LeishMANIAdb
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Proteophosphoglycan ppg4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Proteophosphoglycan ppg4
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
E9AEF4_LEIMA
TriTrypDb:
LmjF.31.1445 , LMJLV39_310022100 * , LMJSD75_310021400
Length:
460

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 40
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 13, no: 1
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005929 cilium 4 15
GO:0042995 cell projection 2 15
GO:0043226 organelle 2 15
GO:0043227 membrane-bounded organelle 3 15
GO:0110165 cellular anatomical entity 1 15
GO:0120025 plasma membrane bounded cell projection 3 15
GO:0016020 membrane 2 4

Expansion

Sequence features

E9AEF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEF4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.325
CLV_NRD_NRD_1 246 248 PF00675 0.543
CLV_NRD_NRD_1 264 266 PF00675 0.543
CLV_PCSK_KEX2_1 246 248 PF00082 0.544
CLV_PCSK_KEX2_1 264 266 PF00082 0.538
CLV_PCSK_KEX2_1 429 431 PF00082 0.605
CLV_PCSK_PC1ET2_1 429 431 PF00082 0.604
CLV_PCSK_SKI1_1 171 175 PF00082 0.517
CLV_PCSK_SKI1_1 3 7 PF00082 0.700
DEG_Nend_Nbox_1 1 3 PF02207 0.521
DEG_SPOP_SBC_1 289 293 PF00917 0.529
DEG_SPOP_SBC_1 296 300 PF00917 0.543
DEG_SPOP_SBC_1 304 308 PF00917 0.504
DEG_SPOP_SBC_1 312 316 PF00917 0.486
DEG_SPOP_SBC_1 320 324 PF00917 0.488
DEG_SPOP_SBC_1 328 332 PF00917 0.488
DEG_SPOP_SBC_1 336 340 PF00917 0.466
DEG_SPOP_SBC_1 344 348 PF00917 0.490
DEG_SPOP_SBC_1 352 356 PF00917 0.480
DEG_SPOP_SBC_1 360 364 PF00917 0.498
DEG_SPOP_SBC_1 368 372 PF00917 0.523
DEG_SPOP_SBC_1 376 380 PF00917 0.529
DEG_SPOP_SBC_1 384 388 PF00917 0.502
DOC_MAPK_gen_1 264 272 PF00069 0.397
DOC_MAPK_MEF2A_6 145 154 PF00069 0.311
DOC_PP1_RVXF_1 169 176 PF00149 0.306
DOC_USP7_MATH_1 179 183 PF00917 0.288
DOC_USP7_MATH_1 214 218 PF00917 0.317
DOC_USP7_MATH_1 446 450 PF00917 0.362
DOC_USP7_MATH_1 72 76 PF00917 0.331
DOC_WW_Pin1_4 31 36 PF00397 0.422
DOC_WW_Pin1_4 435 440 PF00397 0.466
LIG_14-3-3_CanoR_1 171 176 PF00244 0.313
LIG_14-3-3_CanoR_1 192 198 PF00244 0.299
LIG_14-3-3_CanoR_1 246 251 PF00244 0.386
LIG_14-3-3_CanoR_1 264 269 PF00244 0.336
LIG_14-3-3_CanoR_1 3 10 PF00244 0.474
LIG_14-3-3_CanoR_1 44 52 PF00244 0.426
LIG_Actin_WH2_2 156 173 PF00022 0.302
LIG_BIR_III_2 47 51 PF00653 0.397
LIG_deltaCOP1_diTrp_1 261 268 PF00928 0.357
LIG_eIF4E_1 92 98 PF01652 0.298
LIG_FHA_1 197 203 PF00498 0.301
LIG_FHA_1 230 236 PF00498 0.315
LIG_FHA_1 60 66 PF00498 0.408
LIG_FHA_1 9 15 PF00498 0.519
LIG_FHA_2 106 112 PF00498 0.452
LIG_FHA_2 290 296 PF00498 0.509
LIG_FHA_2 298 304 PF00498 0.501
LIG_FHA_2 306 312 PF00498 0.479
LIG_FHA_2 314 320 PF00498 0.478
LIG_FHA_2 322 328 PF00498 0.474
LIG_FHA_2 330 336 PF00498 0.471
LIG_FHA_2 338 344 PF00498 0.468
LIG_FHA_2 346 352 PF00498 0.478
LIG_FHA_2 354 360 PF00498 0.480
LIG_FHA_2 362 368 PF00498 0.515
LIG_FHA_2 370 376 PF00498 0.516
LIG_FHA_2 378 384 PF00498 0.509
LIG_FHA_2 386 392 PF00498 0.517
LIG_FHA_2 408 414 PF00498 0.367
LIG_FHA_2 77 83 PF00498 0.361
LIG_LIR_Gen_1 117 126 PF02991 0.351
LIG_LIR_Gen_1 174 183 PF02991 0.374
LIG_LIR_Gen_1 238 245 PF02991 0.441
LIG_LIR_Gen_1 53 60 PF02991 0.314
LIG_LIR_Nem_3 117 121 PF02991 0.430
LIG_LIR_Nem_3 141 146 PF02991 0.371
LIG_LIR_Nem_3 166 170 PF02991 0.351
LIG_LIR_Nem_3 174 178 PF02991 0.334
LIG_LIR_Nem_3 53 57 PF02991 0.321
LIG_SH2_STAP1 118 122 PF00017 0.338
LIG_SH2_STAP1 203 207 PF00017 0.308
LIG_SH2_STAT3 203 206 PF00017 0.331
LIG_SH3_3 107 113 PF00018 0.452
LIG_SUMO_SIM_par_1 198 205 PF11976 0.314
LIG_TYR_ITIM 116 121 PF00017 0.434
MOD_CK1_1 101 107 PF00069 0.381
MOD_CK1_1 133 139 PF00069 0.341
MOD_CK1_1 166 172 PF00069 0.431
MOD_CK1_1 190 196 PF00069 0.400
MOD_CK1_1 217 223 PF00069 0.418
MOD_CK1_1 437 443 PF00069 0.478
MOD_CK1_1 53 59 PF00069 0.364
MOD_CK2_1 289 295 PF00069 0.503
MOD_CK2_1 297 303 PF00069 0.501
MOD_CK2_1 305 311 PF00069 0.479
MOD_CK2_1 313 319 PF00069 0.487
MOD_CK2_1 321 327 PF00069 0.478
MOD_CK2_1 329 335 PF00069 0.473
MOD_CK2_1 337 343 PF00069 0.469
MOD_CK2_1 345 351 PF00069 0.477
MOD_CK2_1 353 359 PF00069 0.474
MOD_CK2_1 361 367 PF00069 0.507
MOD_CK2_1 369 375 PF00069 0.512
MOD_CK2_1 377 383 PF00069 0.516
MOD_CK2_1 385 391 PF00069 0.539
MOD_CK2_1 43 49 PF00069 0.415
MOD_GlcNHglycan 100 103 PF01048 0.622
MOD_GlcNHglycan 135 138 PF01048 0.610
MOD_GlcNHglycan 159 162 PF01048 0.573
MOD_GlcNHglycan 183 186 PF01048 0.579
MOD_GlcNHglycan 207 210 PF01048 0.633
MOD_GlcNHglycan 416 419 PF01048 0.613
MOD_GlcNHglycan 431 434 PF01048 0.668
MOD_GSK3_1 131 138 PF00069 0.440
MOD_GSK3_1 153 160 PF00069 0.322
MOD_GSK3_1 174 181 PF00069 0.369
MOD_GSK3_1 183 190 PF00069 0.357
MOD_GSK3_1 192 199 PF00069 0.356
MOD_GSK3_1 213 220 PF00069 0.397
MOD_GSK3_1 231 238 PF00069 0.381
MOD_GSK3_1 264 271 PF00069 0.412
MOD_GSK3_1 283 290 PF00069 0.440
MOD_GSK3_1 291 298 PF00069 0.545
MOD_GSK3_1 299 306 PF00069 0.522
MOD_GSK3_1 307 314 PF00069 0.492
MOD_GSK3_1 315 322 PF00069 0.490
MOD_GSK3_1 323 330 PF00069 0.473
MOD_GSK3_1 331 338 PF00069 0.488
MOD_GSK3_1 339 346 PF00069 0.477
MOD_GSK3_1 347 354 PF00069 0.496
MOD_GSK3_1 355 362 PF00069 0.499
MOD_GSK3_1 363 370 PF00069 0.527
MOD_GSK3_1 371 378 PF00069 0.537
MOD_GSK3_1 379 386 PF00069 0.535
MOD_GSK3_1 387 394 PF00069 0.505
MOD_GSK3_1 435 442 PF00069 0.490
MOD_GSK3_1 72 79 PF00069 0.337
MOD_GSK3_1 87 94 PF00069 0.355
MOD_GSK3_1 96 103 PF00069 0.376
MOD_N-GLC_2 254 256 PF02516 0.520
MOD_N-GLC_2 285 287 PF02516 0.619
MOD_NEK2_1 154 159 PF00069 0.312
MOD_NEK2_1 202 207 PF00069 0.390
MOD_NEK2_1 231 236 PF00069 0.425
MOD_NEK2_1 76 81 PF00069 0.327
MOD_NEK2_1 98 103 PF00069 0.354
MOD_NEK2_2 87 92 PF00069 0.298
MOD_OFUCOSY 281 287 PF10250 0.552
MOD_OFUCOSY 84 91 PF10250 0.546
MOD_PIKK_1 202 208 PF00454 0.349
MOD_PK_1 85 91 PF00069 0.313
MOD_PKA_1 246 252 PF00069 0.328
MOD_PKA_1 264 270 PF00069 0.326
MOD_PKA_1 429 435 PF00069 0.427
MOD_PKA_2 229 235 PF00069 0.308
MOD_PKA_2 246 252 PF00069 0.317
MOD_PKA_2 264 270 PF00069 0.326
MOD_PKA_2 429 435 PF00069 0.427
MOD_PKA_2 43 49 PF00069 0.425
MOD_PKA_2 50 56 PF00069 0.351
MOD_Plk_1 116 122 PF00069 0.331
MOD_Plk_2-3 391 397 PF00069 0.444
MOD_Plk_4 171 177 PF00069 0.386
MOD_Plk_4 196 202 PF00069 0.357
MOD_Plk_4 246 252 PF00069 0.331
MOD_Plk_4 92 98 PF00069 0.367
MOD_ProDKin_1 31 37 PF00069 0.419
MOD_ProDKin_1 435 441 PF00069 0.468
TRG_ENDOCYTIC_2 118 121 PF00928 0.432
TRG_ER_diArg_1 245 247 PF00400 0.336
TRG_ER_diArg_1 263 265 PF00400 0.318

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8I9A6 Leishmania donovani 43% 100%
A0A3Q8IFC2 Leishmania donovani 86% 100%
A4HVB0 Leishmania infantum 36% 100%
D1GJ51 Leishmania infantum 32% 99%
E8NHG5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9AGH0 Leishmania infantum 41% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 100%
Q4QGJ6 Leishmania major 35% 80%
Q4QGL4 Leishmania major 38% 100%
Q4QGL5 Leishmania major 32% 84%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS