LeishMANIAdb
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DUF1279 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1279 domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania major
UniProt:
E9AEH3_LEIMA
TriTrypDb:
LmjF.33.2205 , LMJLV39_330032500 * , LMJSD75_330032100 *
Length:
308

Annotations

LeishMANIAdb annotations

A divergent protein family loosely similar in structure to the FAM210 family of poorly-known mitochondrial proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AEH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 181 183 PF00675 0.393
CLV_NRD_NRD_1 218 220 PF00675 0.647
CLV_NRD_NRD_1 294 296 PF00675 0.395
CLV_NRD_NRD_1 297 299 PF00675 0.423
CLV_NRD_NRD_1 31 33 PF00675 0.608
CLV_NRD_NRD_1 67 69 PF00675 0.516
CLV_NRD_NRD_1 89 91 PF00675 0.541
CLV_PCSK_FUR_1 295 299 PF00082 0.372
CLV_PCSK_KEX2_1 181 183 PF00082 0.393
CLV_PCSK_KEX2_1 294 296 PF00082 0.384
CLV_PCSK_KEX2_1 297 299 PF00082 0.410
CLV_PCSK_KEX2_1 31 33 PF00082 0.530
CLV_PCSK_KEX2_1 42 44 PF00082 0.505
CLV_PCSK_KEX2_1 67 69 PF00082 0.516
CLV_PCSK_KEX2_1 89 91 PF00082 0.541
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.552
CLV_PCSK_SKI1_1 185 189 PF00082 0.381
CLV_PCSK_SKI1_1 68 72 PF00082 0.517
CLV_Separin_Metazoa 264 268 PF03568 0.319
DEG_Nend_Nbox_1 1 3 PF02207 0.704
DEG_SPOP_SBC_1 20 24 PF00917 0.612
DOC_MAPK_gen_1 53 63 PF00069 0.628
DOC_MAPK_RevD_3 76 90 PF00069 0.623
DOC_PP4_FxxP_1 197 200 PF00568 0.373
DOC_USP7_MATH_1 144 148 PF00917 0.726
DOC_USP7_MATH_1 186 190 PF00917 0.563
DOC_USP7_MATH_1 20 24 PF00917 0.696
DOC_USP7_MATH_1 246 250 PF00917 0.478
DOC_USP7_MATH_1 45 49 PF00917 0.704
DOC_USP7_MATH_1 95 99 PF00917 0.806
DOC_WW_Pin1_4 115 120 PF00397 0.791
DOC_WW_Pin1_4 41 46 PF00397 0.762
LIG_14-3-3_CanoR_1 160 169 PF00244 0.638
LIG_14-3-3_CanoR_1 185 194 PF00244 0.580
LIG_14-3-3_CanoR_1 43 52 PF00244 0.754
LIG_14-3-3_CanoR_1 89 93 PF00244 0.754
LIG_Actin_WH2_2 282 299 PF00022 0.563
LIG_BRCT_BRCA1_1 281 285 PF00533 0.619
LIG_FHA_1 56 62 PF00498 0.628
LIG_FHA_2 165 171 PF00498 0.654
LIG_FHA_2 69 75 PF00498 0.725
LIG_GBD_Chelix_1 270 278 PF00786 0.380
LIG_LIR_Apic_2 195 200 PF02991 0.373
LIG_LIR_Gen_1 192 202 PF02991 0.477
LIG_LIR_Gen_1 205 214 PF02991 0.302
LIG_LIR_Gen_1 249 258 PF02991 0.376
LIG_LIR_Gen_1 46 57 PF02991 0.622
LIG_LIR_Nem_3 178 183 PF02991 0.638
LIG_LIR_Nem_3 192 197 PF02991 0.458
LIG_LIR_Nem_3 205 211 PF02991 0.302
LIG_LIR_Nem_3 249 253 PF02991 0.394
LIG_LIR_Nem_3 46 52 PF02991 0.722
LIG_Pex14_2 197 201 PF04695 0.373
LIG_Pex14_2 209 213 PF04695 0.373
LIG_SH2_STAT5 198 201 PF00017 0.313
LIG_SH2_STAT5 210 213 PF00017 0.313
LIG_SH3_3 263 269 PF00018 0.347
LIG_SH3_3 58 64 PF00018 0.628
LIG_SUMO_SIM_anti_2 261 267 PF11976 0.275
LIG_ULM_U2AF65_1 297 302 PF00076 0.598
MOD_CK1_1 118 124 PF00069 0.808
MOD_CK1_1 125 131 PF00069 0.680
MOD_CK1_1 147 153 PF00069 0.741
MOD_CK1_1 158 164 PF00069 0.738
MOD_CK1_1 189 195 PF00069 0.641
MOD_CK1_1 41 47 PF00069 0.726
MOD_CK1_1 88 94 PF00069 0.783
MOD_CK2_1 164 170 PF00069 0.711
MOD_CK2_1 68 74 PF00069 0.722
MOD_CMANNOS 247 250 PF00535 0.647
MOD_Cter_Amidation 65 68 PF01082 0.512
MOD_GlcNHglycan 115 118 PF01048 0.496
MOD_GlcNHglycan 127 130 PF01048 0.530
MOD_GlcNHglycan 16 19 PF01048 0.401
MOD_GlcNHglycan 3 6 PF01048 0.493
MOD_GlcNHglycan 74 77 PF01048 0.484
MOD_GlcNHglycan 93 96 PF01048 0.494
MOD_GlcNHglycan 97 100 PF01048 0.513
MOD_GSK3_1 111 118 PF00069 0.795
MOD_GSK3_1 119 126 PF00069 0.709
MOD_GSK3_1 155 162 PF00069 0.730
MOD_GSK3_1 164 171 PF00069 0.709
MOD_GSK3_1 41 48 PF00069 0.712
MOD_GSK3_1 68 75 PF00069 0.718
MOD_GSK3_1 91 98 PF00069 0.747
MOD_NEK2_1 1 6 PF00069 0.698
MOD_NEK2_1 21 26 PF00069 0.549
MOD_NEK2_1 52 57 PF00069 0.713
MOD_PIKK_1 144 150 PF00454 0.758
MOD_PKA_2 159 165 PF00069 0.726
MOD_PKA_2 52 58 PF00069 0.675
MOD_PKA_2 88 94 PF00069 0.737
MOD_Plk_1 192 198 PF00069 0.514
MOD_Plk_4 130 136 PF00069 0.631
MOD_Plk_4 175 181 PF00069 0.638
MOD_Plk_4 202 208 PF00069 0.373
MOD_Plk_4 226 232 PF00069 0.436
MOD_Plk_4 82 88 PF00069 0.652
MOD_ProDKin_1 115 121 PF00069 0.793
MOD_ProDKin_1 41 47 PF00069 0.762
MOD_SUMO_for_1 187 190 PF00179 0.614
TRG_DiLeu_BaLyEn_6 8 13 PF01217 0.700
TRG_ENDOCYTIC_2 198 201 PF00928 0.313
TRG_ENDOCYTIC_2 210 213 PF00928 0.313
TRG_ENDOCYTIC_2 275 278 PF00928 0.419
TRG_ER_diArg_1 180 182 PF00400 0.598
TRG_ER_diArg_1 294 297 PF00400 0.592
TRG_ER_diArg_1 67 69 PF00400 0.722

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0G0 Leptomonas seymouri 41% 100%
A0A3Q8IMI4 Leishmania donovani 82% 100%
A0A422NI31 Trypanosoma rangeli 26% 100%
E9AHN9 Leishmania infantum 82% 100%
E9B459 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS