LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase 7

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase 7
Gene product:
phosphoglycan beta 1,3 galactosyltransferase 7
Species:
Leishmania major
UniProt:
E9AEH8_LEIMA
TriTrypDb:
LmjF.35.0010 , LMJLV39_310043200 * , LMJSD75_020006900
Length:
816

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 15
GO:0016020 membrane 2 53
GO:0031090 organelle membrane 3 15
GO:0098588 bounding membrane of organelle 4 15
GO:0110165 cellular anatomical entity 1 53

Expansion

Sequence features

E9AEH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH8

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0008194 UDP-glycosyltransferase activity 4 15
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 743 747 PF00656 0.302
CLV_NRD_NRD_1 284 286 PF00675 0.614
CLV_NRD_NRD_1 400 402 PF00675 0.648
CLV_NRD_NRD_1 490 492 PF00675 0.640
CLV_NRD_NRD_1 612 614 PF00675 0.548
CLV_NRD_NRD_1 802 804 PF00675 0.518
CLV_NRD_NRD_1 93 95 PF00675 0.471
CLV_PCSK_KEX2_1 106 108 PF00082 0.475
CLV_PCSK_KEX2_1 284 286 PF00082 0.605
CLV_PCSK_KEX2_1 400 402 PF00082 0.646
CLV_PCSK_KEX2_1 612 614 PF00082 0.539
CLV_PCSK_KEX2_1 64 66 PF00082 0.467
CLV_PCSK_KEX2_1 674 676 PF00082 0.618
CLV_PCSK_KEX2_1 769 771 PF00082 0.571
CLV_PCSK_KEX2_1 801 803 PF00082 0.529
CLV_PCSK_KEX2_1 93 95 PF00082 0.472
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.411
CLV_PCSK_PC1ET2_1 64 66 PF00082 0.465
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.569
CLV_PCSK_PC1ET2_1 769 771 PF00082 0.567
CLV_PCSK_SKI1_1 106 110 PF00082 0.273
CLV_PCSK_SKI1_1 401 405 PF00082 0.576
CLV_PCSK_SKI1_1 516 520 PF00082 0.571
CLV_PCSK_SKI1_1 563 567 PF00082 0.549
CLV_PCSK_SKI1_1 613 617 PF00082 0.476
CLV_PCSK_SKI1_1 733 737 PF00082 0.525
CLV_PCSK_SKI1_1 804 808 PF00082 0.504
CLV_Separin_Metazoa 269 273 PF03568 0.328
DEG_Kelch_Keap1_1 292 297 PF01344 0.412
DEG_Nend_UBRbox_1 1 4 PF02207 0.668
DEG_SCF_FBW7_1 452 459 PF00400 0.451
DEG_SPOP_SBC_1 438 442 PF00917 0.332
DOC_CKS1_1 453 458 PF01111 0.454
DOC_CYCLIN_yClb5_NLxxxL_5 561 569 PF00134 0.295
DOC_CYCLIN_yCln2_LP_2 249 255 PF00134 0.333
DOC_CYCLIN_yCln2_LP_2 450 456 PF00134 0.497
DOC_CYCLIN_yCln2_LP_2 633 639 PF00134 0.322
DOC_MAPK_DCC_7 14 24 PF00069 0.655
DOC_MAPK_DCC_7 572 581 PF00069 0.361
DOC_MAPK_gen_1 106 114 PF00069 0.515
DOC_MAPK_gen_1 298 307 PF00069 0.368
DOC_MAPK_gen_1 801 808 PF00069 0.284
DOC_MAPK_JIP1_4 298 304 PF00069 0.351
DOC_MAPK_MEF2A_6 107 116 PF00069 0.548
DOC_MAPK_MEF2A_6 298 307 PF00069 0.320
DOC_MAPK_MEF2A_6 480 487 PF00069 0.414
DOC_MAPK_MEF2A_6 572 581 PF00069 0.350
DOC_MAPK_MEF2A_6 628 635 PF00069 0.300
DOC_MAPK_NFAT4_5 480 488 PF00069 0.330
DOC_MAPK_NFAT4_5 628 636 PF00069 0.290
DOC_PP1_RVXF_1 514 521 PF00149 0.408
DOC_PP1_RVXF_1 588 594 PF00149 0.292
DOC_PP2B_LxvP_1 450 453 PF13499 0.503
DOC_PP2B_LxvP_1 543 546 PF13499 0.302
DOC_PP2B_LxvP_1 633 636 PF13499 0.300
DOC_USP7_MATH_1 222 226 PF00917 0.466
DOC_USP7_MATH_1 241 245 PF00917 0.479
DOC_USP7_MATH_1 256 260 PF00917 0.342
DOC_USP7_MATH_1 289 293 PF00917 0.467
DOC_USP7_MATH_1 37 41 PF00917 0.699
DOC_USP7_MATH_1 371 375 PF00917 0.385
DOC_USP7_MATH_1 438 442 PF00917 0.375
DOC_USP7_MATH_1 693 697 PF00917 0.383
DOC_USP7_MATH_1 811 815 PF00917 0.276
DOC_USP7_MATH_1 92 96 PF00917 0.665
DOC_USP7_UBL2_3 723 727 PF12436 0.308
DOC_WW_Pin1_4 152 157 PF00397 0.456
DOC_WW_Pin1_4 418 423 PF00397 0.455
DOC_WW_Pin1_4 452 457 PF00397 0.431
DOC_WW_Pin1_4 80 85 PF00397 0.634
LIG_14-3-3_CanoR_1 169 177 PF00244 0.448
LIG_14-3-3_CanoR_1 323 327 PF00244 0.435
LIG_14-3-3_CanoR_1 427 431 PF00244 0.386
LIG_14-3-3_CanoR_1 480 484 PF00244 0.303
LIG_14-3-3_CanoR_1 563 570 PF00244 0.363
LIG_14-3-3_CanoR_1 659 665 PF00244 0.289
LIG_14-3-3_CanoR_1 678 685 PF00244 0.276
LIG_14-3-3_CanoR_1 801 807 PF00244 0.321
LIG_14-3-3_CanoR_1 93 100 PF00244 0.685
LIG_Actin_WH2_2 664 680 PF00022 0.310
LIG_Actin_WH2_2 754 771 PF00022 0.329
LIG_BRCT_BRCA1_1 153 157 PF00533 0.423
LIG_EH_1 619 623 PF12763 0.349
LIG_FHA_1 128 134 PF00498 0.457
LIG_FHA_1 14 20 PF00498 0.691
LIG_FHA_1 195 201 PF00498 0.517
LIG_FHA_1 259 265 PF00498 0.454
LIG_FHA_1 338 344 PF00498 0.337
LIG_FHA_1 364 370 PF00498 0.370
LIG_FHA_1 426 432 PF00498 0.357
LIG_FHA_1 438 444 PF00498 0.392
LIG_FHA_1 512 518 PF00498 0.251
LIG_FHA_1 564 570 PF00498 0.346
LIG_FHA_1 576 582 PF00498 0.389
LIG_FHA_1 65 71 PF00498 0.669
LIG_FHA_1 781 787 PF00498 0.330
LIG_FHA_1 803 809 PF00498 0.318
LIG_FHA_2 326 332 PF00498 0.389
LIG_FHA_2 370 376 PF00498 0.470
LIG_LIR_Apic_2 416 422 PF02991 0.333
LIG_LIR_Apic_2 504 508 PF02991 0.416
LIG_LIR_Gen_1 154 161 PF02991 0.498
LIG_LIR_Gen_1 206 217 PF02991 0.398
LIG_LIR_Gen_1 482 488 PF02991 0.363
LIG_LIR_Gen_1 539 549 PF02991 0.341
LIG_LIR_Gen_1 634 645 PF02991 0.324
LIG_LIR_Gen_1 699 710 PF02991 0.354
LIG_LIR_Nem_3 154 160 PF02991 0.497
LIG_LIR_Nem_3 206 212 PF02991 0.406
LIG_LIR_Nem_3 325 329 PF02991 0.437
LIG_LIR_Nem_3 406 411 PF02991 0.358
LIG_LIR_Nem_3 482 487 PF02991 0.330
LIG_LIR_Nem_3 526 531 PF02991 0.393
LIG_LIR_Nem_3 539 545 PF02991 0.309
LIG_LIR_Nem_3 634 640 PF02991 0.353
LIG_LIR_Nem_3 699 705 PF02991 0.358
LIG_NRBOX 111 117 PF00104 0.293
LIG_NRBOX 628 634 PF00104 0.332
LIG_Pex14_2 722 726 PF04695 0.259
LIG_PTB_Apo_2 208 215 PF02174 0.410
LIG_PTB_Phospho_1 208 214 PF10480 0.409
LIG_SH2_CRK 637 641 PF00017 0.300
LIG_SH2_GRB2like 595 598 PF00017 0.303
LIG_SH2_NCK_1 376 380 PF00017 0.399
LIG_SH2_NCK_1 637 641 PF00017 0.296
LIG_SH2_NCK_1 709 713 PF00017 0.268
LIG_SH2_NCK_1 796 800 PF00017 0.304
LIG_SH2_SRC 595 598 PF00017 0.294
LIG_SH2_SRC 796 799 PF00017 0.280
LIG_SH2_STAP1 214 218 PF00017 0.432
LIG_SH2_STAP1 358 362 PF00017 0.369
LIG_SH2_STAP1 523 527 PF00017 0.435
LIG_SH2_STAP1 637 641 PF00017 0.355
LIG_SH2_STAP1 652 656 PF00017 0.283
LIG_SH2_STAP1 796 800 PF00017 0.353
LIG_SH2_STAT3 280 283 PF00017 0.358
LIG_SH2_STAT3 358 361 PF00017 0.374
LIG_SH2_STAT5 347 350 PF00017 0.392
LIG_SH2_STAT5 358 361 PF00017 0.446
LIG_SH2_STAT5 362 365 PF00017 0.385
LIG_SH2_STAT5 397 400 PF00017 0.353
LIG_SH2_STAT5 464 467 PF00017 0.313
LIG_SH2_STAT5 525 528 PF00017 0.348
LIG_SH2_STAT5 533 536 PF00017 0.319
LIG_SH2_STAT5 542 545 PF00017 0.326
LIG_SH2_STAT5 548 551 PF00017 0.324
LIG_SH2_STAT5 637 640 PF00017 0.353
LIG_SH2_STAT5 645 648 PF00017 0.330
LIG_SH2_STAT5 679 682 PF00017 0.344
LIG_SH2_STAT5 716 719 PF00017 0.410
LIG_SH2_STAT5 721 724 PF00017 0.367
LIG_SH2_STAT5 785 788 PF00017 0.359
LIG_SH3_1 709 715 PF00018 0.264
LIG_SH3_3 302 308 PF00018 0.318
LIG_SH3_3 450 456 PF00018 0.473
LIG_SH3_3 526 532 PF00018 0.376
LIG_SH3_3 571 577 PF00018 0.392
LIG_SH3_3 615 621 PF00018 0.315
LIG_SH3_3 687 693 PF00018 0.326
LIG_SH3_3 709 715 PF00018 0.293
LIG_SUMO_SIM_anti_2 139 146 PF11976 0.442
LIG_SUMO_SIM_par_1 577 583 PF11976 0.333
LIG_SUMO_SIM_par_1 628 634 PF11976 0.324
LIG_SxIP_EBH_1 97 107 PF03271 0.571
LIG_TRAF2_1 749 752 PF00917 0.307
LIG_TYR_ITIM 327 332 PF00017 0.419
LIG_TYR_ITIM 635 640 PF00017 0.284
MOD_CK1_1 155 161 PF00069 0.458
MOD_CK1_1 292 298 PF00069 0.442
MOD_CK1_1 356 362 PF00069 0.477
MOD_CK1_1 66 72 PF00069 0.684
MOD_CK1_1 696 702 PF00069 0.316
MOD_CK2_1 136 142 PF00069 0.454
MOD_CK2_1 291 297 PF00069 0.427
MOD_CK2_1 325 331 PF00069 0.386
MOD_CK2_1 369 375 PF00069 0.484
MOD_CK2_1 678 684 PF00069 0.308
MOD_CMANNOS 275 278 PF00535 0.479
MOD_Cter_Amidation 62 65 PF01082 0.462
MOD_GlcNHglycan 179 182 PF01048 0.649
MOD_GlcNHglycan 215 218 PF01048 0.671
MOD_GlcNHglycan 243 246 PF01048 0.688
MOD_GlcNHglycan 35 38 PF01048 0.497
MOD_GlcNHglycan 39 42 PF01048 0.489
MOD_GlcNHglycan 446 449 PF01048 0.625
MOD_GlcNHglycan 468 471 PF01048 0.608
MOD_GlcNHglycan 60 63 PF01048 0.507
MOD_GlcNHglycan 664 667 PF01048 0.473
MOD_GlcNHglycan 742 745 PF01048 0.504
MOD_GlcNHglycan 813 816 PF01048 0.520
MOD_GlcNHglycan 94 97 PF01048 0.454
MOD_GSK3_1 128 135 PF00069 0.426
MOD_GSK3_1 151 158 PF00069 0.476
MOD_GSK3_1 177 184 PF00069 0.473
MOD_GSK3_1 222 229 PF00069 0.494
MOD_GSK3_1 235 242 PF00069 0.402
MOD_GSK3_1 287 294 PF00069 0.446
MOD_GSK3_1 33 40 PF00069 0.700
MOD_GSK3_1 425 432 PF00069 0.405
MOD_GSK3_1 444 451 PF00069 0.411
MOD_GSK3_1 452 459 PF00069 0.359
MOD_GSK3_1 53 60 PF00069 0.702
MOD_GSK3_1 631 638 PF00069 0.305
MOD_GSK3_1 64 71 PF00069 0.658
MOD_GSK3_1 694 701 PF00069 0.349
MOD_GSK3_1 756 763 PF00069 0.354
MOD_N-GLC_1 210 215 PF02516 0.613
MOD_N-GLC_1 226 231 PF02516 0.619
MOD_N-GLC_1 337 342 PF02516 0.529
MOD_N-GLC_1 563 568 PF02516 0.552
MOD_N-GLC_1 740 745 PF02516 0.509
MOD_N-GLC_1 747 752 PF02516 0.552
MOD_N-GLC_1 772 777 PF02516 0.503
MOD_N-GLC_2 87 89 PF02516 0.429
MOD_NEK2_1 118 123 PF00069 0.334
MOD_NEK2_1 177 182 PF00069 0.431
MOD_NEK2_1 240 245 PF00069 0.439
MOD_NEK2_1 363 368 PF00069 0.351
MOD_NEK2_1 565 570 PF00069 0.361
MOD_NEK2_1 622 627 PF00069 0.354
MOD_NEK2_1 631 636 PF00069 0.299
MOD_NEK2_1 85 90 PF00069 0.648
MOD_NEK2_2 194 199 PF00069 0.521
MOD_PIKK_1 132 138 PF00454 0.447
MOD_PIKK_1 25 31 PF00454 0.662
MOD_PIKK_1 287 293 PF00454 0.456
MOD_PIKK_1 511 517 PF00454 0.423
MOD_PIKK_1 694 700 PF00454 0.301
MOD_PIKK_1 756 762 PF00454 0.335
MOD_PIKK_1 99 105 PF00454 0.602
MOD_PK_1 235 241 PF00069 0.387
MOD_PKA_1 491 497 PF00069 0.463
MOD_PKA_1 64 70 PF00069 0.648
MOD_PKA_1 802 808 PF00069 0.286
MOD_PKA_2 13 19 PF00069 0.691
MOD_PKA_2 168 174 PF00069 0.440
MOD_PKA_2 223 229 PF00069 0.489
MOD_PKA_2 292 298 PF00069 0.448
MOD_PKA_2 322 328 PF00069 0.437
MOD_PKA_2 353 359 PF00069 0.390
MOD_PKA_2 426 432 PF00069 0.397
MOD_PKA_2 479 485 PF00069 0.355
MOD_PKA_2 57 63 PF00069 0.675
MOD_PKA_2 64 70 PF00069 0.651
MOD_PKA_2 802 808 PF00069 0.330
MOD_PKA_2 92 98 PF00069 0.662
MOD_Plk_1 203 209 PF00069 0.422
MOD_Plk_1 210 216 PF00069 0.394
MOD_Plk_1 538 544 PF00069 0.310
MOD_Plk_1 740 746 PF00069 0.303
MOD_Plk_1 772 778 PF00069 0.309
MOD_Plk_4 235 241 PF00069 0.404
MOD_Plk_4 322 328 PF00069 0.386
MOD_Plk_4 426 432 PF00069 0.364
MOD_Plk_4 479 485 PF00069 0.314
MOD_Plk_4 538 544 PF00069 0.310
MOD_Plk_4 635 641 PF00069 0.323
MOD_Plk_4 644 650 PF00069 0.294
MOD_Plk_4 701 707 PF00069 0.388
MOD_Plk_4 760 766 PF00069 0.360
MOD_Plk_4 772 778 PF00069 0.320
MOD_Plk_4 802 808 PF00069 0.323
MOD_ProDKin_1 152 158 PF00069 0.456
MOD_ProDKin_1 418 424 PF00069 0.460
MOD_ProDKin_1 452 458 PF00069 0.426
MOD_ProDKin_1 80 86 PF00069 0.636
MOD_SUMO_for_1 722 725 PF00179 0.259
MOD_SUMO_rev_2 486 494 PF00179 0.347
TRG_DiLeu_BaEn_2 712 718 PF01217 0.229
TRG_DiLeu_BaLyEn_6 610 615 PF01217 0.332
TRG_DiLeu_BaLyEn_6 625 630 PF01217 0.294
TRG_ENDOCYTIC_2 329 332 PF00928 0.445
TRG_ENDOCYTIC_2 525 528 PF00928 0.447
TRG_ENDOCYTIC_2 542 545 PF00928 0.247
TRG_ENDOCYTIC_2 637 640 PF00928 0.365
TRG_ENDOCYTIC_2 645 648 PF00928 0.368
TRG_ENDOCYTIC_2 652 655 PF00928 0.314
TRG_ER_diArg_1 284 286 PF00400 0.407
TRG_ER_diArg_1 400 402 PF00400 0.442
TRG_ER_diArg_1 612 614 PF00400 0.332
TRG_ER_diArg_1 800 803 PF00400 0.315
TRG_ER_diArg_1 92 94 PF00400 0.654
TRG_Pf-PMV_PEXEL_1 199 203 PF00026 0.623

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 74% 100%
A0A3S5H4Y6 Leishmania donovani 39% 100%
A0A3S5H4Y9 Leishmania donovani 32% 82%
A0A3S7WT86 Leishmania donovani 35% 79%
A0A3S7WWA6 Leishmania donovani 74% 100%
A0A451EJD9 Leishmania donovani 82% 100%
A0A451EJF4 Leishmania donovani 41% 100%
A0A451EJF6 Leishmania donovani 41% 100%
A0A451EJF8 Leishmania donovani 38% 100%
A0A451EJF9 Leishmania donovani 41% 95%
A4H3A9 Leishmania braziliensis 41% 100%
A4H3B4 Leishmania braziliensis 40% 100%
A4H3B6 Leishmania braziliensis 38% 100%
A4H3B8 Leishmania braziliensis 40% 99%
A4H3B9 Leishmania braziliensis 34% 92%
A4H4W8 Leishmania braziliensis 58% 100%
A4HJ20 Leishmania braziliensis 38% 100%
A4HNK3 Leishmania braziliensis 65% 100%
A4HNK6 Leishmania braziliensis 58% 100%
A4HRL9 Leishmania infantum 41% 100%
A4HRM0 Leishmania infantum 38% 100%
A4HRM1 Leishmania infantum 41% 100%
A4HRS1 Leishmania infantum 41% 95%
A4HRS3 Leishmania infantum 32% 82%
A4HRS5 Leishmania infantum 38% 100%
A4HZM0 Leishmania infantum 84% 100%
A4I7C7 Leishmania infantum 85% 100%
A4IAQ2 Leishmania infantum 80% 100%
E9AC91 Leishmania major 42% 100%
E9AC92 Leishmania major 42% 100%
E9AC94 Leishmania major 33% 69%
E9AC95 Leishmania major 39% 100%
E9AC96 Leishmania major 41% 100%
E9AC98 Leishmania major 33% 100%
E9AHA6 Leishmania infantum 81% 100%
E9AIP8 Leishmania braziliensis 58% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 83%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 69% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
Q4Q5T6 Leishmania major 94% 100%
Q4QCL8 Leishmania major 81% 100%
Q4QFJ3 Leishmania major 36% 79%
Q4QIG9 Leishmania major 80% 100%
Q7YXU9 Leishmania major 81% 100%
Q7YXV1 Leishmania major 81% 96%
Q7YXV2 Leishmania major 79% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS