AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEE9_LEIMA

TriTrypDb:

LmjF.29.2870 , LMJLV39_290037000 , LMJSD75_290037300

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.635
CLV_MEL_PAP_1	193	199	PF00089	0.562
CLV_NRD_NRD_1	122	124	PF00675	0.460
CLV_NRD_NRD_1	150	152	PF00675	0.538
CLV_NRD_NRD_1	195	197	PF00675	0.544
CLV_PCSK_KEX2_1	122	124	PF00082	0.435
CLV_PCSK_KEX2_1	150	152	PF00082	0.410
CLV_PCSK_KEX2_1	195	197	PF00082	0.544
CLV_PCSK_KEX2_1	241	243	PF00082	0.504
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.542
CLV_PCSK_SKI1_1	224	228	PF00082	0.644
CLV_PCSK_SKI1_1	357	361	PF00082	0.469
CLV_PCSK_SKI1_1	5	9	PF00082	0.541
DEG_APCC_DBOX_1	149	157	PF00400	0.397
DOC_ANK_TNKS_1	8	15	PF00023	0.454
DOC_CYCLIN_RxL_1	2	11	PF00134	0.664
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.521
DOC_PP1_RVXF_1	97	104	PF00149	0.425
DOC_PP2B_LxvP_1	278	281	PF13499	0.355
DOC_PP2B_PxIxI_1	95	101	PF00149	0.442
DOC_PP4_FxxP_1	37	40	PF00568	0.600
DOC_USP7_MATH_1	161	165	PF00917	0.543
DOC_USP7_MATH_1	19	23	PF00917	0.641
DOC_USP7_MATH_1	220	224	PF00917	0.636
DOC_USP7_MATH_1	250	254	PF00917	0.468
DOC_USP7_MATH_1	31	35	PF00917	0.586
DOC_USP7_MATH_1	367	371	PF00917	0.425
DOC_USP7_MATH_1	47	51	PF00917	0.535
DOC_USP7_MATH_1	88	92	PF00917	0.508
DOC_WW_Pin1_4	329	334	PF00397	0.608
DOC_WW_Pin1_4	92	97	PF00397	0.501
LIG_14-3-3_CanoR_1	208	212	PF00244	0.433
LIG_14-3-3_CanoR_1	291	299	PF00244	0.502
LIG_14-3-3_CanoR_1	9	16	PF00244	0.634
LIG_Actin_WH2_2	109	124	PF00022	0.544
LIG_BRCT_BRCA1_1	33	37	PF00533	0.622
LIG_FHA_1	184	190	PF00498	0.502
LIG_FHA_1	241	247	PF00498	0.332
LIG_FHA_1	309	315	PF00498	0.400
LIG_FHA_1	333	339	PF00498	0.420
LIG_FHA_1	71	77	PF00498	0.574
LIG_FHA_2	109	115	PF00498	0.505
LIG_FHA_2	128	134	PF00498	0.376
LIG_FHA_2	140	146	PF00498	0.529
LIG_FHA_2	377	383	PF00498	0.414
LIG_LIR_Apic_2	34	40	PF02991	0.613
LIG_LIR_Gen_1	111	121	PF02991	0.454
LIG_LIR_Gen_1	126	135	PF02991	0.311
LIG_LIR_Gen_1	230	237	PF02991	0.510
LIG_LIR_Gen_1	271	282	PF02991	0.398
LIG_LIR_Nem_3	111	116	PF02991	0.452
LIG_LIR_Nem_3	126	132	PF02991	0.297
LIG_LIR_Nem_3	230	236	PF02991	0.480
LIG_LIR_Nem_3	271	277	PF02991	0.398
LIG_MYND_1	348	352	PF01753	0.617
LIG_PDZ_Class_3	380	385	PF00595	0.594
LIG_Pex14_1	125	129	PF04695	0.400
LIG_Rb_pABgroove_1	300	308	PF01858	0.297
LIG_SH2_CRK	233	237	PF00017	0.404
LIG_SH2_CRK	368	372	PF00017	0.480
LIG_SH2_GRB2like	129	132	PF00017	0.463
LIG_SH2_STAP1	211	215	PF00017	0.468
LIG_SH2_STAP1	233	237	PF00017	0.392
LIG_SH2_STAP1	25	29	PF00017	0.687
LIG_SH2_STAT5	129	132	PF00017	0.472
LIG_SH2_STAT5	213	216	PF00017	0.369
LIG_SH3_2	105	110	PF14604	0.305
LIG_SH3_3	102	108	PF00018	0.371
LIG_SH3_3	186	192	PF00018	0.477
LIG_SH3_3	327	333	PF00018	0.573
LIG_SH3_3	342	348	PF00018	0.433
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.381
LIG_SUMO_SIM_par_1	334	341	PF11976	0.401
LIG_UBA3_1	305	312	PF00899	0.302
LIG_UBA3_1	359	366	PF00899	0.516
MOD_CDK_SPxxK_3	92	99	PF00069	0.545
MOD_CK1_1	240	246	PF00069	0.474
MOD_CK1_1	298	304	PF00069	0.487
MOD_CK1_1	332	338	PF00069	0.547
MOD_CK1_1	361	367	PF00069	0.503
MOD_CK2_1	108	114	PF00069	0.547
MOD_CK2_1	127	133	PF00069	0.277
MOD_CK2_1	139	145	PF00069	0.451
MOD_CK2_1	32	38	PF00069	0.686
MOD_CK2_1	376	382	PF00069	0.433
MOD_CK2_1	87	93	PF00069	0.543
MOD_GlcNHglycan	135	138	PF01048	0.559
MOD_GlcNHglycan	163	166	PF01048	0.570
MOD_GlcNHglycan	17	20	PF01048	0.569
MOD_GlcNHglycan	21	24	PF01048	0.581
MOD_GlcNHglycan	217	220	PF01048	0.543
MOD_GlcNHglycan	237	240	PF01048	0.347
MOD_GlcNHglycan	340	343	PF01048	0.395
MOD_GlcNHglycan	90	93	PF01048	0.528
MOD_GSK3_1	15	22	PF00069	0.622
MOD_GSK3_1	220	227	PF00069	0.605
MOD_GSK3_1	246	253	PF00069	0.418
MOD_GSK3_1	328	335	PF00069	0.575
MOD_GSK3_1	355	362	PF00069	0.496
MOD_GSK3_1	377	384	PF00069	0.659
MOD_GSK3_1	88	95	PF00069	0.514
MOD_N-GLC_1	117	122	PF02516	0.523
MOD_N-GLC_1	127	132	PF02516	0.448
MOD_NEK2_1	215	220	PF00069	0.562
MOD_NEK2_1	306	311	PF00069	0.335
MOD_NEK2_1	32	37	PF00069	0.712
MOD_NEK2_1	326	331	PF00069	0.500
MOD_NEK2_1	337	342	PF00069	0.462
MOD_NEK2_1	8	13	PF00069	0.642
MOD_NEK2_2	108	113	PF00069	0.488
MOD_NEK2_2	47	52	PF00069	0.562
MOD_PIKK_1	318	324	PF00454	0.498
MOD_PKA_2	207	213	PF00069	0.362
MOD_PKA_2	290	296	PF00069	0.487
MOD_PKA_2	8	14	PF00069	0.665
MOD_Plk_1	117	123	PF00069	0.487
MOD_Plk_4	108	114	PF00069	0.544
MOD_Plk_4	166	172	PF00069	0.550
MOD_Plk_4	301	307	PF00069	0.386
MOD_Plk_4	32	38	PF00069	0.704
MOD_Plk_4	332	338	PF00069	0.398
MOD_Plk_4	355	361	PF00069	0.453
MOD_Plk_4	367	373	PF00069	0.413
MOD_ProDKin_1	329	335	PF00069	0.596
MOD_ProDKin_1	92	98	PF00069	0.498
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.479
TRG_ENDOCYTIC_2	113	116	PF00928	0.466
TRG_ENDOCYTIC_2	129	132	PF00928	0.281
TRG_ENDOCYTIC_2	206	209	PF00928	0.393
TRG_ENDOCYTIC_2	233	236	PF00928	0.403
TRG_ENDOCYTIC_2	368	371	PF00928	0.431
TRG_ER_diArg_1	121	123	PF00400	0.462
TRG_ER_diArg_1	149	151	PF00400	0.505
TRG_ER_diArg_1	194	196	PF00400	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG75	Leptomonas seymouri	52%	100%
A0A0S4J6P5	Bodo saltans	25%	90%
A0A1X0PAK7	Trypanosomatidae	38%	100%
A0A3S5H7M1	Leishmania donovani	88%	100%
A0A422NJ09	Trypanosoma rangeli	36%	100%
A4H3R2	Leishmania braziliensis	70%	100%
A4I4Y1	Leishmania infantum	88%	100%
C9ZLM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ALD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5B889	Trypanosoma cruzi	39%	93%