RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

E9AEE5_LEIMA

TriTrypDb:

LmjF.29.2830 , LMJLV39_290036600 , LMJSD75_290036900

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEE5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	132	138	PF00089	0.335
CLV_NRD_NRD_1	111	113	PF00675	0.522
CLV_PCSK_KEX2_1	182	184	PF00082	0.359
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.359
CLV_PCSK_SKI1_1	143	147	PF00082	0.393
CLV_PCSK_SKI1_1	182	186	PF00082	0.322
DEG_Nend_Nbox_1	1	3	PF02207	0.712
DOC_MAPK_FxFP_2	161	164	PF00069	0.593
DOC_MAPK_gen_1	110	117	PF00069	0.390
DOC_MAPK_gen_1	95	104	PF00069	0.763
DOC_PP1_RVXF_1	141	147	PF00149	0.593
DOC_PP4_FxxP_1	161	164	PF00568	0.553
DOC_USP7_MATH_1	103	107	PF00917	0.644
DOC_USP7_MATH_1	26	30	PF00917	0.717
DOC_USP7_MATH_1	60	64	PF00917	0.687
DOC_WW_Pin1_4	28	33	PF00397	0.776
DOC_WW_Pin1_4	85	90	PF00397	0.762
LIG_14-3-3_CanoR_1	148	153	PF00244	0.593
LIG_14-3-3_CanoR_1	95	105	PF00244	0.720
LIG_FHA_1	188	194	PF00498	0.561
LIG_FHA_1	97	103	PF00498	0.705
LIG_FHA_2	123	129	PF00498	0.552
LIG_FHA_2	72	78	PF00498	0.790
LIG_LIR_Gen_1	131	139	PF02991	0.535
LIG_LIR_Nem_3	131	136	PF02991	0.535
LIG_MYND_1	52	56	PF01753	0.794
LIG_SH2_CRK	156	160	PF00017	0.535
LIG_SH2_STAT3	111	114	PF00017	0.507
LIG_SH2_STAT3	119	122	PF00017	0.535
LIG_SH2_STAT3	30	33	PF00017	0.682
LIG_SH2_STAT3	47	50	PF00017	0.669
LIG_SH2_STAT5	119	122	PF00017	0.517
LIG_SH2_STAT5	160	163	PF00017	0.530
LIG_SH2_STAT5	2	5	PF00017	0.795
LIG_SH2_STAT5	30	33	PF00017	0.709
LIG_SH2_STAT5	67	70	PF00017	0.795
LIG_SH3_3	35	41	PF00018	0.694
LIG_SH3_3	65	71	PF00018	0.698
LIG_SH3_3	99	105	PF00018	0.671
MOD_CK1_1	17	23	PF00069	0.722
MOD_CK1_1	197	203	PF00069	0.637
MOD_CK1_1	25	31	PF00069	0.489
MOD_CK2_1	103	109	PF00069	0.708
MOD_CK2_1	71	77	PF00069	0.737
MOD_Cter_Amidation	180	183	PF01082	0.359
MOD_GlcNHglycan	125	128	PF01048	0.359
MOD_GlcNHglycan	165	168	PF01048	0.362
MOD_GlcNHglycan	197	200	PF01048	0.721
MOD_GlcNHglycan	24	27	PF01048	0.735
MOD_GSK3_1	194	201	PF00069	0.653
MOD_GSK3_1	22	29	PF00069	0.699
MOD_GSK3_1	3	10	PF00069	0.732
MOD_GSK3_1	80	87	PF00069	0.736
MOD_N-GLC_1	17	22	PF02516	0.634
MOD_N-GLC_1	6	11	PF02516	0.717
MOD_N-GLC_1	84	89	PF02516	0.797
MOD_N-GLC_1	96	101	PF02516	0.811
MOD_NEK2_1	84	89	PF00069	0.728
MOD_PIKK_1	17	23	PF00454	0.611
MOD_PIKK_1	58	64	PF00454	0.781
MOD_PIKK_1	7	13	PF00454	0.684
MOD_PIKK_1	96	102	PF00454	0.710
MOD_PKA_2	147	153	PF00069	0.559
MOD_Plk_1	96	102	PF00069	0.808
MOD_Plk_4	128	134	PF00069	0.593
MOD_Plk_4	71	77	PF00069	0.763
MOD_ProDKin_1	28	34	PF00069	0.776
MOD_ProDKin_1	85	91	PF00069	0.761
TRG_ENDOCYTIC_2	156	159	PF00928	0.535
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K2	Leptomonas seymouri	80%	100%
A0A1X0P9U2	Trypanosomatidae	62%	95%
A0A3Q8IRM8	Leishmania donovani	100%	100%
A4HHU0	Leishmania braziliensis	93%	100%
A4I4Y5	Leishmania infantum	100%	100%
C9ZKJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	87%
E9ALE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%