Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEE4_LEIMA

TriTrypDb:

LmjF.29.2820 , LMJLV39_290036500 , LMJSD75_290036800

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AEE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.558
CLV_C14_Caspase3-7	77	81	PF00656	0.401
CLV_C14_Caspase3-7	91	95	PF00656	0.447
CLV_NRD_NRD_1	234	236	PF00675	0.412
CLV_NRD_NRD_1	41	43	PF00675	0.467
CLV_PCSK_KEX2_1	234	236	PF00082	0.412
CLV_PCSK_KEX2_1	41	43	PF00082	0.467
CLV_PCSK_SKI1_1	179	183	PF00082	0.456
CLV_PCSK_SKI1_1	235	239	PF00082	0.447
CLV_PCSK_SKI1_1	41	45	PF00082	0.399
DEG_APCC_DBOX_1	128	136	PF00400	0.495
DEG_APCC_DBOX_1	234	242	PF00400	0.411
DOC_CYCLIN_RxL_1	38	46	PF00134	0.412
DOC_MAPK_DCC_7	153	161	PF00069	0.256
DOC_MAPK_gen_1	129	137	PF00069	0.533
DOC_MAPK_gen_1	234	240	PF00069	0.534
DOC_MAPK_MEF2A_6	153	161	PF00069	0.290
DOC_PP1_RVXF_1	131	138	PF00149	0.470
DOC_PP4_FxxP_1	50	53	PF00568	0.530
DOC_USP7_MATH_1	32	36	PF00917	0.523
DOC_WW_Pin1_4	89	94	PF00397	0.382
LIG_14-3-3_CanoR_1	42	48	PF00244	0.411
LIG_BRCT_BRCA1_1	144	148	PF00533	0.468
LIG_BRCT_BRCA1_1	164	168	PF00533	0.167
LIG_Clathr_ClatBox_1	204	208	PF01394	0.339
LIG_deltaCOP1_diTrp_1	80	87	PF00928	0.382
LIG_FHA_1	173	179	PF00498	0.571
LIG_FHA_1	180	186	PF00498	0.428
LIG_FHA_1	19	25	PF00498	0.709
LIG_FHA_2	197	203	PF00498	0.400
LIG_FHA_2	228	234	PF00498	0.389
LIG_FHA_2	25	31	PF00498	0.384
LIG_FHA_2	62	68	PF00498	0.652
LIG_FHA_2	75	81	PF00498	0.424
LIG_GBD_Chelix_1	114	122	PF00786	0.293
LIG_LIR_Gen_1	145	156	PF02991	0.438
LIG_LIR_Gen_1	46	53	PF02991	0.513
LIG_LIR_Nem_3	145	151	PF02991	0.480
LIG_LIR_Nem_3	46	50	PF02991	0.434
LIG_Pex14_1	112	116	PF04695	0.282
LIG_Pex14_1	170	174	PF04695	0.420
LIG_Pex14_1	40	44	PF04695	0.429
LIG_Pex14_1	83	87	PF04695	0.349
LIG_SH2_NCK_1	164	168	PF00017	0.400
LIG_SH2_STAP1	164	168	PF00017	0.400
LIG_SH2_STAP1	174	178	PF00017	0.462
LIG_SH2_STAT3	127	130	PF00017	0.466
LIG_SH2_STAT3	236	239	PF00017	0.345
LIG_SH2_STAT5	127	130	PF00017	0.466
LIG_SH2_STAT5	174	177	PF00017	0.420
LIG_SH2_STAT5	180	183	PF00017	0.341
LIG_SH2_STAT5	236	239	PF00017	0.431
LIG_SH2_STAT5	47	50	PF00017	0.459
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.411
LIG_SUMO_SIM_par_1	202	209	PF11976	0.331
LIG_TRAF2_1	11	14	PF00917	0.564
LIG_UBA3_1	96	105	PF00899	0.342
MOD_CK2_1	196	202	PF00069	0.465
MOD_CK2_1	227	233	PF00069	0.370
MOD_CK2_1	61	67	PF00069	0.412
MOD_GlcNHglycan	189	192	PF01048	0.531
MOD_GSK3_1	20	27	PF00069	0.608
MOD_GSK3_1	68	75	PF00069	0.543
MOD_NEK2_1	122	127	PF00069	0.448
MOD_NEK2_1	159	164	PF00069	0.393
MOD_NEK2_1	172	177	PF00069	0.535
MOD_NEK2_1	196	201	PF00069	0.381
MOD_NEK2_1	20	25	PF00069	0.578
MOD_NEK2_1	43	48	PF00069	0.324
MOD_NEK2_1	5	10	PF00069	0.651
MOD_NEK2_1	87	92	PF00069	0.498
MOD_NEK2_2	174	179	PF00069	0.465
MOD_PIKK_1	48	54	PF00454	0.505
MOD_PIKK_1	5	11	PF00454	0.576
MOD_PKA_2	196	202	PF00069	0.399
MOD_PKB_1	131	139	PF00069	0.478
MOD_Plk_1	133	139	PF00069	0.553
MOD_Plk_1	172	178	PF00069	0.417
MOD_Plk_2-3	61	67	PF00069	0.580
MOD_Plk_4	108	114	PF00069	0.419
MOD_Plk_4	133	139	PF00069	0.493
MOD_Plk_4	43	49	PF00069	0.395
MOD_ProDKin_1	89	95	PF00069	0.375
MOD_SUMO_for_1	200	203	PF00179	0.355
TRG_DiLeu_BaEn_4	202	208	PF01217	0.437
TRG_ENDOCYTIC_2	47	50	PF00928	0.459
TRG_ER_diArg_1	128	131	PF00400	0.468
TRG_ER_diArg_1	192	195	PF00400	0.515
TRG_ER_diArg_1	234	236	PF00400	0.412
TRG_ER_diArg_1	40	42	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM0	Leptomonas seymouri	57%	100%
A0A1X0P8Z9	Trypanosomatidae	33%	94%
A0A3S7X2Y0	Leishmania donovani	93%	100%
A0A422NET6	Trypanosoma rangeli	29%	90%
A4HHT9	Leishmania braziliensis	81%	100%
A4I4Y6	Leishmania infantum	93%	100%
C9ZKJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%