START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEG9_LEIMA

TriTrypDb:

LmjF.32.3548 , LMJLV39_320043400 , LMJSD75_320043400

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.693
CLV_C14_Caspase3-7	376	380	PF00656	0.599
CLV_NRD_NRD_1	11	13	PF00675	0.477
CLV_NRD_NRD_1	112	114	PF00675	0.566
CLV_NRD_NRD_1	176	178	PF00675	0.617
CLV_NRD_NRD_1	207	209	PF00675	0.545
CLV_NRD_NRD_1	336	338	PF00675	0.609
CLV_NRD_NRD_1	358	360	PF00675	0.593
CLV_NRD_NRD_1	73	75	PF00675	0.593
CLV_PCSK_KEX2_1	11	13	PF00082	0.477
CLV_PCSK_KEX2_1	112	114	PF00082	0.566
CLV_PCSK_KEX2_1	176	178	PF00082	0.617
CLV_PCSK_KEX2_1	278	280	PF00082	0.587
CLV_PCSK_KEX2_1	451	453	PF00082	0.782
CLV_PCSK_KEX2_1	73	75	PF00082	0.593
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.587
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.782
CLV_PCSK_SKI1_1	11	15	PF00082	0.475
CLV_PCSK_SKI1_1	130	134	PF00082	0.520
CLV_PCSK_SKI1_1	198	202	PF00082	0.514
DOC_ANK_TNKS_1	179	186	PF00023	0.635
DOC_CKS1_1	312	317	PF01111	0.554
DOC_MAPK_FxFP_2	131	134	PF00069	0.513
DOC_MAPK_FxFP_2	63	66	PF00069	0.568
DOC_MAPK_gen_1	176	184	PF00069	0.621
DOC_MAPK_gen_1	278	286	PF00069	0.572
DOC_MAPK_gen_1	337	344	PF00069	0.514
DOC_MAPK_gen_1	410	418	PF00069	0.567
DOC_PP4_FxxP_1	131	134	PF00568	0.513
DOC_PP4_FxxP_1	141	144	PF00568	0.502
DOC_PP4_FxxP_1	297	300	PF00568	0.540
DOC_PP4_FxxP_1	440	443	PF00568	0.654
DOC_PP4_FxxP_1	63	66	PF00568	0.568
DOC_USP7_MATH_1	259	263	PF00917	0.579
DOC_USP7_MATH_1	378	382	PF00917	0.649
DOC_USP7_MATH_1	66	70	PF00917	0.566
DOC_USP7_UBL2_3	209	213	PF12436	0.541
DOC_USP7_UBL2_3	395	399	PF12436	0.616
DOC_WW_Pin1_4	112	117	PF00397	0.551
DOC_WW_Pin1_4	311	316	PF00397	0.562
DOC_WW_Pin1_4	36	41	PF00397	0.578
DOC_WW_Pin1_4	64	69	PF00397	0.567
LIG_14-3-3_CanoR_1	112	116	PF00244	0.551
LIG_14-3-3_CanoR_1	117	123	PF00244	0.512
LIG_14-3-3_CanoR_1	125	130	PF00244	0.466
LIG_14-3-3_CanoR_1	232	238	PF00244	0.563
LIG_14-3-3_CanoR_1	25	31	PF00244	0.502
LIG_14-3-3_CanoR_1	301	307	PF00244	0.508
LIG_14-3-3_CanoR_1	73	77	PF00244	0.601
LIG_BRCT_BRCA1_1	100	104	PF00533	0.569
LIG_BRCT_BRCA1_1	127	131	PF00533	0.541
LIG_eIF4E_1	265	271	PF01652	0.548
LIG_EVH1_1	42	46	PF00568	0.570
LIG_FHA_1	138	144	PF00498	0.545
LIG_FHA_1	232	238	PF00498	0.595
LIG_FHA_1	240	246	PF00498	0.383
LIG_FHA_1	3	9	PF00498	0.466
LIG_FHA_1	383	389	PF00498	0.527
LIG_FHA_2	153	159	PF00498	0.697
LIG_FHA_2	170	176	PF00498	0.683
LIG_LIR_Apic_2	128	134	PF02991	0.525
LIG_LIR_Apic_2	140	144	PF02991	0.493
LIG_LIR_Apic_2	156	162	PF02991	0.598
LIG_LIR_Apic_2	288	294	PF02991	0.514
LIG_LIR_Apic_2	320	325	PF02991	0.530
LIG_LIR_Apic_2	437	443	PF02991	0.631
LIG_LIR_Gen_1	186	197	PF02991	0.549
LIG_LIR_Gen_1	211	222	PF02991	0.548
LIG_LIR_Gen_1	305	313	PF02991	0.518
LIG_LIR_Gen_1	369	378	PF02991	0.516
LIG_LIR_Nem_3	140	145	PF02991	0.562
LIG_LIR_Nem_3	186	192	PF02991	0.570
LIG_LIR_Nem_3	211	217	PF02991	0.564
LIG_LIR_Nem_3	29	35	PF02991	0.497
LIG_LIR_Nem_3	305	309	PF02991	0.518
LIG_LIR_Nem_3	369	373	PF02991	0.506
LIG_LIR_Nem_3	58	63	PF02991	0.568
LIG_MLH1_MIPbox_1	100	104	PF16413	0.569
LIG_NRBOX	308	314	PF00104	0.527
LIG_Pex14_2	142	146	PF04695	0.582
LIG_SH2_CRK	267	271	PF00017	0.541
LIG_SH2_CRK	291	295	PF00017	0.554
LIG_SH2_CRK	370	374	PF00017	0.567
LIG_SH2_GRB2like	432	435	PF00017	0.628
LIG_SH2_PTP2	306	309	PF00017	0.495
LIG_SH2_SRC	159	162	PF00017	0.694
LIG_SH2_SRC	214	217	PF00017	0.517
LIG_SH2_STAP1	214	218	PF00017	0.539
LIG_SH2_STAP1	267	271	PF00017	0.502
LIG_SH2_STAP1	368	372	PF00017	0.517
LIG_SH2_STAT5	103	106	PF00017	0.576
LIG_SH2_STAT5	122	125	PF00017	0.438
LIG_SH2_STAT5	254	257	PF00017	0.565
LIG_SH2_STAT5	306	309	PF00017	0.521
LIG_SH2_STAT5	351	354	PF00017	0.600
LIG_SH2_STAT5	53	56	PF00017	0.573
LIG_SH3_1	37	43	PF00018	0.491
LIG_SH3_3	37	43	PF00018	0.603
LIG_SH3_3	86	92	PF00018	0.619
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.469
LIG_SUMO_SIM_par_1	385	391	PF11976	0.476
LIG_TRAF2_1	167	170	PF00917	0.748
LIG_TYR_ITIM	304	309	PF00017	0.515
LIG_WW_2	40	43	PF00397	0.600
MOD_CDK_SPK_2	112	117	PF00069	0.551
MOD_CK1_1	152	158	PF00069	0.621
MOD_CK1_1	223	229	PF00069	0.631
MOD_CK1_1	305	311	PF00069	0.501
MOD_CK2_1	152	158	PF00069	0.621
MOD_CK2_1	401	407	PF00069	0.595
MOD_CK2_1	441	447	PF00069	0.746
MOD_Cter_Amidation	449	452	PF01082	0.789
MOD_GlcNHglycan	201	204	PF01048	0.569
MOD_GSK3_1	145	152	PF00069	0.604
MOD_GSK3_1	199	206	PF00069	0.547
MOD_GSK3_1	282	289	PF00069	0.572
MOD_GSK3_1	378	385	PF00069	0.635
MOD_GSK3_1	98	105	PF00069	0.568
MOD_N-GLC_1	259	264	PF02516	0.571
MOD_N-GLC_1	282	287	PF02516	0.564
MOD_NEK2_1	111	116	PF00069	0.555
MOD_NEK2_1	199	204	PF00069	0.550
MOD_NEK2_1	231	236	PF00069	0.545
MOD_NEK2_1	342	347	PF00069	0.491
MOD_NEK2_1	382	387	PF00069	0.530
MOD_NEK2_1	55	60	PF00069	0.564
MOD_NEK2_2	203	208	PF00069	0.523
MOD_NEK2_2	48	53	PF00069	0.581
MOD_NEK2_2	98	103	PF00069	0.569
MOD_OFUCOSY	191	196	PF10250	0.452
MOD_PIKK_1	220	226	PF00454	0.508
MOD_PIKK_1	342	348	PF00454	0.492
MOD_PKA_1	359	365	PF00069	0.590
MOD_PKA_2	111	117	PF00069	0.555
MOD_PKA_2	124	130	PF00069	0.466
MOD_PKA_2	231	237	PF00069	0.553
MOD_PKA_2	26	32	PF00069	0.503
MOD_PKA_2	323	329	PF00069	0.670
MOD_PKA_2	72	78	PF00069	0.599
MOD_Plk_1	148	154	PF00069	0.600
MOD_Plk_1	259	265	PF00069	0.547
MOD_Plk_1	282	288	PF00069	0.551
MOD_Plk_2-3	169	175	PF00069	0.690
MOD_Plk_2-3	402	408	PF00069	0.579
MOD_Plk_4	137	143	PF00069	0.539
MOD_Plk_4	259	265	PF00069	0.543
MOD_Plk_4	368	374	PF00069	0.610
MOD_Plk_4	427	433	PF00069	0.570
MOD_Plk_4	66	72	PF00069	0.571
MOD_Plk_4	98	104	PF00069	0.568
MOD_ProDKin_1	112	118	PF00069	0.546
MOD_ProDKin_1	311	317	PF00069	0.587
MOD_ProDKin_1	36	42	PF00069	0.578
MOD_ProDKin_1	64	70	PF00069	0.568
MOD_SUMO_rev_2	215	223	PF00179	0.544
MOD_SUMO_rev_2	444	453	PF00179	0.717
TRG_DiLeu_BaEn_1	3	8	PF01217	0.465
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.494
TRG_ENDOCYTIC_2	214	217	PF00928	0.556
TRG_ENDOCYTIC_2	267	270	PF00928	0.545
TRG_ENDOCYTIC_2	306	309	PF00928	0.521
TRG_ENDOCYTIC_2	32	35	PF00928	0.493
TRG_ENDOCYTIC_2	370	373	PF00928	0.545
TRG_ER_diArg_1	10	12	PF00400	0.474
TRG_ER_diArg_1	111	113	PF00400	0.571
TRG_ER_diArg_1	25	28	PF00400	0.492
TRG_ER_diArg_1	57	60	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.723
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH56	Leishmania donovani	94%	100%
A4HKZ3	Leishmania braziliensis	73%	100%
A4I8H4	Leishmania infantum	94%	100%
E9B3D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q4S1	Leishmania major	100%	90%