Ribonuclease inhibitor-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease inhibitor-like protein

Species:

Leishmania major

UniProt:

E9AEE3_LEIMA

TriTrypDb:

LmjF.29.2810 , LMJLV39_290036400 , LMJSD75_290036700

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	18
GO:0005929	cilium	4	16
GO:0042995	cell projection	2	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0120025	plasma membrane bounded cell projection	3	16
GO:0031514	motile cilium	5	1

Expansion

Sequence features

E9AEE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.630
CLV_C14_Caspase3-7	651	655	PF00656	0.452
CLV_C14_Caspase3-7	706	710	PF00656	0.552
CLV_NRD_NRD_1	499	501	PF00675	0.304
CLV_NRD_NRD_1	595	597	PF00675	0.480
CLV_NRD_NRD_1	608	610	PF00675	0.409
CLV_NRD_NRD_1	675	677	PF00675	0.530
CLV_NRD_NRD_1	723	725	PF00675	0.534
CLV_NRD_NRD_1	733	735	PF00675	0.640
CLV_PCSK_KEX2_1	199	201	PF00082	0.387
CLV_PCSK_KEX2_1	499	501	PF00082	0.304
CLV_PCSK_KEX2_1	583	585	PF00082	0.456
CLV_PCSK_KEX2_1	595	597	PF00082	0.397
CLV_PCSK_KEX2_1	608	610	PF00082	0.412
CLV_PCSK_KEX2_1	649	651	PF00082	0.548
CLV_PCSK_KEX2_1	675	677	PF00082	0.564
CLV_PCSK_KEX2_1	733	735	PF00082	0.669
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.387
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.544
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.563
CLV_PCSK_SKI1_1	224	228	PF00082	0.455
CLV_PCSK_SKI1_1	463	467	PF00082	0.426
CLV_PCSK_SKI1_1	551	555	PF00082	0.550
CLV_PCSK_SKI1_1	676	680	PF00082	0.503
CLV_PCSK_SKI1_1	733	737	PF00082	0.634
CLV_Separin_Metazoa	258	262	PF03568	0.395
DEG_APCC_KENBOX_2	567	571	PF00400	0.429
DEG_Nend_UBRbox_2	1	3	PF02207	0.680
DEG_SCF_FBW7_2	248	254	PF00400	0.512
DOC_ANK_TNKS_1	75	82	PF00023	0.681
DOC_CKS1_1	248	253	PF01111	0.507
DOC_CYCLIN_RxL_1	221	231	PF00134	0.433
DOC_CYCLIN_RxL_1	494	507	PF00134	0.276
DOC_CYCLIN_yClb5_NLxxxL_5	493	502	PF00134	0.321
DOC_MAPK_gen_1	199	209	PF00069	0.397
DOC_MAPK_gen_1	446	455	PF00069	0.433
DOC_MAPK_gen_1	489	498	PF00069	0.321
DOC_MAPK_HePTP_8	197	209	PF00069	0.321
DOC_MAPK_MEF2A_6	200	209	PF00069	0.336
DOC_PP2B_LxvP_1	553	556	PF13499	0.491
DOC_PP4_FxxP_1	151	154	PF00568	0.472
DOC_USP7_MATH_1	4	8	PF00917	0.703
DOC_USP7_UBL2_3	485	489	PF12436	0.423
DOC_WW_Pin1_4	247	252	PF00397	0.520
LIG_14-3-3_CanoR_1	172	179	PF00244	0.464
LIG_14-3-3_CanoR_1	200	205	PF00244	0.441
LIG_14-3-3_CanoR_1	268	276	PF00244	0.427
LIG_14-3-3_CanoR_1	290	295	PF00244	0.292
LIG_14-3-3_CanoR_1	296	306	PF00244	0.315
LIG_14-3-3_CanoR_1	31	37	PF00244	0.695
LIG_14-3-3_CanoR_1	516	522	PF00244	0.340
LIG_14-3-3_CanoR_1	54	63	PF00244	0.560
LIG_14-3-3_CanoR_1	633	639	PF00244	0.540
LIG_14-3-3_CanoR_1	67	77	PF00244	0.511
LIG_Actin_WH2_2	371	388	PF00022	0.437
LIG_APCC_ABBAyCdc20_2	202	208	PF00400	0.321
LIG_BRCT_BRCA1_1	511	515	PF00533	0.404
LIG_BRCT_BRCA1_1	59	63	PF00533	0.607
LIG_BRCT_BRCA1_1	6	10	PF00533	0.502
LIG_Clathr_ClatBox_1	204	208	PF01394	0.346
LIG_CtBP_PxDLS_1	480	485	PF00389	0.321
LIG_DLG_GKlike_1	290	297	PF00625	0.421
LIG_FHA_1	110	116	PF00498	0.520
LIG_FHA_1	382	388	PF00498	0.372
LIG_FHA_1	550	556	PF00498	0.595
LIG_FHA_1	638	644	PF00498	0.596
LIG_FHA_1	69	75	PF00498	0.582
LIG_FHA_2	320	326	PF00498	0.425
LIG_FHA_2	649	655	PF00498	0.549
LIG_FHA_2	697	703	PF00498	0.602
LIG_LIR_Gen_1	135	144	PF02991	0.431
LIG_LIR_Gen_1	174	181	PF02991	0.466
LIG_LIR_Gen_1	355	364	PF02991	0.348
LIG_LIR_Gen_1	525	536	PF02991	0.322
LIG_LIR_Gen_1	85	94	PF02991	0.539
LIG_LIR_Nem_3	135	141	PF02991	0.434
LIG_LIR_Nem_3	174	179	PF02991	0.472
LIG_LIR_Nem_3	355	359	PF02991	0.353
LIG_LIR_Nem_3	525	531	PF02991	0.310
LIG_LIR_Nem_3	85	91	PF02991	0.526
LIG_MYND_1	75	79	PF01753	0.700
LIG_PTB_Apo_2	527	534	PF02174	0.208
LIG_PTB_Phospho_1	527	533	PF10480	0.208
LIG_SH2_NCK_1	351	355	PF00017	0.474
LIG_SH2_STAP1	48	52	PF00017	0.650
LIG_SH2_STAP1	70	74	PF00017	0.648
LIG_SH2_STAP1	84	88	PF00017	0.557
LIG_SH2_STAT5	356	359	PF00017	0.432
LIG_SH2_STAT5	533	536	PF00017	0.458
LIG_SH2_STAT5	70	73	PF00017	0.667
LIG_SH2_STAT5	84	87	PF00017	0.496
LIG_SUMO_SIM_par_1	177	182	PF11976	0.315
LIG_SUMO_SIM_par_1	231	236	PF11976	0.373
LIG_SUMO_SIM_par_1	374	379	PF11976	0.420
LIG_TRFH_1	10	14	PF08558	0.463
LIG_TYR_ITIM	354	359	PF00017	0.447
LIG_WRC_WIRS_1	88	93	PF05994	0.510
MOD_CK1_1	109	115	PF00069	0.541
MOD_CK1_1	171	177	PF00069	0.439
MOD_CK1_1	292	298	PF00069	0.242
MOD_CK1_1	381	387	PF00069	0.424
MOD_CK1_1	40	46	PF00069	0.560
MOD_CK1_1	408	414	PF00069	0.408
MOD_CK1_1	415	421	PF00069	0.432
MOD_CK1_1	549	555	PF00069	0.597
MOD_CK1_1	57	63	PF00069	0.662
MOD_CK1_1	622	628	PF00069	0.466
MOD_CK2_1	283	289	PF00069	0.370
MOD_CK2_1	311	317	PF00069	0.460
MOD_CK2_1	319	325	PF00069	0.425
MOD_CK2_1	639	645	PF00069	0.473
MOD_Cter_Amidation	731	734	PF01082	0.670
MOD_GlcNHglycan	142	145	PF01048	0.434
MOD_GlcNHglycan	161	164	PF01048	0.385
MOD_GlcNHglycan	180	184	PF01048	0.196
MOD_GlcNHglycan	285	288	PF01048	0.366
MOD_GlcNHglycan	313	316	PF01048	0.438
MOD_GlcNHglycan	366	370	PF01048	0.439
MOD_GlcNHglycan	378	381	PF01048	0.476
MOD_GlcNHglycan	387	390	PF01048	0.300
MOD_GlcNHglycan	621	624	PF01048	0.476
MOD_GSK3_1	376	383	PF00069	0.374
MOD_GSK3_1	40	47	PF00069	0.450
MOD_GSK3_1	408	415	PF00069	0.412
MOD_GSK3_1	464	471	PF00069	0.333
MOD_GSK3_1	637	644	PF00069	0.556
MOD_N-GLC_1	200	205	PF02516	0.298
MOD_N-GLC_1	228	233	PF02516	0.370
MOD_N-GLC_1	269	274	PF02516	0.328
MOD_N-GLC_1	290	295	PF02516	0.291
MOD_N-GLC_1	297	302	PF02516	0.309
MOD_N-GLC_1	405	410	PF02516	0.431
MOD_N-GLC_1	433	438	PF02516	0.278
MOD_N-GLC_1	468	473	PF02516	0.318
MOD_N-GLC_1	489	494	PF02516	0.262
MOD_N-GLC_1	517	522	PF02516	0.322
MOD_N-GLC_1	529	534	PF02516	0.288
MOD_N-GLC_1	549	554	PF02516	0.556
MOD_N-GLC_2	462	464	PF02516	0.433
MOD_NEK2_1	179	184	PF00069	0.272
MOD_NEK2_1	269	274	PF00069	0.310
MOD_NEK2_1	283	288	PF00069	0.287
MOD_NEK2_1	297	302	PF00069	0.185
MOD_NEK2_1	32	37	PF00069	0.638
MOD_NEK2_1	376	381	PF00069	0.383
MOD_NEK2_1	385	390	PF00069	0.296
MOD_NEK2_1	412	417	PF00069	0.431
MOD_NEK2_1	440	445	PF00069	0.292
MOD_NEK2_1	55	60	PF00069	0.627
MOD_NEK2_1	648	653	PF00069	0.649
MOD_PIKK_1	38	44	PF00454	0.630
MOD_PIKK_1	57	63	PF00454	0.328
MOD_PIKK_1	701	707	PF00454	0.655
MOD_PKA_2	171	177	PF00069	0.473
MOD_PKA_2	289	295	PF00069	0.413
MOD_PKA_2	30	36	PF00069	0.650
MOD_PKA_2	385	391	PF00069	0.317
MOD_PKA_2	44	50	PF00069	0.580
MOD_PKA_2	546	552	PF00069	0.448
MOD_PKA_2	632	638	PF00069	0.496
MOD_PKA_2	668	674	PF00069	0.469
MOD_Plk_1	200	206	PF00069	0.298
MOD_Plk_1	228	234	PF00069	0.376
MOD_Plk_1	290	296	PF00069	0.213
MOD_Plk_1	405	411	PF00069	0.426
MOD_Plk_1	433	439	PF00069	0.289
MOD_Plk_1	489	495	PF00069	0.277
MOD_Plk_1	517	523	PF00069	0.285
MOD_Plk_1	529	535	PF00069	0.268
MOD_Plk_1	549	555	PF00069	0.483
MOD_Plk_4	174	180	PF00069	0.384
MOD_Plk_4	228	234	PF00069	0.365
MOD_Plk_4	32	38	PF00069	0.672
MOD_Plk_4	549	555	PF00069	0.597
MOD_ProDKin_1	247	253	PF00069	0.515
MOD_SUMO_for_1	710	713	PF00179	0.649
MOD_SUMO_rev_2	642	648	PF00179	0.502
MOD_SUMO_rev_2	706	712	PF00179	0.623
TRG_DiLeu_BaEn_1	113	118	PF01217	0.397
TRG_DiLeu_BaLyEn_6	688	693	PF01217	0.580
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.691
TRG_DiLeu_LyEn_5	113	118	PF01217	0.456
TRG_ENDOCYTIC_2	176	179	PF00928	0.370
TRG_ENDOCYTIC_2	351	354	PF00928	0.447
TRG_ENDOCYTIC_2	356	359	PF00928	0.405
TRG_ENDOCYTIC_2	528	531	PF00928	0.319
TRG_ER_diArg_1	498	500	PF00400	0.304
TRG_ER_diArg_1	594	596	PF00400	0.488
TRG_ER_diArg_1	607	609	PF00400	0.436
TRG_ER_diArg_1	674	676	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	609	613	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	679	683	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I557	Leptomonas seymouri	72%	100%
A0A0S4IPG0	Bodo saltans	45%	98%
A0A0S4JDM4	Bodo saltans	24%	100%
A0A0S4JL02	Bodo saltans	25%	100%
A0A1X0NMB3	Trypanosomatidae	25%	100%
A0A1X0P9A4	Trypanosomatidae	53%	100%
A0A3Q8IEN3	Leishmania donovani	93%	100%
A0A3R7RCX5	Trypanosoma rangeli	23%	100%
A0A422MVT9	Trypanosoma rangeli	24%	68%
A0A422NEU0	Trypanosoma rangeli	52%	100%
A4HHT8	Leishmania braziliensis	82%	100%
A4I4Y7	Leishmania infantum	93%	100%
C9ZKJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9ALE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AZQ5	Trypanosoma cruzi	25%	100%
V5BC66	Trypanosoma cruzi	53%	100%