Intraflagellar transport protein 56

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative intraflagellar transport protein C3

Species:

Leishmania major

UniProt:

E9AED8_LEIMA

TriTrypDb:

LmjF.29.2760 , LMJLV39_290035900 , LMJSD75_290036200

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0030990	intraciliary transport particle	2	2
GO:0030992	intraciliary transport particle B	2	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0097546	ciliary base	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AED8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0010970	transport along microtubule	4	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0035720	intraciliary anterograde transport	4	2
GO:0035735	intraciliary transport involved in cilium assembly	4	2
GO:0042073	intraciliary transport	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0099111	microtubule-based transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0044877	protein-containing complex binding	2	2
GO:0120170	intraciliary transport particle B binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	492	496	PF00656	0.396
CLV_NRD_NRD_1	18	20	PF00675	0.614
CLV_NRD_NRD_1	9	11	PF00675	0.614
CLV_PCSK_KEX2_1	566	568	PF00082	0.506
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.525
CLV_PCSK_SKI1_1	129	133	PF00082	0.341
CLV_PCSK_SKI1_1	179	183	PF00082	0.371
CLV_PCSK_SKI1_1	240	244	PF00082	0.487
CLV_PCSK_SKI1_1	348	352	PF00082	0.485
CLV_PCSK_SKI1_1	388	392	PF00082	0.352
CLV_PCSK_SKI1_1	561	565	PF00082	0.464
CLV_PCSK_SKI1_1	85	89	PF00082	0.370
DEG_Nend_Nbox_1	1	3	PF02207	0.583
DOC_MAPK_gen_1	186	195	PF00069	0.476
DOC_MAPK_gen_1	240	250	PF00069	0.502
DOC_MAPK_gen_1	447	457	PF00069	0.365
DOC_MAPK_gen_1	504	511	PF00069	0.331
DOC_MAPK_MEF2A_6	186	195	PF00069	0.360
DOC_MAPK_MEF2A_6	243	252	PF00069	0.509
DOC_MAPK_MEF2A_6	378	387	PF00069	0.340
DOC_MAPK_NFAT4_5	243	251	PF00069	0.507
DOC_PP1_SILK_1	465	470	PF00149	0.486
DOC_USP7_MATH_1	241	245	PF00917	0.490
DOC_USP7_MATH_1	417	421	PF00917	0.339
DOC_USP7_MATH_1	423	427	PF00917	0.398
DOC_USP7_MATH_1	521	525	PF00917	0.389
DOC_USP7_UBL2_3	243	247	PF12436	0.485
DOC_USP7_UBL2_3	557	561	PF12436	0.376
DOC_WW_Pin1_4	24	29	PF00397	0.640
LIG_14-3-3_CanoR_1	168	178	PF00244	0.496
LIG_14-3-3_CanoR_1	240	250	PF00244	0.419
LIG_14-3-3_CanoR_1	254	258	PF00244	0.457
LIG_14-3-3_CanoR_1	477	483	PF00244	0.481
LIG_BRCT_BRCA1_1	371	375	PF00533	0.329
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.465
LIG_EH1_1	525	533	PF00400	0.299
LIG_FHA_1	170	176	PF00498	0.492
LIG_FHA_1	254	260	PF00498	0.484
LIG_FHA_1	43	49	PF00498	0.400
LIG_FHA_1	434	440	PF00498	0.376
LIG_FHA_2	136	142	PF00498	0.412
LIG_FHA_2	152	158	PF00498	0.335
LIG_FHA_2	25	31	PF00498	0.616
LIG_FHA_2	318	324	PF00498	0.435
LIG_FHA_2	44	50	PF00498	0.385
LIG_FXI_DFP_1	377	381	PF00024	0.396
LIG_LIR_Gen_1	307	318	PF02991	0.375
LIG_LIR_Gen_1	349	358	PF02991	0.362
LIG_LIR_Gen_1	397	407	PF02991	0.324
LIG_LIR_Gen_1	523	534	PF02991	0.302
LIG_LIR_Gen_1	57	67	PF02991	0.305
LIG_LIR_Nem_3	176	181	PF02991	0.365
LIG_LIR_Nem_3	185	191	PF02991	0.376
LIG_LIR_Nem_3	203	207	PF02991	0.373
LIG_LIR_Nem_3	349	354	PF02991	0.358
LIG_LIR_Nem_3	372	377	PF02991	0.340
LIG_LIR_Nem_3	379	383	PF02991	0.336
LIG_LIR_Nem_3	397	403	PF02991	0.335
LIG_LIR_Nem_3	57	63	PF02991	0.428
LIG_LIR_Nem_3	65	69	PF02991	0.533
LIG_LIR_Nem_3	82	87	PF02991	0.221
LIG_MLH1_MIPbox_1	371	375	PF16413	0.329
LIG_NRP_CendR_1	566	568	PF00754	0.582
LIG_Pex14_2	512	516	PF04695	0.375
LIG_PTB_Apo_2	105	112	PF02174	0.360
LIG_PTB_Apo_2	470	477	PF02174	0.337
LIG_PTB_Phospho_1	470	476	PF10480	0.328
LIG_REV1ctd_RIR_1	372	380	PF16727	0.345
LIG_SH2_CRK	178	182	PF00017	0.355
LIG_SH2_CRK	188	192	PF00017	0.349
LIG_SH2_CRK	84	88	PF00017	0.314
LIG_SH2_GRB2like	106	109	PF00017	0.503
LIG_SH2_GRB2like	219	222	PF00017	0.503
LIG_SH2_NCK_1	414	418	PF00017	0.472
LIG_SH2_SRC	402	405	PF00017	0.317
LIG_SH2_SRC	414	417	PF00017	0.338
LIG_SH2_SRC	500	503	PF00017	0.375
LIG_SH2_STAP1	171	175	PF00017	0.462
LIG_SH2_STAP1	205	209	PF00017	0.338
LIG_SH2_STAP1	219	223	PF00017	0.383
LIG_SH2_STAP1	310	314	PF00017	0.502
LIG_SH2_STAP1	435	439	PF00017	0.360
LIG_SH2_STAP1	483	487	PF00017	0.316
LIG_SH2_STAT3	333	336	PF00017	0.492
LIG_SH2_STAT5	100	103	PF00017	0.354
LIG_SH2_STAT5	166	169	PF00017	0.473
LIG_SH2_STAT5	171	174	PF00017	0.414
LIG_SH2_STAT5	194	197	PF00017	0.349
LIG_SH2_STAT5	199	202	PF00017	0.372
LIG_SH2_STAT5	215	218	PF00017	0.259
LIG_SH2_STAT5	258	261	PF00017	0.572
LIG_SH2_STAT5	333	336	PF00017	0.376
LIG_SH2_STAT5	353	356	PF00017	0.276
LIG_SH2_STAT5	373	376	PF00017	0.342
LIG_SH2_STAT5	386	389	PF00017	0.318
LIG_SH2_STAT5	393	396	PF00017	0.229
LIG_SH2_STAT5	402	405	PF00017	0.317
LIG_SH2_STAT5	435	438	PF00017	0.362
LIG_SH2_STAT5	456	459	PF00017	0.386
LIG_SH2_STAT5	500	503	PF00017	0.375
LIG_SH2_STAT5	60	63	PF00017	0.308
LIG_SH3_3	119	125	PF00018	0.519
LIG_SH3_3	284	290	PF00018	0.483
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.346
LIG_SUMO_SIM_par_1	420	427	PF11976	0.490
LIG_SUMO_SIM_par_1	86	92	PF11976	0.392
LIG_TRAF2_1	27	30	PF00917	0.599
LIG_TRAF2_1	320	323	PF00917	0.456
LIG_TRAF2_1	517	520	PF00917	0.390
LIG_TYR_ITIM	202	207	PF00017	0.468
LIG_TYR_ITIM	58	63	PF00017	0.308
LIG_UBA3_1	130	137	PF00899	0.361
LIG_UBA3_1	384	391	PF00899	0.353
LIG_UBA3_1	525	530	PF00899	0.409
LIG_UBA3_1	552	561	PF00899	0.362
MOD_CK1_1	356	362	PF00069	0.493
MOD_CK1_1	42	48	PF00069	0.401
MOD_CK1_1	434	440	PF00069	0.329
MOD_CK1_1	54	60	PF00069	0.438
MOD_CK2_1	107	113	PF00069	0.405
MOD_CK2_1	135	141	PF00069	0.411
MOD_CK2_1	24	30	PF00069	0.591
MOD_CK2_1	317	323	PF00069	0.404
MOD_CK2_1	43	49	PF00069	0.382
MOD_CK2_1	493	499	PF00069	0.533
MOD_CK2_1	59	65	PF00069	0.401
MOD_Cter_Amidation	502	505	PF01082	0.350
MOD_GlcNHglycan	221	224	PF01048	0.383
MOD_GlcNHglycan	356	359	PF01048	0.497
MOD_GlcNHglycan	4	7	PF01048	0.603
MOD_GlcNHglycan	478	481	PF01048	0.466
MOD_GlcNHglycan	53	56	PF01048	0.495
MOD_GlcNHglycan	69	72	PF01048	0.257
MOD_GSK3_1	215	222	PF00069	0.389
MOD_GSK3_1	356	363	PF00069	0.399
MOD_GSK3_1	39	46	PF00069	0.402
MOD_GSK3_1	392	399	PF00069	0.490
MOD_GSK3_1	50	57	PF00069	0.434
MOD_N-GLC_1	107	112	PF02516	0.337
MOD_N-GLC_1	96	101	PF02516	0.428
MOD_N-GLC_2	473	475	PF02516	0.329
MOD_NEK2_1	1	6	PF00069	0.598
MOD_NEK2_1	107	112	PF00069	0.494
MOD_NEK2_1	252	257	PF00069	0.450
MOD_NEK2_1	433	438	PF00069	0.370
MOD_NEK2_1	439	444	PF00069	0.324
MOD_NEK2_1	461	466	PF00069	0.553
MOD_NEK2_1	50	55	PF00069	0.398
MOD_NEK2_1	67	72	PF00069	0.324
MOD_NEK2_2	386	391	PF00069	0.350
MOD_NEK2_2	521	526	PF00069	0.334
MOD_PIKK_1	318	324	PF00454	0.501
MOD_PIKK_1	337	343	PF00454	0.235
MOD_PKA_2	253	259	PF00069	0.472
MOD_PKA_2	360	366	PF00069	0.521
MOD_PKA_2	476	482	PF00069	0.486
MOD_Plk_1	205	211	PF00069	0.341
MOD_Plk_1	396	402	PF00069	0.343
MOD_Plk_1	417	423	PF00069	0.348
MOD_Plk_1	431	437	PF00069	0.354
MOD_Plk_1	532	538	PF00069	0.395
MOD_Plk_1	96	102	PF00069	0.443
MOD_Plk_4	207	213	PF00069	0.503
MOD_Plk_4	253	259	PF00069	0.574
MOD_Plk_4	280	286	PF00069	0.506
MOD_Plk_4	369	375	PF00069	0.339
MOD_Plk_4	396	402	PF00069	0.343
MOD_Plk_4	417	423	PF00069	0.483
MOD_Plk_4	43	49	PF00069	0.382
MOD_Plk_4	434	440	PF00069	0.346
MOD_Plk_4	521	527	PF00069	0.390
MOD_Plk_4	96	102	PF00069	0.443
MOD_ProDKin_1	24	30	PF00069	0.634
MOD_SUMO_for_1	242	245	PF00179	0.474
MOD_SUMO_for_1	429	432	PF00179	0.376
MOD_SUMO_for_1	457	460	PF00179	0.433
MOD_SUMO_rev_2	140	145	PF00179	0.361
MOD_SUMO_rev_2	244	249	PF00179	0.473
MOD_SUMO_rev_2	558	565	PF00179	0.411
TRG_DiLeu_BaEn_1	245	250	PF01217	0.364
TRG_DiLeu_BaEn_1	308	313	PF01217	0.348
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.474
TRG_ENDOCYTIC_2	178	181	PF00928	0.356
TRG_ENDOCYTIC_2	188	191	PF00928	0.356
TRG_ENDOCYTIC_2	194	197	PF00928	0.329
TRG_ENDOCYTIC_2	199	202	PF00928	0.336
TRG_ENDOCYTIC_2	204	207	PF00928	0.344
TRG_ENDOCYTIC_2	234	237	PF00928	0.513
TRG_ENDOCYTIC_2	310	313	PF00928	0.365
TRG_ENDOCYTIC_2	373	376	PF00928	0.348
TRG_ENDOCYTIC_2	60	63	PF00928	0.400
TRG_ENDOCYTIC_2	69	72	PF00928	0.333
TRG_ENDOCYTIC_2	84	87	PF00928	0.357
TRG_ER_diLys_1	564	568	PF00400	0.494
TRG_NES_CRM1_1	279	291	PF08389	0.473
TRG_NES_CRM1_1	460	474	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K7	Leptomonas seymouri	83%	100%
A0A0S4KM55	Bodo saltans	64%	100%
A0A1X0PAC6	Trypanosomatidae	67%	100%
A0A3Q8IEI7	Leishmania donovani	98%	100%
A0A3R7NBU5	Trypanosoma rangeli	67%	100%
A0AVF1	Homo sapiens	49%	100%
A4HHT3	Leishmania braziliensis	93%	100%
A4I4Z3	Leishmania infantum	98%	100%
A4III8	Xenopus tropicalis	51%	100%
A8JA42	Chlamydomonas reinhardtii	48%	100%
C9ZKK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9ALE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4R7Z9	Macaca fascicularis	50%	100%
Q57ZL2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	67%	100%
Q5PR66	Danio rerio	52%	100%
Q5U2N8	Rattus norvegicus	49%	100%
Q8BS45	Mus musculus	49%	100%
Q95QT8	Caenorhabditis elegans	35%	99%
V5BXA0	Trypanosoma cruzi	68%	100%