Pyruvate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pyruvate kinase

Gene product:

pyruvate kinase

Species:

Leishmania major

UniProt:

E9AEI0_LEIMA

TriTrypDb:

LmjF.35.0030 , LMJLV39_350005100 , LMJSD75_350005300

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AEI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEI0

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0006082	organic acid metabolic process	3	3
GO:0006090	pyruvate metabolic process	7	3
GO:0006091	generation of precursor metabolites and energy	3	3
GO:0006096	glycolytic process	5	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006163	purine nucleotide metabolic process	5	3
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006753	nucleoside phosphate metabolic process	4	3
GO:0006757	obsolete ATP generation from ADP	4	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009117	nucleotide metabolic process	5	3
GO:0009132	nucleoside diphosphate metabolic process	5	3
GO:0009135	purine nucleoside diphosphate metabolic process	6	3
GO:0009141	nucleoside triphosphate metabolic process	5	3
GO:0009144	purine nucleoside triphosphate metabolic process	6	3
GO:0009150	purine ribonucleotide metabolic process	6	3
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	3
GO:0009185	ribonucleoside diphosphate metabolic process	6	3
GO:0009199	ribonucleoside triphosphate metabolic process	6	3
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	3
GO:0009259	ribonucleotide metabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0016310	phosphorylation	5	3
GO:0019637	organophosphate metabolic process	3	3
GO:0019693	ribose phosphate metabolic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0046031	ADP metabolic process	7	3
GO:0046034	ATP metabolic process	7	3
GO:0046483	heterocycle metabolic process	3	3
GO:0046939	obsolete nucleotide phosphorylation	6	3
GO:0055086	nucleobase-containing small molecule metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0072521	purine-containing compound metabolic process	4	3
GO:1901135	carbohydrate derivative metabolic process	3	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0000287	magnesium ion binding	5	18
GO:0003824	catalytic activity	1	18
GO:0004743	pyruvate kinase activity	5	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016301	kinase activity	4	18
GO:0016740	transferase activity	2	18
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	18
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0030955	potassium ion binding	6	18
GO:0031420	alkali metal ion binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0043169	cation binding	3	18
GO:0043531	ADP binding	4	3
GO:0046872	metal ion binding	4	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.540
CLV_NRD_NRD_1	175	177	PF00675	0.326
CLV_NRD_NRD_1	223	225	PF00675	0.400
CLV_PCSK_KEX2_1	175	177	PF00082	0.366
CLV_PCSK_SKI1_1	104	108	PF00082	0.432
CLV_PCSK_SKI1_1	224	228	PF00082	0.333
CLV_PCSK_SKI1_1	494	498	PF00082	0.353
DOC_CYCLIN_RxL_1	491	499	PF00134	0.507
DOC_MAPK_gen_1	134	144	PF00069	0.597
DOC_MAPK_gen_1	393	400	PF00069	0.557
DOC_MAPK_gen_1	454	464	PF00069	0.521
DOC_MAPK_MEF2A_6	263	270	PF00069	0.519
DOC_MAPK_MEF2A_6	393	400	PF00069	0.570
DOC_MAPK_MEF2A_6	414	422	PF00069	0.570
DOC_MAPK_MEF2A_6	457	464	PF00069	0.504
DOC_USP7_MATH_1	188	192	PF00917	0.488
DOC_USP7_MATH_1	312	316	PF00917	0.519
DOC_USP7_MATH_1	380	384	PF00917	0.518
DOC_USP7_MATH_1	385	389	PF00917	0.520
LIG_14-3-3_CanoR_1	425	434	PF00244	0.521
LIG_14-3-3_CanoR_1	50	60	PF00244	0.513
LIG_APCC_ABBA_1	478	483	PF00400	0.474
LIG_BIR_II_1	1	5	PF00653	0.398
LIG_BRCT_BRCA1_1	439	443	PF00533	0.615
LIG_FHA_1	105	111	PF00498	0.556
LIG_FHA_1	20	26	PF00498	0.467
LIG_FHA_1	295	301	PF00498	0.519
LIG_FHA_1	30	36	PF00498	0.448
LIG_FHA_1	421	427	PF00498	0.539
LIG_FHA_1	433	439	PF00498	0.488
LIG_FHA_1	491	497	PF00498	0.521
LIG_FHA_1	7	13	PF00498	0.535
LIG_FHA_2	169	175	PF00498	0.601
LIG_FHA_2	308	314	PF00498	0.519
LIG_Integrin_RGD_1	263	265	PF01839	0.319
LIG_KLC1_Yacidic_2	123	128	PF13176	0.519
LIG_LIR_Gen_1	128	136	PF02991	0.590
LIG_LIR_Gen_1	140	149	PF02991	0.615
LIG_LIR_Gen_1	207	217	PF02991	0.519
LIG_LIR_Gen_1	360	367	PF02991	0.574
LIG_LIR_Gen_1	473	482	PF02991	0.584
LIG_LIR_Nem_3	11	16	PF02991	0.444
LIG_LIR_Nem_3	123	129	PF02991	0.540
LIG_LIR_Nem_3	140	144	PF02991	0.519
LIG_LIR_Nem_3	207	213	PF02991	0.519
LIG_LIR_Nem_3	360	364	PF02991	0.575
LIG_LIR_Nem_3	473	479	PF02991	0.584
LIG_LRP6_Inhibitor_1	362	368	PF00058	0.421
LIG_MLH1_MIPbox_1	439	443	PF16413	0.615
LIG_PCNA_yPIPBox_3	349	362	PF02747	0.615
LIG_PTB_Apo_2	316	323	PF02174	0.553
LIG_SH2_CRK	129	133	PF00017	0.632
LIG_SH2_CRK	476	480	PF00017	0.595
LIG_SH2_GRB2like	129	132	PF00017	0.632
LIG_SH2_GRB2like	489	492	PF00017	0.586
LIG_SH2_PTP2	141	144	PF00017	0.615
LIG_SH2_SRC	141	144	PF00017	0.615
LIG_SH2_STAP1	390	394	PF00017	0.553
LIG_SH2_STAP1	476	480	PF00017	0.421
LIG_SH2_STAT3	489	492	PF00017	0.482
LIG_SH2_STAT5	109	112	PF00017	0.588
LIG_SH2_STAT5	126	129	PF00017	0.448
LIG_SH2_STAT5	141	144	PF00017	0.519
LIG_SH2_STAT5	361	364	PF00017	0.526
LIG_SH2_STAT5	470	473	PF00017	0.515
LIG_SH3_1	412	418	PF00018	0.519
LIG_SH3_3	132	138	PF00018	0.605
LIG_SH3_3	175	181	PF00018	0.537
LIG_SH3_3	182	188	PF00018	0.492
LIG_SH3_3	265	271	PF00018	0.529
LIG_SH3_3	412	418	PF00018	0.519
LIG_SUMO_SIM_anti_2	145	152	PF11976	0.615
LIG_SUMO_SIM_anti_2	233	238	PF11976	0.540
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.621
LIG_SUMO_SIM_par_1	396	401	PF11976	0.511
LIG_SUMO_SIM_par_1	493	499	PF11976	0.643
LIG_SUMO_SIM_par_1	8	14	PF11976	0.588
LIG_TRAF2_1	376	379	PF00917	0.506
LIG_TYR_ITIM	127	132	PF00017	0.529
LIG_UBA3_1	234	239	PF00899	0.540
LIG_WRC_WIRS_1	210	215	PF05994	0.519
MOD_CK1_1	31	37	PF00069	0.490
MOD_CK1_1	331	337	PF00069	0.519
MOD_CK1_1	44	50	PF00069	0.527
MOD_CK1_1	54	60	PF00069	0.527
MOD_CK2_1	248	254	PF00069	0.587
MOD_CK2_1	307	313	PF00069	0.519
MOD_CK2_1	373	379	PF00069	0.484
MOD_CK2_1	385	391	PF00069	0.482
MOD_CK2_1	8	14	PF00069	0.460
MOD_GlcNHglycan	190	193	PF01048	0.397
MOD_GlcNHglycan	215	218	PF01048	0.415
MOD_GlcNHglycan	330	333	PF01048	0.319
MOD_GlcNHglycan	355	358	PF01048	0.319
MOD_GlcNHglycan	375	378	PF01048	0.267
MOD_GlcNHglycan	383	386	PF01048	0.300
MOD_GlcNHglycan	405	408	PF01048	0.343
MOD_GlcNHglycan	43	46	PF01048	0.290
MOD_GSK3_1	104	111	PF00069	0.570
MOD_GSK3_1	158	165	PF00069	0.615
MOD_GSK3_1	209	216	PF00069	0.529
MOD_GSK3_1	24	31	PF00069	0.490
MOD_GSK3_1	381	388	PF00069	0.525
MOD_GSK3_1	421	428	PF00069	0.523
MOD_GSK3_1	470	477	PF00069	0.421
MOD_N-GLC_1	130	135	PF02516	0.354
MOD_N-GLC_1	432	437	PF02516	0.353
MOD_N-GLC_1	490	495	PF02516	0.274
MOD_N-GLC_1	51	56	PF02516	0.312
MOD_N-GLC_1	6	11	PF02516	0.485
MOD_NEK2_1	162	167	PF00069	0.615
MOD_NEK2_1	299	304	PF00069	0.528
MOD_NEK2_1	363	368	PF00069	0.447
MOD_NEK2_1	400	405	PF00069	0.524
MOD_NEK2_1	41	46	PF00069	0.503
MOD_NEK2_1	432	437	PF00069	0.525
MOD_NEK2_1	464	469	PF00069	0.609
MOD_NEK2_1	51	56	PF00069	0.525
MOD_NEK2_1	8	13	PF00069	0.576
MOD_NEK2_2	385	390	PF00069	0.553
MOD_NEK2_2	437	442	PF00069	0.615
MOD_PIKK_1	29	35	PF00454	0.481
MOD_PIKK_1	294	300	PF00454	0.519
MOD_PIKK_1	432	438	PF00454	0.581
MOD_PKA_2	19	25	PF00069	0.373
MOD_PKA_2	307	313	PF00069	0.519
MOD_Plk_1	158	164	PF00069	0.519
MOD_Plk_1	474	480	PF00069	0.483
MOD_Plk_1	490	496	PF00069	0.471
MOD_Plk_1	6	12	PF00069	0.490
MOD_Plk_4	137	143	PF00069	0.529
MOD_Plk_4	209	215	PF00069	0.519
MOD_Plk_4	248	254	PF00069	0.567
MOD_Plk_4	385	391	PF00069	0.553
MOD_Plk_4	437	443	PF00069	0.544
MOD_Plk_4	474	480	PF00069	0.429
MOD_Plk_4	8	14	PF00069	0.433
MOD_SUMO_rev_2	388	394	PF00179	0.572
MOD_SUMO_rev_2	477	486	PF00179	0.421
TRG_DiLeu_BaEn_3	254	260	PF01217	0.615
TRG_ENDOCYTIC_2	129	132	PF00928	0.532
TRG_ENDOCYTIC_2	141	144	PF00928	0.519
TRG_ENDOCYTIC_2	361	364	PF00928	0.526
TRG_ENDOCYTIC_2	476	479	PF00928	0.492
TRG_Pf-PMV_PEXEL_1	494	499	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX8	Leptomonas seymouri	89%	100%
A0A0S4JHN6	Bodo saltans	65%	100%
A0A1X0P7Q1	Trypanosomatidae	78%	100%
A0A3Q8IES7	Leishmania donovani	99%	100%
A0A3S7X8M0	Leishmania donovani	98%	98%
A0A422NPT0	Trypanosoma rangeli	76%	100%
A4HM36	Leishmania braziliensis	93%	100%
A4HM39	Leishmania braziliensis	93%	100%
A4HM41	Leishmania braziliensis	92%	100%
A4IAQ1	Leishmania infantum	99%	98%
A4IAQ4	Leishmania infantum	98%	100%
B0B7Q0	Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)	41%	100%
B8BJ39	Oryza sativa subsp. indica	33%	95%
B8BM17	Oryza sativa subsp. indica	35%	95%
C9ZZZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
C9ZZZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AEH9	Leishmania major	99%	100%
E9B5P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O05118	Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)	34%	100%
O08309	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	41%	100%
O44006	Eimeria tenella	44%	94%
O51323	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	36%	100%
O62619	Drosophila melanogaster	51%	94%
O65595	Arabidopsis thaliana	44%	100%
O94122	Agaricus bisporus	49%	94%
P00548	Gallus gallus	49%	94%
P00549	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P0AD61	Escherichia coli (strain K12)	46%	100%
P0AD62	Escherichia coli O157:H7	46%	100%
P0CE21	Chlamydia trachomatis (strain D/UW-3/Cx)	41%	100%
P11974	Oryctolagus cuniculus	49%	94%
P11979	Felis catus	49%	94%
P11980	Rattus norvegicus	49%	94%
P12928	Rattus norvegicus	47%	87%
P14618	Homo sapiens	50%	94%
P21599	Escherichia coli (strain K12)	37%	100%
P22200	Solanum tuberosum	43%	98%
P22360	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	49%	95%
P30613	Homo sapiens	49%	87%
P30614	Yarrowia lipolytica (strain CLIB 122 / E 150)	50%	97%
P30615	Trypanosoma brucei brucei	75%	100%
P30616	Trypanosoma brucei brucei	75%	100%
P31865	Hypocrea jecorina	50%	93%
P32044	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	34%	92%
P34038	Lactobacillus delbrueckii subsp. bulgaricus	41%	85%
P43924	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	100%
P46614	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	99%
P47458	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	38%	98%
P51181	Bacillus licheniformis	48%	85%
P51182	Sporosarcina psychrophila	46%	85%
P52480	Mus musculus	50%	94%
P52489	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	99%
P53657	Mus musculus	47%	87%
P55964	Ricinus communis	36%	100%
P57404	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	34%	100%
P70789	Agrobacterium vitis	39%	100%
P73534	Synechocystis sp. (strain PCC 6803 / Kazusa)	39%	84%
P77983	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	44%	100%
P78031	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	37%	98%
P80885	Bacillus subtilis (strain 168)	48%	85%
P94939	Mycobacterium intracellulare	38%	100%
P9WKE4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	38%	100%
P9WKE5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	38%	100%
Q02499	Geobacillus stearothermophilus	44%	85%
Q07637	Lactococcus lactis subsp. lactis (strain IL1403)	35%	99%
Q10208	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	98%
Q12669	Aspergillus niger	50%	95%
Q27686	Leishmania mexicana	96%	100%
Q27788	Trypanoplasma borreli	58%	100%
Q29536	Canis lupus familiaris	48%	87%
Q2FG40	Staphylococcus aureus (strain USA300)	43%	85%
Q2FXM9	Staphylococcus aureus (strain NCTC 8325 / PS 47)	43%	85%
Q2QXR8	Oryza sativa subsp. japonica	35%	95%
Q2RAK2	Oryza sativa subsp. japonica	33%	95%
Q2YTE3	Staphylococcus aureus (strain bovine RF122 / ET3-1)	43%	85%
Q40545	Nicotiana tabacum	32%	84%
Q40546	Nicotiana tabacum	36%	89%
Q42806	Glycine max	44%	98%
Q42954	Nicotiana tabacum	45%	98%
Q43117	Ricinus communis	32%	86%
Q44473	Agrobacterium vitis	37%	100%
Q46078	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	39%	100%
Q46289	Clostridium perfringens (strain 13 / Type A)	43%	100%
Q49YC7	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	43%	85%
Q4L739	Staphylococcus haemolyticus (strain JCSC1435)	43%	85%
Q54RF5	Dictyostelium discoideum	47%	98%
Q55863	Synechocystis sp. (strain PCC 6803 / Kazusa)	39%	100%
Q56301	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	37%	100%
Q57572	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
Q5HF76	Staphylococcus aureus (strain COL)	43%	85%
Q5HNK7	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	44%	85%
Q5NVN0	Pongo abelii	49%	94%
Q6BS75	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	48%	99%
Q6FIS9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	51%	100%
Q6FV12	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	50%	98%
Q6G8M9	Staphylococcus aureus (strain MSSA476)	43%	85%
Q6GG09	Staphylococcus aureus (strain MRSA252)	43%	85%
Q759A9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	50%	100%
Q7A0N4	Staphylococcus aureus (strain MW2)	43%	85%
Q7A559	Staphylococcus aureus (strain N315)	43%	85%
Q7RVA8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	95%
Q875M9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	51%	100%
Q875S4	Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)	51%	100%
Q875Z9	Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630)	49%	100%
Q89AI8	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	34%	100%
Q8CS69	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	44%	85%
Q8FP04	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	40%	100%
Q8K9M3	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	34%	100%
Q8SQP0	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8Z6K2	Salmonella typhi	44%	100%
Q8ZNW0	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	38%	100%
Q8ZYE0	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	27%	100%
Q92122	Xenopus laevis	49%	95%
Q93Z53	Arabidopsis thaliana	37%	87%
Q99TG5	Staphylococcus aureus (strain Mu50 / ATCC 700699)	43%	85%
Q9FLW9	Arabidopsis thaliana	36%	86%
Q9LIK0	Arabidopsis thaliana	33%	84%
Q9PK61	Chlamydia muridarum (strain MoPn / Nigg)	41%	100%
Q9WY51	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	33%	100%
Q9YEU2	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
Q9Z984	Chlamydia pneumoniae	39%	100%
V5C1M1	Trypanosoma cruzi	76%	100%