Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEC6_LEIMA

TriTrypDb:

LmjF.29.2640 , LMJLV39_290034500 , LMJSD75_290034900

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.406
CLV_NRD_NRD_1	422	424	PF00675	0.380
CLV_PCSK_KEX2_1	422	424	PF00082	0.380
CLV_PCSK_SKI1_1	175	179	PF00082	0.407
CLV_PCSK_SKI1_1	213	217	PF00082	0.353
CLV_PCSK_SKI1_1	318	322	PF00082	0.362
CLV_PCSK_SKI1_1	400	404	PF00082	0.401
DEG_COP1_1	290	297	PF00400	0.493
DEG_SCF_SKP2-CKS1_1	212	219	PF00560	0.508
DOC_CYCLIN_RxL_1	420	429	PF00134	0.419
DOC_MAPK_gen_1	347	354	PF00069	0.522
DOC_MAPK_MEF2A_6	129	137	PF00069	0.318
DOC_MAPK_MEF2A_6	292	299	PF00069	0.514
DOC_MAPK_MEF2A_6	347	354	PF00069	0.508
DOC_MAPK_MEF2A_6	88	95	PF00069	0.459
DOC_PP1_RVXF_1	421	428	PF00149	0.500
DOC_USP7_MATH_1	259	263	PF00917	0.508
DOC_WW_Pin1_4	141	146	PF00397	0.648
DOC_WW_Pin1_4	213	218	PF00397	0.555
DOC_WW_Pin1_4	257	262	PF00397	0.553
LIG_14-3-3_CanoR_1	175	181	PF00244	0.418
LIG_14-3-3_CanoR_1	230	235	PF00244	0.542
LIG_14-3-3_CanoR_1	336	343	PF00244	0.563
LIG_14-3-3_CanoR_1	391	399	PF00244	0.479
LIG_14-3-3_CanoR_1	75	83	PF00244	0.486
LIG_Actin_WH2_2	383	399	PF00022	0.523
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	24	28	PF00533	0.551
LIG_CaM_IQ_9	222	238	PF13499	0.514
LIG_FAT_LD_1	48	56	PF03623	0.569
LIG_FHA_1	219	225	PF00498	0.453
LIG_FHA_1	270	276	PF00498	0.491
LIG_FHA_1	319	325	PF00498	0.360
LIG_FHA_1	336	342	PF00498	0.449
LIG_FHA_1	346	352	PF00498	0.340
LIG_FHA_1	382	388	PF00498	0.484
LIG_FHA_1	401	407	PF00498	0.528
LIG_FHA_1	64	70	PF00498	0.538
LIG_FHA_2	427	433	PF00498	0.418
LIG_FHA_2	79	85	PF00498	0.561
LIG_LIR_Gen_1	239	248	PF02991	0.423
LIG_LIR_Gen_1	296	303	PF02991	0.479
LIG_LIR_Gen_1	359	368	PF02991	0.543
LIG_LIR_Nem_3	183	189	PF02991	0.621
LIG_LIR_Nem_3	239	244	PF02991	0.450
LIG_LIR_Nem_3	25	31	PF02991	0.707
LIG_LIR_Nem_3	296	302	PF02991	0.421
LIG_LIR_Nem_3	359	363	PF02991	0.472
LIG_NRBOX	297	303	PF00104	0.488
LIG_PDZ_Class_2	436	441	PF00595	0.585
LIG_Pex14_1	431	435	PF04695	0.390
LIG_Pex14_2	427	431	PF04695	0.484
LIG_SH2_GRB2like	368	371	PF00017	0.623
LIG_SH2_NCK_1	368	372	PF00017	0.629
LIG_SH2_STAP1	73	77	PF00017	0.538
LIG_SH2_STAT3	223	226	PF00017	0.508
LIG_SH2_STAT5	11	14	PF00017	0.589
LIG_SH2_STAT5	223	226	PF00017	0.508
LIG_SH2_STAT5	254	257	PF00017	0.416
LIG_SH2_STAT5	356	359	PF00017	0.473
LIG_SH2_STAT5	368	371	PF00017	0.597
LIG_SH2_STAT5	420	423	PF00017	0.413
LIG_SH2_STAT5	426	429	PF00017	0.394
LIG_SH3_3	191	197	PF00018	0.562
LIG_SH3_3	55	61	PF00018	0.551
LIG_SUMO_SIM_anti_2	245	253	PF11976	0.486
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.410
LIG_SUMO_SIM_anti_2	348	355	PF11976	0.392
LIG_SUMO_SIM_par_1	110	116	PF11976	0.491
LIG_SUMO_SIM_par_1	348	355	PF11976	0.502
LIG_SUMO_SIM_par_1	91	97	PF11976	0.455
LIG_TRAF2_1	61	64	PF00917	0.595
LIG_TRAF2_1	77	80	PF00917	0.329
LIG_UBA3_1	353	362	PF00899	0.327
LIG_WRC_WIRS_1	203	208	PF05994	0.516
MOD_CDK_SPxK_1	213	219	PF00069	0.510
MOD_CK1_1	144	150	PF00069	0.616
MOD_CK1_1	169	175	PF00069	0.437
MOD_CK1_1	260	266	PF00069	0.556
MOD_CK1_1	325	331	PF00069	0.505
MOD_CK1_1	59	65	PF00069	0.501
MOD_CK1_1	78	84	PF00069	0.542
MOD_CK2_1	339	345	PF00069	0.581
MOD_CK2_1	426	432	PF00069	0.403
MOD_CK2_1	78	84	PF00069	0.535
MOD_GlcNHglycan	146	149	PF01048	0.634
MOD_GlcNHglycan	171	174	PF01048	0.491
MOD_GlcNHglycan	304	308	PF01048	0.552
MOD_GlcNHglycan	324	327	PF01048	0.361
MOD_GlcNHglycan	44	47	PF01048	0.550
MOD_GlcNHglycan	75	78	PF01048	0.423
MOD_GSK3_1	139	146	PF00069	0.513
MOD_GSK3_1	165	172	PF00069	0.465
MOD_GSK3_1	259	266	PF00069	0.462
MOD_GSK3_1	318	325	PF00069	0.338
MOD_GSK3_1	335	342	PF00069	0.364
MOD_GSK3_1	59	66	PF00069	0.529
MOD_N-GLC_1	169	174	PF02516	0.495
MOD_N-GLC_1	277	282	PF02516	0.472
MOD_N-GLC_1	369	374	PF02516	0.608
MOD_NEK2_1	113	118	PF00069	0.376
MOD_NEK2_1	165	170	PF00069	0.456
MOD_NEK2_1	224	229	PF00069	0.496
MOD_NEK2_1	276	281	PF00069	0.433
MOD_NEK2_1	302	307	PF00069	0.519
MOD_NEK2_1	363	368	PF00069	0.481
MOD_NEK2_1	51	56	PF00069	0.524
MOD_NEK2_1	94	99	PF00069	0.438
MOD_PIKK_1	260	266	PF00454	0.634
MOD_PIKK_1	325	331	PF00454	0.425
MOD_PIKK_1	363	369	PF00454	0.504
MOD_PIKK_1	75	81	PF00454	0.443
MOD_PKA_2	229	235	PF00069	0.520
MOD_PKA_2	335	341	PF00069	0.579
MOD_PKA_2	5	11	PF00069	0.658
MOD_Plk_1	277	283	PF00069	0.473
MOD_Plk_4	199	205	PF00069	0.432
MOD_Plk_4	219	225	PF00069	0.496
MOD_ProDKin_1	141	147	PF00069	0.653
MOD_ProDKin_1	213	219	PF00069	0.554
MOD_ProDKin_1	257	263	PF00069	0.560
MOD_SUMO_rev_2	394	399	PF00179	0.486
MOD_SUMO_rev_2	57	66	PF00179	0.568
MOD_SUMO_rev_2	76	83	PF00179	0.327
TRG_DiLeu_BaEn_1	359	364	PF01217	0.527
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.482
TRG_ER_diArg_1	31	34	PF00400	0.651
TRG_ER_diArg_1	347	350	PF00400	0.514
TRG_ER_diArg_1	421	423	PF00400	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y5	Leptomonas seymouri	52%	96%
A0A0S4IKI5	Bodo saltans	29%	97%
A0A1X0P918	Trypanosomatidae	36%	95%
A0A3Q8IFJ3	Leishmania donovani	94%	100%
A0A3R7K871	Trypanosoma rangeli	39%	100%
A4HHR2	Leishmania braziliensis	79%	100%
A4I4X2	Leishmania infantum	94%	100%
C9ZKY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ALG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BSL0	Trypanosoma cruzi	38%	100%