LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein (pseudogene)
Species:
Leishmania major
UniProt:
E9AEH7_LEIMA
TriTrypDb:
LmjF.34.3645 , LMJLV39_340042700 * , LMJSD75_340043100 *
Length:
105

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 2
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AEH7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.465
CLV_NRD_NRD_1 87 89 PF00675 0.490
DOC_PP1_RVXF_1 74 80 PF00149 0.643
DOC_USP7_MATH_1 10 14 PF00917 0.267
DOC_USP7_UBL2_3 76 80 PF12436 0.638
DOC_WW_Pin1_4 17 22 PF00397 0.247
DOC_WW_Pin1_4 28 33 PF00397 0.436
DOC_WW_Pin1_4 39 44 PF00397 0.282
LIG_eIF4E_1 58 64 PF01652 0.426
LIG_FHA_2 9 15 PF00498 0.247
LIG_GBD_Chelix_1 52 60 PF00786 0.292
LIG_LIR_Nem_3 59 64 PF02991 0.530
LIG_SH2_SRC 34 37 PF00017 0.396
LIG_SH2_STAT5 34 37 PF00017 0.396
LIG_SH2_STAT5 58 61 PF00017 0.314
MOD_CK1_1 20 26 PF00069 0.545
MOD_CK2_1 8 14 PF00069 0.328
MOD_GlcNHglycan 100 103 PF01048 0.455
MOD_GlcNHglycan 22 25 PF01048 0.612
MOD_GlcNHglycan 68 71 PF01048 0.480
MOD_GSK3_1 20 27 PF00069 0.556
MOD_GSK3_1 66 73 PF00069 0.723
MOD_NEK2_1 56 61 PF00069 0.325
MOD_NEK2_1 72 77 PF00069 0.653
MOD_Plk_4 48 54 PF00069 0.345
MOD_Plk_4 56 62 PF00069 0.395
MOD_ProDKin_1 17 23 PF00069 0.247
MOD_ProDKin_1 28 34 PF00069 0.437
MOD_ProDKin_1 39 45 PF00069 0.282
TRG_ER_diArg_1 65 68 PF00400 0.571
TRG_NLS_MonoCore_2 87 92 PF00514 0.627
TRG_NLS_MonoExtC_3 87 92 PF00514 0.687
TRG_NLS_MonoExtN_4 85 92 PF00514 0.644

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P279 Leptomonas seymouri 41% 67%
A0A3Q8ILG5 Leishmania donovani 72% 98%
A4HB83 Leishmania braziliensis 53% 94%
E9B5F4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS