START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AED5_LEIMA

TriTrypDb:

LmjF.29.2730 , LMJLV39_290035600 , LMJSD75_290035900

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AED5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	20
GO:0008289	lipid binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.450
CLV_PCSK_KEX2_1	275	277	PF00082	0.767
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.767
CLV_PCSK_SKI1_1	15	19	PF00082	0.355
CLV_PCSK_SKI1_1	162	166	PF00082	0.310
CLV_PCSK_SKI1_1	171	175	PF00082	0.288
CLV_PCSK_SKI1_1	207	211	PF00082	0.394
CLV_PCSK_SKI1_1	237	241	PF00082	0.376
CLV_PCSK_SKI1_1	334	338	PF00082	0.480
CLV_PCSK_SKI1_1	68	72	PF00082	0.353
DEG_APCC_DBOX_1	14	22	PF00400	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DEG_SIAH_1	302	310	PF03145	0.533
DOC_MAPK_gen_1	12	21	PF00069	0.455
DOC_MAPK_gen_1	25	32	PF00069	0.345
DOC_PP4_FxxP_1	117	120	PF00568	0.295
DOC_USP7_MATH_1	189	193	PF00917	0.253
DOC_USP7_MATH_1	268	272	PF00917	0.706
DOC_USP7_MATH_1	31	35	PF00917	0.416
DOC_USP7_UBL2_3	215	219	PF12436	0.361
DOC_USP7_UBL2_3	48	52	PF12436	0.254
DOC_WW_Pin1_4	242	247	PF00397	0.417
DOC_WW_Pin1_4	291	296	PF00397	0.598
LIG_14-3-3_CanoR_1	311	318	PF00244	0.639
LIG_14-3-3_CanoR_1	360	365	PF00244	0.482
LIG_14-3-3_CanoR_1	88	92	PF00244	0.362
LIG_Actin_WH2_2	325	340	PF00022	0.549
LIG_EH1_1	309	317	PF00400	0.503
LIG_eIF4E_1	310	316	PF01652	0.623
LIG_FHA_1	177	183	PF00498	0.398
LIG_FHA_1	311	317	PF00498	0.557
LIG_FHA_1	91	97	PF00498	0.339
LIG_FHA_2	342	348	PF00498	0.502
LIG_FHA_2	360	366	PF00498	0.533
LIG_HCF-1_HBM_1	231	234	PF13415	0.388
LIG_LIR_Apic_2	166	172	PF02991	0.366
LIG_LIR_Apic_2	242	246	PF02991	0.359
LIG_LIR_Gen_1	125	133	PF02991	0.294
LIG_LIR_Gen_1	139	148	PF02991	0.305
LIG_LIR_Gen_1	14	24	PF02991	0.423
LIG_LIR_Gen_1	97	104	PF02991	0.297
LIG_LIR_Nem_3	109	115	PF02991	0.252
LIG_LIR_Nem_3	131	135	PF02991	0.302
LIG_LIR_Nem_3	139	143	PF02991	0.312
LIG_LIR_Nem_3	217	223	PF02991	0.383
LIG_LIR_Nem_3	97	102	PF02991	0.342
LIG_MYND_1	246	250	PF01753	0.494
LIG_PDZ_Class_2	361	366	PF00595	0.617
LIG_Pex14_1	243	247	PF04695	0.393
LIG_Pex14_1	38	42	PF04695	0.279
LIG_PTB_Apo_2	120	127	PF02174	0.298
LIG_PTB_Apo_2	134	141	PF02174	0.301
LIG_PTB_Phospho_1	134	140	PF10480	0.412
LIG_SH2_CRK	321	325	PF00017	0.432
LIG_SH2_CRK	79	83	PF00017	0.299
LIG_SH2_CRK	99	103	PF00017	0.339
LIG_SH2_NCK_1	99	103	PF00017	0.295
LIG_SH2_PTP2	169	172	PF00017	0.366
LIG_SH2_SRC	247	250	PF00017	0.497
LIG_SH2_STAP1	113	117	PF00017	0.295
LIG_SH2_STAP1	216	220	PF00017	0.474
LIG_SH2_STAP1	42	46	PF00017	0.379
LIG_SH2_STAT5	140	143	PF00017	0.391
LIG_SH2_STAT5	169	172	PF00017	0.273
LIG_SH2_STAT5	183	186	PF00017	0.259
LIG_SH2_STAT5	223	226	PF00017	0.414
LIG_SH2_STAT5	247	250	PF00017	0.486
LIG_SH2_STAT5	348	351	PF00017	0.442
LIG_SH2_STAT5	8	11	PF00017	0.480
LIG_SH3_2	150	155	PF14604	0.370
LIG_SH3_2	306	311	PF14604	0.661
LIG_SH3_3	112	118	PF00018	0.362
LIG_SH3_3	147	153	PF00018	0.375
LIG_SH3_3	300	306	PF00018	0.616
LIG_TRAF2_1	282	285	PF00917	0.584
LIG_TYR_ITIM	110	115	PF00017	0.397
LIG_TYR_ITIM	77	82	PF00017	0.370
LIG_UBA3_1	18	26	PF00899	0.341
LIG_UBA3_1	349	353	PF00899	0.534
MOD_CK1_1	163	169	PF00069	0.313
MOD_CK1_1	33	39	PF00069	0.348
MOD_CK2_1	128	134	PF00069	0.279
MOD_CK2_1	268	274	PF00069	0.620
MOD_CK2_1	279	285	PF00069	0.770
MOD_CK2_1	341	347	PF00069	0.535
MOD_GlcNHglycan	270	273	PF01048	0.714
MOD_GlcNHglycan	279	284	PF01048	0.729
MOD_GlcNHglycan	329	332	PF01048	0.293
MOD_GlcNHglycan	35	38	PF01048	0.233
MOD_GSK3_1	189	196	PF00069	0.274
MOD_GSK3_1	254	261	PF00069	0.606
MOD_GSK3_1	310	317	PF00069	0.620
MOD_GSK3_1	33	40	PF00069	0.312
MOD_N-GLC_1	143	148	PF02516	0.299
MOD_NEK2_1	200	205	PF00069	0.295
MOD_NEK2_1	290	295	PF00069	0.635
MOD_NEK2_1	298	303	PF00069	0.562
MOD_NEK2_2	235	240	PF00069	0.259
MOD_PIKK_1	176	182	PF00454	0.356
MOD_PK_1	160	166	PF00069	0.279
MOD_PKA_2	176	182	PF00069	0.427
MOD_PKA_2	310	316	PF00069	0.652
MOD_PKA_2	359	365	PF00069	0.472
MOD_PKA_2	64	70	PF00069	0.360
MOD_PKA_2	87	93	PF00069	0.346
MOD_Plk_1	332	338	PF00069	0.475
MOD_Plk_4	193	199	PF00069	0.345
MOD_Plk_4	42	48	PF00069	0.324
MOD_ProDKin_1	242	248	PF00069	0.415
MOD_ProDKin_1	291	297	PF00069	0.596
MOD_SUMO_for_1	47	50	PF00179	0.416
MOD_SUMO_rev_2	4	14	PF00179	0.585
MOD_SUMO_rev_2	44	54	PF00179	0.416
TRG_ENDOCYTIC_2	112	115	PF00928	0.281
TRG_ENDOCYTIC_2	140	143	PF00928	0.386
TRG_ENDOCYTIC_2	16	19	PF00928	0.357
TRG_ENDOCYTIC_2	321	324	PF00928	0.420
TRG_ENDOCYTIC_2	79	82	PF00928	0.308
TRG_ENDOCYTIC_2	99	102	PF00928	0.325
TRG_ER_diArg_1	159	162	PF00400	0.315
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.252
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J9	Leptomonas seymouri	75%	99%
A0A0S4KH88	Bodo saltans	47%	93%
A0A1X0P910	Trypanosomatidae	51%	97%
A0A3Q8IBA5	Leishmania donovani	34%	100%
A0A3Q8IJ21	Leishmania donovani	95%	100%
A0A3R7KCX0	Trypanosoma rangeli	49%	100%
A0A422MZR8	Trypanosoma rangeli	34%	100%
A4H6L4	Leishmania braziliensis	35%	100%
A4HHT0	Leishmania braziliensis	83%	100%
A4HUZ7	Leishmania infantum	33%	89%
A4I4Z0	Leishmania infantum	95%	100%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ALF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9ANN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4QGZ1	Leishmania major	33%	100%
Q9Y365	Homo sapiens	32%	100%
V5BC62	Trypanosoma cruzi	50%	100%
V5DT41	Trypanosoma cruzi	35%	100%