Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9AEH1_LEIMA

TriTrypDb:

LmjF.33.1535

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	31	33	PF00675	0.498
CLV_NRD_NRD_1	86	88	PF00675	0.613
CLV_PCSK_FUR_1	29	33	PF00082	0.497
CLV_PCSK_KEX2_1	31	33	PF00082	0.498
CLV_PCSK_KEX2_1	86	88	PF00082	0.613
CLV_PCSK_PC7_1	27	33	PF00082	0.424
CLV_PCSK_SKI1_1	41	45	PF00082	0.489
CLV_Separin_Metazoa	178	182	PF03568	0.461
DEG_Nend_UBRbox_3	1	3	PF02207	0.442
DOC_ANK_TNKS_1	170	177	PF00023	0.471
DOC_PP2B_LxvP_1	107	110	PF13499	0.404
DOC_PP2B_LxvP_1	12	15	PF13499	0.287
DOC_USP7_MATH_1	129	133	PF00917	0.704
LIG_14-3-3_CanoR_1	128	138	PF00244	0.699
LIG_14-3-3_CanoR_1	171	175	PF00244	0.579
LIG_14-3-3_CanoR_1	53	59	PF00244	0.392
LIG_14-3-3_CanoR_1	86	93	PF00244	0.481
LIG_14-3-3_CanoR_1	95	104	PF00244	0.341
LIG_BRCT_BRCA1_1	12	16	PF00533	0.287
LIG_FHA_1	142	148	PF00498	0.404
LIG_FHA_2	131	137	PF00498	0.660
LIG_FHA_2	95	101	PF00498	0.287
LIG_LIR_Gen_1	40	48	PF02991	0.604
LIG_LIR_Nem_3	13	19	PF02991	0.386
LIG_LIR_Nem_3	136	142	PF02991	0.345
LIG_LIR_Nem_3	40	45	PF02991	0.603
LIG_Pex14_2	139	143	PF04695	0.287
LIG_Rb_LxCxE_1	40	57	PF01857	0.604
LIG_SH2_STAP1	61	65	PF00017	0.328
LIG_SUMO_SIM_anti_2	105	110	PF11976	0.287
LIG_SUMO_SIM_par_1	143	148	PF11976	0.404
LIG_SUMO_SIM_par_1	19	25	PF11976	0.457
LIG_SUMO_SIM_par_1	8	13	PF11976	0.287
LIG_WRC_WIRS_1	78	83	PF05994	0.476
MOD_CK1_1	167	173	PF00069	0.524
MOD_CK1_1	22	28	PF00069	0.616
MOD_CK1_1	89	95	PF00069	0.505
MOD_CK2_1	22	28	PF00069	0.758
MOD_CK2_1	94	100	PF00069	0.262
MOD_GlcNHglycan	172	175	PF01048	0.680
MOD_GlcNHglycan	88	91	PF01048	0.699
MOD_GSK3_1	141	148	PF00069	0.468
MOD_GSK3_1	153	160	PF00069	0.625
MOD_GSK3_1	161	168	PF00069	0.558
MOD_GSK3_1	44	51	PF00069	0.748
MOD_LATS_1	163	169	PF00433	0.493
MOD_LATS_1	84	90	PF00433	0.408
MOD_NEK2_1	10	15	PF00069	0.305
MOD_NEK2_1	141	146	PF00069	0.462
MOD_NEK2_1	19	24	PF00069	0.535
MOD_PIKK_1	165	171	PF00454	0.490
MOD_PKA_1	86	92	PF00069	0.415
MOD_PKA_2	164	170	PF00069	0.532
MOD_PKA_2	86	92	PF00069	0.481
MOD_PKA_2	94	100	PF00069	0.304
MOD_Plk_4	77	83	PF00069	0.477
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.404
TRG_ENDOCYTIC_2	61	64	PF00928	0.404
TRG_ER_diArg_1	180	183	PF00400	0.462
TRG_ER_diArg_1	85	87	PF00400	0.404
TRG_ER_diLys_1	186	189	PF00400	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6P1	Leishmania donovani	74%	95%
E9AHN6	Leishmania infantum	75%	95%