Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEH0_LEIMA

TriTrypDb:

LmjF.33.0765 , LMJLV39_330014500 , LMJSD75_330014300

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEH0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.617
CLV_C14_Caspase3-7	284	288	PF00656	0.550
CLV_C14_Caspase3-7	378	382	PF00656	0.517
CLV_NRD_NRD_1	178	180	PF00675	0.754
CLV_NRD_NRD_1	291	293	PF00675	0.583
CLV_NRD_NRD_1	316	318	PF00675	0.620
CLV_NRD_NRD_1	371	373	PF00675	0.560
CLV_NRD_NRD_1	66	68	PF00675	0.634
CLV_PCSK_FUR_1	176	180	PF00082	0.635
CLV_PCSK_KEX2_1	178	180	PF00082	0.754
CLV_PCSK_KEX2_1	290	292	PF00082	0.629
CLV_PCSK_KEX2_1	316	318	PF00082	0.569
CLV_PCSK_KEX2_1	65	67	PF00082	0.638
CLV_PCSK_SKI1_1	209	213	PF00082	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SCF_FBW7_1	217	224	PF00400	0.638
DEG_SCF_FBW7_1	41	47	PF00400	0.592
DEG_SPOP_SBC_1	320	324	PF00917	0.580
DEG_SPOP_SBC_1	44	48	PF00917	0.613
DOC_CKS1_1	210	215	PF01111	0.612
DOC_CKS1_1	218	223	PF01111	0.576
DOC_CKS1_1	226	231	PF01111	0.530
DOC_CKS1_1	272	277	PF01111	0.550
DOC_CKS1_1	41	46	PF01111	0.591
DOC_PP4_FxxP_1	2	5	PF00568	0.622
DOC_PP4_FxxP_1	210	213	PF00568	0.610
DOC_PP4_FxxP_1	38	41	PF00568	0.615
DOC_USP7_MATH_1	145	149	PF00917	0.696
DOC_USP7_MATH_1	193	197	PF00917	0.662
DOC_USP7_MATH_1	211	215	PF00917	0.598
DOC_USP7_MATH_1	221	225	PF00917	0.601
DOC_USP7_MATH_1	315	319	PF00917	0.738
DOC_USP7_MATH_1	320	324	PF00917	0.616
DOC_USP7_MATH_1	359	363	PF00917	0.441
DOC_USP7_MATH_1	408	412	PF00917	0.684
DOC_USP7_MATH_1	68	72	PF00917	0.621
DOC_USP7_MATH_1	98	102	PF00917	0.595
DOC_WW_Pin1_4	100	105	PF00397	0.725
DOC_WW_Pin1_4	109	114	PF00397	0.710
DOC_WW_Pin1_4	167	172	PF00397	0.741
DOC_WW_Pin1_4	184	189	PF00397	0.605
DOC_WW_Pin1_4	203	208	PF00397	0.619
DOC_WW_Pin1_4	209	214	PF00397	0.576
DOC_WW_Pin1_4	217	222	PF00397	0.573
DOC_WW_Pin1_4	225	230	PF00397	0.615
DOC_WW_Pin1_4	25	30	PF00397	0.721
DOC_WW_Pin1_4	271	276	PF00397	0.555
DOC_WW_Pin1_4	391	396	PF00397	0.568
DOC_WW_Pin1_4	40	45	PF00397	0.692
DOC_WW_Pin1_4	54	59	PF00397	0.536
LIG_14-3-3_CanoR_1	118	122	PF00244	0.583
LIG_14-3-3_CanoR_1	134	140	PF00244	0.606
LIG_14-3-3_CanoR_1	178	184	PF00244	0.651
LIG_14-3-3_CanoR_1	254	260	PF00244	0.585
LIG_14-3-3_CanoR_1	316	320	PF00244	0.607
LIG_14-3-3_CanoR_1	387	395	PF00244	0.576
LIG_14-3-3_CanoR_1	67	73	PF00244	0.607
LIG_BIR_III_4	381	385	PF00653	0.491
LIG_FHA_1	1	7	PF00498	0.594
LIG_FHA_1	134	140	PF00498	0.585
LIG_FHA_2	154	160	PF00498	0.677
LIG_FHA_2	332	338	PF00498	0.513
LIG_FHA_2	376	382	PF00498	0.560
LIG_LIR_Apic_2	208	213	PF02991	0.618
LIG_LIR_Apic_2	214	218	PF02991	0.641
LIG_LIR_Apic_2	255	260	PF02991	0.538
LIG_LIR_Apic_2	35	41	PF02991	0.618
LIG_LIR_Nem_3	236	240	PF02991	0.653
LIG_LIR_Nem_3	303	309	PF02991	0.599
LIG_LIR_Nem_3	88	94	PF02991	0.556
LIG_LYPXL_yS_3	91	94	PF13949	0.559
LIG_Pex14_1	306	310	PF04695	0.508
LIG_SH2_NCK_1	257	261	PF00017	0.539
LIG_SH2_STAP1	310	314	PF00017	0.513
LIG_SH2_STAT5	280	283	PF00017	0.616
LIG_SH3_3	215	221	PF00018	0.584
LIG_SH3_3	223	229	PF00018	0.555
LIG_SH3_3	269	275	PF00018	0.566
LIG_SH3_3	38	44	PF00018	0.776
LIG_SUMO_SIM_anti_2	135	143	PF11976	0.584
LIG_SUMO_SIM_par_1	77	83	PF11976	0.587
LIG_TRAF2_1	198	201	PF00917	0.609
LIG_TYR_ITIM	89	94	PF00017	0.555
MOD_CDC14_SPxK_1	206	209	PF00782	0.526
MOD_CDK_SPxK_1	203	209	PF00069	0.532
MOD_CK1_1	108	114	PF00069	0.587
MOD_CK1_1	130	136	PF00069	0.525
MOD_CK1_1	137	143	PF00069	0.583
MOD_CK1_1	167	173	PF00069	0.585
MOD_CK1_1	17	23	PF00069	0.662
MOD_CK1_1	181	187	PF00069	0.532
MOD_CK1_1	216	222	PF00069	0.679
MOD_CK1_1	255	261	PF00069	0.618
MOD_CK1_1	299	305	PF00069	0.563
MOD_CK1_1	376	382	PF00069	0.614
MOD_CK1_1	389	395	PF00069	0.538
MOD_CK1_1	403	409	PF00069	0.597
MOD_CK1_1	45	51	PF00069	0.632
MOD_CK1_1	57	63	PF00069	0.775
MOD_CK1_1	71	77	PF00069	0.551
MOD_CK1_1	80	86	PF00069	0.585
MOD_CK2_1	21	27	PF00069	0.789
MOD_CK2_1	255	261	PF00069	0.704
MOD_CK2_1	270	276	PF00069	0.507
MOD_CK2_1	30	36	PF00069	0.539
MOD_CK2_1	315	321	PF00069	0.642
MOD_CK2_1	331	337	PF00069	0.449
MOD_Cter_Amidation	63	66	PF01082	0.625
MOD_DYRK1A_RPxSP_1	54	58	PF00069	0.598
MOD_GlcNHglycan	107	110	PF01048	0.654
MOD_GlcNHglycan	147	150	PF01048	0.713
MOD_GlcNHglycan	155	159	PF01048	0.574
MOD_GlcNHglycan	16	19	PF01048	0.752
MOD_GlcNHglycan	200	204	PF01048	0.535
MOD_GlcNHglycan	230	233	PF01048	0.643
MOD_GlcNHglycan	248	251	PF01048	0.692
MOD_GlcNHglycan	257	260	PF01048	0.735
MOD_GlcNHglycan	283	286	PF01048	0.612
MOD_GlcNHglycan	293	297	PF01048	0.593
MOD_GlcNHglycan	302	305	PF01048	0.529
MOD_GlcNHglycan	344	349	PF01048	0.491
MOD_GlcNHglycan	377	381	PF01048	0.580
MOD_GlcNHglycan	388	391	PF01048	0.523
MOD_GlcNHglycan	395	398	PF01048	0.586
MOD_GlcNHglycan	405	408	PF01048	0.671
MOD_GlcNHglycan	59	62	PF01048	0.698
MOD_GSK3_1	105	112	PF00069	0.623
MOD_GSK3_1	126	133	PF00069	0.728
MOD_GSK3_1	17	24	PF00069	0.628
MOD_GSK3_1	178	185	PF00069	0.777
MOD_GSK3_1	199	206	PF00069	0.567
MOD_GSK3_1	209	216	PF00069	0.812
MOD_GSK3_1	217	224	PF00069	0.662
MOD_GSK3_1	292	299	PF00069	0.735
MOD_GSK3_1	315	322	PF00069	0.583
MOD_GSK3_1	359	366	PF00069	0.426
MOD_GSK3_1	389	396	PF00069	0.637
MOD_GSK3_1	4	11	PF00069	0.573
MOD_GSK3_1	40	47	PF00069	0.580
MOD_GSK3_1	409	416	PF00069	0.515
MOD_GSK3_1	67	74	PF00069	0.800
MOD_LATS_1	177	183	PF00433	0.536
MOD_N-GLC_1	14	19	PF02516	0.550
MOD_N-GLC_1	299	304	PF02516	0.714
MOD_NEK2_1	270	275	PF00069	0.638
MOD_NEK2_1	281	286	PF00069	0.555
MOD_NEK2_1	298	303	PF00069	0.588
MOD_NEK2_1	360	365	PF00069	0.436
MOD_PIKK_1	252	258	PF00454	0.618
MOD_PK_1	127	133	PF00069	0.607
MOD_PKA_1	178	184	PF00069	0.634
MOD_PKA_1	291	297	PF00069	0.628
MOD_PKA_1	66	72	PF00069	0.625
MOD_PKA_2	117	123	PF00069	0.587
MOD_PKA_2	126	132	PF00069	0.586
MOD_PKA_2	133	139	PF00069	0.599
MOD_PKA_2	164	170	PF00069	0.578
MOD_PKA_2	178	184	PF00069	0.700
MOD_PKA_2	291	297	PF00069	0.635
MOD_PKA_2	315	321	PF00069	0.773
MOD_PKA_2	386	392	PF00069	0.581
MOD_PKA_2	398	404	PF00069	0.592
MOD_PKA_2	408	414	PF00069	0.591
MOD_PKA_2	66	72	PF00069	0.607
MOD_PKB_1	176	184	PF00069	0.599
MOD_PKB_1	290	298	PF00069	0.631
MOD_PKB_1	65	73	PF00069	0.623
MOD_Plk_2-3	331	337	PF00069	0.449
MOD_Plk_4	137	143	PF00069	0.708
MOD_Plk_4	331	337	PF00069	0.436
MOD_Plk_4	363	369	PF00069	0.420
MOD_ProDKin_1	100	106	PF00069	0.724
MOD_ProDKin_1	109	115	PF00069	0.710
MOD_ProDKin_1	167	173	PF00069	0.739
MOD_ProDKin_1	184	190	PF00069	0.605
MOD_ProDKin_1	203	209	PF00069	0.619
MOD_ProDKin_1	217	223	PF00069	0.577
MOD_ProDKin_1	225	231	PF00069	0.695
MOD_ProDKin_1	25	31	PF00069	0.722
MOD_ProDKin_1	271	277	PF00069	0.552
MOD_ProDKin_1	391	397	PF00069	0.569
MOD_ProDKin_1	40	46	PF00069	0.694
MOD_ProDKin_1	54	60	PF00069	0.536
TRG_DiLeu_BaEn_4	200	206	PF01217	0.536
TRG_ENDOCYTIC_2	91	94	PF00928	0.562
TRG_ER_diArg_1	176	179	PF00400	0.739
TRG_ER_diArg_1	290	292	PF00400	0.623
TRG_ER_diArg_1	315	317	PF00400	0.592
TRG_ER_diArg_1	65	67	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S8	Leptomonas seymouri	39%	98%
A0A3Q8ITW3	Leishmania donovani	90%	100%
A4HLB7	Leishmania braziliensis	63%	100%
E9AHN3	Leishmania infantum	90%	100%
E9B3Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%