FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3',5'-cyclic nucleotide phosphodiesterase, putative

Species:

Leishmania major

UniProt:

E9AED0_LEIMA

TriTrypDb:

LmjF.29.2680 , LMJLV39_290035100 , LMJSD75_290035400

Length:

1084

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AED0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AED0

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	7
GO:0009987	cellular process	1	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	7
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	7
GO:0005488	binding	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.461
CLV_MEL_PAP_1	571	577	PF00089	0.338
CLV_NRD_NRD_1	1008	1010	PF00675	0.508
CLV_NRD_NRD_1	187	189	PF00675	0.471
CLV_NRD_NRD_1	231	233	PF00675	0.515
CLV_NRD_NRD_1	69	71	PF00675	0.330
CLV_NRD_NRD_1	778	780	PF00675	0.231
CLV_NRD_NRD_1	894	896	PF00675	0.530
CLV_NRD_NRD_1	971	973	PF00675	0.497
CLV_PCSK_FUR_1	1006	1010	PF00082	0.449
CLV_PCSK_KEX2_1	1006	1008	PF00082	0.519
CLV_PCSK_KEX2_1	187	189	PF00082	0.471
CLV_PCSK_KEX2_1	26	28	PF00082	0.295
CLV_PCSK_KEX2_1	643	645	PF00082	0.295
CLV_PCSK_KEX2_1	971	973	PF00082	0.527
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.295
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.295
CLV_PCSK_SKI1_1	1008	1012	PF00082	0.508
CLV_PCSK_SKI1_1	1066	1070	PF00082	0.499
CLV_PCSK_SKI1_1	187	191	PF00082	0.439
CLV_PCSK_SKI1_1	26	30	PF00082	0.309
CLV_PCSK_SKI1_1	264	268	PF00082	0.546
CLV_PCSK_SKI1_1	379	383	PF00082	0.475
CLV_PCSK_SKI1_1	439	443	PF00082	0.415
CLV_PCSK_SKI1_1	450	454	PF00082	0.397
CLV_PCSK_SKI1_1	488	492	PF00082	0.453
CLV_PCSK_SKI1_1	773	777	PF00082	0.231
CLV_PCSK_SKI1_1	869	873	PF00082	0.629
CLV_PCSK_SKI1_1	899	903	PF00082	0.546
CLV_PCSK_SKI1_1	909	913	PF00082	0.484
CLV_Separin_Metazoa	419	423	PF03568	0.476
CLV_Separin_Metazoa	954	958	PF03568	0.487
DEG_APCC_DBOX_1	455	463	PF00400	0.458
DEG_APCC_DBOX_1	487	495	PF00400	0.457
DEG_APCC_DBOX_1	778	786	PF00400	0.231
DEG_APCC_KENBOX_2	33	37	PF00400	0.295
DEG_SCF_FBW7_2	946	952	PF00400	0.497
DEG_SPOP_SBC_1	100	104	PF00917	0.526
DOC_CDC14_PxL_1	546	554	PF14671	0.406
DOC_CKS1_1	694	699	PF01111	0.348
DOC_CKS1_1	946	951	PF01111	0.502
DOC_CYCLIN_RxL_1	795	806	PF00134	0.309
DOC_MAPK_DCC_7	544	554	PF00069	0.377
DOC_MAPK_gen_1	920	929	PF00069	0.479
DOC_MAPK_HePTP_8	571	583	PF00069	0.382
DOC_MAPK_MEF2A_6	488	495	PF00069	0.502
DOC_MAPK_MEF2A_6	574	583	PF00069	0.381
DOC_MAPK_MEF2A_6	755	763	PF00069	0.348
DOC_PP1_RVXF_1	642	649	PF00149	0.348
DOC_PP4_FxxP_1	823	826	PF00568	0.295
DOC_PP4_FxxP_1	862	865	PF00568	0.426
DOC_USP7_MATH_1	142	146	PF00917	0.548
DOC_USP7_MATH_1	22	26	PF00917	0.251
DOC_USP7_MATH_1	251	255	PF00917	0.455
DOC_USP7_MATH_1	503	507	PF00917	0.730
DOC_USP7_MATH_1	658	662	PF00917	0.348
DOC_USP7_MATH_1	804	808	PF00917	0.348
DOC_USP7_UBL2_3	149	153	PF12436	0.409
DOC_WW_Pin1_4	1058	1063	PF00397	0.598
DOC_WW_Pin1_4	693	698	PF00397	0.503
DOC_WW_Pin1_4	800	805	PF00397	0.472
DOC_WW_Pin1_4	837	842	PF00397	0.295
DOC_WW_Pin1_4	935	940	PF00397	0.532
DOC_WW_Pin1_4	945	950	PF00397	0.537
LIG_14-3-3_CanoR_1	27	31	PF00244	0.295
LIG_14-3-3_CanoR_1	450	459	PF00244	0.402
LIG_14-3-3_CanoR_1	589	593	PF00244	0.414
LIG_14-3-3_CanoR_1	729	734	PF00244	0.348
LIG_14-3-3_CanoR_1	773	778	PF00244	0.386
LIG_14-3-3_CanoR_1	808	813	PF00244	0.348
LIG_14-3-3_CanoR_1	843	849	PF00244	0.389
LIG_14-3-3_CanoR_1	869	874	PF00244	0.576
LIG_14-3-3_CanoR_1	992	1000	PF00244	0.559
LIG_Actin_WH2_2	235	251	PF00022	0.460
LIG_Actin_WH2_2	437	452	PF00022	0.384
LIG_APCC_ABBA_1	583	588	PF00400	0.415
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BRCT_BRCA1_1	24	28	PF00533	0.251
LIG_BRCT_BRCA1_1	660	664	PF00533	0.348
LIG_BRCT_BRCA1_2	660	666	PF00533	0.309
LIG_CaM_NSCaTE_8	483	490	PF13499	0.503
LIG_deltaCOP1_diTrp_1	553	557	PF00928	0.376
LIG_DLG_GKlike_1	808	816	PF00625	0.348
LIG_FHA_1	1076	1082	PF00498	0.565
LIG_FHA_1	265	271	PF00498	0.543
LIG_FHA_1	318	324	PF00498	0.495
LIG_FHA_1	400	406	PF00498	0.537
LIG_FHA_1	694	700	PF00498	0.457
LIG_FHA_1	707	713	PF00498	0.278
LIG_FHA_1	910	916	PF00498	0.497
LIG_FHA_1	945	951	PF00498	0.713
LIG_FHA_1	978	984	PF00498	0.576
LIG_FHA_2	101	107	PF00498	0.478
LIG_FHA_2	291	297	PF00498	0.409
LIG_FHA_2	356	362	PF00498	0.482
LIG_FHA_2	405	411	PF00498	0.487
LIG_FHA_2	470	476	PF00498	0.421
LIG_FHA_2	526	532	PF00498	0.458
LIG_FHA_2	557	563	PF00498	0.362
LIG_FHA_2	637	643	PF00498	0.295
LIG_FHA_2	88	94	PF00498	0.602
LIG_FHA_2	946	952	PF00498	0.497
LIG_GBD_Chelix_1	989	997	PF00786	0.559
LIG_LIR_Apic_2	522	527	PF02991	0.443
LIG_LIR_Apic_2	735	740	PF02991	0.348
LIG_LIR_Apic_2	821	826	PF02991	0.295
LIG_LIR_Apic_2	859	865	PF02991	0.489
LIG_LIR_Gen_1	219	227	PF02991	0.476
LIG_LIR_Gen_1	25	33	PF02991	0.251
LIG_LIR_Gen_1	556	563	PF02991	0.433
LIG_LIR_Gen_1	689	699	PF02991	0.295
LIG_LIR_Nem_3	219	223	PF02991	0.478
LIG_LIR_Nem_3	25	31	PF02991	0.251
LIG_LIR_Nem_3	532	538	PF02991	0.465
LIG_LIR_Nem_3	556	560	PF02991	0.490
LIG_LIR_Nem_3	670	676	PF02991	0.350
LIG_LIR_Nem_3	689	694	PF02991	0.295
LIG_LIR_Nem_3	713	717	PF02991	0.348
LIG_LYPXL_yS_3	535	538	PF13949	0.411
LIG_MYND_1	632	636	PF01753	0.231
LIG_MYND_3	549	553	PF01753	0.394
LIG_NRBOX	135	141	PF00104	0.431
LIG_OCRL_FandH_1	725	737	PF00620	0.348
LIG_PCNA_yPIPBox_3	127	140	PF02747	0.450
LIG_Pex14_2	819	823	PF04695	0.350
LIG_PTAP_UEV_1	56	61	PF05743	0.309
LIG_Rb_pABgroove_1	822	830	PF01858	0.286
LIG_REV1ctd_RIR_1	28	37	PF16727	0.295
LIG_SH2_CRK	625	629	PF00017	0.286
LIG_SH2_CRK	676	680	PF00017	0.309
LIG_SH2_GRB2like	611	614	PF00017	0.295
LIG_SH2_SRC	473	476	PF00017	0.511
LIG_SH2_STAP1	284	288	PF00017	0.529
LIG_SH2_STAP1	747	751	PF00017	0.348
LIG_SH2_STAT3	330	333	PF00017	0.526
LIG_SH2_STAT5	1038	1041	PF00017	0.622
LIG_SH2_STAT5	673	676	PF00017	0.302
LIG_SH2_STAT5	852	855	PF00017	0.555
LIG_SH3_1	798	804	PF00018	0.348
LIG_SH3_2	57	62	PF14604	0.309
LIG_SH3_3	1044	1050	PF00018	0.591
LIG_SH3_3	2	8	PF00018	0.488
LIG_SH3_3	54	60	PF00018	0.279
LIG_SH3_3	798	804	PF00018	0.295
LIG_SH3_3	943	949	PF00018	0.525
LIG_SUMO_SIM_anti_2	134	141	PF11976	0.424
LIG_SUMO_SIM_anti_2	926	931	PF11976	0.487
LIG_SUMO_SIM_par_1	287	293	PF11976	0.400
LIG_TRAF2_1	114	117	PF00917	0.465
LIG_TRAF2_1	241	244	PF00917	0.507
LIG_TRAF2_1	293	296	PF00917	0.437
LIG_TRAF2_1	416	419	PF00917	0.472
LIG_TRAF2_1	472	475	PF00917	0.515
LIG_TRAF2_1	855	858	PF00917	0.615
LIG_TRAF2_1	982	985	PF00917	0.522
LIG_TYR_ITIM	533	538	PF00017	0.445
LIG_TYR_ITIM	674	679	PF00017	0.402
LIG_UBA3_1	136	143	PF00899	0.431
LIG_UBA3_1	634	643	PF00899	0.295
MOD_CDC14_SPxK_1	840	843	PF00782	0.348
MOD_CDK_SPK_2	935	940	PF00069	0.497
MOD_CDK_SPxK_1	837	843	PF00069	0.348
MOD_CK1_1	1061	1067	PF00069	0.662
MOD_CK1_1	110	116	PF00069	0.470
MOD_CK1_1	160	166	PF00069	0.464
MOD_CK1_1	399	405	PF00069	0.415
MOD_CK1_1	47	53	PF00069	0.459
MOD_CK1_1	506	512	PF00069	0.617
MOD_CK1_1	803	809	PF00069	0.348
MOD_CK1_1	837	843	PF00069	0.328
MOD_CK1_1	876	882	PF00069	0.521
MOD_CK1_1	945	951	PF00069	0.571
MOD_CK1_1	991	997	PF00069	0.506
MOD_CK2_1	100	106	PF00069	0.503
MOD_CK2_1	1069	1075	PF00069	0.572
MOD_CK2_1	110	116	PF00069	0.487
MOD_CK2_1	238	244	PF00069	0.635
MOD_CK2_1	269	275	PF00069	0.551
MOD_CK2_1	290	296	PF00069	0.434
MOD_CK2_1	355	361	PF00069	0.481
MOD_CK2_1	404	410	PF00069	0.489
MOD_CK2_1	469	475	PF00069	0.493
MOD_CK2_1	525	531	PF00069	0.463
MOD_CK2_1	556	562	PF00069	0.419
MOD_CK2_1	636	642	PF00069	0.295
MOD_CK2_1	729	735	PF00069	0.348
MOD_CK2_1	75	81	PF00069	0.462
MOD_CK2_1	879	885	PF00069	0.685
MOD_CMANNOS	480	483	PF00535	0.499
MOD_GlcNHglycan	1071	1074	PF01048	0.509
MOD_GlcNHglycan	1078	1081	PF01048	0.505
MOD_GlcNHglycan	112	115	PF01048	0.460
MOD_GlcNHglycan	159	162	PF01048	0.525
MOD_GlcNHglycan	16	19	PF01048	0.295
MOD_GlcNHglycan	166	169	PF01048	0.513
MOD_GlcNHglycan	197	200	PF01048	0.440
MOD_GlcNHglycan	366	369	PF01048	0.506
MOD_GlcNHglycan	49	52	PF01048	0.295
MOD_GlcNHglycan	505	508	PF01048	0.655
MOD_GlcNHglycan	808	811	PF01048	0.299
MOD_GSK3_1	1033	1040	PF00069	0.643
MOD_GSK3_1	160	167	PF00069	0.455
MOD_GSK3_1	22	29	PF00069	0.303
MOD_GSK3_1	243	250	PF00069	0.476
MOD_GSK3_1	252	259	PF00069	0.444
MOD_GSK3_1	290	297	PF00069	0.584
MOD_GSK3_1	396	403	PF00069	0.504
MOD_GSK3_1	43	50	PF00069	0.397
MOD_GSK3_1	502	509	PF00069	0.723
MOD_GSK3_1	51	58	PF00069	0.295
MOD_GSK3_1	665	672	PF00069	0.280
MOD_GSK3_1	800	807	PF00069	0.348
MOD_GSK3_1	869	876	PF00069	0.796
MOD_N-GLC_1	132	137	PF02516	0.441
MOD_NEK2_1	154	159	PF00069	0.461
MOD_NEK2_1	252	257	PF00069	0.495
MOD_NEK2_1	363	368	PF00069	0.509
MOD_NEK2_1	43	48	PF00069	0.295
MOD_NEK2_1	466	471	PF00069	0.545
MOD_NEK2_1	598	603	PF00069	0.373
MOD_NEK2_1	627	632	PF00069	0.374
MOD_NEK2_1	669	674	PF00069	0.276
MOD_NEK2_1	699	704	PF00069	0.295
MOD_NEK2_1	856	861	PF00069	0.444
MOD_NEK2_2	51	56	PF00069	0.270
MOD_PIKK_1	404	410	PF00454	0.528
MOD_PIKK_1	75	81	PF00454	0.504
MOD_PIKK_1	869	875	PF00454	0.581
MOD_PIKK_1	87	93	PF00454	0.499
MOD_PKA_1	26	32	PF00069	0.295
MOD_PKA_2	26	32	PF00069	0.295
MOD_PKA_2	588	594	PF00069	0.411
MOD_PKA_2	75	81	PF00069	0.457
MOD_PKA_2	985	991	PF00069	0.556
MOD_Plk_1	132	138	PF00069	0.444
MOD_Plk_1	294	300	PF00069	0.533
MOD_Plk_1	587	593	PF00069	0.306
MOD_Plk_1	669	675	PF00069	0.289
MOD_Plk_2-3	132	138	PF00069	0.459
MOD_Plk_2-3	181	187	PF00069	0.408
MOD_Plk_2-3	219	225	PF00069	0.478
MOD_Plk_2-3	355	361	PF00069	0.481
MOD_Plk_2-3	556	562	PF00069	0.419
MOD_Plk_2-3	743	749	PF00069	0.348
MOD_Plk_4	132	138	PF00069	0.444
MOD_Plk_4	51	57	PF00069	0.286
MOD_Plk_4	525	531	PF00069	0.485
MOD_Plk_4	669	675	PF00069	0.276
MOD_Plk_4	722	728	PF00069	0.295
MOD_Plk_4	729	735	PF00069	0.295
MOD_Plk_4	757	763	PF00069	0.308
MOD_ProDKin_1	1058	1064	PF00069	0.594
MOD_ProDKin_1	693	699	PF00069	0.503
MOD_ProDKin_1	800	806	PF00069	0.472
MOD_ProDKin_1	837	843	PF00069	0.295
MOD_ProDKin_1	935	941	PF00069	0.535
MOD_ProDKin_1	945	951	PF00069	0.529
MOD_SUMO_for_1	1068	1071	PF00179	0.590
MOD_SUMO_for_1	178	181	PF00179	0.484
MOD_SUMO_for_1	216	219	PF00179	0.518
MOD_SUMO_for_1	227	230	PF00179	0.425
MOD_SUMO_for_1	393	396	PF00179	0.521
MOD_SUMO_rev_2	104	113	PF00179	0.526
MOD_SUMO_rev_2	174	184	PF00179	0.466
MOD_SUMO_rev_2	219	227	PF00179	0.398
MOD_SUMO_rev_2	738	746	PF00179	0.348
TRG_DiLeu_BaEn_1	132	137	PF01217	0.432
TRG_DiLeu_BaEn_1	436	441	PF01217	0.488
TRG_DiLeu_BaEn_1	568	573	PF01217	0.440
TRG_DiLeu_BaEn_1	713	718	PF01217	0.348
TRG_DiLeu_BaEn_4	243	249	PF01217	0.458
TRG_DiLeu_BaEn_4	307	313	PF01217	0.452
TRG_ENDOCYTIC_2	535	538	PF00928	0.465
TRG_ENDOCYTIC_2	625	628	PF00928	0.295
TRG_ENDOCYTIC_2	676	679	PF00928	0.441
TRG_ER_diArg_1	1006	1009	PF00400	0.530
TRG_ER_diArg_1	187	189	PF00400	0.471
TRG_ER_diArg_1	971	973	PF00400	0.527
TRG_NES_CRM1_1	816	829	PF08389	0.286
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	739	743	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	920	924	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I536	Leptomonas seymouri	42%	90%
A0A3S7X2S6	Leishmania donovani	90%	100%
A4HHS5	Leishmania braziliensis	73%	100%
A4I4X6	Leishmania infantum	90%	100%
E9ALF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%