NEK2_1	423	428	PF00069	0.311
MOD_NEK2_1	456	461	PF00069	0.583
MOD_NEK2_1	464	469	PF00069	0.294
MOD_NEK2_1	491	496	PF00069	0.266
MOD_NEK2_1	499	504	PF00069	0.265
MOD_NEK2_1	515	520	PF00069	0.275
MOD_NEK2_1	556	561	PF00069	0.555
MOD_NEK2_2	125	130	PF00069	0.279
MOD_NEK2_2	363	368	PF00069	0.513
MOD_PIKK_1	38	44	PF00454	0.565
MOD_PKA_1	284	290	PF00069	0.501
MOD_PKA_2	284	290	PF00069	0.589
MOD_PKA_2	361	367	PF00069	0.605
MOD_PKA_2	38	44	PF00069	0.592
MOD_PKA_2	457	463	PF00069	0.473
MOD_PKA_2	572	578	PF00069	0.759
MOD_Plk_1	215	221	PF00069	0.351
MOD_Plk_1	446	452	PF00069	0.567
MOD_Plk_1	522	528	PF00069	0.331
MOD_Plk_2-3	302	308	PF00069	0.747
MOD_Plk_4	125	131	PF00069	0.367
MOD_Plk_4	207	213	PF00069	0.448
MOD_Plk_4	233	239	PF00069	0.286
MOD_Plk_4	329	335	PF00069	0.618
MOD_Plk_4	363	369	PF00069	0.449
MOD_Plk_4	374	380	PF00069	0.350
MOD_Plk_4	415	421	PF00069	0.277
MOD_Plk_4	430	436	PF00069	0.412
MOD_Plk_4	457	463	PF00069	0.484
MOD_Plk_4	522	528	PF00069	0.255
MOD_Plk_4	78	84	PF00069	0.326
MOD_ProDKin_1	166	172	PF00069	0.628
MOD_ProDKin_1	193	199	PF00069	0.297
MOD_ProDKin_1	24	30	PF00069	0.752
MOD_ProDKin_1	296	302	PF00069	0.668
TRG_DiLeu_BaEn_1	46	51	PF01217	0.596
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.279
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.361
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.473
TRG_ENDOCYTIC_2	188	191	PF00928	0.317
TRG_ENDOCYTIC_2	200	203	PF00928	0.232
TRG_ENDOCYTIC_2	331	334	PF00928	0.611
TRG_ENDOCYTIC_2	403	406	PF00928	0.290
TRG_ER_diArg_1	184	186	PF00400	0.552
TRG_ER_diArg_1	283	285	PF00400	0.519
TRG_ER_diArg_1	546	549	PF00400	0.536
TRG_NLS_MonoExtN_4	448	455	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD62	Leptomonas seymouri	68%	100%
A0A1X0NIY1	Trypanosomatidae	54%	88%
A0A3Q8IIM6	Leishmania donovani	94%	100%
A0A3R7RF53	Trypanosoma rangeli	50%	98%
A4HM47	Leishmania braziliensis	81%	100%
A4IAQ9	Leishmania infantum	94%	100%
D0A2F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
E9B5P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B392	Trypanosoma cruzi	50%	98%