Leucine rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9AEF0_LEIMA

TriTrypDb:

LmjF.29.2880 , LMJLV39_290037200 , LMJSD75_290037500

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0005929	cilium	4	22
GO:0019005	SCF ubiquitin ligase complex	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	22
GO:0043226	organelle	2	22
GO:0043227	membrane-bounded organelle	3	22
GO:0110165	cellular anatomical entity	1	22
GO:0120025	plasma membrane bounded cell projection	3	22
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2
GO:0016020	membrane	2	2

Expansion

Sequence features

E9AEF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEF0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.494
CLV_C14_Caspase3-7	491	495	PF00656	0.448
CLV_NRD_NRD_1	511	513	PF00675	0.442
CLV_NRD_NRD_1	706	708	PF00675	0.363
CLV_NRD_NRD_1	734	736	PF00675	0.558
CLV_NRD_NRD_1	738	740	PF00675	0.732
CLV_PCSK_FUR_1	704	708	PF00082	0.322
CLV_PCSK_KEX2_1	301	303	PF00082	0.297
CLV_PCSK_KEX2_1	511	513	PF00082	0.443
CLV_PCSK_KEX2_1	706	708	PF00082	0.348
CLV_PCSK_KEX2_1	734	736	PF00082	0.547
CLV_PCSK_KEX2_1	738	740	PF00082	0.728
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.276
CLV_PCSK_PC7_1	734	740	PF00082	0.433
CLV_PCSK_SKI1_1	169	173	PF00082	0.367
CLV_PCSK_SKI1_1	181	185	PF00082	0.298
CLV_PCSK_SKI1_1	27	31	PF00082	0.671
CLV_PCSK_SKI1_1	346	350	PF00082	0.320
CLV_PCSK_SKI1_1	469	473	PF00082	0.325
CLV_PCSK_SKI1_1	511	515	PF00082	0.323
CLV_PCSK_SKI1_1	556	560	PF00082	0.551
CLV_PCSK_SKI1_1	58	62	PF00082	0.586
CLV_PCSK_SKI1_1	616	620	PF00082	0.376
CLV_PCSK_SKI1_1	644	648	PF00082	0.391
CLV_PCSK_SKI1_1	681	685	PF00082	0.363
DEG_MDM2_SWIB_1	729	736	PF02201	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.440
DEG_ODPH_VHL_1	381	392	PF01847	0.259
DEG_ODPH_VHL_1	516	527	PF01847	0.285
DEG_ODPH_VHL_1	606	617	PF01847	0.341
DOC_CDC14_PxL_1	270	278	PF14671	0.387
DOC_CDC14_PxL_1	384	392	PF14671	0.299
DOC_CDC14_PxL_1	519	527	PF14671	0.303
DOC_CDC14_PxL_1	654	662	PF14671	0.422
DOC_CDC14_PxL_1	699	707	PF14671	0.444
DOC_CKS1_1	9	14	PF01111	0.398
DOC_CYCLIN_RxL_1	495	504	PF00134	0.307
DOC_CYCLIN_RxL_1	54	65	PF00134	0.365
DOC_CYCLIN_yClb5_NLxxxL_5	448	457	PF00134	0.271
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.465
DOC_MAPK_gen_1	180	186	PF00069	0.445
DOC_MAPK_gen_1	588	597	PF00069	0.449
DOC_MAPK_gen_1	678	687	PF00069	0.510
DOC_MAPK_MEF2A_6	207	215	PF00069	0.524
DOC_MAPK_MEF2A_6	320	327	PF00069	0.416
DOC_MAPK_MEF2A_6	678	687	PF00069	0.423
DOC_PP1_RVXF_1	679	685	PF00149	0.407
DOC_PP1_RVXF_1	724	730	PF00149	0.399
DOC_PP2B_LxvP_1	198	201	PF13499	0.353
DOC_PP4_FxxP_1	9	12	PF00568	0.394
DOC_USP7_MATH_1	111	115	PF00917	0.620
DOC_USP7_MATH_1	202	206	PF00917	0.410
DOC_USP7_MATH_1	441	445	PF00917	0.330
DOC_USP7_MATH_1	620	624	PF00917	0.436
DOC_USP7_MATH_1	710	714	PF00917	0.357
DOC_USP7_MATH_1	79	83	PF00917	0.461
DOC_WW_Pin1_4	124	129	PF00397	0.500
DOC_WW_Pin1_4	246	251	PF00397	0.611
DOC_WW_Pin1_4	609	614	PF00397	0.537
DOC_WW_Pin1_4	771	776	PF00397	0.594
DOC_WW_Pin1_4	8	13	PF00397	0.405
LIG_14-3-3_CanoR_1	118	124	PF00244	0.546
LIG_14-3-3_CanoR_1	131	138	PF00244	0.314
LIG_14-3-3_CanoR_1	154	160	PF00244	0.389
LIG_14-3-3_CanoR_1	189	198	PF00244	0.420
LIG_14-3-3_CanoR_1	253	258	PF00244	0.373
LIG_14-3-3_CanoR_1	302	306	PF00244	0.327
LIG_14-3-3_CanoR_1	341	348	PF00244	0.443
LIG_14-3-3_CanoR_1	371	378	PF00244	0.449
LIG_14-3-3_CanoR_1	391	400	PF00244	0.459
LIG_14-3-3_CanoR_1	469	478	PF00244	0.491
LIG_14-3-3_CanoR_1	511	517	PF00244	0.478
LIG_14-3-3_CanoR_1	601	607	PF00244	0.303
LIG_14-3-3_CanoR_1	62	69	PF00244	0.367
LIG_14-3-3_CanoR_1	691	697	PF00244	0.565
LIG_Actin_WH2_2	165	182	PF00022	0.364
LIG_Actin_WH2_2	467	483	PF00022	0.290
LIG_Actin_WH2_2	555	573	PF00022	0.422
LIG_BRCT_BRCA1_1	368	372	PF00533	0.256
LIG_BRCT_BRCA1_1	413	417	PF00533	0.423
LIG_BRCT_BRCA1_1	593	597	PF00533	0.237
LIG_BRCT_BRCA1_1	93	97	PF00533	0.552
LIG_Clathr_ClatBox_1	682	686	PF01394	0.387
LIG_FHA_1	145	151	PF00498	0.602
LIG_FHA_1	234	240	PF00498	0.396
LIG_FHA_1	249	255	PF00498	0.398
LIG_FHA_1	264	270	PF00498	0.492
LIG_FHA_1	42	48	PF00498	0.514
LIG_FHA_1	488	494	PF00498	0.288
LIG_FHA_1	557	563	PF00498	0.313
LIG_FHA_1	71	77	PF00498	0.335
LIG_FHA_2	371	377	PF00498	0.426
LIG_FHA_2	772	778	PF00498	0.659
LIG_IBAR_NPY_1	222	224	PF08397	0.472
LIG_IRF3_LxIS_1	718	724	PF10401	0.370
LIG_LIR_Gen_1	192	202	PF02991	0.352
LIG_LIR_Gen_1	459	468	PF02991	0.420
LIG_LIR_Nem_3	104	108	PF02991	0.459
LIG_LIR_Nem_3	135	141	PF02991	0.567
LIG_LIR_Nem_3	158	164	PF02991	0.355
LIG_LIR_Nem_3	192	198	PF02991	0.514
LIG_LIR_Nem_3	217	221	PF02991	0.616
LIG_LIR_Nem_3	459	465	PF02991	0.457
LIG_LIR_Nem_3	574	580	PF02991	0.385
LIG_LIR_Nem_3	730	736	PF02991	0.420
LIG_LIR_Nem_3	94	100	PF02991	0.495
LIG_MAD2	526	534	PF02301	0.271
LIG_NRBOX	193	199	PF00104	0.302
LIG_NRBOX	56	62	PF00104	0.359
LIG_PCNA_APIM_2	25	31	PF02747	0.373
LIG_Pex14_2	174	178	PF04695	0.491
LIG_Pex14_2	729	733	PF04695	0.397
LIG_SH2_CRK	105	109	PF00017	0.398
LIG_SH2_CRK	161	165	PF00017	0.403
LIG_SH2_CRK	195	199	PF00017	0.337
LIG_SH2_STAP1	133	137	PF00017	0.308
LIG_SH2_STAP1	195	199	PF00017	0.337
LIG_SH2_STAP1	39	43	PF00017	0.414
LIG_SH2_STAT3	224	227	PF00017	0.475
LIG_SH2_STAT5	16	19	PF00017	0.563
LIG_SH2_STAT5	173	176	PF00017	0.597
LIG_SH2_STAT5	195	198	PF00017	0.486
LIG_SH2_STAT5	329	332	PF00017	0.450
LIG_SH2_STAT5	347	350	PF00017	0.393
LIG_SH2_STAT5	731	734	PF00017	0.660
LIG_SH3_3	761	767	PF00018	0.526
LIG_SUMO_SIM_anti_2	324	329	PF11976	0.256
LIG_SUMO_SIM_par_1	10	17	PF11976	0.390
LIG_SUMO_SIM_par_1	146	151	PF11976	0.423
LIG_SUMO_SIM_par_1	321	326	PF11976	0.330
LIG_TRFH_1	219	223	PF08558	0.476
LIG_TRFH_1	224	228	PF08558	0.461
LIG_TYR_ITIM	159	164	PF00017	0.365
LIG_TYR_ITIM	345	350	PF00017	0.410
LIG_WRC_WIRS_1	15	20	PF05994	0.395
MOD_CDK_SPK_2	609	614	PF00069	0.295
MOD_CDK_SPxxK_3	124	131	PF00069	0.539
MOD_CDK_SPxxK_3	246	253	PF00069	0.329
MOD_CDK_SPxxK_3	609	616	PF00069	0.293
MOD_CDK_SPxxK_3	771	778	PF00069	0.519
MOD_CK1_1	14	20	PF00069	0.393
MOD_CK1_1	144	150	PF00069	0.416
MOD_CK1_1	263	269	PF00069	0.554
MOD_CK1_1	37	43	PF00069	0.378
MOD_CK2_1	203	209	PF00069	0.496
MOD_CK2_1	350	356	PF00069	0.529
MOD_CK2_1	370	376	PF00069	0.346
MOD_CK2_1	440	446	PF00069	0.448
MOD_CK2_1	485	491	PF00069	0.356
MOD_CK2_1	587	593	PF00069	0.458
MOD_CK2_1	62	68	PF00069	0.389
MOD_GlcNHglycan	115	118	PF01048	0.571
MOD_GlcNHglycan	128	131	PF01048	0.489
MOD_GlcNHglycan	149	153	PF01048	0.471
MOD_GlcNHglycan	181	184	PF01048	0.549
MOD_GlcNHglycan	191	194	PF01048	0.345
MOD_GlcNHglycan	393	396	PF01048	0.447
MOD_GlcNHglycan	429	432	PF01048	0.439
MOD_GlcNHglycan	474	477	PF01048	0.470
MOD_GlcNHglycan	487	490	PF01048	0.276
MOD_GlcNHglycan	609	612	PF01048	0.383
MOD_GlcNHglycan	622	625	PF01048	0.356
MOD_GlcNHglycan	667	670	PF01048	0.436
MOD_GlcNHglycan	673	676	PF01048	0.411
MOD_GlcNHglycan	699	702	PF01048	0.488
MOD_GlcNHglycan	712	715	PF01048	0.514
MOD_GlcNHglycan	722	726	PF01048	0.375
MOD_GlcNHglycan	91	94	PF01048	0.452
MOD_GSK3_1	113	120	PF00069	0.506
MOD_GSK3_1	144	151	PF00069	0.499
MOD_GSK3_1	17	24	PF00069	0.376
MOD_GSK3_1	189	196	PF00069	0.383
MOD_GSK3_1	242	249	PF00069	0.560
MOD_GSK3_1	346	353	PF00069	0.350
MOD_GSK3_1	366	373	PF00069	0.450
MOD_GSK3_1	37	44	PF00069	0.374
MOD_GSK3_1	411	418	PF00069	0.395
MOD_GSK3_1	456	463	PF00069	0.460
MOD_GSK3_1	485	492	PF00069	0.515
MOD_GSK3_1	501	508	PF00069	0.342
MOD_GSK3_1	575	582	PF00069	0.388
MOD_GSK3_1	587	594	PF00069	0.518
MOD_GSK3_1	7	14	PF00069	0.540
MOD_GSK3_1	79	86	PF00069	0.403
MOD_N-GLC_1	263	268	PF02516	0.470
MOD_N-GLC_1	460	465	PF02516	0.378
MOD_N-GLC_1	505	510	PF02516	0.392
MOD_N-GLC_1	671	676	PF02516	0.458
MOD_N-GLC_1	710	715	PF02516	0.510
MOD_N-GLC_2	4	6	PF02516	0.406
MOD_N-GLC_2	452	454	PF02516	0.283
MOD_N-GLC_2	497	499	PF02516	0.546
MOD_N-GLC_2	632	634	PF02516	0.501
MOD_N-GLC_2	664	666	PF02516	0.272
MOD_N-GLC_2	677	679	PF02516	0.272
MOD_NEK2_1	148	153	PF00069	0.407
MOD_NEK2_1	172	177	PF00069	0.614
MOD_NEK2_1	179	184	PF00069	0.610
MOD_NEK2_1	348	353	PF00069	0.460
MOD_NEK2_1	393	398	PF00069	0.434
MOD_NEK2_1	429	434	PF00069	0.388
MOD_NEK2_1	507	512	PF00069	0.441
MOD_NEK2_1	640	645	PF00069	0.366
MOD_NEK2_1	7	12	PF00069	0.416
MOD_NEK2_1	721	726	PF00069	0.531
MOD_PIKK_1	340	346	PF00454	0.474
MOD_PK_1	591	597	PF00069	0.236
MOD_PK_1	659	665	PF00069	0.287
MOD_PKA_1	301	307	PF00069	0.579
MOD_PKA_1	511	517	PF00069	0.435
MOD_PKA_1	734	740	PF00069	0.552
MOD_PKA_2	117	123	PF00069	0.490
MOD_PKA_2	233	239	PF00069	0.395
MOD_PKA_2	301	307	PF00069	0.399
MOD_PKA_2	340	346	PF00069	0.280
MOD_PKA_2	370	376	PF00069	0.375
MOD_PKA_2	511	517	PF00069	0.429
MOD_PKA_2	587	593	PF00069	0.352
MOD_PKA_2	734	740	PF00069	0.636
MOD_PKA_2	89	95	PF00069	0.454
MOD_PKB_1	389	397	PF00069	0.270
MOD_Plk_1	21	27	PF00069	0.355
MOD_Plk_1	263	269	PF00069	0.524
MOD_Plk_1	277	283	PF00069	0.598
MOD_Plk_1	323	329	PF00069	0.386
MOD_Plk_1	556	562	PF00069	0.372
MOD_Plk_1	573	579	PF00069	0.500
MOD_Plk_1	710	716	PF00069	0.594
MOD_Plk_2-3	287	293	PF00069	0.343
MOD_Plk_4	11	17	PF00069	0.415
MOD_Plk_4	173	179	PF00069	0.504
MOD_Plk_4	193	199	PF00069	0.461
MOD_Plk_4	301	307	PF00069	0.447
MOD_Plk_4	323	329	PF00069	0.377
MOD_Plk_4	557	563	PF00069	0.442
MOD_Plk_4	79	85	PF00069	0.355
MOD_ProDKin_1	124	130	PF00069	0.494
MOD_ProDKin_1	246	252	PF00069	0.606
MOD_ProDKin_1	609	615	PF00069	0.532
MOD_ProDKin_1	771	777	PF00069	0.596
MOD_ProDKin_1	8	14	PF00069	0.403
MOD_SUMO_rev_2	20	25	PF00179	0.360
MOD_SUMO_rev_2	458	468	PF00179	0.287
TRG_DiLeu_BaEn_1	3	8	PF01217	0.415
TRG_DiLeu_BaEn_1	557	562	PF01217	0.450
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.250
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.387
TRG_ENDOCYTIC_2	105	108	PF00928	0.414
TRG_ENDOCYTIC_2	133	136	PF00928	0.436
TRG_ENDOCYTIC_2	161	164	PF00928	0.407
TRG_ENDOCYTIC_2	195	198	PF00928	0.559
TRG_ENDOCYTIC_2	218	221	PF00928	0.635
TRG_ENDOCYTIC_2	347	350	PF00928	0.384
TRG_ER_diArg_1	252	255	PF00400	0.316
TRG_ER_diArg_1	388	391	PF00400	0.287
TRG_ER_diArg_1	478	481	PF00400	0.447
TRG_ER_diArg_1	511	513	PF00400	0.463
TRG_ER_diArg_1	523	526	PF00400	0.469
TRG_ER_diArg_1	613	616	PF00400	0.307
TRG_ER_diArg_1	658	661	PF00400	0.269
TRG_ER_diArg_1	703	706	PF00400	0.442
TRG_ER_diArg_1	733	735	PF00400	0.551
TRG_ER_diArg_1	738	741	PF00400	0.574
TRG_NES_CRM1_1	356	368	PF08389	0.285
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	498	503	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F9	Leptomonas seymouri	34%	100%
A0A0N0P8N9	Leptomonas seymouri	33%	100%
A0A3Q8IAE2	Leishmania donovani	26%	100%
A0A3S5H5M6	Leishmania donovani	26%	100%
A0A3S7X2V4	Leishmania donovani	87%	100%
A0A451EJK8	Leishmania donovani	25%	73%
A4H3H4	Leishmania braziliensis	24%	80%
A4H3R1	Leishmania braziliensis	69%	100%
A4H4H0	Leishmania braziliensis	24%	100%
A4HSP5	Leishmania infantum	26%	100%
C9ZK22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	95%
D0A4F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	92%
E9ACE9	Leishmania major	26%	78%
E9AG21	Leishmania infantum	25%	77%
E9AGT5	Leishmania infantum	28%	100%
E9AHJ6	Leishmania infantum	87%	100%
E9AIU4	Leishmania braziliensis	24%	100%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QJ77	Leishmania major	26%	100%
V5BXQ3	Trypanosoma cruzi	23%	84%