Ribosomal protein L37

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L37

Species:

Leishmania major

UniProt:

E9AEH2_LEIMA

TriTrypDb:

LmjF.33.1955 , LMJLV39_330029400 , LMJSD75_330029000

Length:

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Ribosomal L37

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	10
GO:0044391	ribosomal subunit	3	3
GO:1990904	ribonucleoprotein complex	2	10
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005840	ribosome	5	10

Expansion

Sequence features

E9AEH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH2

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	13
GO:0019843	rRNA binding	5	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.279
CLV_NRD_NRD_1	45	47	PF00675	0.279
CLV_NRD_NRD_1	57	59	PF00675	0.421
CLV_NRD_NRD_1	72	74	PF00675	0.408
CLV_PCSK_KEX2_1	20	22	PF00082	0.279
CLV_PCSK_KEX2_1	44	46	PF00082	0.279
CLV_PCSK_KEX2_1	55	57	PF00082	0.423
CLV_PCSK_KEX2_1	72	74	PF00082	0.408
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.423
CLV_PCSK_PC7_1	41	47	PF00082	0.279
CLV_PCSK_SKI1_1	52	56	PF00082	0.403
CLV_PCSK_SKI1_1	65	69	PF00082	0.413
DOC_CKS1_1	78	83	PF01111	0.586
DOC_PP4_FxxP_1	78	81	PF00568	0.560
DOC_USP7_MATH_1	40	44	PF00917	0.315
DOC_WW_Pin1_4	77	82	PF00397	0.575
LIG_14-3-3_CanoR_1	24	28	PF00244	0.376
LIG_14-3-3_CanoR_1	46	52	PF00244	0.279
LIG_FHA_1	13	19	PF00498	0.279
LIG_SH2_STAT3	27	30	PF00017	0.315
LIG_SH2_STAT5	66	69	PF00017	0.407
MOD_CDK_SPK_2	77	82	PF00069	0.567
MOD_N-GLC_1	47	52	PF02516	0.279
MOD_NEK2_2	47	52	PF00069	0.315
MOD_PKA_1	56	62	PF00069	0.409
MOD_PKA_2	23	29	PF00069	0.360
MOD_PKA_2	40	46	PF00069	0.315
MOD_PKA_2	56	62	PF00069	0.409
MOD_PKB_1	56	64	PF00069	0.441
MOD_Plk_1	47	53	PF00069	0.279
MOD_ProDKin_1	77	83	PF00069	0.583
TRG_ENDOCYTIC_2	66	69	PF00928	0.459
TRG_ER_diArg_1	44	46	PF00400	0.279
TRG_ER_diArg_1	56	58	PF00400	0.438
TRG_ER_diArg_1	63	66	PF00400	0.410
TRG_ER_diArg_1	72	74	PF00400	0.408
TRG_NLS_Bipartite_1	44	59	PF00514	0.279
TRG_NLS_MonoCore_2	54	59	PF00514	0.438
TRG_NLS_MonoExtN_4	52	59	PF00514	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q8	Leptomonas seymouri	99%	100%
A0A0S4IIV4	Bodo saltans	89%	99%
A0A1D8PF45	Candida albicans (strain SC5314 / ATCC MYA-2876)	56%	92%
A0A3Q8IHK7	Leishmania donovani	100%	100%
A0A3S7XA17	Leishmania donovani	98%	100%
A2BN31	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	49%	100%
A3CS13	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	54%	100%
A3DN33	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	53%	100%
A4FX24	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	48%	100%
A4HNH2	Leishmania braziliensis	97%	100%
A4IC63	Leishmania infantum	100%	100%
A6UPF4	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	46%	100%
A6UTQ8	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	44%	100%
A6VG90	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	48%	100%
A9AAG2	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	46%	100%
B6YUU6	Thermococcus onnurineus (strain NA1)	47%	100%
B8D688	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	56%	100%
C5A1H2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	47%	100%
C9ZYE0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	94%	99%
E9AFY3	Leishmania major	100%	100%
E9AHN8	Leishmania infantum	100%	100%
E9B433	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E9B736	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O44125	Schistosoma mansoni	57%	94%
P05733	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	91%
P0DJ24	Tetrahymena thermophila (strain SB210)	53%	88%
P49166	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	57%	94%
P49622	Caenorhabditis elegans	54%	91%
P51402	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	55%	94%
P54011	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	52%	100%
P59289	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	93%
P61927	Homo sapiens	53%	86%
P61928	Rattus norvegicus	53%	86%
P62885	Leishmania donovani	100%	100%
P62886	Leishmania infantum	100%	100%
P79244	Bos taurus	53%	86%
Q2FT51	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	48%	100%
Q43292	Arabidopsis thaliana	61%	87%
Q54MG6	Dictyostelium discoideum	58%	91%
Q5JIE1	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	47%	100%
Q6BPF6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	56%	94%
Q6LY46	Methanococcus maripaludis (strain S2 / LL)	48%	100%
Q8LEM8	Arabidopsis thaliana	59%	87%
Q8LFH7	Arabidopsis thaliana	59%	87%
Q8SRH5	Encephalitozoon cuniculi (strain GB-M1)	50%	92%
Q8TYS1	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	52%	100%
Q90YT1	Ictalurus punctatus	56%	86%
Q962S7	Spodoptera frugiperda	60%	90%
Q9C0T1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	58%	90%
Q9D823	Mus musculus	53%	86%
Q9P836	Candida albicans	55%	94%
Q9VXX8	Drosophila melanogaster	63%	89%
Q9W1U6	Drosophila melanogaster	54%	93%
Q9YEQ4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	56%	100%