Cnd3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nuclear condensing complex subunits, C-term domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AEC7_LEIMA

TriTrypDb:

LmjF.29.2650 , LMJLV39_290034600 , LMJSD75_290035000

Length:

1039

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000793	condensed chromosome	6	2
GO:0000796	condensin complex	3	11
GO:0005654	nucleoplasm	2	2
GO:0005694	chromosome	5	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0044815	DNA packaging complex	2	11
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEC7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0007076	mitotic chromosome condensation	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	11
GO:0030261	chromosome condensation	6	11
GO:0051276	chromosome organization	5	11
GO:0051301	cell division	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:1903047	mitotic cell cycle process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.432
CLV_C14_Caspase3-7	477	481	PF00656	0.398
CLV_C14_Caspase3-7	958	962	PF00656	0.651
CLV_C14_Caspase3-7	963	967	PF00656	0.520
CLV_C14_Caspase3-7	981	985	PF00656	0.314
CLV_NRD_NRD_1	198	200	PF00675	0.342
CLV_NRD_NRD_1	208	210	PF00675	0.429
CLV_NRD_NRD_1	324	326	PF00675	0.377
CLV_NRD_NRD_1	503	505	PF00675	0.417
CLV_NRD_NRD_1	515	517	PF00675	0.388
CLV_NRD_NRD_1	75	77	PF00675	0.432
CLV_NRD_NRD_1	823	825	PF00675	0.196
CLV_NRD_NRD_1	843	845	PF00675	0.307
CLV_PCSK_KEX2_1	1017	1019	PF00082	0.592
CLV_PCSK_KEX2_1	1035	1037	PF00082	0.479
CLV_PCSK_KEX2_1	326	328	PF00082	0.477
CLV_PCSK_KEX2_1	515	517	PF00082	0.437
CLV_PCSK_KEX2_1	651	653	PF00082	0.326
CLV_PCSK_KEX2_1	688	690	PF00082	0.309
CLV_PCSK_KEX2_1	75	77	PF00082	0.353
CLV_PCSK_KEX2_1	771	773	PF00082	0.339
CLV_PCSK_KEX2_1	823	825	PF00082	0.306
CLV_PCSK_KEX2_1	982	984	PF00082	0.493
CLV_PCSK_PC1ET2_1	1017	1019	PF00082	0.600
CLV_PCSK_PC1ET2_1	1035	1037	PF00082	0.589
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.477
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.450
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.326
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.307
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.339
CLV_PCSK_PC1ET2_1	982	984	PF00082	0.484
CLV_PCSK_SKI1_1	200	204	PF00082	0.375
CLV_PCSK_SKI1_1	210	214	PF00082	0.375
CLV_PCSK_SKI1_1	245	249	PF00082	0.415
CLV_PCSK_SKI1_1	254	258	PF00082	0.368
CLV_PCSK_SKI1_1	392	396	PF00082	0.501
CLV_PCSK_SKI1_1	407	411	PF00082	0.334
CLV_PCSK_SKI1_1	458	462	PF00082	0.360
CLV_PCSK_SKI1_1	473	477	PF00082	0.334
CLV_PCSK_SKI1_1	484	488	PF00082	0.379
CLV_PCSK_SKI1_1	516	520	PF00082	0.436
CLV_PCSK_SKI1_1	542	546	PF00082	0.328
CLV_PCSK_SKI1_1	688	692	PF00082	0.275
CLV_PCSK_SKI1_1	785	789	PF00082	0.302
CLV_PCSK_SKI1_1	823	827	PF00082	0.306
CLV_PCSK_SKI1_1	983	987	PF00082	0.459
DEG_APCC_DBOX_1	429	437	PF00400	0.375
DEG_APCC_DBOX_1	545	553	PF00400	0.437
DEG_SPOP_SBC_1	9	13	PF00917	0.503
DOC_CYCLIN_RxL_1	404	414	PF00134	0.334
DOC_MAPK_gen_1	35	43	PF00069	0.450
DOC_MAPK_gen_1	539	549	PF00069	0.377
DOC_MAPK_HePTP_8	870	882	PF00069	0.539
DOC_MAPK_MEF2A_6	53	62	PF00069	0.411
DOC_MAPK_MEF2A_6	542	551	PF00069	0.372
DOC_MAPK_MEF2A_6	873	882	PF00069	0.539
DOC_PP1_RVXF_1	390	397	PF00149	0.485
DOC_PP1_RVXF_1	433	440	PF00149	0.330
DOC_PP1_RVXF_1	514	521	PF00149	0.493
DOC_PP1_RVXF_1	795	802	PF00149	0.533
DOC_PP2B_LxvP_1	366	369	PF13499	0.423
DOC_PP2B_LxvP_1	486	489	PF13499	0.357
DOC_USP7_MATH_1	119	123	PF00917	0.488
DOC_USP7_MATH_1	166	170	PF00917	0.471
DOC_USP7_MATH_1	172	176	PF00917	0.460
DOC_USP7_MATH_1	269	273	PF00917	0.390
DOC_USP7_MATH_1	459	463	PF00917	0.412
DOC_USP7_MATH_1	478	482	PF00917	0.321
DOC_USP7_MATH_1	587	591	PF00917	0.502
DOC_USP7_MATH_1	623	627	PF00917	0.560
DOC_USP7_MATH_1	741	745	PF00917	0.539
DOC_USP7_MATH_1	793	797	PF00917	0.526
DOC_USP7_MATH_1	8	12	PF00917	0.683
DOC_USP7_MATH_1	851	855	PF00917	0.515
DOC_USP7_MATH_2	312	318	PF00917	0.404
DOC_USP7_MATH_2	445	451	PF00917	0.500
DOC_USP7_UBL2_3	35	39	PF12436	0.470
DOC_USP7_UBL2_3	684	688	PF12436	0.507
DOC_WW_Pin1_4	1002	1007	PF00397	0.697
DOC_WW_Pin1_4	308	313	PF00397	0.383
DOC_WW_Pin1_4	464	469	PF00397	0.414
LIG_14-3-3_CanoR_1	1020	1027	PF00244	0.658
LIG_14-3-3_CanoR_1	315	321	PF00244	0.457
LIG_14-3-3_CanoR_1	327	337	PF00244	0.438
LIG_14-3-3_CanoR_1	407	413	PF00244	0.353
LIG_14-3-3_CanoR_1	430	434	PF00244	0.367
LIG_14-3-3_CanoR_1	458	464	PF00244	0.411
LIG_14-3-3_CanoR_1	491	495	PF00244	0.518
LIG_14-3-3_CanoR_1	689	695	PF00244	0.507
LIG_14-3-3_CanoR_1	804	811	PF00244	0.498
LIG_14-3-3_CanoR_1	853	857	PF00244	0.462
LIG_14-3-3_CanoR_1	867	871	PF00244	0.420
LIG_14-3-3_CanoR_1	873	881	PF00244	0.459
LIG_14-3-3_CanoR_1	945	953	PF00244	0.423
LIG_Actin_WH2_2	113	131	PF00022	0.348
LIG_Actin_WH2_2	429	444	PF00022	0.377
LIG_Actin_WH2_2	48	66	PF00022	0.316
LIG_APCC_ABBA_1	413	418	PF00400	0.364
LIG_BIR_III_2	388	392	PF00653	0.588
LIG_BIR_III_2	562	566	PF00653	0.507
LIG_BRCT_BRCA1_1	1021	1025	PF00533	0.707
LIG_BRCT_BRCA1_1	492	496	PF00533	0.557
LIG_CaM_IQ_9	170	186	PF13499	0.369
LIG_Clathr_ClatBox_1	334	338	PF01394	0.311
LIG_deltaCOP1_diTrp_1	234	242	PF00928	0.328
LIG_EH1_1	1024	1032	PF00400	0.639
LIG_EH1_1	728	736	PF00400	0.539
LIG_FHA_1	1011	1017	PF00498	0.712
LIG_FHA_1	181	187	PF00498	0.356
LIG_FHA_1	329	335	PF00498	0.422
LIG_FHA_1	340	346	PF00498	0.355
LIG_FHA_1	362	368	PF00498	0.461
LIG_FHA_1	470	476	PF00498	0.396
LIG_FHA_1	586	592	PF00498	0.431
LIG_FHA_1	824	830	PF00498	0.573
LIG_FHA_2	13	19	PF00498	0.493
LIG_FHA_2	192	198	PF00498	0.439
LIG_FHA_2	356	362	PF00498	0.497
LIG_FHA_2	465	471	PF00498	0.430
LIG_FHA_2	956	962	PF00498	0.667
LIG_Integrin_RGD_1	560	562	PF01839	0.260
LIG_LIR_Gen_1	122	131	PF02991	0.331
LIG_LIR_Gen_1	234	243	PF02991	0.299
LIG_LIR_Gen_1	292	302	PF02991	0.426
LIG_LIR_Gen_1	311	321	PF02991	0.350
LIG_LIR_Gen_1	450	460	PF02991	0.417
LIG_LIR_Gen_1	493	502	PF02991	0.475
LIG_LIR_Gen_1	527	537	PF02991	0.413
LIG_LIR_Gen_1	711	717	PF02991	0.504
LIG_LIR_Nem_3	122	127	PF02991	0.318
LIG_LIR_Nem_3	13	19	PF02991	0.483
LIG_LIR_Nem_3	214	220	PF02991	0.536
LIG_LIR_Nem_3	234	239	PF02991	0.223
LIG_LIR_Nem_3	292	297	PF02991	0.433
LIG_LIR_Nem_3	311	316	PF02991	0.374
LIG_LIR_Nem_3	393	399	PF02991	0.530
LIG_LIR_Nem_3	411	416	PF02991	0.376
LIG_LIR_Nem_3	450	455	PF02991	0.425
LIG_LIR_Nem_3	480	486	PF02991	0.369
LIG_LIR_Nem_3	493	499	PF02991	0.371
LIG_LIR_Nem_3	527	533	PF02991	0.419
LIG_LIR_Nem_3	604	608	PF02991	0.446
LIG_LIR_Nem_3	711	716	PF02991	0.504
LIG_LIR_Nem_3	760	765	PF02991	0.504
LIG_LIR_Nem_3	782	787	PF02991	0.539
LIG_LIR_Nem_3	988	994	PF02991	0.560
LIG_MYND_1	308	312	PF01753	0.493
LIG_NRBOX	185	191	PF00104	0.351
LIG_NRBOX	405	411	PF00104	0.313
LIG_PCNA_PIPBox_1	548	557	PF02747	0.317
LIG_PCNA_TLS_4	210	217	PF02747	0.375
LIG_PCNA_yPIPBox_3	542	555	PF02747	0.314
LIG_Pex14_2	88	92	PF04695	0.411
LIG_REV1ctd_RIR_1	759	767	PF16727	0.539
LIG_SH2_CRK	569	573	PF00017	0.539
LIG_SH2_CRK	78	82	PF00017	0.374
LIG_SH2_GRB2like	250	253	PF00017	0.415
LIG_SH2_NCK_1	313	317	PF00017	0.450
LIG_SH2_NCK_1	384	388	PF00017	0.470
LIG_SH2_PTP2	305	308	PF00017	0.457
LIG_SH2_SRC	144	147	PF00017	0.391
LIG_SH2_SRC	250	253	PF00017	0.465
LIG_SH2_SRC	382	385	PF00017	0.428
LIG_SH2_STAP1	294	298	PF00017	0.302
LIG_SH2_STAP1	416	420	PF00017	0.499
LIG_SH2_STAP1	809	813	PF00017	0.533
LIG_SH2_STAT5	216	219	PF00017	0.321
LIG_SH2_STAT5	246	249	PF00017	0.387
LIG_SH2_STAT5	305	308	PF00017	0.457
LIG_SH2_STAT5	421	424	PF00017	0.427
LIG_SH2_STAT5	530	533	PF00017	0.524
LIG_SH2_STAT5	697	700	PF00017	0.507
LIG_SH2_STAT5	738	741	PF00017	0.475
LIG_SH2_STAT5	757	760	PF00017	0.417
LIG_SH2_STAT5	809	812	PF00017	0.502
LIG_SH2_STAT5	903	906	PF00017	0.376
LIG_SH3_3	1000	1006	PF00018	0.638
LIG_SH3_3	253	259	PF00018	0.430
LIG_Sin3_3	343	350	PF02671	0.422
LIG_SUMO_SIM_anti_2	877	886	PF11976	0.470
LIG_SUMO_SIM_par_1	408	414	PF11976	0.445
LIG_SUMO_SIM_par_1	606	613	PF11976	0.478
LIG_SUMO_SIM_par_1	877	886	PF11976	0.529
LIG_TRAF2_1	467	470	PF00917	0.432
LIG_TRAF2_1	836	839	PF00917	0.556
LIG_TRAF2_1	978	981	PF00917	0.440
LIG_TRFH_1	905	909	PF08558	0.479
LIG_UBA3_1	202	210	PF00899	0.427
LIG_UBA3_1	433	442	PF00899	0.329
LIG_UBA3_1	482	487	PF00899	0.373
LIG_UBA3_1	60	64	PF00899	0.368
LIG_WRC_WIRS_1	121	126	PF05994	0.391
LIG_WRC_WIRS_1	602	607	PF05994	0.446
LIG_WRC_WIRS_1	758	763	PF05994	0.486
MOD_CDK_SPxxK_3	308	315	PF00069	0.381
MOD_CK1_1	12	18	PF00069	0.509
MOD_CK1_1	134	140	PF00069	0.542
MOD_CK1_1	355	361	PF00069	0.516
MOD_CK1_1	855	861	PF00069	0.462
MOD_CK1_1	866	872	PF00069	0.442
MOD_CK1_1	91	97	PF00069	0.497
MOD_CK1_1	955	961	PF00069	0.651
MOD_CK1_1	964	970	PF00069	0.507
MOD_CK2_1	119	125	PF00069	0.409
MOD_CK2_1	12	18	PF00069	0.525
MOD_CK2_1	308	314	PF00069	0.382
MOD_CK2_1	355	361	PF00069	0.523
MOD_CK2_1	464	470	PF00069	0.434
MOD_CK2_1	526	532	PF00069	0.443
MOD_CK2_1	660	666	PF00069	0.464
MOD_CK2_1	697	703	PF00069	0.396
MOD_CK2_1	741	747	PF00069	0.507
MOD_CK2_1	866	872	PF00069	0.446
MOD_Cter_Amidation	175	178	PF01082	0.392
MOD_Cter_Amidation	502	505	PF01082	0.425
MOD_GlcNHglycan	105	108	PF01048	0.359
MOD_GlcNHglycan	174	177	PF01048	0.456
MOD_GlcNHglycan	28	31	PF01048	0.407
MOD_GlcNHglycan	316	319	PF01048	0.478
MOD_GlcNHglycan	46	49	PF01048	0.247
MOD_GlcNHglycan	476	479	PF01048	0.432
MOD_GlcNHglycan	699	702	PF01048	0.300
MOD_GlcNHglycan	710	713	PF01048	0.304
MOD_GlcNHglycan	857	860	PF01048	0.284
MOD_GlcNHglycan	963	966	PF01048	0.628
MOD_GSK3_1	127	134	PF00069	0.376
MOD_GSK3_1	425	432	PF00069	0.413
MOD_GSK3_1	469	476	PF00069	0.397
MOD_GSK3_1	478	485	PF00069	0.361
MOD_GSK3_1	660	667	PF00069	0.524
MOD_GSK3_1	693	700	PF00069	0.443
MOD_GSK3_1	741	748	PF00069	0.529
MOD_GSK3_1	757	764	PF00069	0.378
MOD_GSK3_1	8	15	PF00069	0.586
MOD_GSK3_1	803	810	PF00069	0.539
MOD_GSK3_1	851	858	PF00069	0.559
MOD_GSK3_1	952	959	PF00069	0.732
MOD_N-GLC_1	134	139	PF02516	0.459
MOD_N-GLC_1	269	274	PF02516	0.429
MOD_N-GLC_1	426	431	PF02516	0.374
MOD_N-GLC_1	849	854	PF02516	0.282
MOD_N-GLC_1	955	960	PF02516	0.698
MOD_NEK2_1	101	106	PF00069	0.529
MOD_NEK2_1	297	302	PF00069	0.420
MOD_NEK2_1	377	382	PF00069	0.362
MOD_NEK2_1	482	487	PF00069	0.374
MOD_NEK2_1	555	560	PF00069	0.309
MOD_NEK2_1	690	695	PF00069	0.455
MOD_NEK2_1	761	766	PF00069	0.442
MOD_NEK2_1	887	892	PF00069	0.489
MOD_NEK2_1	914	919	PF00069	0.395
MOD_NEK2_1	921	926	PF00069	0.452
MOD_NEK2_2	478	483	PF00069	0.419
MOD_NEK2_2	757	762	PF00069	0.493
MOD_OFUCOSY	714	719	PF10250	0.260
MOD_PIKK_1	180	186	PF00454	0.350
MOD_PIKK_1	361	367	PF00454	0.559
MOD_PIKK_1	555	561	PF00454	0.304
MOD_PIKK_1	610	616	PF00454	0.470
MOD_PIKK_1	872	878	PF00454	0.559
MOD_PK_1	395	401	PF00069	0.498
MOD_PKA_1	745	751	PF00069	0.539
MOD_PKA_1	823	829	PF00069	0.506
MOD_PKA_2	1019	1025	PF00069	0.645
MOD_PKA_2	314	320	PF00069	0.465
MOD_PKA_2	352	358	PF00069	0.441
MOD_PKA_2	429	435	PF00069	0.381
MOD_PKA_2	490	496	PF00069	0.514
MOD_PKA_2	503	509	PF00069	0.344
MOD_PKA_2	803	809	PF00069	0.498
MOD_PKA_2	823	829	PF00069	0.350
MOD_PKA_2	843	849	PF00069	0.480
MOD_PKA_2	852	858	PF00069	0.386
MOD_PKA_2	866	872	PF00069	0.412
MOD_PKA_2	88	94	PF00069	0.448
MOD_PKA_2	944	950	PF00069	0.494
MOD_Plk_1	269	275	PF00069	0.436
MOD_Plk_1	361	367	PF00069	0.472
MOD_Plk_1	526	532	PF00069	0.493
MOD_Plk_1	623	629	PF00069	0.470
MOD_Plk_4	1026	1032	PF00069	0.609
MOD_Plk_4	269	275	PF00069	0.434
MOD_Plk_4	281	287	PF00069	0.301
MOD_Plk_4	372	378	PF00069	0.330
MOD_Plk_4	408	414	PF00069	0.426
MOD_Plk_4	429	435	PF00069	0.375
MOD_Plk_4	447	453	PF00069	0.262
MOD_Plk_4	478	484	PF00069	0.368
MOD_Plk_4	601	607	PF00069	0.454
MOD_Plk_4	693	699	PF00069	0.517
MOD_Plk_4	757	763	PF00069	0.488
MOD_ProDKin_1	1002	1008	PF00069	0.698
MOD_ProDKin_1	308	314	PF00069	0.382
MOD_ProDKin_1	464	470	PF00069	0.412
MOD_SUMO_for_1	1009	1012	PF00179	0.631
MOD_SUMO_for_1	1016	1019	PF00179	0.615
MOD_SUMO_for_1	533	536	PF00179	0.410
MOD_SUMO_rev_2	284	293	PF00179	0.523
MOD_SUMO_rev_2	388	394	PF00179	0.468
MOD_SUMO_rev_2	535	544	PF00179	0.363
MOD_SUMO_rev_2	700	707	PF00179	0.429
TRG_DiLeu_BaEn_1	146	151	PF01217	0.480
TRG_DiLeu_BaEn_1	363	368	PF01217	0.355
TRG_DiLeu_BaEn_2	907	913	PF01217	0.513
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.456
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.459
TRG_DiLeu_BaLyEn_6	686	691	PF01217	0.539
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.558
TRG_ENDOCYTIC_2	294	297	PF00928	0.307
TRG_ENDOCYTIC_2	313	316	PF00928	0.367
TRG_ENDOCYTIC_2	530	533	PF00928	0.409
TRG_ENDOCYTIC_2	569	572	PF00928	0.539
TRG_ENDOCYTIC_2	78	81	PF00928	0.377
TRG_ER_diArg_1	1036	1039	PF00400	0.585
TRG_ER_diArg_1	74	76	PF00400	0.486
TRG_NES_CRM1_1	403	418	PF08389	0.328
TRG_NLS_Bipartite_1	1017	1039	PF00514	0.628
TRG_NLS_Bipartite_1	504	519	PF00514	0.502
TRG_NLS_MonoExtN_4	1033	1039	PF00514	0.628
TRG_NLS_MonoExtN_4	35	41	PF00514	0.405
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	576	581	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU9	Leptomonas seymouri	75%	100%
A0A0S4KHM0	Bodo saltans	38%	88%
A0A1X0P9B4	Trypanosomatidae	51%	95%
A0A3Q8IFD1	Leishmania donovani	95%	100%
A0A3R7LU33	Trypanosoma rangeli	51%	98%
A4HHR3	Leishmania braziliensis	87%	100%
A4I4X3	Leishmania infantum	95%	100%
C9ZKY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9ALF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%