Prohibitin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prohibitin

Gene product:

prohibitin, putative

Species:

Leishmania major

UniProt:

E9AEI4_LEIMA

TriTrypDb:

LmjF.35.0070 , LMJLV39_350005700 , LMJSD75_350005800

Length:

292

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial prohibitins, although no distinct transit signal can be discerned in this protein. A rather conserved family of proteins. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005743	mitochondrial inner membrane	5	12
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	12
GO:0031090	organelle membrane	3	12
GO:0031966	mitochondrial membrane	4	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AEI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEI4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.364
CLV_PCSK_FUR_1	169	173	PF00082	0.426
CLV_PCSK_KEX2_1	154	156	PF00082	0.431
CLV_PCSK_KEX2_1	171	173	PF00082	0.488
CLV_PCSK_KEX2_1	241	243	PF00082	0.626
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.426
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.426
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.626
CLV_PCSK_SKI1_1	282	286	PF00082	0.680
CLV_PCSK_SKI1_1	37	41	PF00082	0.546
CLV_PCSK_SKI1_1	47	51	PF00082	0.411
DOC_ANK_TNKS_1	59	66	PF00023	0.324
DOC_CKS1_1	73	78	PF01111	0.226
DOC_CYCLIN_yCln2_LP_2	73	79	PF00134	0.226
DOC_MAPK_gen_1	169	177	PF00069	0.237
DOC_MAPK_gen_1	241	249	PF00069	0.420
DOC_PP1_RVXF_1	35	42	PF00149	0.286
DOC_PP1_RVXF_1	45	52	PF00149	0.217
DOC_PP4_FxxP_1	40	43	PF00568	0.350
DOC_PP4_FxxP_1	68	71	PF00568	0.251
DOC_SPAK_OSR1_1	172	176	PF12202	0.226
DOC_USP7_MATH_1	156	160	PF00917	0.226
DOC_USP7_MATH_1	89	93	PF00917	0.242
DOC_WW_Pin1_4	72	77	PF00397	0.226
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BRCT_BRCA1_1	37	41	PF00533	0.278
LIG_EH1_1	159	167	PF00400	0.251
LIG_FHA_1	190	196	PF00498	0.237
LIG_FHA_1	73	79	PF00498	0.234
LIG_FHA_2	259	265	PF00498	0.440
LIG_FHA_2	59	65	PF00498	0.226
LIG_Integrin_isoDGR_2	267	269	PF01839	0.648
LIG_LIR_Apic_2	38	43	PF02991	0.371
LIG_LIR_Gen_1	275	286	PF02991	0.459
LIG_LIR_Nem_3	113	119	PF02991	0.249
LIG_LIR_Nem_3	275	281	PF02991	0.444
LIG_LIR_Nem_3	31	36	PF02991	0.467
LIG_MLH1_MIPbox_1	37	41	PF16413	0.278
LIG_PCNA_PIPBox_1	109	118	PF02747	0.261
LIG_PCNA_yPIPBox_3	105	116	PF02747	0.261
LIG_Pex14_2	68	72	PF04695	0.251
LIG_PTB_Apo_2	240	247	PF02174	0.317
LIG_PTB_Apo_2	56	63	PF02174	0.292
LIG_PTB_Phospho_1	56	62	PF10480	0.292
LIG_RPA_C_Fungi	251	263	PF08784	0.532
LIG_SH2_CRK	36	40	PF00017	0.344
LIG_SH2_GRB2like	191	194	PF00017	0.328
LIG_SH2_GRB2like	278	281	PF00017	0.589
LIG_SH2_PTP2	278	281	PF00017	0.562
LIG_SH2_SRC	271	274	PF00017	0.440
LIG_SH2_SRC	278	281	PF00017	0.452
LIG_SH2_STAP1	126	130	PF00017	0.269
LIG_SH2_STAP1	191	195	PF00017	0.269
LIG_SH2_STAT5	191	194	PF00017	0.323
LIG_SH2_STAT5	271	274	PF00017	0.461
LIG_SH2_STAT5	278	281	PF00017	0.452
LIG_SUMO_SIM_par_1	84	90	PF11976	0.405
LIG_TRAF2_1	215	218	PF00917	0.269
MOD_CK2_1	58	64	PF00069	0.269
MOD_GlcNHglycan	21	24	PF01048	0.373
MOD_GlcNHglycan	287	291	PF01048	0.626
MOD_GlcNHglycan	91	94	PF01048	0.361
MOD_GSK3_1	126	133	PF00069	0.306
MOD_GSK3_1	254	261	PF00069	0.461
MOD_GSK3_1	87	94	PF00069	0.281
MOD_N-GLC_1	146	151	PF02516	0.284
MOD_N-GLC_1	58	63	PF02516	0.361
MOD_NEK2_1	35	40	PF00069	0.353
MOD_NEK2_2	28	33	PF00069	0.367
MOD_PIKK_1	180	186	PF00454	0.269
MOD_Plk_1	178	184	PF00069	0.291
MOD_Plk_1	58	64	PF00069	0.284
MOD_Plk_4	126	132	PF00069	0.274
MOD_Plk_4	231	237	PF00069	0.533
MOD_Plk_4	273	279	PF00069	0.481
MOD_Plk_4	28	34	PF00069	0.317
MOD_Plk_4	35	41	PF00069	0.321
MOD_ProDKin_1	72	78	PF00069	0.269
MOD_SUMO_rev_2	190	200	PF00179	0.269
TRG_DiLeu_BaEn_1	231	236	PF01217	0.421
TRG_ENDOCYTIC_2	119	122	PF00928	0.269
TRG_ENDOCYTIC_2	12	15	PF00928	0.405
TRG_ENDOCYTIC_2	278	281	PF00928	0.589
TRG_ENDOCYTIC_2	36	39	PF00928	0.375
TRG_NES_CRM1_1	275	287	PF08389	0.598
TRG_NES_CRM1_1	96	109	PF08389	0.269
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M3	Leptomonas seymouri	92%	96%
A0A0N1IKI8	Leptomonas seymouri	41%	100%
A0A0S4IYJ7	Bodo saltans	40%	100%
A0A0S4JRD4	Bodo saltans	70%	94%
A0A1X0NJ09	Trypanosomatidae	75%	98%
A0A1X0NYS7	Trypanosomatidae	46%	100%
A0A3R7K7X6	Trypanosoma rangeli	73%	96%
A0A3S7WU67	Leishmania donovani	40%	100%
A0A3S7X8M7	Leishmania donovani	99%	100%
A4H8T9	Leishmania braziliensis	40%	100%
A4HM46	Leishmania braziliensis	99%	100%
A4HX59	Leishmania infantum	40%	100%
A4IAQ8	Leishmania infantum	99%	100%
A9UMS3	Xenopus tropicalis	46%	97%
C9ZVT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A2F6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	99%
E9AQX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B5P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O04331	Arabidopsis thaliana	47%	100%
O35129	Mus musculus	46%	98%
O49460	Arabidopsis thaliana	52%	100%
O94550	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
P24156	Drosophila melanogaster	44%	100%
P35232	Homo sapiens	44%	100%
P40961	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P50085	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	94%
P50093	Caenorhabditis elegans	48%	99%
P67778	Mus musculus	45%	100%
P67779	Rattus norvegicus	45%	100%
P84173	Gallus gallus	41%	100%
Q2HJ97	Bos taurus	46%	98%
Q3T165	Bos taurus	44%	100%
Q4QEK4	Leishmania major	40%	100%
Q54GI9	Dictyostelium discoideum	44%	100%
Q54Q31	Dictyostelium discoideum	46%	100%
Q58237	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q5RB19	Pongo abelii	46%	98%
Q5XIH7	Rattus norvegicus	46%	98%
Q5ZMN3	Gallus gallus	47%	97%
Q99623	Homo sapiens	46%	98%
Q9BKU4	Caenorhabditis elegans	42%	100%
Q9FFH5	Arabidopsis thaliana	48%	100%
Q9LK25	Arabidopsis thaliana	46%	100%
Q9LY99	Arabidopsis thaliana	43%	100%
Q9P7H3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
Q9SIL6	Arabidopsis thaliana	48%	100%
Q9ZNT7	Arabidopsis thaliana	48%	100%
V5DJ73	Trypanosoma cruzi	42%	100%
V5DJR3	Trypanosoma cruzi	74%	95%