SB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps23 core domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AEF7_LEIMA

TriTrypDb:

LmjF.32.0985

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000813	ESCRT I complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0036452	ESCRT complex	2	2
GO:0098796	membrane protein complex	2	2
GO:0005768	endosome	7	10
GO:0031410	cytoplasmic vesicle	6	10
GO:0031982	vesicle	4	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0097708	intracellular vesicle	5	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AEF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEF7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0007034	vacuolar transport	4	2
GO:0007041	lysosomal transport	5	2
GO:0008104	protein localization	4	13
GO:0008333	endosome to lysosome transport	5	2
GO:0009987	cellular process	1	13
GO:0015031	protein transport	4	13
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	13
GO:0045184	establishment of protein localization	3	13
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051641	cellular localization	2	13
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	13
GO:0071702	organic substance transport	4	13
GO:0071705	nitrogen compound transport	4	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	328	334	PF00089	0.443
CLV_NRD_NRD_1	207	209	PF00675	0.517
CLV_NRD_NRD_1	65	67	PF00675	0.542
CLV_PCSK_KEX2_1	302	304	PF00082	0.300
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.361
CLV_PCSK_SKI1_1	209	213	PF00082	0.546
CLV_PCSK_SKI1_1	229	233	PF00082	0.460
CLV_PCSK_SKI1_1	335	339	PF00082	0.405
CLV_PCSK_SKI1_1	387	391	PF00082	0.456
CLV_PCSK_SKI1_1	405	409	PF00082	0.431
CLV_TASPASE1	255	261	PF01112	0.675
DEG_APCC_DBOX_1	386	394	PF00400	0.517
DEG_APCC_DBOX_1	400	408	PF00400	0.376
DEG_Nend_UBRbox_2	1	3	PF02207	0.535
DEG_SCF_FBW7_1	346	351	PF00400	0.593
DOC_CKS1_1	345	350	PF01111	0.727
DOC_CKS1_1	73	78	PF01111	0.528
DOC_CYCLIN_RxL_1	276	286	PF00134	0.491
DOC_CYCLIN_RxL_1	320	334	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	96	99	PF00134	0.581
DOC_MAPK_gen_1	208	215	PF00069	0.564
DOC_MAPK_gen_1	335	345	PF00069	0.573
DOC_PP2B_LxvP_1	96	99	PF13499	0.530
DOC_PP4_FxxP_1	345	348	PF00568	0.491
DOC_USP7_MATH_1	12	16	PF00917	0.373
DOC_USP7_MATH_1	162	166	PF00917	0.661
DOC_USP7_MATH_1	181	185	PF00917	0.635
DOC_USP7_MATH_1	69	73	PF00917	0.355
DOC_WW_Pin1_4	16	21	PF00397	0.508
DOC_WW_Pin1_4	344	349	PF00397	0.678
DOC_WW_Pin1_4	354	359	PF00397	0.765
DOC_WW_Pin1_4	65	70	PF00397	0.517
DOC_WW_Pin1_4	72	77	PF00397	0.552
LIG_14-3-3_CanoR_1	131	136	PF00244	0.425
LIG_14-3-3_CanoR_1	182	186	PF00244	0.571
LIG_14-3-3_CanoR_1	331	337	PF00244	0.476
LIG_14-3-3_CanoR_1	46	50	PF00244	0.473
LIG_Actin_WH2_2	111	129	PF00022	0.447
LIG_BRCT_BRCA1_1	142	146	PF00533	0.473
LIG_FHA_1	25	31	PF00498	0.432
LIG_FHA_1	291	297	PF00498	0.575
LIG_FHA_1	349	355	PF00498	0.778
LIG_FHA_1	369	375	PF00498	0.574
LIG_FHA_1	73	79	PF00498	0.496
LIG_FHA_2	260	266	PF00498	0.614
LIG_FHA_2	305	311	PF00498	0.538
LIG_IRF3_LxIS_1	136	143	PF10401	0.471
LIG_LIR_Apic_2	15	20	PF02991	0.523
LIG_LIR_Gen_1	60	69	PF02991	0.533
LIG_LIR_LC3C_4	75	80	PF02991	0.515
LIG_LIR_Nem_3	147	153	PF02991	0.411
LIG_LIR_Nem_3	15	21	PF02991	0.500
LIG_LIR_Nem_3	31	36	PF02991	0.275
LIG_LIR_Nem_3	60	65	PF02991	0.504
LIG_LYPXL_yS_3	150	153	PF13949	0.472
LIG_NRBOX	135	141	PF00104	0.403
LIG_OCRL_FandH_1	322	334	PF00620	0.574
LIG_PCNA_PIPBox_1	236	245	PF02747	0.537
LIG_PCNA_yPIPBox_3	229	243	PF02747	0.600
LIG_SH2_CRK	18	22	PF00017	0.492
LIG_SH2_NCK_1	18	22	PF00017	0.417
LIG_SH2_SRC	242	245	PF00017	0.635
LIG_SH2_SRC	28	31	PF00017	0.490
LIG_SH2_STAP1	36	40	PF00017	0.520
LIG_SH2_STAT3	87	90	PF00017	0.522
LIG_SH2_STAT5	204	207	PF00017	0.437
LIG_SH2_STAT5	214	217	PF00017	0.449
LIG_SH2_STAT5	242	245	PF00017	0.628
LIG_SH2_STAT5	311	314	PF00017	0.470
LIG_SH2_STAT5	329	332	PF00017	0.413
LIG_SH3_1	359	365	PF00018	0.679
LIG_SH3_2	362	367	PF14604	0.747
LIG_SH3_3	126	132	PF00018	0.545
LIG_SH3_3	269	275	PF00018	0.559
LIG_SH3_3	340	346	PF00018	0.597
LIG_SH3_3	355	361	PF00018	0.789
LIG_SH3_3	92	98	PF00018	0.487
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.480
LIG_SUMO_SIM_anti_2	291	299	PF11976	0.480
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.519
LIG_SUMO_SIM_anti_2	75	82	PF11976	0.451
LIG_SUMO_SIM_par_1	137	144	PF11976	0.375
LIG_SUMO_SIM_par_1	193	199	PF11976	0.541
LIG_SUMO_SIM_par_1	291	299	PF11976	0.504
LIG_SUMO_SIM_par_1	75	82	PF11976	0.433
LIG_TRAF2_1	262	265	PF00917	0.631
LIG_TYR_ITIM	148	153	PF00017	0.517
LIG_UBA3_1	212	217	PF00899	0.487
LIG_WRC_WIRS_1	80	85	PF05994	0.493
MOD_CDK_SPK_2	354	359	PF00069	0.688
MOD_CK1_1	110	116	PF00069	0.508
MOD_CK1_1	169	175	PF00069	0.721
MOD_CK1_1	24	30	PF00069	0.490
MOD_CK1_1	357	363	PF00069	0.732
MOD_CK1_1	72	78	PF00069	0.512
MOD_CK2_1	218	224	PF00069	0.515
MOD_CK2_1	259	265	PF00069	0.595
MOD_CK2_1	304	310	PF00069	0.452
MOD_CK2_1	357	363	PF00069	0.743
MOD_GlcNHglycan	171	174	PF01048	0.686
MOD_GlcNHglycan	175	178	PF01048	0.632
MOD_GlcNHglycan	23	26	PF01048	0.423
MOD_GlcNHglycan	340	343	PF01048	0.581
MOD_GlcNHglycan	379	382	PF01048	0.594
MOD_GlcNHglycan	92	95	PF01048	0.471
MOD_GSK3_1	12	19	PF00069	0.535
MOD_GSK3_1	158	165	PF00069	0.603
MOD_GSK3_1	169	176	PF00069	0.662
MOD_GSK3_1	24	31	PF00069	0.417
MOD_GSK3_1	344	351	PF00069	0.684
MOD_GSK3_1	61	68	PF00069	0.490
MOD_N-GLC_1	218	223	PF02516	0.560
MOD_N-GLC_1	247	252	PF02516	0.582
MOD_N-GLC_1	313	318	PF02516	0.352
MOD_NEK2_1	1	6	PF00069	0.502
MOD_NEK2_1	218	223	PF00069	0.560
MOD_NEK2_1	336	341	PF00069	0.635
MOD_NEK2_2	61	66	PF00069	0.424
MOD_PIKK_1	12	18	PF00454	0.479
MOD_PIKK_1	69	75	PF00454	0.499
MOD_PKA_2	181	187	PF00069	0.543
MOD_PKA_2	330	336	PF00069	0.495
MOD_PKA_2	45	51	PF00069	0.476
MOD_Plk_1	1	7	PF00069	0.528
MOD_Plk_1	247	253	PF00069	0.580
MOD_Plk_1	259	265	PF00069	0.585
MOD_Plk_1	290	296	PF00069	0.510
MOD_Plk_1	395	401	PF00069	0.580
MOD_Plk_2-3	166	172	PF00069	0.487
MOD_Plk_4	107	113	PF00069	0.475
MOD_Plk_4	131	137	PF00069	0.408
MOD_Plk_4	181	187	PF00069	0.617
MOD_Plk_4	248	254	PF00069	0.648
MOD_ProDKin_1	16	22	PF00069	0.499
MOD_ProDKin_1	344	350	PF00069	0.682
MOD_ProDKin_1	354	360	PF00069	0.780
MOD_ProDKin_1	65	71	PF00069	0.511
MOD_ProDKin_1	72	78	PF00069	0.547
MOD_SUMO_for_1	301	304	PF00179	0.561
TRG_DiLeu_BaEn_2	120	126	PF01217	0.506
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.538
TRG_ENDOCYTIC_2	109	112	PF00928	0.509
TRG_ENDOCYTIC_2	133	136	PF00928	0.369
TRG_ENDOCYTIC_2	150	153	PF00928	0.451
TRG_ENDOCYTIC_2	18	21	PF00928	0.480
TRG_ENDOCYTIC_2	204	207	PF00928	0.475
TRG_ENDOCYTIC_2	329	332	PF00928	0.577
TRG_NES_CRM1_1	137	149	PF08389	0.419
TRG_NES_CRM1_1	388	403	PF08389	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L8	Leptomonas seymouri	70%	100%
A0A0S4KPG1	Bodo saltans	29%	84%
A0A1X0NUM5	Trypanosomatidae	35%	96%
A0A3Q8IJ55	Leishmania donovani	93%	100%
A0A422P1F9	Trypanosoma rangeli	29%	100%
A0A422P1H3	Trypanosoma rangeli	34%	96%
A4HK80	Leishmania braziliensis	78%	100%
A4I7R5	Leishmania infantum	93%	100%
D0A9X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	90%
E9B2M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BQQ0	Trypanosoma cruzi	34%	96%