FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3',5'-cyclic nucleotide phosphodiesterase, putative

Species:

Leishmania major

UniProt:

E9AED0_LEIMA

TriTrypDb:

LmjF.29.2680 , LMJLV39_290035100 , LMJSD75_290035400

Length:

1084

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AED0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED0

Function

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Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	7
GO:0009987	cellular process	1	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	7
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	7
GO:0005488	binding	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.461
CLV_MEL_PAP_1	571	577	PF00089	0.338
CLV_NRD_NRD_1	1008	1010	PF00675	0.508
CLV_NRD_NRD_1	187	189	PF00675	0.471
CLV_NRD_NRD_1	231	233	PF00675	0.515
CLV_NRD_NRD_1	69	71	PF00675	0.330
CLV_NRD_NRD_1	778	780	PF00675	0.231
CLV_NRD_NRD_1	894	896	PF00675	0.530
CLV_NRD_NRD_1	971	973	PF00675	0.497
CLV_PCSK_FUR_1	1006	1010	PF00082	0.449

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I536	Leptomonas seymouri	42%	90%
A0A3S7X2S6	Leishmania donovani	90%	100%
A4HHS5	Leishmania braziliensis	73%	100%
A4I4X6	Leishmania infantum	90%	100%
E9ALF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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