Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AED1_LEIMA

TriTrypDb:

LmjF.29.2690 , LMJLV39_290035200 , LMJSD75_290035500

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AED1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.697
CLV_PCSK_SKI1_1	23	27	PF00082	0.781
DEG_Nend_UBRbox_2	1	3	PF02207	0.755
DEG_SPOP_SBC_1	170	174	PF00917	0.700
DOC_PP2B_LxvP_1	12	15	PF13499	0.569
DOC_PP2B_LxvP_1	51	54	PF13499	0.744
DOC_PP4_FxxP_1	79	82	PF00568	0.784
DOC_PP4_MxPP_1	97	100	PF00568	0.766
DOC_USP7_MATH_1	114	118	PF00917	0.746
DOC_USP7_MATH_1	170	174	PF00917	0.696
DOC_USP7_MATH_1	216	220	PF00917	0.739
DOC_USP7_MATH_1	254	258	PF00917	0.641
DOC_USP7_MATH_1	275	279	PF00917	0.718
DOC_USP7_MATH_1	286	290	PF00917	0.724
DOC_USP7_MATH_1	52	56	PF00917	0.637
DOC_WW_Pin1_4	108	113	PF00397	0.792
DOC_WW_Pin1_4	142	147	PF00397	0.672
DOC_WW_Pin1_4	165	170	PF00397	0.714
DOC_WW_Pin1_4	185	190	PF00397	0.724
DOC_WW_Pin1_4	218	223	PF00397	0.761
DOC_WW_Pin1_4	269	274	PF00397	0.733
DOC_WW_Pin1_4	86	91	PF00397	0.674
LIG_AP2alpha_2	240	242	PF02296	0.651
LIG_BRCT_BRCA1_1	191	195	PF00533	0.793
LIG_CSL_BTD_1	92	95	PF09270	0.693
LIG_EVH1_1	79	83	PF00568	0.705
LIG_FHA_1	186	192	PF00498	0.736
LIG_FHA_1	294	300	PF00498	0.674
LIG_FHA_2	219	225	PF00498	0.672
LIG_LIR_Apic_2	132	136	PF02991	0.584
LIG_LIR_Gen_1	224	232	PF02991	0.603
LIG_LYPXL_yS_3	64	67	PF13949	0.659
LIG_SH2_CRK	133	137	PF00017	0.612
LIG_SH2_NCK_1	253	257	PF00017	0.777
LIG_SH2_STAP1	171	175	PF00017	0.750
LIG_SH2_STAT3	115	118	PF00017	0.745
LIG_SH2_STAT3	60	63	PF00017	0.630
LIG_SH2_STAT5	115	118	PF00017	0.764
LIG_SH2_STAT5	171	174	PF00017	0.826
LIG_SH3_1	235	241	PF00018	0.584
LIG_SH3_3	10	16	PF00018	0.609
LIG_SH3_3	156	162	PF00018	0.597
LIG_SH3_3	175	181	PF00018	0.632
LIG_SH3_3	203	209	PF00018	0.733
LIG_SH3_3	210	216	PF00018	0.658
LIG_SH3_3	226	232	PF00018	0.706
LIG_SH3_3	235	241	PF00018	0.701
LIG_SH3_3	77	83	PF00018	0.699
LIG_SH3_3	84	90	PF00018	0.611
LIG_SH3_3	95	101	PF00018	0.672
LIG_SH3_4	161	168	PF00018	0.679
MOD_CDK_SPK_2	269	274	PF00069	0.733
MOD_CK1_1	200	206	PF00069	0.643
MOD_CK2_1	218	224	PF00069	0.671
MOD_GlcNHglycan	19	22	PF01048	0.598
MOD_GlcNHglycan	199	202	PF01048	0.639
MOD_GlcNHglycan	256	259	PF01048	0.707
MOD_GSK3_1	165	172	PF00069	0.717
MOD_GSK3_1	185	192	PF00069	0.682
MOD_GSK3_1	196	203	PF00069	0.544
MOD_GSK3_1	248	255	PF00069	0.692
MOD_GSK3_1	26	33	PF00069	0.584
MOD_GSK3_1	275	282	PF00069	0.637
MOD_GSK3_1	82	89	PF00069	0.679
MOD_N-GLC_1	106	111	PF02516	0.791
MOD_N-GLC_1	201	206	PF02516	0.625
MOD_NEK2_1	131	136	PF00069	0.595
MOD_NEK2_1	139	144	PF00069	0.612
MOD_NEK2_1	150	155	PF00069	0.515
MOD_NEK2_1	196	201	PF00069	0.726
MOD_PIKK_1	114	120	PF00454	0.686
MOD_PIKK_1	248	254	PF00454	0.670
MOD_PIKK_1	286	292	PF00454	0.817
MOD_Plk_1	106	112	PF00069	0.792
MOD_Plk_1	223	229	PF00069	0.780
MOD_Plk_1	267	273	PF00069	0.726
MOD_ProDKin_1	108	114	PF00069	0.789
MOD_ProDKin_1	142	148	PF00069	0.675
MOD_ProDKin_1	165	171	PF00069	0.718
MOD_ProDKin_1	185	191	PF00069	0.724
MOD_ProDKin_1	218	224	PF00069	0.762
MOD_ProDKin_1	269	275	PF00069	0.734
MOD_ProDKin_1	86	92	PF00069	0.676
MOD_SUMO_rev_2	2	8	PF00179	0.667
TRG_ENDOCYTIC_2	128	131	PF00928	0.617
TRG_ENDOCYTIC_2	64	67	PF00928	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA0	Leptomonas seymouri	50%	99%
A0A3S7X2X0	Leishmania donovani	91%	100%
A4HHS6	Leishmania braziliensis	68%	100%
A4I4X7	Leishmania infantum	91%	100%
E9ALF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%