Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEE6_LEIMA

TriTrypDb:

LmjF.29.2840 , LMJLV39_290036700 , LMJSD75_290037000

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AEE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	225	227	PF00675	0.425
CLV_NRD_NRD_1	86	88	PF00675	0.557
CLV_PCSK_KEX2_1	225	227	PF00082	0.445
CLV_PCSK_KEX2_1	86	88	PF00082	0.588
CLV_PCSK_SKI1_1	150	154	PF00082	0.450
CLV_PCSK_SKI1_1	225	229	PF00082	0.378
CLV_PCSK_SKI1_1	36	40	PF00082	0.658
CLV_PCSK_SKI1_1	58	62	PF00082	0.686
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.317
DOC_CYCLIN_yCln2_LP_2	60	66	PF00134	0.653
DOC_MAPK_MEF2A_6	198	207	PF00069	0.383
DOC_MAPK_MEF2A_6	93	102	PF00069	0.455
DOC_PP1_RVXF_1	233	239	PF00149	0.311
DOC_PP2B_LxvP_1	64	67	PF13499	0.545
DOC_USP7_MATH_1	154	158	PF00917	0.435
DOC_USP7_MATH_1	300	304	PF00917	0.511
DOC_USP7_MATH_1	71	75	PF00917	0.460
DOC_WW_Pin1_4	133	138	PF00397	0.378
DOC_WW_Pin1_4	215	220	PF00397	0.454
DOC_WW_Pin1_4	59	64	PF00397	0.691
LIG_14-3-3_CanoR_1	131	137	PF00244	0.464
LIG_14-3-3_CanoR_1	29	37	PF00244	0.454
LIG_APCC_ABBA_1	98	103	PF00400	0.628
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_BIR_III_4	274	278	PF00653	0.336
LIG_BRCT_BRCA1_1	257	261	PF00533	0.487
LIG_deltaCOP1_diTrp_1	233	238	PF00928	0.288
LIG_eIF4E_1	202	208	PF01652	0.318
LIG_FHA_1	287	293	PF00498	0.434
LIG_FHA_1	32	38	PF00498	0.542
LIG_FHA_2	114	120	PF00498	0.427
LIG_FHA_2	250	256	PF00498	0.258
LIG_FHA_2	304	310	PF00498	0.385
LIG_LIR_Apic_2	133	137	PF02991	0.392
LIG_LIR_Apic_2	170	175	PF02991	0.504
LIG_LIR_Gen_1	188	199	PF02991	0.444
LIG_LIR_Gen_1	212	220	PF02991	0.418
LIG_LIR_Gen_1	243	253	PF02991	0.333
LIG_LIR_Gen_1	258	268	PF02991	0.287
LIG_LIR_Gen_1	271	281	PF02991	0.343
LIG_LIR_Nem_3	188	194	PF02991	0.496
LIG_LIR_Nem_3	212	216	PF02991	0.394
LIG_LIR_Nem_3	243	249	PF02991	0.279
LIG_LIR_Nem_3	258	264	PF02991	0.257
LIG_LIR_Nem_3	271	276	PF02991	0.291
LIG_PCNA_PIPBox_1	142	151	PF02747	0.417
LIG_PDZ_Class_3	306	311	PF00595	0.418
LIG_Pex14_2	213	217	PF04695	0.413
LIG_PTB_Apo_2	275	282	PF02174	0.380
LIG_SH2_CRK	134	138	PF00017	0.453
LIG_SH2_CRK	191	195	PF00017	0.336
LIG_SH2_CRK	301	305	PF00017	0.330
LIG_SH2_GRB2like	172	175	PF00017	0.418
LIG_SH2_GRB2like	191	194	PF00017	0.184
LIG_SH2_NCK_1	134	138	PF00017	0.365
LIG_SH2_NCK_1	172	176	PF00017	0.421
LIG_SH2_SRC	172	175	PF00017	0.418
LIG_SH2_STAP1	295	299	PF00017	0.413
LIG_SH2_STAP1	301	305	PF00017	0.471
LIG_SH2_STAT5	134	137	PF00017	0.453
LIG_SH2_STAT5	202	205	PF00017	0.329
LIG_SH3_3	213	219	PF00018	0.354
LIG_SUMO_SIM_par_1	288	296	PF11976	0.349
MOD_CK1_1	133	139	PF00069	0.564
MOD_CK1_1	182	188	PF00069	0.481
MOD_CK1_1	206	212	PF00069	0.463
MOD_CK1_1	303	309	PF00069	0.629
MOD_CK2_1	113	119	PF00069	0.384
MOD_CK2_1	71	77	PF00069	0.527
MOD_Cter_Amidation	84	87	PF01082	0.578
MOD_DYRK1A_RPxSP_1	215	219	PF00069	0.353
MOD_GlcNHglycan	110	113	PF01048	0.451
MOD_GlcNHglycan	164	167	PF01048	0.393
MOD_GlcNHglycan	242	245	PF01048	0.333
MOD_GlcNHglycan	306	309	PF01048	0.481
MOD_GlcNHglycan	40	43	PF01048	0.505
MOD_GSK3_1	102	109	PF00069	0.443
MOD_GSK3_1	126	133	PF00069	0.523
MOD_GSK3_1	245	252	PF00069	0.274
MOD_GSK3_1	300	307	PF00069	0.518
MOD_NEK2_1	1	6	PF00069	0.643
MOD_NEK2_1	108	113	PF00069	0.426
MOD_NEK2_1	138	143	PF00069	0.396
MOD_NEK2_1	203	208	PF00069	0.441
MOD_NEK2_1	25	30	PF00069	0.475
MOD_NEK2_1	286	291	PF00069	0.347
MOD_NEK2_1	37	42	PF00069	0.545
MOD_NEK2_1	69	74	PF00069	0.565
MOD_PIKK_1	138	144	PF00454	0.386
MOD_PKA_2	130	136	PF00069	0.464
MOD_PKA_2	28	34	PF00069	0.538
MOD_PKA_2	49	55	PF00069	0.591
MOD_PKB_1	87	95	PF00069	0.510
MOD_Plk_1	31	37	PF00069	0.494
MOD_Plk_4	203	209	PF00069	0.456
MOD_Plk_4	245	251	PF00069	0.295
MOD_Plk_4	300	306	PF00069	0.459
MOD_ProDKin_1	133	139	PF00069	0.373
MOD_ProDKin_1	215	221	PF00069	0.448
MOD_ProDKin_1	59	65	PF00069	0.690
MOD_SUMO_rev_2	92	100	PF00179	0.389
TRG_DiLeu_BaEn_4	120	126	PF01217	0.481
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.434
TRG_ENDOCYTIC_2	191	194	PF00928	0.365
TRG_ENDOCYTIC_2	202	205	PF00928	0.440
TRG_ENDOCYTIC_2	301	304	PF00928	0.333
TRG_ER_diArg_1	234	237	PF00400	0.389
TRG_ER_diArg_1	86	89	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z2	Leptomonas seymouri	45%	100%
A0A1X0P8Z8	Trypanosomatidae	28%	91%
A0A3Q8IBQ4	Leishmania donovani	84%	99%
A4H3R5	Leishmania braziliensis	63%	100%
A4I4Y4	Leishmania infantum	84%	99%
C9ZKJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%
E9ALE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BSV9	Trypanosoma cruzi	36%	100%