Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-specific phospholipase-like protein

Species:

Leishmania major

UniProt:

E9AEI1_LEIMA

TriTrypDb:

LmjF.35.0040 , LMJLV39_350005300 , LMJSD75_350005400

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEI1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	19
GO:0007165	signal transduction	2	19
GO:0008152	metabolic process	1	19
GO:0009056	catabolic process	2	19
GO:0009987	cellular process	1	19
GO:0016042	lipid catabolic process	4	19
GO:0035556	intracellular signal transduction	3	19
GO:0044238	primary metabolic process	2	19
GO:0048015	phosphatidylinositol-mediated signaling	5	3
GO:0048017	inositol lipid-mediated signaling	4	3
GO:0050789	regulation of biological process	2	19
GO:0050794	regulation of cellular process	3	19
GO:0065007	biological regulation	1	19
GO:0071704	organic substance metabolic process	2	19
GO:1901575	organic substance catabolic process	3	19

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004435	phosphatidylinositol phospholipase C activity	7	19
GO:0004620	phospholipase activity	5	19
GO:0004629	phospholipase C activity	6	19
GO:0005488	binding	1	17
GO:0005509	calcium ion binding	5	17
GO:0008081	phosphoric diester hydrolase activity	5	19
GO:0016298	lipase activity	4	19
GO:0016787	hydrolase activity	2	19
GO:0016788	hydrolase activity, acting on ester bonds	3	19
GO:0042578	phosphoric ester hydrolase activity	4	19
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.464
CLV_C14_Caspase3-7	425	429	PF00656	0.392
CLV_C14_Caspase3-7	535	539	PF00656	0.376
CLV_C14_Caspase3-7	618	622	PF00656	0.599
CLV_NRD_NRD_1	129	131	PF00675	0.442
CLV_NRD_NRD_1	16	18	PF00675	0.637
CLV_NRD_NRD_1	467	469	PF00675	0.510
CLV_PCSK_KEX2_1	129	131	PF00082	0.447
CLV_PCSK_KEX2_1	467	469	PF00082	0.510
CLV_PCSK_SKI1_1	130	134	PF00082	0.521
CLV_PCSK_SKI1_1	266	270	PF00082	0.321
CLV_PCSK_SKI1_1	328	332	PF00082	0.333
CLV_PCSK_SKI1_1	361	365	PF00082	0.418
CLV_PCSK_SKI1_1	415	419	PF00082	0.394
CLV_PCSK_SKI1_1	421	425	PF00082	0.380
CLV_PCSK_SKI1_1	43	47	PF00082	0.403
CLV_PCSK_SKI1_1	703	707	PF00082	0.461
DEG_APCC_DBOX_1	420	428	PF00400	0.360
DEG_MDM2_SWIB_1	104	111	PF02201	0.472
DEG_SPOP_SBC_1	486	490	PF00917	0.509
DOC_CKS1_1	722	727	PF01111	0.372
DOC_MAPK_gen_1	27	36	PF00069	0.470
DOC_MAPK_gen_1	38	47	PF00069	0.438
DOC_MAPK_gen_1	436	443	PF00069	0.337
DOC_MAPK_gen_1	660	669	PF00069	0.325
DOC_MAPK_MEF2A_6	390	398	PF00069	0.406
DOC_MAPK_MEF2A_6	41	49	PF00069	0.463
DOC_MAPK_MEF2A_6	662	671	PF00069	0.441
DOC_PP1_RVXF_1	157	163	PF00149	0.455
DOC_PP1_RVXF_1	359	365	PF00149	0.348
DOC_PP4_FxxP_1	376	379	PF00568	0.388
DOC_PP4_FxxP_1	722	725	PF00568	0.485
DOC_SPAK_OSR1_1	236	240	PF12202	0.486
DOC_USP7_MATH_1	141	145	PF00917	0.476
DOC_USP7_MATH_1	213	217	PF00917	0.454
DOC_USP7_MATH_1	479	483	PF00917	0.432
DOC_USP7_MATH_1	594	598	PF00917	0.324
DOC_USP7_MATH_1	75	79	PF00917	0.381
DOC_USP7_UBL2_3	436	440	PF12436	0.363
DOC_USP7_UBL2_3	84	88	PF12436	0.513
DOC_WW_Pin1_4	245	250	PF00397	0.495
DOC_WW_Pin1_4	400	405	PF00397	0.282
DOC_WW_Pin1_4	430	435	PF00397	0.323
DOC_WW_Pin1_4	47	52	PF00397	0.489
DOC_WW_Pin1_4	512	517	PF00397	0.248
DOC_WW_Pin1_4	721	726	PF00397	0.445
LIG_14-3-3_CanoR_1	118	122	PF00244	0.444
LIG_14-3-3_CanoR_1	129	133	PF00244	0.481
LIG_14-3-3_CanoR_1	17	26	PF00244	0.574
LIG_14-3-3_CanoR_1	220	229	PF00244	0.477
LIG_14-3-3_CanoR_1	251	256	PF00244	0.359
LIG_14-3-3_CanoR_1	262	269	PF00244	0.518
LIG_14-3-3_CanoR_1	291	299	PF00244	0.538
LIG_14-3-3_CanoR_1	35	41	PF00244	0.334
LIG_14-3-3_CanoR_1	487	492	PF00244	0.559
LIG_14-3-3_CanoR_1	521	530	PF00244	0.416
LIG_Actin_WH2_2	19	37	PF00022	0.509
LIG_Actin_WH2_2	440	458	PF00022	0.389
LIG_APCC_ABBA_1	629	634	PF00400	0.522
LIG_APCC_ABBAyCdc20_2	628	634	PF00400	0.334
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BRCT_BRCA1_1	613	617	PF00533	0.296
LIG_BRCT_BRCA1_1	66	70	PF00533	0.514
LIG_DLG_GKlike_1	251	258	PF00625	0.365
LIG_FHA_1	167	173	PF00498	0.568
LIG_FHA_1	271	277	PF00498	0.448
LIG_FHA_1	357	363	PF00498	0.319
LIG_FHA_1	472	478	PF00498	0.570
LIG_FHA_1	522	528	PF00498	0.296
LIG_FHA_1	600	606	PF00498	0.436
LIG_FHA_1	624	630	PF00498	0.421
LIG_FHA_1	638	644	PF00498	0.459
LIG_FHA_1	662	668	PF00498	0.369
LIG_FHA_1	678	684	PF00498	0.389
LIG_FHA_1	708	714	PF00498	0.419
LIG_FHA_1	722	728	PF00498	0.370
LIG_FHA_2	112	118	PF00498	0.439
LIG_FHA_2	129	135	PF00498	0.475
LIG_FHA_2	2	8	PF00498	0.665
LIG_FHA_2	228	234	PF00498	0.458
LIG_FHA_2	368	374	PF00498	0.406
LIG_FHA_2	400	406	PF00498	0.400
LIG_FHA_2	533	539	PF00498	0.368
LIG_FHA_2	613	619	PF00498	0.574
LIG_LIR_Apic_2	341	346	PF02991	0.388
LIG_LIR_Apic_2	373	379	PF02991	0.388
LIG_LIR_Apic_2	721	725	PF02991	0.340
LIG_LIR_Gen_1	107	116	PF02991	0.408
LIG_LIR_Gen_1	119	125	PF02991	0.401
LIG_LIR_Gen_1	161	168	PF02991	0.499
LIG_LIR_Gen_1	200	208	PF02991	0.436
LIG_LIR_Gen_1	232	239	PF02991	0.440
LIG_LIR_Gen_1	254	260	PF02991	0.513
LIG_LIR_Gen_1	270	279	PF02991	0.353
LIG_LIR_Gen_1	67	76	PF02991	0.455
LIG_LIR_Gen_1	695	705	PF02991	0.334
LIG_LIR_Nem_3	107	111	PF02991	0.358
LIG_LIR_Nem_3	119	124	PF02991	0.318
LIG_LIR_Nem_3	146	151	PF02991	0.518
LIG_LIR_Nem_3	161	165	PF02991	0.379
LIG_LIR_Nem_3	200	204	PF02991	0.421
LIG_LIR_Nem_3	232	237	PF02991	0.417
LIG_LIR_Nem_3	254	259	PF02991	0.435
LIG_LIR_Nem_3	270	275	PF02991	0.377
LIG_LIR_Nem_3	48	52	PF02991	0.376
LIG_PCNA_yPIPBox_3	135	149	PF02747	0.575
LIG_Pex14_2	104	108	PF04695	0.439
LIG_Pex14_2	201	205	PF04695	0.430
LIG_Pex14_2	70	74	PF04695	0.380
LIG_Pex14_2	94	98	PF04695	0.507
LIG_PTB_Apo_2	167	174	PF02174	0.368
LIG_REV1ctd_RIR_1	202	210	PF16727	0.273
LIG_SH2_GRB2like	207	210	PF00017	0.421
LIG_SH2_SRC	503	506	PF00017	0.282
LIG_SH2_SRC	58	61	PF00017	0.483
LIG_SH2_STAT3	374	377	PF00017	0.355
LIG_SH2_STAT3	96	99	PF00017	0.438
LIG_SH2_STAT5	207	210	PF00017	0.455
LIG_SH2_STAT5	303	306	PF00017	0.333
LIG_SH2_STAT5	312	315	PF00017	0.331
LIG_SH2_STAT5	432	435	PF00017	0.398
LIG_SH2_STAT5	503	506	PF00017	0.372
LIG_SH2_STAT5	582	585	PF00017	0.346
LIG_SH2_STAT5	588	591	PF00017	0.379
LIG_SH2_STAT5	96	99	PF00017	0.423
LIG_SH3_3	580	586	PF00018	0.352
LIG_SUMO_SIM_par_1	391	397	PF11976	0.337
LIG_SUMO_SIM_par_1	473	478	PF11976	0.561
LIG_SUMO_SIM_par_1	639	646	PF11976	0.349
LIG_TRAF2_1	230	233	PF00917	0.481
LIG_TRFH_1	275	279	PF08558	0.435
LIG_TRFH_1	582	586	PF08558	0.333
LIG_WRC_WIRS_1	46	51	PF05994	0.471
MOD_CDK_SPxK_1	245	251	PF00069	0.501
MOD_CDK_SPxK_1	430	436	PF00069	0.388
MOD_CK1_1	10	16	PF00069	0.627
MOD_CK1_1	166	172	PF00069	0.421
MOD_CK1_1	270	276	PF00069	0.455
MOD_CK1_1	308	314	PF00069	0.309
MOD_CK1_1	320	326	PF00069	0.319
MOD_CK1_1	430	436	PF00069	0.406
MOD_CK1_1	482	488	PF00069	0.423
MOD_CK1_1	611	617	PF00069	0.344
MOD_CK1_1	637	643	PF00069	0.508
MOD_CK1_1	677	683	PF00069	0.480
MOD_CK1_1	707	713	PF00069	0.519
MOD_CK1_1	721	727	PF00069	0.329
MOD_CK2_1	1	7	PF00069	0.624
MOD_CK2_1	10	16	PF00069	0.531
MOD_CK2_1	111	117	PF00069	0.414
MOD_CK2_1	158	164	PF00069	0.421
MOD_CK2_1	213	219	PF00069	0.514
MOD_CK2_1	227	233	PF00069	0.418
MOD_CK2_1	399	405	PF00069	0.400
MOD_CK2_1	499	505	PF00069	0.343
MOD_GlcNHglycan	269	272	PF01048	0.417
MOD_GlcNHglycan	460	463	PF01048	0.626
MOD_GlcNHglycan	477	480	PF01048	0.471
MOD_GlcNHglycan	532	535	PF01048	0.392
MOD_GlcNHglycan	596	599	PF01048	0.528
MOD_GlcNHglycan	676	679	PF01048	0.523
MOD_GlcNHglycan	706	709	PF01048	0.505
MOD_GSK3_1	187	194	PF00069	0.403
MOD_GSK3_1	3	10	PF00069	0.604
MOD_GSK3_1	304	311	PF00069	0.347
MOD_GSK3_1	400	407	PF00069	0.421
MOD_GSK3_1	471	478	PF00069	0.622
MOD_GSK3_1	482	489	PF00069	0.418
MOD_GSK3_1	521	528	PF00069	0.326
MOD_GSK3_1	532	539	PF00069	0.373
MOD_GSK3_1	59	66	PF00069	0.499
MOD_GSK3_1	608	615	PF00069	0.538
MOD_GSK3_1	75	82	PF00069	0.403
MOD_N-GLC_1	141	146	PF02516	0.576
MOD_N-GLC_1	305	310	PF02516	0.390
MOD_N-GLC_1	651	656	PF02516	0.356
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	104	109	PF00069	0.479
MOD_NEK2_1	116	121	PF00069	0.507
MOD_NEK2_1	133	138	PF00069	0.351
MOD_NEK2_1	267	272	PF00069	0.268
MOD_NEK2_1	304	309	PF00069	0.353
MOD_NEK2_1	34	39	PF00069	0.458
MOD_NEK2_1	422	427	PF00069	0.379
MOD_NEK2_1	455	460	PF00069	0.598
MOD_NEK2_1	471	476	PF00069	0.366
MOD_NEK2_2	213	218	PF00069	0.470
MOD_NEK2_2	718	723	PF00069	0.335
MOD_OFUCOSY	188	195	PF10250	0.366
MOD_PIKK_1	99	105	PF00454	0.374
MOD_PKA_1	17	23	PF00069	0.330
MOD_PKA_2	117	123	PF00069	0.435
MOD_PKA_2	128	134	PF00069	0.468
MOD_PKA_2	219	225	PF00069	0.361
MOD_PKA_2	261	267	PF00069	0.562
MOD_PKA_2	290	296	PF00069	0.463
MOD_PKA_2	34	40	PF00069	0.510
MOD_PKA_2	486	492	PF00069	0.576
MOD_Plk_1	11	17	PF00069	0.659
MOD_Plk_1	116	122	PF00069	0.479
MOD_Plk_1	141	147	PF00069	0.527
MOD_Plk_1	163	169	PF00069	0.486
MOD_Plk_1	232	238	PF00069	0.466
MOD_Plk_1	427	433	PF00069	0.324
MOD_Plk_1	620	626	PF00069	0.428
MOD_Plk_1	651	657	PF00069	0.329
MOD_Plk_2-3	117	123	PF00069	0.459
MOD_Plk_2-3	7	13	PF00069	0.431
MOD_Plk_4	117	123	PF00069	0.451
MOD_Plk_4	251	257	PF00069	0.500
MOD_Plk_4	280	286	PF00069	0.407
MOD_Plk_4	29	35	PF00069	0.392
MOD_Plk_4	308	314	PF00069	0.333
MOD_Plk_4	499	505	PF00069	0.446
MOD_Plk_4	64	70	PF00069	0.497
MOD_Plk_4	643	649	PF00069	0.450
MOD_Plk_4	712	718	PF00069	0.444
MOD_Plk_4	723	729	PF00069	0.588
MOD_ProDKin_1	245	251	PF00069	0.490
MOD_ProDKin_1	400	406	PF00069	0.282
MOD_ProDKin_1	430	436	PF00069	0.323
MOD_ProDKin_1	47	53	PF00069	0.496
MOD_ProDKin_1	512	518	PF00069	0.248
MOD_ProDKin_1	721	727	PF00069	0.460
MOD_SUMO_rev_2	10	20	PF00179	0.632
MOD_SUMO_rev_2	453	458	PF00179	0.574
TRG_DiLeu_BaEn_2	145	151	PF01217	0.381
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.533
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.311
TRG_ENDOCYTIC_2	148	151	PF00928	0.608
TRG_ENDOCYTIC_2	198	201	PF00928	0.402
TRG_ENDOCYTIC_2	327	330	PF00928	0.372
TRG_ENDOCYTIC_2	542	545	PF00928	0.343
TRG_ENDOCYTIC_2	697	700	PF00928	0.378
TRG_ER_diArg_1	627	630	PF00400	0.245
TRG_NES_CRM1_1	412	428	PF08389	0.314
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N0	Leptomonas seymouri	31%	99%
A0A0N1IKD7	Leptomonas seymouri	61%	97%
A0A0S4ITT3	Bodo saltans	31%	84%
A0A0S4J9Y4	Bodo saltans	32%	100%
A0A0S4JUS2	Bodo saltans	31%	100%
A0A1X0P2K1	Trypanosomatidae	34%	99%
A0A3Q8IF05	Leishmania donovani	33%	99%
A0A3S7X8U7	Leishmania donovani	92%	100%
A0A422N571	Trypanosoma rangeli	35%	100%
A4HCK9	Leishmania braziliensis	30%	100%
A4HM43	Leishmania braziliensis	79%	100%
A4I027	Leishmania infantum	32%	93%
A4I5X4	Leishmania infantum	33%	99%
A4IAQ5	Leishmania infantum	92%	100%
A5D6R3	Danio rerio	30%	93%
E9B168	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	99%
E9B5P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P10688	Rattus norvegicus	30%	96%
P10895	Bos taurus	31%	96%
P40977	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	81%
Q15111	Homo sapiens	29%	67%
Q1RML2	Bos taurus	27%	100%
Q2VRL0	Gallus gallus	29%	100%
Q32NH8	Xenopus laevis	29%	96%
Q39032	Arabidopsis thaliana	25%	100%
Q39033	Arabidopsis thaliana	26%	100%
Q3USB7	Mus musculus	28%	67%
Q4Q6Z7	Leishmania major	33%	99%
Q4QBH9	Leishmania major	30%	100%
Q5RET0	Pongo abelii	29%	96%
Q62688	Rattus norvegicus	28%	67%
Q62711	Rattus norvegicus	28%	94%
Q6NMA7	Arabidopsis thaliana	23%	100%
Q7YRU3	Sus scrofa	31%	100%
Q86YW0	Homo sapiens	28%	100%
Q8GV43	Arabidopsis thaliana	27%	100%
Q8K2J0	Mus musculus	31%	93%
Q8K4D7	Mus musculus	27%	100%
Q8N3E9	Homo sapiens	31%	92%
Q8R3B1	Mus musculus	29%	96%
Q944C2	Arabidopsis thaliana	27%	100%
Q9BRC7	Homo sapiens	29%	96%