Ribosomal protein L37

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L37

Species:

Leishmania major

UniProt:

E9AEH2_LEIMA

TriTrypDb:

LmjF.33.1955 , LMJLV39_330029400 , LMJSD75_330029000

Length:

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Ribosomal L37

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005840	ribosome	5	10
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0044391	ribosomal subunit	3	3

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Expansion

Sequence features

E9AEH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH2

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	13
GO:0019843	rRNA binding	5	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.279
CLV_NRD_NRD_1	45	47	PF00675	0.279
CLV_NRD_NRD_1	57	59	PF00675	0.421
CLV_NRD_NRD_1	72	74	PF00675	0.408
CLV_PCSK_KEX2_1	20	22	PF00082	0.279
CLV_PCSK_KEX2_1	44	46	PF00082	0.279
CLV_PCSK_KEX2_1	55	57	PF00082	0.423
CLV_PCSK_KEX2_1	72	74	PF00082	0.408
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.423
CLV_PCSK_PC7_1	41	47	PF00082	0.279

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q8	Leptomonas seymouri	99%	100%
A0A0S4IIV4	Bodo saltans	89%	99%
A0A1D8PF45	Candida albicans (strain SC5314 / ATCC MYA-2876)	56%	92%
A0A3Q8IHK7	Leishmania donovani	100%	100%
A0A3S7XA17	Leishmania donovani	98%	100%
A2BN31	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	49%	100%
A3CS13	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	54%	100%
A3DN33	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	53%	100%
A4FX24	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	48%	100%
A4HNH2	Leishmania braziliensis	97%	100%

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