LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania major
UniProt:
E9AEH5_LEIMA
TriTrypDb:
Length:
101

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEH5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 43 45 PF00675 0.461
CLV_NRD_NRD_1 66 68 PF00675 0.554
CLV_PCSK_KEX2_1 43 45 PF00082 0.571
CLV_PCSK_SKI1_1 44 48 PF00082 0.502
DOC_MAPK_MEF2A_6 72 80 PF00069 0.494
DOC_USP7_UBL2_3 68 72 PF12436 0.562
DOC_WW_Pin1_4 14 19 PF00397 0.694
DOC_WW_Pin1_4 44 49 PF00397 0.601
LIG_14-3-3_CanoR_1 22 28 PF00244 0.561
LIG_PDZ_Class_3 96 101 PF00595 0.547
LIG_SH3_3 2 8 PF00018 0.595
LIG_SH3_3 58 64 PF00018 0.410
LIG_SUMO_SIM_anti_2 58 63 PF11976 0.408
LIG_SUMO_SIM_par_1 51 56 PF11976 0.540
MOD_GlcNHglycan 55 58 PF01048 0.526
MOD_NEK2_1 23 28 PF00069 0.675
MOD_NEK2_1 53 58 PF00069 0.628
MOD_PKA_1 67 73 PF00069 0.564
MOD_Plk_1 70 76 PF00069 0.559
MOD_Plk_4 55 61 PF00069 0.606
MOD_ProDKin_1 14 20 PF00069 0.693
MOD_ProDKin_1 44 50 PF00069 0.600
TRG_ER_diArg_1 42 44 PF00400 0.464

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X794 Leishmania donovani 83% 90%
A4I9D7 Leishmania infantum 85% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS