LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania major
UniProt:
E9AEF1_LEIMA
TriTrypDb:
LmjF.30.0495
Length:
108

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEF1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEF1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 90 94 PF00656 0.540
CLV_NRD_NRD_1 64 66 PF00675 0.737
CLV_NRD_NRD_1 88 90 PF00675 0.723
CLV_PCSK_KEX2_1 22 24 PF00082 0.647
CLV_PCSK_KEX2_1 66 68 PF00082 0.686
CLV_PCSK_KEX2_1 87 89 PF00082 0.688
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.647
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.686
CLV_PCSK_PC7_1 84 90 PF00082 0.676
CLV_PCSK_SKI1_1 13 17 PF00082 0.459
CLV_PCSK_SKI1_1 5 9 PF00082 0.530
DOC_ANK_TNKS_1 88 95 PF00023 0.540
DOC_MAPK_gen_1 3 12 PF00069 0.544
DOC_MAPK_MEF2A_6 101 108 PF00069 0.514
DOC_MAPK_MEF2A_6 5 14 PF00069 0.484
DOC_PP2B_LxvP_1 34 37 PF13499 0.713
LIG_14-3-3_CanoR_1 5 14 PF00244 0.484
LIG_BIR_II_1 1 5 PF00653 0.520
LIG_EVH1_1 34 38 PF00568 0.715
LIG_FHA_1 29 35 PF00498 0.696
LIG_PDZ_Class_2 103 108 PF00595 0.516
LIG_SH2_PTP2 103 106 PF00017 0.591
LIG_SH2_SRC 103 106 PF00017 0.512
LIG_SH2_STAT5 103 106 PF00017 0.591
LIG_SH3_3 32 38 PF00018 0.707
MOD_GlcNHglycan 31 34 PF01048 0.785
MOD_GSK3_1 68 75 PF00069 0.660
MOD_LATS_1 11 17 PF00433 0.486
MOD_NEK2_1 72 77 PF00069 0.667
MOD_PKB_1 3 11 PF00069 0.491
TRG_ENDOCYTIC_2 103 106 PF00928 0.591
TRG_ER_diArg_1 87 89 PF00400 0.719
TRG_NLS_MonoExtC_3 64 69 PF00514 0.687
TRG_Pf-PMV_PEXEL_1 13 17 PF00026 0.498

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X386 Leishmania donovani 88% 100%
E9AHJ7 Leishmania infantum 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS