Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9AEH6_LEIMA

TriTrypDb:

LmjF.34.0175 , LMJLV39_340007000 , LMJSD75_340007000

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.747
CLV_NRD_NRD_1	417	419	PF00675	0.724
CLV_NRD_NRD_1	616	618	PF00675	0.758
CLV_NRD_NRD_1	630	632	PF00675	0.570
CLV_NRD_NRD_1	9	11	PF00675	0.653
CLV_PCSK_FUR_1	614	618	PF00082	0.694
CLV_PCSK_KEX2_1	417	419	PF00082	0.724
CLV_PCSK_KEX2_1	616	618	PF00082	0.758
CLV_PCSK_KEX2_1	629	631	PF00082	0.575
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.750
CLV_PCSK_SKI1_1	365	369	PF00082	0.596
CLV_PCSK_SKI1_1	531	535	PF00082	0.655
CLV_PCSK_SKI1_1	607	611	PF00082	0.734
DEG_SCF_FBW7_1	218	224	PF00400	0.714
DEG_SPOP_SBC_1	176	180	PF00917	0.659
DOC_CKS1_1	211	216	PF01111	0.756
DOC_CKS1_1	218	223	PF01111	0.708
DOC_CKS1_1	287	292	PF01111	0.701
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.685
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.742
DOC_PP2B_LxvP_1	255	258	PF13499	0.653
DOC_USP7_MATH_1	119	123	PF00917	0.668
DOC_USP7_MATH_1	145	149	PF00917	0.716
DOC_USP7_MATH_1	157	161	PF00917	0.603
DOC_USP7_MATH_1	162	166	PF00917	0.528
DOC_USP7_MATH_1	221	225	PF00917	0.718
DOC_USP7_MATH_1	248	252	PF00917	0.734
DOC_USP7_MATH_1	308	312	PF00917	0.789
DOC_USP7_MATH_1	315	319	PF00917	0.668
DOC_USP7_MATH_1	356	360	PF00917	0.578
DOC_USP7_MATH_1	397	401	PF00917	0.783
DOC_USP7_MATH_1	416	420	PF00917	0.509
DOC_USP7_MATH_1	423	427	PF00917	0.615
DOC_USP7_MATH_1	43	47	PF00917	0.731
DOC_USP7_MATH_1	529	533	PF00917	0.758
DOC_USP7_MATH_1	535	539	PF00917	0.724
DOC_USP7_MATH_2	523	529	PF00917	0.709
DOC_WW_Pin1_4	137	142	PF00397	0.792
DOC_WW_Pin1_4	183	188	PF00397	0.702
DOC_WW_Pin1_4	190	195	PF00397	0.651
DOC_WW_Pin1_4	210	215	PF00397	0.525
DOC_WW_Pin1_4	217	222	PF00397	0.706
DOC_WW_Pin1_4	235	240	PF00397	0.526
DOC_WW_Pin1_4	244	249	PF00397	0.676
DOC_WW_Pin1_4	266	271	PF00397	0.681
DOC_WW_Pin1_4	27	32	PF00397	0.670
DOC_WW_Pin1_4	277	282	PF00397	0.617
DOC_WW_Pin1_4	286	291	PF00397	0.522
DOC_WW_Pin1_4	304	309	PF00397	0.557
DOC_WW_Pin1_4	324	329	PF00397	0.469
DOC_WW_Pin1_4	331	336	PF00397	0.653
DOC_WW_Pin1_4	342	347	PF00397	0.496
DOC_WW_Pin1_4	389	394	PF00397	0.780
DOC_WW_Pin1_4	411	416	PF00397	0.761
DOC_WW_Pin1_4	46	51	PF00397	0.573
DOC_WW_Pin1_4	498	503	PF00397	0.616
DOC_WW_Pin1_4	55	60	PF00397	0.639
LIG_14-3-3_CanoR_1	109	114	PF00244	0.693
LIG_14-3-3_CanoR_1	16	25	PF00244	0.706
LIG_14-3-3_CanoR_1	365	375	PF00244	0.782
LIG_14-3-3_CanoR_1	417	421	PF00244	0.769
LIG_14-3-3_CanoR_1	460	469	PF00244	0.714
LIG_14-3-3_CanoR_1	516	524	PF00244	0.599
LIG_14-3-3_CanoR_1	556	562	PF00244	0.708
LIG_14-3-3_CanoR_1	592	596	PF00244	0.783
LIG_14-3-3_CanoR_1	603	611	PF00244	0.624
LIG_14-3-3_CanoR_1	616	621	PF00244	0.710
LIG_14-3-3_CanoR_1	630	634	PF00244	0.570
LIG_AP2alpha_2	492	494	PF02296	0.668
LIG_BIR_II_1	1	5	PF00653	0.762
LIG_BIR_III_2	138	142	PF00653	0.721
LIG_BRCT_BRCA1_1	1	5	PF00533	0.698
LIG_BRCT_BRCA1_1	139	143	PF00533	0.721
LIG_BRCT_BRCA1_1	279	283	PF00533	0.672
LIG_BRCT_BRCA1_1	344	348	PF00533	0.754
LIG_BRCT_BRCA1_1	432	436	PF00533	0.750
LIG_BRCT_BRCA1_1	48	52	PF00533	0.691
LIG_BRCT_BRCA1_1	520	524	PF00533	0.777
LIG_BRCT_BRCA1_1	547	551	PF00533	0.643
LIG_BRCT_BRCA1_1	57	61	PF00533	0.572
LIG_CaM_IQ_9	608	624	PF13499	0.695
LIG_FHA_1	177	183	PF00498	0.692
LIG_FHA_1	509	515	PF00498	0.581
LIG_FHA_1	606	612	PF00498	0.579
LIG_FHA_2	165	171	PF00498	0.755
LIG_FHA_2	350	356	PF00498	0.569
LIG_FHA_2	377	383	PF00498	0.688
LIG_FHA_2	473	479	PF00498	0.721
LIG_FHA_2	487	493	PF00498	0.601
LIG_Integrin_RGD_1	136	138	PF01839	0.722
LIG_IRF3_LxIS_1	333	339	PF10401	0.653
LIG_LIR_Apic_2	419	423	PF02991	0.731
LIG_LIR_Gen_1	320	330	PF02991	0.684
LIG_LIR_Gen_1	49	59	PF02991	0.553
LIG_LIR_Gen_1	491	502	PF02991	0.745
LIG_LIR_Nem_3	320	325	PF02991	0.691
LIG_LIR_Nem_3	345	351	PF02991	0.760
LIG_LIR_Nem_3	433	438	PF02991	0.684
LIG_LIR_Nem_3	49	55	PF02991	0.566
LIG_LIR_Nem_3	491	497	PF02991	0.741
LIG_LIR_Nem_3	58	64	PF02991	0.513
LIG_MLH1_MIPbox_1	2	6	PF16413	0.697
LIG_MLH1_MIPbox_1	432	436	PF16413	0.750
LIG_PDZ_Class_1	629	634	PF00595	0.596
LIG_Pex14_2	197	201	PF04695	0.758
LIG_Pex14_2	273	277	PF04695	0.702
LIG_Pex14_2	494	498	PF04695	0.636
LIG_PTAP_UEV_1	339	344	PF05743	0.673
LIG_SH2_CRK	322	326	PF00017	0.718
LIG_SH2_CRK	420	424	PF00017	0.700
LIG_SH2_NCK_1	37	41	PF00017	0.572
LIG_SH2_STAT3	265	268	PF00017	0.564
LIG_SH3_3	139	145	PF00018	0.767
LIG_SH3_3	151	157	PF00018	0.566
LIG_SH3_3	264	270	PF00018	0.657
LIG_SH3_3	29	35	PF00018	0.626
LIG_SH3_3	337	343	PF00018	0.713
LIG_SH3_3	387	393	PF00018	0.726
LIG_SH3_3	44	50	PF00018	0.621
LIG_SH3_3	53	59	PF00018	0.666
LIG_SUMO_SIM_anti_2	251	256	PF11976	0.661
LIG_SUMO_SIM_par_1	334	339	PF11976	0.653
LIG_TRAF2_1	452	455	PF00917	0.783
LIG_TRAF2_1	547	550	PF00917	0.694
LIG_WRC_WIRS_1	432	437	PF05994	0.750
LIG_WRC_WIRS_1	98	103	PF05994	0.758
MOD_CDC14_SPxK_1	414	417	PF00782	0.759
MOD_CDK_SPK_2	55	60	PF00069	0.729
MOD_CDK_SPxK_1	411	417	PF00069	0.761
MOD_CDK_SPxxK_3	411	418	PF00069	0.763
MOD_CK1_1	100	106	PF00069	0.764
MOD_CK1_1	120	126	PF00069	0.492
MOD_CK1_1	17	23	PF00069	0.699
MOD_CK1_1	180	186	PF00069	0.748
MOD_CK1_1	199	205	PF00069	0.502
MOD_CK1_1	224	230	PF00069	0.748
MOD_CK1_1	286	292	PF00069	0.731
MOD_CK1_1	359	365	PF00069	0.733
MOD_CK1_1	369	375	PF00069	0.638
MOD_CK1_1	400	406	PF00069	0.705
MOD_CK1_1	431	437	PF00069	0.708
MOD_CK1_1	46	52	PF00069	0.622
MOD_CK1_1	472	478	PF00069	0.697
MOD_CK1_1	545	551	PF00069	0.640
MOD_CK1_1	558	564	PF00069	0.608
MOD_CK1_1	598	604	PF00069	0.723
MOD_CK2_1	109	115	PF00069	0.790
MOD_CK2_1	349	355	PF00069	0.576
MOD_CK2_1	400	406	PF00069	0.713
MOD_CK2_1	423	429	PF00069	0.685
MOD_CK2_1	472	478	PF00069	0.691
MOD_CK2_1	506	512	PF00069	0.705
MOD_CK2_1	544	550	PF00069	0.598
MOD_GlcNHglycan	119	122	PF01048	0.729
MOD_GlcNHglycan	123	126	PF01048	0.697
MOD_GlcNHglycan	133	136	PF01048	0.636
MOD_GlcNHglycan	147	150	PF01048	0.560
MOD_GlcNHglycan	164	167	PF01048	0.551
MOD_GlcNHglycan	198	201	PF01048	0.716
MOD_GlcNHglycan	206	209	PF01048	0.675
MOD_GlcNHglycan	226	229	PF01048	0.535
MOD_GlcNHglycan	340	343	PF01048	0.733
MOD_GlcNHglycan	368	371	PF01048	0.777
MOD_GlcNHglycan	462	465	PF01048	0.752
MOD_GlcNHglycan	520	523	PF01048	0.758
MOD_GlcNHglycan	527	530	PF01048	0.655
MOD_GlcNHglycan	537	540	PF01048	0.552
MOD_GlcNHglycan	573	576	PF01048	0.786
MOD_GSK3_1	117	124	PF00069	0.760
MOD_GSK3_1	137	144	PF00069	0.782
MOD_GSK3_1	16	23	PF00069	0.735
MOD_GSK3_1	176	183	PF00069	0.750
MOD_GSK3_1	186	193	PF00069	0.600
MOD_GSK3_1	195	202	PF00069	0.506
MOD_GSK3_1	213	220	PF00069	0.578
MOD_GSK3_1	244	251	PF00069	0.713
MOD_GSK3_1	285	292	PF00069	0.756
MOD_GSK3_1	304	311	PF00069	0.599
MOD_GSK3_1	320	327	PF00069	0.534
MOD_GSK3_1	334	341	PF00069	0.558
MOD_GSK3_1	365	372	PF00069	0.675
MOD_GSK3_1	400	407	PF00069	0.711
MOD_GSK3_1	424	431	PF00069	0.712
MOD_GSK3_1	46	53	PF00069	0.740
MOD_GSK3_1	468	475	PF00069	0.726
MOD_GSK3_1	523	530	PF00069	0.710
MOD_GSK3_1	531	538	PF00069	0.715
MOD_GSK3_1	591	598	PF00069	0.746
MOD_GSK3_1	601	608	PF00069	0.676
MOD_GSK3_1	67	74	PF00069	0.636
MOD_GSK3_1	81	88	PF00069	0.525
MOD_LATS_1	14	20	PF00433	0.687
MOD_N-GLC_1	14	19	PF02516	0.688
MOD_N-GLC_1	248	253	PF02516	0.732
MOD_N-GLC_1	445	450	PF02516	0.685
MOD_N-GLC_1	595	600	PF02516	0.724
MOD_N-GLC_1	72	77	PF02516	0.751
MOD_NEK2_1	195	200	PF00069	0.744
MOD_NEK2_1	283	288	PF00069	0.731
MOD_NEK2_1	366	371	PF00069	0.720
MOD_NEK2_1	447	452	PF00069	0.599
MOD_NEK2_1	69	74	PF00069	0.754
MOD_NEK2_1	83	88	PF00069	0.620
MOD_NEK2_1	94	99	PF00069	0.604
MOD_PIKK_1	199	205	PF00454	0.695
MOD_PIKK_1	447	453	PF00454	0.597
MOD_PIKK_1	598	604	PF00454	0.723
MOD_PK_1	109	115	PF00069	0.631
MOD_PKA_1	616	622	PF00069	0.761
MOD_PKA_2	359	365	PF00069	0.783
MOD_PKA_2	377	383	PF00069	0.540
MOD_PKA_2	416	422	PF00069	0.748
MOD_PKA_2	515	521	PF00069	0.584
MOD_PKA_2	555	561	PF00069	0.708
MOD_PKA_2	565	571	PF00069	0.608
MOD_PKA_2	578	584	PF00069	0.602
MOD_PKA_2	591	597	PF00069	0.732
MOD_PKA_2	602	608	PF00069	0.636
MOD_PKA_2	616	622	PF00069	0.705
MOD_PKA_2	9	15	PF00069	0.708
MOD_PKB_1	107	115	PF00069	0.725
MOD_PKB_1	363	371	PF00069	0.596
MOD_PKB_1	614	622	PF00069	0.696
MOD_Plk_1	248	254	PF00069	0.708
MOD_Plk_1	283	289	PF00069	0.757
MOD_Plk_1	428	434	PF00069	0.743
MOD_Plk_1	445	451	PF00069	0.552
MOD_Plk_1	595	601	PF00069	0.693
MOD_Plk_1	622	628	PF00069	0.688
MOD_Plk_1	72	78	PF00069	0.752
MOD_Plk_4	147	153	PF00069	0.759
MOD_Plk_4	213	219	PF00069	0.775
MOD_Plk_4	221	227	PF00069	0.672
MOD_Plk_4	250	256	PF00069	0.663
MOD_Plk_4	260	266	PF00069	0.553
MOD_Plk_4	320	326	PF00069	0.752
MOD_Plk_4	431	437	PF00069	0.747
MOD_Plk_4	565	571	PF00069	0.616
MOD_Plk_4	578	584	PF00069	0.547
MOD_ProDKin_1	137	143	PF00069	0.793
MOD_ProDKin_1	183	189	PF00069	0.697
MOD_ProDKin_1	190	196	PF00069	0.654
MOD_ProDKin_1	210	216	PF00069	0.524
MOD_ProDKin_1	217	223	PF00069	0.708
MOD_ProDKin_1	235	241	PF00069	0.527
MOD_ProDKin_1	244	250	PF00069	0.675
MOD_ProDKin_1	266	272	PF00069	0.684
MOD_ProDKin_1	27	33	PF00069	0.672
MOD_ProDKin_1	277	283	PF00069	0.618
MOD_ProDKin_1	286	292	PF00069	0.524
MOD_ProDKin_1	304	310	PF00069	0.555
MOD_ProDKin_1	324	330	PF00069	0.471
MOD_ProDKin_1	331	337	PF00069	0.652
MOD_ProDKin_1	342	348	PF00069	0.501
MOD_ProDKin_1	389	395	PF00069	0.780
MOD_ProDKin_1	411	417	PF00069	0.761
MOD_ProDKin_1	46	52	PF00069	0.574
MOD_ProDKin_1	498	504	PF00069	0.615
MOD_ProDKin_1	55	61	PF00069	0.642
TRG_DiLeu_BaEn_1	320	325	PF01217	0.754
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.556
TRG_ENDOCYTIC_2	322	325	PF00928	0.720
TRG_ENDOCYTIC_2	37	40	PF00928	0.573
TRG_ER_diArg_1	106	109	PF00400	0.721
TRG_ER_diArg_1	363	366	PF00400	0.729
TRG_ER_diArg_1	383	386	PF00400	0.586
TRG_ER_diArg_1	614	617	PF00400	0.751
TRG_NLS_Bipartite_1	616	633	PF00514	0.756

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IUC2	Leishmania donovani	87%	100%
A4HAD5	Leishmania braziliensis	54%	100%
A4I9I7	Leishmania infantum	88%	100%
E9B4I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%