RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AED2_LEIMA

TriTrypDb:

LmjF.29.2700 , LMJLV39_290035300 , LMJSD75_290035600

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AED2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.502
CLV_C14_Caspase3-7	286	290	PF00656	0.593
CLV_NRD_NRD_1	102	104	PF00675	0.354
CLV_NRD_NRD_1	16	18	PF00675	0.372
CLV_NRD_NRD_1	325	327	PF00675	0.376
CLV_NRD_NRD_1	7	9	PF00675	0.463
CLV_NRD_NRD_1	739	741	PF00675	0.432
CLV_NRD_NRD_1	96	98	PF00675	0.351
CLV_PCSK_KEX2_1	102	104	PF00082	0.354
CLV_PCSK_KEX2_1	16	18	PF00082	0.372
CLV_PCSK_KEX2_1	199	201	PF00082	0.468
CLV_PCSK_KEX2_1	209	211	PF00082	0.415
CLV_PCSK_KEX2_1	325	327	PF00082	0.376
CLV_PCSK_KEX2_1	519	521	PF00082	0.331
CLV_PCSK_KEX2_1	7	9	PF00082	0.463
CLV_PCSK_KEX2_1	739	741	PF00082	0.407
CLV_PCSK_KEX2_1	755	757	PF00082	0.444
CLV_PCSK_KEX2_1	96	98	PF00082	0.313
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.427
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.371
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.331
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.395
CLV_PCSK_SKI1_1	236	240	PF00082	0.396
CLV_PCSK_SKI1_1	275	279	PF00082	0.390
CLV_PCSK_SKI1_1	298	302	PF00082	0.403
CLV_PCSK_SKI1_1	496	500	PF00082	0.475
CLV_PCSK_SKI1_1	513	517	PF00082	0.290
CLV_PCSK_SKI1_1	526	530	PF00082	0.310
CLV_PCSK_SKI1_1	545	549	PF00082	0.284
CLV_PCSK_SKI1_1	557	561	PF00082	0.391
CLV_PCSK_SKI1_1	574	578	PF00082	0.261
CLV_PCSK_SKI1_1	7	11	PF00082	0.459
CLV_PCSK_SKI1_1	920	924	PF00082	0.442
CLV_Separin_Metazoa	380	384	PF03568	0.565
CLV_Separin_Metazoa	914	918	PF03568	0.546
DEG_APCC_DBOX_1	235	243	PF00400	0.618
DEG_APCC_DBOX_1	573	581	PF00400	0.592
DEG_APCC_DBOX_1	672	680	PF00400	0.585
DEG_APCC_DBOX_1	79	87	PF00400	0.554
DEG_MDM2_SWIB_1	183	191	PF02201	0.574
DEG_Nend_Nbox_1	1	3	PF02207	0.725
DOC_ANK_TNKS_1	772	779	PF00023	0.658
DOC_CKS1_1	693	698	PF01111	0.583
DOC_CYCLIN_RxL_1	243	256	PF00134	0.546
DOC_CYCLIN_RxL_1	272	282	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	848	854	PF00134	0.509
DOC_MAPK_gen_1	16	24	PF00069	0.589
DOC_MAPK_gen_1	519	527	PF00069	0.519
DOC_MAPK_gen_1	862	871	PF00069	0.365
DOC_MAPK_gen_1	917	926	PF00069	0.581
DOC_MAPK_MEF2A_6	520	529	PF00069	0.598
DOC_MAPK_MEF2A_6	862	871	PF00069	0.335
DOC_PP2B_LxvP_1	686	689	PF13499	0.656
DOC_PP2B_LxvP_1	762	765	PF13499	0.617
DOC_PP2B_LxvP_1	769	772	PF13499	0.614
DOC_PP4_FxxP_1	648	651	PF00568	0.633
DOC_USP7_MATH_1	110	114	PF00917	0.582
DOC_USP7_MATH_1	155	159	PF00917	0.578
DOC_USP7_MATH_1	176	180	PF00917	0.559
DOC_USP7_MATH_1	205	209	PF00917	0.613
DOC_USP7_MATH_1	262	266	PF00917	0.641
DOC_USP7_MATH_1	40	44	PF00917	0.730
DOC_USP7_MATH_1	441	445	PF00917	0.628
DOC_USP7_MATH_1	537	541	PF00917	0.637
DOC_USP7_MATH_1	582	586	PF00917	0.599
DOC_USP7_MATH_1	748	752	PF00917	0.611
DOC_USP7_MATH_1	818	822	PF00917	0.575
DOC_USP7_MATH_1	852	856	PF00917	0.382
DOC_USP7_MATH_1	918	922	PF00917	0.658
DOC_USP7_MATH_1	95	99	PF00917	0.618
DOC_USP7_MATH_1	982	986	PF00917	0.673
DOC_USP7_MATH_2	765	771	PF00917	0.627
DOC_WW_Pin1_4	15	20	PF00397	0.562
DOC_WW_Pin1_4	260	265	PF00397	0.572
DOC_WW_Pin1_4	689	694	PF00397	0.684
DOC_WW_Pin1_4	90	95	PF00397	0.621
LIG_14-3-3_CanoR_1	167	172	PF00244	0.524
LIG_14-3-3_CanoR_1	180	190	PF00244	0.590
LIG_14-3-3_CanoR_1	27	37	PF00244	0.744
LIG_14-3-3_CanoR_1	318	323	PF00244	0.561
LIG_14-3-3_CanoR_1	383	388	PF00244	0.540
LIG_14-3-3_CanoR_1	545	551	PF00244	0.574
LIG_14-3-3_CanoR_1	673	679	PF00244	0.598
LIG_14-3-3_CanoR_1	739	744	PF00244	0.577
LIG_14-3-3_CanoR_1	756	765	PF00244	0.611
LIG_14-3-3_CanoR_1	917	923	PF00244	0.579
LIG_14-3-3_CanoR_1	96	105	PF00244	0.574
LIG_Actin_WH2_2	71	86	PF00022	0.476
LIG_APCC_ABBA_1	129	134	PF00400	0.581
LIG_BIR_III_2	533	537	PF00653	0.605
LIG_BIR_III_2	961	965	PF00653	0.682
LIG_BRCT_BRCA1_1	17	21	PF00533	0.651
LIG_BRCT_BRCA1_1	443	447	PF00533	0.539
LIG_BRCT_BRCA1_1	813	817	PF00533	0.600
LIG_BRCT_BRCA1_1	843	847	PF00533	0.423
LIG_CaM_NSCaTE_8	556	563	PF13499	0.589
LIG_deltaCOP1_diTrp_1	406	415	PF00928	0.563
LIG_DLG_GKlike_1	17	24	PF00625	0.560
LIG_EH1_1	375	383	PF00400	0.548
LIG_EH1_1	900	908	PF00400	0.575
LIG_EVH1_2	717	721	PF00568	0.613
LIG_FHA_1	161	167	PF00498	0.541
LIG_FHA_1	432	438	PF00498	0.576
LIG_FHA_1	44	50	PF00498	0.616
LIG_FHA_1	470	476	PF00498	0.589
LIG_FHA_1	570	576	PF00498	0.555
LIG_FHA_1	584	590	PF00498	0.515
LIG_FHA_1	777	783	PF00498	0.581
LIG_FHA_2	280	286	PF00498	0.617
LIG_FHA_2	352	358	PF00498	0.613
LIG_FHA_2	611	617	PF00498	0.597
LIG_GBD_Chelix_1	465	473	PF00786	0.371
LIG_GBD_Chelix_1	542	550	PF00786	0.394
LIG_LIR_Apic_2	646	651	PF02991	0.630
LIG_LIR_Gen_1	18	28	PF02991	0.654
LIG_LIR_Gen_1	184	195	PF02991	0.642
LIG_LIR_Gen_1	263	274	PF02991	0.553
LIG_LIR_Gen_1	703	711	PF02991	0.482
LIG_LIR_Gen_1	942	951	PF02991	0.569
LIG_LIR_Nem_3	18	24	PF02991	0.653
LIG_LIR_Nem_3	184	190	PF02991	0.656
LIG_LIR_Nem_3	263	269	PF02991	0.550
LIG_LIR_Nem_3	444	450	PF02991	0.460
LIG_LIR_Nem_3	623	628	PF02991	0.584
LIG_LIR_Nem_3	703	707	PF02991	0.496
LIG_LIR_Nem_3	844	850	PF02991	0.425
LIG_LIR_Nem_3	855	861	PF02991	0.280
LIG_LIR_Nem_3	883	889	PF02991	0.439
LIG_LIR_Nem_3	929	934	PF02991	0.577
LIG_LIR_Nem_3	942	947	PF02991	0.416
LIG_NRBOX	292	298	PF00104	0.615
LIG_NRBOX	511	517	PF00104	0.583
LIG_NRBOX	682	688	PF00104	0.626
LIG_Pex14_2	183	187	PF04695	0.670
LIG_Pex14_2	662	666	PF04695	0.581
LIG_Rb_pABgroove_1	248	256	PF01858	0.618
LIG_REV1ctd_RIR_1	883	892	PF16727	0.534
LIG_RPA_C_Fungi	735	747	PF08784	0.482
LIG_SH2_CRK	809	813	PF00017	0.427
LIG_SH2_GRB2like	766	769	PF00017	0.504
LIG_SH2_NCK_1	454	458	PF00017	0.544
LIG_SH2_PTP2	68	71	PF00017	0.552
LIG_SH2_PTP2	877	880	PF00017	0.425
LIG_SH2_SRC	68	71	PF00017	0.552
LIG_SH2_STAP1	172	176	PF00017	0.257
LIG_SH2_STAP1	704	708	PF00017	0.443
LIG_SH2_STAP1	859	863	PF00017	0.475
LIG_SH2_STAP1	889	893	PF00017	0.476
LIG_SH2_STAT3	591	594	PF00017	0.463
LIG_SH2_STAT5	375	378	PF00017	0.363
LIG_SH2_STAT5	430	433	PF00017	0.493
LIG_SH2_STAT5	68	71	PF00017	0.552
LIG_SH2_STAT5	727	730	PF00017	0.367
LIG_SH2_STAT5	833	836	PF00017	0.299
LIG_SH2_STAT5	877	880	PF00017	0.422
LIG_SH3_1	325	331	PF00018	0.509
LIG_SH3_3	268	274	PF00018	0.516
LIG_SH3_3	325	331	PF00018	0.527
LIG_SH3_3	34	40	PF00018	0.698
LIG_SH3_3	426	432	PF00018	0.515
LIG_SH3_3	636	642	PF00018	0.514
LIG_SH3_3	647	653	PF00018	0.416
LIG_SH3_3	690	696	PF00018	0.583
LIG_SH3_3	870	876	PF00018	0.332
LIG_SH3_3	930	936	PF00018	0.549
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.519
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.423
LIG_SUMO_SIM_par_1	167	173	PF11976	0.499
LIG_SxIP_EBH_1	343	356	PF03271	0.340
LIG_TRAF2_1	377	380	PF00917	0.483
LIG_TRAF2_1	911	914	PF00917	0.538
LIG_TRFH_1	847	851	PF08558	0.372
LIG_TYR_ITIM	702	707	PF00017	0.476
LIG_TYR_ITIM	764	769	PF00017	0.521
LIG_WW_3	272	276	PF00397	0.467
LIG_WW_3	493	497	PF00397	0.469
MOD_CDC14_SPxK_1	93	96	PF00782	0.520
MOD_CDK_SPxK_1	90	96	PF00069	0.523
MOD_CDK_SPxxK_3	692	699	PF00069	0.473
MOD_CDK_SPxxK_3	90	97	PF00069	0.475
MOD_CK1_1	170	176	PF00069	0.510
MOD_CK1_1	231	237	PF00069	0.567
MOD_CK1_1	265	271	PF00069	0.535
MOD_CK1_1	43	49	PF00069	0.610
MOD_CK1_1	570	576	PF00069	0.545
MOD_CK1_1	677	683	PF00069	0.482
MOD_CK1_1	692	698	PF00069	0.574
MOD_CK1_1	734	740	PF00069	0.517
MOD_CK1_1	751	757	PF00069	0.544
MOD_CK1_1	840	846	PF00069	0.360
MOD_CK2_1	155	161	PF00069	0.513
MOD_CK2_1	17	23	PF00069	0.493
MOD_CK2_1	191	197	PF00069	0.543
MOD_CK2_1	279	285	PF00069	0.503
MOD_CK2_1	351	357	PF00069	0.566
MOD_CK2_1	610	616	PF00069	0.487
MOD_CK2_1	908	914	PF00069	0.579
MOD_GlcNHglycan	12	15	PF01048	0.536
MOD_GlcNHglycan	183	186	PF01048	0.485
MOD_GlcNHglycan	331	334	PF01048	0.527
MOD_GlcNHglycan	369	372	PF01048	0.477
MOD_GlcNHglycan	475	478	PF01048	0.453
MOD_GlcNHglycan	505	508	PF01048	0.400
MOD_GlcNHglycan	539	542	PF01048	0.489
MOD_GlcNHglycan	552	555	PF01048	0.398
MOD_GlcNHglycan	750	753	PF01048	0.498
MOD_GlcNHglycan	758	761	PF01048	0.482
MOD_GlcNHglycan	769	772	PF01048	0.266
MOD_GlcNHglycan	800	803	PF01048	0.528
MOD_GlcNHglycan	813	816	PF01048	0.380
MOD_GlcNHglycan	818	821	PF01048	0.310
MOD_GlcNHglycan	829	832	PF01048	0.377
MOD_GlcNHglycan	843	846	PF01048	0.330
MOD_GlcNHglycan	852	855	PF01048	0.469
MOD_GlcNHglycan	894	897	PF01048	0.581
MOD_GlcNHglycan	910	913	PF01048	0.515
MOD_GlcNHglycan	980	983	PF01048	0.588
MOD_GSK3_1	258	265	PF00069	0.507
MOD_GSK3_1	279	286	PF00069	0.481
MOD_GSK3_1	314	321	PF00069	0.417
MOD_GSK3_1	407	414	PF00069	0.353
MOD_GSK3_1	461	468	PF00069	0.425
MOD_GSK3_1	469	476	PF00069	0.374
MOD_GSK3_1	537	544	PF00069	0.491
MOD_GSK3_1	546	553	PF00069	0.506
MOD_GSK3_1	583	590	PF00069	0.427
MOD_GSK3_1	674	681	PF00069	0.488
MOD_GSK3_1	731	738	PF00069	0.396
MOD_GSK3_1	778	785	PF00069	0.560
MOD_GSK3_1	837	844	PF00069	0.357
MOD_GSK3_1	850	857	PF00069	0.319
MOD_GSK3_1	978	985	PF00069	0.614
MOD_N-GLC_1	407	412	PF02516	0.485
MOD_N-GLC_1	461	466	PF02516	0.443
MOD_N-GLC_1	767	772	PF02516	0.552
MOD_NEK2_1	1	6	PF00069	0.554
MOD_NEK2_1	10	15	PF00069	0.489
MOD_NEK2_1	191	196	PF00069	0.472
MOD_NEK2_1	242	247	PF00069	0.496
MOD_NEK2_1	313	318	PF00069	0.368
MOD_NEK2_1	344	349	PF00069	0.424
MOD_NEK2_1	381	386	PF00069	0.504
MOD_NEK2_1	407	412	PF00069	0.407
MOD_NEK2_1	413	418	PF00069	0.394
MOD_NEK2_1	469	474	PF00069	0.406
MOD_NEK2_1	503	508	PF00069	0.474
MOD_NEK2_1	546	551	PF00069	0.556
MOD_NEK2_1	610	615	PF00069	0.479
MOD_NEK2_1	678	683	PF00069	0.459
MOD_NEK2_1	723	728	PF00069	0.415
MOD_NEK2_1	816	821	PF00069	0.412
MOD_NEK2_1	827	832	PF00069	0.389
MOD_NEK2_1	880	885	PF00069	0.365
MOD_NEK2_1	949	954	PF00069	0.486
MOD_NEK2_2	508	513	PF00069	0.351
MOD_NEK2_2	778	783	PF00069	0.538
MOD_NEK2_2	79	84	PF00069	0.446
MOD_NEK2_2	918	923	PF00069	0.531
MOD_PK_1	167	173	PF00069	0.391
MOD_PK_1	383	389	PF00069	0.355
MOD_PK_1	739	745	PF00069	0.492
MOD_PKA_1	739	745	PF00069	0.491
MOD_PKA_1	96	102	PF00069	0.393
MOD_PKA_2	28	34	PF00069	0.585
MOD_PKA_2	367	373	PF00069	0.466
MOD_PKA_2	399	405	PF00069	0.483
MOD_PKA_2	617	623	PF00069	0.494
MOD_PKA_2	739	745	PF00069	0.526
MOD_PKA_2	782	788	PF00069	0.525
MOD_PKA_2	79	85	PF00069	0.417
MOD_PKA_2	95	101	PF00069	0.370
MOD_Plk_1	461	467	PF00069	0.473
MOD_Plk_1	570	576	PF00069	0.501
MOD_Plk_1	620	626	PF00069	0.501
MOD_Plk_1	658	664	PF00069	0.476
MOD_Plk_1	973	979	PF00069	0.603
MOD_Plk_2-3	289	295	PF00069	0.505
MOD_Plk_4	125	131	PF00069	0.336
MOD_Plk_4	167	173	PF00069	0.279
MOD_Plk_4	17	23	PF00069	0.551
MOD_Plk_4	318	324	PF00069	0.450
MOD_Plk_4	345	351	PF00069	0.433
MOD_Plk_4	587	593	PF00069	0.481
MOD_Plk_4	620	626	PF00069	0.445
MOD_Plk_4	643	649	PF00069	0.483
MOD_Plk_4	658	664	PF00069	0.373
MOD_Plk_4	674	680	PF00069	0.401
MOD_Plk_4	723	729	PF00069	0.464
MOD_Plk_4	739	745	PF00069	0.485
MOD_Plk_4	854	860	PF00069	0.505
MOD_Plk_4	881	887	PF00069	0.350
MOD_ProDKin_1	15	21	PF00069	0.440
MOD_ProDKin_1	260	266	PF00069	0.457
MOD_ProDKin_1	689	695	PF00069	0.608
MOD_ProDKin_1	90	96	PF00069	0.523
MOD_SUMO_rev_2	193	201	PF00179	0.578
TRG_DiLeu_BaEn_1	433	438	PF01217	0.462
TRG_DiLeu_BaEn_1	484	489	PF01217	0.492
TRG_DiLeu_BaEn_1	703	708	PF01217	0.373
TRG_DiLeu_BaEn_1	902	907	PF01217	0.449
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.455
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.511
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.498
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.333
TRG_DiLeu_LyEn_5	433	438	PF01217	0.462
TRG_ENDOCYTIC_2	310	313	PF00928	0.392
TRG_ENDOCYTIC_2	375	378	PF00928	0.456
TRG_ENDOCYTIC_2	704	707	PF00928	0.351
TRG_ENDOCYTIC_2	766	769	PF00928	0.490
TRG_ENDOCYTIC_2	877	880	PF00928	0.465
TRG_ENDOCYTIC_2	944	947	PF00928	0.499
TRG_ER_diArg_1	102	104	PF00400	0.473
TRG_ER_diArg_1	15	17	PF00400	0.463
TRG_ER_diArg_1	324	326	PF00400	0.453
TRG_ER_diArg_1	699	702	PF00400	0.338
TRG_ER_diArg_1	739	741	PF00400	0.582
TRG_ER_diArg_1	863	866	PF00400	0.485
TRG_ER_FFAT_2	726	738	PF00635	0.401
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	626	630	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	920	925	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	978	983	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY92	Leptomonas seymouri	49%	98%
A0A1X0P9B3	Trypanosomatidae	24%	99%
A0A3S7X2T5	Leishmania donovani	92%	100%
A0A422NEU9	Trypanosoma rangeli	27%	99%
A4HHS7	Leishmania braziliensis	77%	100%
A4I4X8	Leishmania infantum	93%	100%
C9ZKL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
E9ALF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%