LeishMANIAdb
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FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FYVE-type domain-containing protein
Gene product:
3',5'-cyclic nucleotide phosphodiesterase, putative
Species:
Leishmania major
UniProt:
E9AED0_LEIMA
TriTrypDb:
LmjF.29.2680 , LMJLV39_290035100 * , LMJSD75_290035400 *
Length:
1084

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

E9AED0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED0

Function

Biological processes
TermNameLevelCount
GO:0007165 signal transduction 2 7
GO:0009987 cellular process 1 7
GO:0050789 regulation of biological process 2 7
GO:0050794 regulation of cellular process 3 7
GO:0065007 biological regulation 1 7
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 7
GO:0004112 cyclic-nucleotide phosphodiesterase activity 6 7
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7 7
GO:0005488 binding 1 7
GO:0008081 phosphoric diester hydrolase activity 5 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0042578 phosphoric ester hydrolase activity 4 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 131 135 PF00656 0.461
CLV_MEL_PAP_1 571 577 PF00089 0.338
CLV_NRD_NRD_1 1008 1010 PF00675 0.508
CLV_NRD_NRD_1 187 189 PF00675 0.471
CLV_NRD_NRD_1 231 233 PF00675 0.515
CLV_NRD_NRD_1 69 71 PF00675 0.330
CLV_NRD_NRD_1 778 780 PF00675 0.231
CLV_NRD_NRD_1 894 896 PF00675 0.530
CLV_NRD_NRD_1 971 973 PF00675 0.497
CLV_PCSK_FUR_1 1006 1010 PF00082 0.449
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I536 Leptomonas seymouri 42% 90%
A0A3S7X2S6 Leishmania donovani 90% 100%
A4HHS5 Leishmania braziliensis 73% 100%
A4I4X6 Leishmania infantum 90% 100%
E9ALF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS