Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEI3_LEIMA

TriTrypDb:

LmjF.35.0060 , LMJLV39_350005600 , LMJSD75_350005700

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	519	523	PF00656	0.441
CLV_NRD_NRD_1	172	174	PF00675	0.489
CLV_NRD_NRD_1	319	321	PF00675	0.427
CLV_NRD_NRD_1	360	362	PF00675	0.437
CLV_NRD_NRD_1	391	393	PF00675	0.463
CLV_NRD_NRD_1	470	472	PF00675	0.533
CLV_NRD_NRD_1	500	502	PF00675	0.568
CLV_NRD_NRD_1	538	540	PF00675	0.427
CLV_NRD_NRD_1	568	570	PF00675	0.418
CLV_NRD_NRD_1	625	627	PF00675	0.524
CLV_NRD_NRD_1	640	642	PF00675	0.519
CLV_NRD_NRD_1	653	655	PF00675	0.472
CLV_PCSK_FUR_1	317	321	PF00082	0.398
CLV_PCSK_FUR_1	623	627	PF00082	0.537
CLV_PCSK_KEX2_1	172	174	PF00082	0.407
CLV_PCSK_KEX2_1	249	251	PF00082	0.637
CLV_PCSK_KEX2_1	319	321	PF00082	0.427
CLV_PCSK_KEX2_1	359	361	PF00082	0.479
CLV_PCSK_KEX2_1	391	393	PF00082	0.463
CLV_PCSK_KEX2_1	409	411	PF00082	0.389
CLV_PCSK_KEX2_1	470	472	PF00082	0.610
CLV_PCSK_KEX2_1	499	501	PF00082	0.582
CLV_PCSK_KEX2_1	538	540	PF00082	0.427
CLV_PCSK_KEX2_1	568	570	PF00082	0.388
CLV_PCSK_KEX2_1	611	613	PF00082	0.461
CLV_PCSK_KEX2_1	625	627	PF00082	0.458
CLV_PCSK_KEX2_1	642	644	PF00082	0.570
CLV_PCSK_KEX2_1	653	655	PF00082	0.453
CLV_PCSK_KEX2_1	77	79	PF00082	0.419
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.616
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.645
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.429
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.647
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.498
CLV_PCSK_PC7_1	564	570	PF00082	0.414
CLV_PCSK_PC7_1	607	613	PF00082	0.544
CLV_PCSK_PC7_1	73	79	PF00082	0.439
CLV_PCSK_SKI1_1	106	110	PF00082	0.388
CLV_PCSK_SKI1_1	299	303	PF00082	0.518
CLV_PCSK_SKI1_1	445	449	PF00082	0.472
CLV_PCSK_SKI1_1	521	525	PF00082	0.467
CLV_PCSK_SKI1_1	661	665	PF00082	0.588
DEG_APCC_DBOX_1	520	528	PF00400	0.465
DEG_Nend_UBRbox_3	1	3	PF02207	0.372
DOC_ANK_TNKS_1	500	507	PF00023	0.565
DOC_CDC14_PxL_1	37	45	PF14671	0.453
DOC_CKS1_1	252	257	PF01111	0.665
DOC_MAPK_gen_1	115	124	PF00069	0.252
DOC_MAPK_gen_1	331	340	PF00069	0.651
DOC_MAPK_gen_1	359	365	PF00069	0.432
DOC_MAPK_gen_1	391	399	PF00069	0.567
DOC_MAPK_gen_1	470	478	PF00069	0.453
DOC_MAPK_gen_1	623	631	PF00069	0.459
DOC_MAPK_MEF2A_6	331	340	PF00069	0.615
DOC_PIKK_1	30	37	PF02985	0.321
DOC_PP4_FxxP_1	227	230	PF00568	0.674
DOC_USP7_MATH_1	155	159	PF00917	0.470
DOC_USP7_MATH_1	175	179	PF00917	0.647
DOC_USP7_MATH_1	206	210	PF00917	0.758
DOC_USP7_MATH_1	265	269	PF00917	0.668
DOC_USP7_MATH_1	443	447	PF00917	0.451
DOC_USP7_UBL2_3	453	457	PF12436	0.454
DOC_WW_Pin1_4	237	242	PF00397	0.750
DOC_WW_Pin1_4	251	256	PF00397	0.561
DOC_WW_Pin1_4	291	296	PF00397	0.599
LIG_14-3-3_CanoR_1	201	211	PF00244	0.509
LIG_14-3-3_CanoR_1	236	241	PF00244	0.561
LIG_14-3-3_CanoR_1	299	309	PF00244	0.621
LIG_14-3-3_CanoR_1	514	520	PF00244	0.578
LIG_14-3-3_CanoR_1	641	651	PF00244	0.540
LIG_14-3-3_CanoR_1	78	83	PF00244	0.446
LIG_Actin_WH2_2	445	462	PF00022	0.565
LIG_Actin_WH2_2	508	523	PF00022	0.505
LIG_APCC_ABBA_1	124	129	PF00400	0.304
LIG_BRCT_BRCA1_1	342	346	PF00533	0.478
LIG_CaM_NSCaTE_8	7	14	PF13499	0.464
LIG_EH1_1	219	227	PF00400	0.469
LIG_eIF4E_1	87	93	PF01652	0.316
LIG_FHA_1	162	168	PF00498	0.493
LIG_FHA_1	251	257	PF00498	0.582
LIG_FHA_1	46	52	PF00498	0.479
LIG_FHA_1	470	476	PF00498	0.455
LIG_FHA_2	102	108	PF00498	0.486
LIG_FHA_2	226	232	PF00498	0.541
LIG_FHA_2	278	284	PF00498	0.734
LIG_FHA_2	30	36	PF00498	0.465
LIG_FHA_2	330	336	PF00498	0.594
LIG_FHA_2	337	343	PF00498	0.622
LIG_FHA_2	643	649	PF00498	0.448
LIG_LIR_Apic_2	132	137	PF02991	0.415
LIG_LIR_Apic_2	224	230	PF02991	0.601
LIG_LIR_Gen_1	120	127	PF02991	0.453
LIG_LIR_Gen_1	59	69	PF02991	0.312
LIG_LIR_Nem_3	120	124	PF02991	0.310
LIG_LIR_Nem_3	5	10	PF02991	0.408
LIG_LIR_Nem_3	59	64	PF02991	0.340
LIG_LIR_Nem_3	66	72	PF02991	0.319
LIG_LYPXL_yS_3	40	43	PF13949	0.453
LIG_PCNA_PIPBox_1	363	372	PF02747	0.543
LIG_Pex14_1	139	143	PF04695	0.355
LIG_PTB_Apo_2	50	57	PF02174	0.395
LIG_SH2_CRK	134	138	PF00017	0.401
LIG_SH2_CRK	97	101	PF00017	0.379
LIG_SH2_SRC	143	146	PF00017	0.411
LIG_SH2_STAP1	143	147	PF00017	0.341
LIG_SH2_STAT5	87	90	PF00017	0.389
LIG_SH2_STAT5	91	94	PF00017	0.337
LIG_SH3_1	249	255	PF00018	0.562
LIG_SH3_3	149	155	PF00018	0.405
LIG_SH3_3	179	185	PF00018	0.618
LIG_SH3_3	226	232	PF00018	0.645
LIG_SH3_3	249	255	PF00018	0.507
LIG_SH3_3	35	41	PF00018	0.587
LIG_SUMO_SIM_par_1	474	480	PF11976	0.480
LIG_TRAF2_1	186	189	PF00917	0.679
LIG_TRAF2_1	44	47	PF00917	0.530
LIG_TRAF2_1	462	465	PF00917	0.435
LIG_TYR_ITIM	38	43	PF00017	0.463
LIG_TYR_ITIM	89	94	PF00017	0.317
MOD_CK1_1	307	313	PF00069	0.637
MOD_CK1_1	428	434	PF00069	0.429
MOD_CK1_1	45	51	PF00069	0.369
MOD_CK2_1	101	107	PF00069	0.487
MOD_CK2_1	155	161	PF00069	0.525
MOD_CK2_1	20	26	PF00069	0.618
MOD_CK2_1	225	231	PF00069	0.570
MOD_CK2_1	283	289	PF00069	0.670
MOD_CK2_1	329	335	PF00069	0.429
MOD_CK2_1	41	47	PF00069	0.400
MOD_CK2_1	414	420	PF00069	0.449
MOD_CK2_1	513	519	PF00069	0.497
MOD_CK2_1	642	648	PF00069	0.455
MOD_GlcNHglycan	177	180	PF01048	0.684
MOD_GlcNHglycan	22	25	PF01048	0.608
MOD_GlcNHglycan	267	270	PF01048	0.617
MOD_GlcNHglycan	280	283	PF01048	0.665
MOD_GlcNHglycan	444	448	PF01048	0.470
MOD_GSK3_1	125	132	PF00069	0.509
MOD_GSK3_1	173	180	PF00069	0.655
MOD_GSK3_1	192	199	PF00069	0.662
MOD_GSK3_1	202	209	PF00069	0.613
MOD_GSK3_1	265	272	PF00069	0.705
MOD_GSK3_1	297	304	PF00069	0.561
MOD_GSK3_1	336	343	PF00069	0.597
MOD_GSK3_1	41	48	PF00069	0.554
MOD_GSK3_1	78	85	PF00069	0.485
MOD_N-GLC_1	56	61	PF02516	0.534
MOD_N-GLC_1	573	578	PF02516	0.414
MOD_N-GLC_1	78	83	PF02516	0.502
MOD_NEK2_1	109	114	PF00069	0.442
MOD_NEK2_1	127	132	PF00069	0.427
MOD_NEK2_1	193	198	PF00069	0.762
MOD_NEK2_1	225	230	PF00069	0.543
MOD_NEK2_1	301	306	PF00069	0.584
MOD_NEK2_1	336	341	PF00069	0.495
MOD_NEK2_1	56	61	PF00069	0.474
MOD_NEK2_2	101	106	PF00069	0.399
MOD_PIKK_1	173	179	PF00454	0.602
MOD_PIKK_1	384	390	PF00454	0.472
MOD_PIKK_1	513	519	PF00454	0.482
MOD_PIKK_1	573	579	PF00454	0.525
MOD_PIKK_1	642	648	PF00454	0.506
MOD_PKA_1	642	648	PF00069	0.446
MOD_PKA_1	77	83	PF00069	0.400
MOD_PKA_2	200	206	PF00069	0.553
MOD_PKA_2	277	283	PF00069	0.511
MOD_PKA_2	384	390	PF00069	0.549
MOD_PKA_2	469	475	PF00069	0.559
MOD_PKA_2	513	519	PF00069	0.588
MOD_PKA_2	642	648	PF00069	0.484
MOD_PKA_2	77	83	PF00069	0.427
MOD_PKB_1	324	332	PF00069	0.386
MOD_Plk_1	143	149	PF00069	0.503
MOD_Plk_1	29	35	PF00069	0.412
MOD_Plk_1	329	335	PF00069	0.552
MOD_Plk_1	336	342	PF00069	0.531
MOD_Plk_1	443	449	PF00069	0.407
MOD_Plk_1	45	51	PF00069	0.374
MOD_Plk_1	56	62	PF00069	0.377
MOD_Plk_1	78	84	PF00069	0.388
MOD_Plk_2-3	635	641	PF00069	0.522
MOD_Plk_4	143	149	PF00069	0.443
MOD_Plk_4	46	52	PF00069	0.484
MOD_Plk_4	82	88	PF00069	0.365
MOD_ProDKin_1	237	243	PF00069	0.751
MOD_ProDKin_1	251	257	PF00069	0.562
MOD_ProDKin_1	291	297	PF00069	0.595
MOD_SUMO_for_1	452	455	PF00179	0.474
TRG_DiLeu_BaEn_2	119	125	PF01217	0.447
TRG_DiLeu_BaEn_2	45	51	PF01217	0.412
TRG_DiLeu_BaEn_4	188	194	PF01217	0.565
TRG_ENDOCYTIC_2	40	43	PF00928	0.453
TRG_ENDOCYTIC_2	91	94	PF00928	0.292
TRG_ENDOCYTIC_2	97	100	PF00928	0.350
TRG_ER_diArg_1	171	173	PF00400	0.549
TRG_ER_diArg_1	319	322	PF00400	0.441
TRG_ER_diArg_1	359	361	PF00400	0.560
TRG_ER_diArg_1	378	381	PF00400	0.367
TRG_ER_diArg_1	499	501	PF00400	0.615
TRG_ER_diArg_1	545	548	PF00400	0.511
TRG_ER_diArg_1	561	564	PF00400	0.385
TRG_ER_diArg_1	568	571	PF00400	0.426
TRG_ER_diArg_1	594	597	PF00400	0.609
TRG_ER_diArg_1	623	626	PF00400	0.459
TRG_ER_diArg_1	641	644	PF00400	0.564
TRG_ER_diArg_1	652	654	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	661	665	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P614	Leptomonas seymouri	46%	96%
A0A0S4JK29	Bodo saltans	27%	84%
A0A1X0NJ66	Trypanosomatidae	31%	100%
A0A3R7KU75	Trypanosoma rangeli	32%	100%
A0A3S7X8L7	Leishmania donovani	91%	100%
A4HM45	Leishmania braziliensis	74%	99%
A4IAQ7	Leishmania infantum	91%	100%
D0A2F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BNB8	Trypanosoma cruzi	30%	100%