Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Right handed beta helix region, putative

Species:

Leishmania major

UniProt:

E9AED3_LEIMA

TriTrypDb:

LmjF.29.2710 , LMJLV39_290035400 , LMJSD75_290035700

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AED3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.368
CLV_NRD_NRD_1	93	95	PF00675	0.274
DOC_MAPK_gen_1	200	206	PF00069	0.363
DOC_USP7_MATH_1	270	274	PF00917	0.546
DOC_USP7_MATH_1	57	61	PF00917	0.640
DOC_WW_Pin1_4	32	37	PF00397	0.279
LIG_APCC_ABBA_1	179	184	PF00400	0.417
LIG_FHA_1	117	123	PF00498	0.414
LIG_FHA_1	176	182	PF00498	0.440
LIG_FHA_1	262	268	PF00498	0.490
LIG_FHA_1	29	35	PF00498	0.381
LIG_FHA_1	3	9	PF00498	0.434
LIG_FHA_1	40	46	PF00498	0.426
LIG_FHA_1	71	77	PF00498	0.336
LIG_FHA_2	146	152	PF00498	0.381
LIG_LIR_Gen_1	251	261	PF02991	0.329
LIG_LIR_Nem_3	143	147	PF02991	0.435
LIG_LIR_Nem_3	176	182	PF02991	0.314
LIG_LIR_Nem_3	218	224	PF02991	0.525
LIG_LIR_Nem_3	251	256	PF02991	0.323
LIG_LRP6_Inhibitor_1	169	175	PF00058	0.286
LIG_REV1ctd_RIR_1	225	235	PF16727	0.376
LIG_SH2_STAP1	183	187	PF00017	0.441
LIG_SH2_STAT5	138	141	PF00017	0.329
LIG_SH2_STAT5	205	208	PF00017	0.331
LIG_SH3_3	30	36	PF00018	0.558
LIG_SH3_3	4	10	PF00018	0.540
LIG_SH3_3	40	46	PF00018	0.500
LIG_SUMO_SIM_par_1	30	35	PF11976	0.342
LIG_SUMO_SIM_par_1	72	77	PF11976	0.442
MOD_CK1_1	238	244	PF00069	0.394
MOD_CK1_1	60	66	PF00069	0.672
MOD_CK2_1	140	146	PF00069	0.308
MOD_GlcNHglycan	187	190	PF01048	0.472
MOD_GlcNHglycan	237	240	PF01048	0.441
MOD_GlcNHglycan	261	264	PF01048	0.453
MOD_GlcNHglycan	76	79	PF01048	0.448
MOD_GSK3_1	238	245	PF00069	0.400
MOD_GSK3_1	28	35	PF00069	0.454
MOD_GSK3_1	66	73	PF00069	0.473
MOD_GSK3_1	74	81	PF00069	0.394
MOD_N-GLC_1	47	52	PF02516	0.426
MOD_N-GLC_1	78	83	PF02516	0.349
MOD_NEK2_1	116	121	PF00069	0.205
MOD_NEK2_1	140	145	PF00069	0.356
MOD_NEK2_1	227	232	PF00069	0.393
MOD_NEK2_1	242	247	PF00069	0.292
MOD_NEK2_1	39	44	PF00069	0.518
MOD_NEK2_1	47	52	PF00069	0.468
MOD_NEK2_2	118	123	PF00069	0.308
MOD_NEK2_2	270	275	PF00069	0.502
MOD_PIKK_1	145	151	PF00454	0.302
MOD_PKA_1	185	191	PF00069	0.351
MOD_PKA_2	233	239	PF00069	0.323
MOD_PKB_1	173	181	PF00069	0.400
MOD_Plk_1	175	181	PF00069	0.400
MOD_Plk_1	215	221	PF00069	0.348
MOD_Plk_1	39	45	PF00069	0.389
MOD_Plk_1	47	53	PF00069	0.333
MOD_Plk_1	78	84	PF00069	0.308
MOD_Plk_2-3	192	198	PF00069	0.334
MOD_Plk_4	2	8	PF00069	0.476
MOD_Plk_4	28	34	PF00069	0.446
MOD_Plk_4	66	72	PF00069	0.506
MOD_ProDKin_1	32	38	PF00069	0.285
TRG_DiLeu_BaEn_4	40	46	PF01217	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL58	Leptomonas seymouri	55%	99%
A0A0S4KFM6	Bodo saltans	38%	100%
A0A1X0P907	Trypanosomatidae	49%	100%
A0A3Q8IDZ0	Leishmania donovani	96%	100%
A0A422NEU4	Trypanosoma rangeli	48%	100%
A4HHS8	Leishmania braziliensis	82%	100%
A4I4X9	Leishmania infantum	96%	100%
C9ZKL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ALF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5C239	Trypanosoma cruzi	49%	100%