Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9AEH4_LEIMA

TriTrypDb:

LmjF.33.2835 , LMJLV39_330039600 , LMJSD75_330039100

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 1
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AEH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.774
CLV_NRD_NRD_1	269	271	PF00675	0.484
CLV_NRD_NRD_1	284	286	PF00675	0.510
CLV_NRD_NRD_1	288	290	PF00675	0.533
CLV_NRD_NRD_1	373	375	PF00675	0.639
CLV_NRD_NRD_1	7	9	PF00675	0.761
CLV_PCSK_KEX2_1	197	199	PF00082	0.739
CLV_PCSK_KEX2_1	269	271	PF00082	0.484
CLV_PCSK_KEX2_1	288	290	PF00082	0.533
CLV_PCSK_KEX2_1	7	9	PF00082	0.761
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.785
DEG_SCF_FBW7_1	381	388	PF00400	0.774
DEG_SPOP_SBC_1	147	151	PF00917	0.627
DEG_SPOP_SBC_1	158	162	PF00917	0.537
DEG_SPOP_SBC_1	424	428	PF00917	0.792
DOC_MAPK_gen_1	374	380	PF00069	0.670
DOC_MAPK_MEF2A_6	205	213	PF00069	0.266
DOC_PP4_FxxP_1	290	293	PF00568	0.760
DOC_USP7_MATH_1	101	105	PF00917	0.643
DOC_USP7_MATH_1	147	151	PF00917	0.598
DOC_USP7_MATH_1	153	157	PF00917	0.595
DOC_USP7_MATH_1	2	6	PF00917	0.631
DOC_USP7_MATH_1	317	321	PF00917	0.714
DOC_USP7_MATH_1	329	333	PF00917	0.803
DOC_USP7_MATH_1	363	367	PF00917	0.780
DOC_USP7_MATH_1	385	389	PF00917	0.686
DOC_USP7_MATH_1	57	61	PF00917	0.491
DOC_USP7_MATH_1	96	100	PF00917	0.614
DOC_USP7_UBL2_3	69	73	PF12436	0.556
DOC_WW_Pin1_4	174	179	PF00397	0.656
DOC_WW_Pin1_4	190	195	PF00397	0.458
DOC_WW_Pin1_4	381	386	PF00397	0.826
DOC_WW_Pin1_4	401	406	PF00397	0.642
LIG_14-3-3_CanoR_1	13	19	PF00244	0.665
LIG_14-3-3_CanoR_1	154	158	PF00244	0.484
LIG_14-3-3_CanoR_1	257	262	PF00244	0.727
LIG_Actin_WH2_2	39	57	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.730
LIG_BIR_III_1	1	5	PF00653	0.730
LIG_BIR_III_3	1	5	PF00653	0.730
LIG_BRCT_BRCA1_1	132	136	PF00533	0.560
LIG_BRCT_BRCA1_1	155	159	PF00533	0.485
LIG_deltaCOP1_diTrp_1	131	136	PF00928	0.477
LIG_deltaCOP1_diTrp_1	433	438	PF00928	0.845
LIG_FHA_1	205	211	PF00498	0.366
LIG_FHA_1	313	319	PF00498	0.771
LIG_FHA_1	357	363	PF00498	0.783
LIG_Integrin_RGD_1	262	264	PF01839	0.480
LIG_LIR_Gen_1	305	314	PF02991	0.829
LIG_LIR_Gen_1	330	341	PF02991	0.840
LIG_LIR_Nem_3	305	310	PF02991	0.756
LIG_Pex14_1	132	136	PF04695	0.477
LIG_Rb_pABgroove_1	27	35	PF01858	0.449
LIG_SH2_CRK	258	262	PF00017	0.849
LIG_SH2_STAP1	33	37	PF00017	0.470
LIG_SH2_STAT3	291	294	PF00017	0.792
LIG_SH2_STAT5	258	261	PF00017	0.848
LIG_SH3_3	357	363	PF00018	0.796
LIG_SH3_3	418	424	PF00018	0.699
LIG_TRAF2_1	86	89	PF00917	0.590
LIG_UBA3_1	306	313	PF00899	0.831
LIG_UBA3_1	370	377	PF00899	0.672
MOD_CDK_SPxxK_3	190	197	PF00069	0.588
MOD_CDK_SPxxK_3	401	408	PF00069	0.800
MOD_CK1_1	103	109	PF00069	0.545
MOD_CK1_1	113	119	PF00069	0.649
MOD_CK1_1	121	127	PF00069	0.496
MOD_CK1_1	135	141	PF00069	0.532
MOD_CK1_1	149	155	PF00069	0.589
MOD_CK1_1	162	168	PF00069	0.491
MOD_CK1_1	177	183	PF00069	0.577
MOD_CK1_1	350	356	PF00069	0.837
MOD_CK1_1	366	372	PF00069	0.667
MOD_CK1_1	388	394	PF00069	0.700
MOD_CK1_1	79	85	PF00069	0.648
MOD_CK2_1	103	109	PF00069	0.529
MOD_CK2_1	160	166	PF00069	0.594
MOD_CK2_1	390	396	PF00069	0.793
MOD_CK2_1	83	89	PF00069	0.646
MOD_Cter_Amidation	283	286	PF01082	0.477
MOD_GlcNHglycan	120	123	PF01048	0.807
MOD_GlcNHglycan	141	144	PF01048	0.744
MOD_GlcNHglycan	151	154	PF01048	0.754
MOD_GlcNHglycan	230	233	PF01048	0.575
MOD_GlcNHglycan	244	247	PF01048	0.546
MOD_GlcNHglycan	274	277	PF01048	0.480
MOD_GlcNHglycan	319	322	PF01048	0.657
MOD_GlcNHglycan	34	38	PF01048	0.613
MOD_GlcNHglycan	353	356	PF01048	0.617
MOD_GlcNHglycan	390	393	PF01048	0.594
MOD_GlcNHglycan	414	417	PF01048	0.594
MOD_GlcNHglycan	9	12	PF01048	0.634
MOD_GlcNHglycan	98	101	PF01048	0.746
MOD_GSK3_1	113	120	PF00069	0.615
MOD_GSK3_1	122	129	PF00069	0.529
MOD_GSK3_1	131	138	PF00069	0.428
MOD_GSK3_1	148	155	PF00069	0.604
MOD_GSK3_1	157	164	PF00069	0.604
MOD_GSK3_1	174	181	PF00069	0.461
MOD_GSK3_1	183	190	PF00069	0.556
MOD_GSK3_1	242	249	PF00069	0.757
MOD_GSK3_1	323	330	PF00069	0.776
MOD_GSK3_1	347	354	PF00069	0.850
MOD_GSK3_1	361	368	PF00069	0.688
MOD_GSK3_1	381	388	PF00069	0.631
MOD_GSK3_1	391	398	PF00069	0.738
MOD_GSK3_1	79	86	PF00069	0.574
MOD_GSK3_1	92	99	PF00069	0.550
MOD_LATS_1	255	261	PF00433	0.724
MOD_N-GLC_1	183	188	PF02516	0.808
MOD_NEK2_1	118	123	PF00069	0.485
MOD_NEK2_1	159	164	PF00069	0.589
MOD_NEK2_1	182	187	PF00069	0.590
MOD_NEK2_1	271	276	PF00069	0.778
MOD_NEK2_1	347	352	PF00069	0.848
MOD_NEK2_1	380	385	PF00069	0.692
MOD_NEK2_1	397	402	PF00069	0.726
MOD_NEK2_2	132	137	PF00069	0.479
MOD_PIKK_1	141	147	PF00454	0.587
MOD_PIKK_1	2	8	PF00454	0.652
MOD_PIKK_1	234	240	PF00454	0.658
MOD_PIKK_1	361	367	PF00454	0.684
MOD_PIKK_1	425	431	PF00454	0.791
MOD_PIKK_1	79	85	PF00454	0.558
MOD_PKA_1	7	13	PF00069	0.542
MOD_PKA_2	14	20	PF00069	0.643
MOD_PKA_2	153	159	PF00069	0.587
MOD_PKA_2	204	210	PF00069	0.252
MOD_PKA_2	242	248	PF00069	0.713
MOD_PKA_2	256	262	PF00069	0.734
MOD_PKA_2	272	278	PF00069	0.647
MOD_PKA_2	323	329	PF00069	0.727
MOD_PKA_2	407	413	PF00069	0.834
MOD_PKA_2	50	56	PF00069	0.447
MOD_PKA_2	7	13	PF00069	0.679
MOD_Plk_2-3	110	116	PF00069	0.483
MOD_Plk_4	14	20	PF00069	0.675
MOD_Plk_4	246	252	PF00069	0.687
MOD_Plk_4	366	372	PF00069	0.679
MOD_ProDKin_1	174	180	PF00069	0.654
MOD_ProDKin_1	190	196	PF00069	0.458
MOD_ProDKin_1	381	387	PF00069	0.827
MOD_ProDKin_1	401	407	PF00069	0.643
TRG_ENDOCYTIC_2	258	261	PF00928	0.848
TRG_ENDOCYTIC_2	268	271	PF00928	0.730
TRG_ENDOCYTIC_2	68	71	PF00928	0.557
TRG_ER_diArg_1	268	270	PF00400	0.685
TRG_ER_diArg_1	287	289	PF00400	0.718
TRG_NLS_Bipartite_1	269	289	PF00514	0.681
TRG_NLS_MonoCore_2	284	289	PF00514	0.681
TRG_NLS_MonoExtC_3	284	289	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.789

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH37	Leishmania donovani	71%	93%
A4HLZ5	Leishmania braziliensis	39%	100%
E9AHS1	Leishmania infantum	77%	100%