SAM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 24

Species:

Leishmania major

UniProt:

E9AEC5_LEIMA

TriTrypDb:

LmjF.29.2630 , LMJLV39_290034400 , LMJSD75_290034800

Length:

1232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	5
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AEC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1181	1185	PF00656	0.730
CLV_C14_Caspase3-7	423	427	PF00656	0.743
CLV_C14_Caspase3-7	526	530	PF00656	0.672
CLV_C14_Caspase3-7	551	555	PF00656	0.588
CLV_C14_Caspase3-7	797	801	PF00656	0.714
CLV_NRD_NRD_1	1051	1053	PF00675	0.374
CLV_NRD_NRD_1	1090	1092	PF00675	0.443
CLV_NRD_NRD_1	127	129	PF00675	0.499
CLV_NRD_NRD_1	300	302	PF00675	0.341
CLV_NRD_NRD_1	579	581	PF00675	0.401
CLV_NRD_NRD_1	643	645	PF00675	0.473
CLV_NRD_NRD_1	877	879	PF00675	0.390
CLV_NRD_NRD_1	914	916	PF00675	0.359
CLV_PCSK_KEX2_1	1051	1053	PF00082	0.388
CLV_PCSK_KEX2_1	1089	1091	PF00082	0.438
CLV_PCSK_KEX2_1	127	129	PF00082	0.501
CLV_PCSK_KEX2_1	282	284	PF00082	0.354
CLV_PCSK_KEX2_1	364	366	PF00082	0.427
CLV_PCSK_KEX2_1	543	545	PF00082	0.477
CLV_PCSK_KEX2_1	643	645	PF00082	0.424
CLV_PCSK_KEX2_1	877	879	PF00082	0.432
CLV_PCSK_KEX2_1	914	916	PF00082	0.359
CLV_PCSK_PC1ET2_1	1089	1091	PF00082	0.438
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.404
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.333
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.477
CLV_PCSK_PC7_1	123	129	PF00082	0.492
CLV_PCSK_SKI1_1	101	105	PF00082	0.383
CLV_PCSK_SKI1_1	123	127	PF00082	0.394
CLV_PCSK_SKI1_1	282	286	PF00082	0.369
CLV_PCSK_SKI1_1	315	319	PF00082	0.401
CLV_PCSK_SKI1_1	336	340	PF00082	0.344
CLV_PCSK_SKI1_1	489	493	PF00082	0.445
CLV_PCSK_SKI1_1	496	500	PF00082	0.387
CLV_PCSK_SKI1_1	630	634	PF00082	0.496
CLV_PCSK_SKI1_1	643	647	PF00082	0.286
CLV_PCSK_SKI1_1	835	839	PF00082	0.485
CLV_Separin_Metazoa	690	694	PF03568	0.639
DEG_APCC_DBOX_1	100	108	PF00400	0.504
DEG_APCC_DBOX_1	335	343	PF00400	0.672
DEG_APCC_DBOX_1	775	783	PF00400	0.591
DEG_APCC_DBOX_1	913	921	PF00400	0.589
DEG_MDM2_SWIB_1	148	155	PF02201	0.594
DOC_ANK_TNKS_1	73	80	PF00023	0.550
DOC_ANK_TNKS_1	876	883	PF00023	0.567
DOC_CYCLIN_RxL_1	1016	1027	PF00134	0.626
DOC_CYCLIN_RxL_1	1031	1041	PF00134	0.618
DOC_MAPK_gen_1	580	587	PF00069	0.634
DOC_MAPK_MEF2A_6	496	503	PF00069	0.565
DOC_MAPK_MEF2A_6	580	587	PF00069	0.564
DOC_MAPK_MEF2A_6	693	702	PF00069	0.552
DOC_MAPK_MEF2A_6	914	921	PF00069	0.523
DOC_PP1_RVXF_1	951	957	PF00149	0.542
DOC_PP2B_LxvP_1	1080	1083	PF13499	0.628
DOC_PP2B_LxvP_1	611	614	PF13499	0.573
DOC_PP4_MxPP_1	1	4	PF00568	0.448
DOC_USP7_MATH_1	1024	1028	PF00917	0.565
DOC_USP7_MATH_1	1160	1164	PF00917	0.806
DOC_USP7_MATH_1	1200	1204	PF00917	0.670
DOC_USP7_MATH_1	213	217	PF00917	0.619
DOC_USP7_MATH_1	309	313	PF00917	0.534
DOC_USP7_MATH_1	358	362	PF00917	0.598
DOC_USP7_MATH_1	373	377	PF00917	0.489
DOC_USP7_MATH_1	4	8	PF00917	0.491
DOC_USP7_MATH_1	676	680	PF00917	0.577
DOC_USP7_MATH_1	709	713	PF00917	0.629
DOC_USP7_MATH_1	801	805	PF00917	0.759
DOC_USP7_MATH_1	859	863	PF00917	0.628
DOC_USP7_MATH_1	965	969	PF00917	0.573
DOC_USP7_UBL2_3	1085	1089	PF12436	0.574
DOC_USP7_UBL2_3	582	586	PF12436	0.520
DOC_USP7_UBL2_3	987	991	PF12436	0.613
DOC_WW_Pin1_4	1171	1176	PF00397	0.826
DOC_WW_Pin1_4	118	123	PF00397	0.706
DOC_WW_Pin1_4	130	135	PF00397	0.729
DOC_WW_Pin1_4	164	169	PF00397	0.639
DOC_WW_Pin1_4	256	261	PF00397	0.609
DOC_WW_Pin1_4	42	47	PF00397	0.677
DOC_WW_Pin1_4	733	738	PF00397	0.566
DOC_WW_Pin1_4	835	840	PF00397	0.642
LIG_14-3-3_CanoR_1	1118	1122	PF00244	0.673
LIG_14-3-3_CanoR_1	127	133	PF00244	0.770
LIG_14-3-3_CanoR_1	336	345	PF00244	0.581
LIG_14-3-3_CanoR_1	643	651	PF00244	0.673
LIG_14-3-3_CanoR_1	685	692	PF00244	0.614
LIG_14-3-3_CanoR_1	774	783	PF00244	0.576
LIG_14-3-3_CanoR_1	84	91	PF00244	0.565
LIG_14-3-3_CanoR_1	914	918	PF00244	0.525
LIG_14-3-3_CanoR_1	967	976	PF00244	0.628
LIG_Actin_WH2_2	270	288	PF00022	0.562
LIG_Actin_WH2_2	380	397	PF00022	0.586
LIG_Actin_WH2_2	962	979	PF00022	0.589
LIG_BIR_II_1	1	5	PF00653	0.444
LIG_BRCT_BRCA1_1	1	5	PF00533	0.387
LIG_BRCT_BRCA1_1	447	451	PF00533	0.650
LIG_BRCT_BRCA1_1	628	632	PF00533	0.643
LIG_BRCT_BRCA1_1	647	651	PF00533	0.461
LIG_CORNRBOX	393	401	PF00104	0.513
LIG_FHA_1	134	140	PF00498	0.660
LIG_FHA_1	156	162	PF00498	0.650
LIG_FHA_1	177	183	PF00498	0.613
LIG_FHA_1	25	31	PF00498	0.349
LIG_FHA_1	462	468	PF00498	0.570
LIG_FHA_1	47	53	PF00498	0.636
LIG_FHA_1	493	499	PF00498	0.605
LIG_FHA_1	607	613	PF00498	0.577
LIG_FHA_1	634	640	PF00498	0.613
LIG_FHA_1	743	749	PF00498	0.615
LIG_FHA_1	778	784	PF00498	0.550
LIG_FHA_1	905	911	PF00498	0.600
LIG_FHA_1	940	946	PF00498	0.570
LIG_FHA_1	961	967	PF00498	0.518
LIG_FHA_2	1007	1013	PF00498	0.600
LIG_FHA_2	1030	1036	PF00498	0.570
LIG_FHA_2	1066	1072	PF00498	0.673
LIG_FHA_2	1118	1124	PF00498	0.619
LIG_FHA_2	179	185	PF00498	0.570
LIG_FHA_2	188	194	PF00498	0.521
LIG_FHA_2	339	345	PF00498	0.549
LIG_FHA_2	436	442	PF00498	0.593
LIG_FHA_2	504	510	PF00498	0.716
LIG_FHA_2	524	530	PF00498	0.678
LIG_FHA_2	549	555	PF00498	0.739
LIG_FHA_2	566	572	PF00498	0.661
LIG_FHA_2	574	580	PF00498	0.729
LIG_FHA_2	685	691	PF00498	0.623
LIG_FHA_2	745	751	PF00498	0.600
LIG_FHA_2	805	811	PF00498	0.619
LIG_FHA_2	84	90	PF00498	0.600
LIG_FHA_2	861	867	PF00498	0.539
LIG_FHA_2	929	935	PF00498	0.643
LIG_LIR_Gen_1	1015	1024	PF02991	0.604
LIG_LIR_Gen_1	184	191	PF02991	0.611
LIG_LIR_Gen_1	251	260	PF02991	0.514
LIG_LIR_Gen_1	269	278	PF02991	0.521
LIG_LIR_Gen_1	561	572	PF02991	0.553
LIG_LIR_Gen_1	629	639	PF02991	0.562
LIG_LIR_Gen_1	648	657	PF02991	0.563
LIG_LIR_Gen_1	674	684	PF02991	0.592
LIG_LIR_Gen_1	731	737	PF02991	0.560
LIG_LIR_Nem_3	1012	1017	PF02991	0.617
LIG_LIR_Nem_3	149	155	PF02991	0.563
LIG_LIR_Nem_3	184	189	PF02991	0.607
LIG_LIR_Nem_3	251	256	PF02991	0.511
LIG_LIR_Nem_3	269	273	PF02991	0.535
LIG_LIR_Nem_3	27	31	PF02991	0.308
LIG_LIR_Nem_3	304	310	PF02991	0.589
LIG_LIR_Nem_3	561	567	PF02991	0.543
LIG_LIR_Nem_3	629	635	PF02991	0.575
LIG_LIR_Nem_3	648	654	PF02991	0.560
LIG_LIR_Nem_3	674	680	PF02991	0.583
LIG_NRBOX	1109	1115	PF00104	0.675
LIG_PCNA_yPIPBox_3	1107	1118	PF02747	0.659
LIG_PCNA_yPIPBox_3	485	496	PF02747	0.619
LIG_PCNA_yPIPBox_3	693	703	PF02747	0.556
LIG_PCNA_yPIPBox_3	991	1004	PF02747	0.571
LIG_PDZ_Class_1	1227	1232	PF00595	0.692
LIG_Pex14_2	148	152	PF04695	0.592
LIG_SH2_STAP1	1215	1219	PF00017	0.681
LIG_SH2_STAT5	1017	1020	PF00017	0.612
LIG_SH2_STAT5	178	181	PF00017	0.577
LIG_SH3_1	1051	1057	PF00018	0.615
LIG_SH3_2	1177	1182	PF14604	0.631
LIG_SH3_2	839	844	PF14604	0.579
LIG_SH3_3	1051	1057	PF00018	0.692
LIG_SH3_3	1174	1180	PF00018	0.692
LIG_SH3_3	136	142	PF00018	0.701
LIG_SH3_3	206	212	PF00018	0.701
LIG_SH3_3	339	345	PF00018	0.580
LIG_SH3_3	475	481	PF00018	0.573
LIG_SH3_3	836	842	PF00018	0.586
LIG_SUMO_SIM_anti_2	1035	1041	PF11976	0.592
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.600
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.523
LIG_SUMO_SIM_anti_2	933	940	PF11976	0.626
LIG_SUMO_SIM_par_1	113	119	PF11976	0.631
LIG_SUMO_SIM_par_1	432	438	PF11976	0.635
LIG_TRAF2_1	1041	1044	PF00917	0.652
LIG_TRAF2_1	238	241	PF00917	0.603
LIG_TRAF2_1	410	413	PF00917	0.609
LIG_TRAF2_1	576	579	PF00917	0.600
LIG_TRAF2_1	687	690	PF00917	0.580
LIG_TRAF2_1	712	715	PF00917	0.611
LIG_TRAF2_1	863	866	PF00917	0.588
LIG_UBA3_1	1036	1040	PF00899	0.574
LIG_WRC_WIRS_1	183	188	PF05994	0.577
MOD_CDK_SPK_2	118	123	PF00069	0.698
MOD_CDK_SPK_2	130	135	PF00069	0.697
MOD_CDK_SPxxK_3	733	740	PF00069	0.566
MOD_CK1_1	118	124	PF00069	0.738
MOD_CK1_1	1203	1209	PF00069	0.741
MOD_CK1_1	130	136	PF00069	0.699
MOD_CK1_1	164	170	PF00069	0.650
MOD_CK1_1	548	554	PF00069	0.685
MOD_CK1_1	65	71	PF00069	0.548
MOD_CK1_1	675	681	PF00069	0.615
MOD_CK1_1	777	783	PF00069	0.551
MOD_CK1_1	804	810	PF00069	0.738
MOD_CK1_1	960	966	PF00069	0.589
MOD_CK2_1	1006	1012	PF00069	0.517
MOD_CK2_1	1029	1035	PF00069	0.626
MOD_CK2_1	1038	1044	PF00069	0.618
MOD_CK2_1	1065	1071	PF00069	0.679
MOD_CK2_1	1092	1098	PF00069	0.729
MOD_CK2_1	1160	1166	PF00069	0.753
MOD_CK2_1	140	146	PF00069	0.651
MOD_CK2_1	164	170	PF00069	0.666
MOD_CK2_1	178	184	PF00069	0.533
MOD_CK2_1	187	193	PF00069	0.585
MOD_CK2_1	318	324	PF00069	0.647
MOD_CK2_1	337	343	PF00069	0.572
MOD_CK2_1	401	407	PF00069	0.565
MOD_CK2_1	503	509	PF00069	0.651
MOD_CK2_1	565	571	PF00069	0.664
MOD_CK2_1	573	579	PF00069	0.734
MOD_CK2_1	678	684	PF00069	0.642
MOD_CK2_1	709	715	PF00069	0.644
MOD_CK2_1	733	739	PF00069	0.659
MOD_CK2_1	804	810	PF00069	0.706
MOD_CK2_1	860	866	PF00069	0.532
MOD_CK2_1	928	934	PF00069	0.599
MOD_CK2_1	937	943	PF00069	0.516
MOD_CK2_1	965	971	PF00069	0.570
MOD_CK2_1	987	993	PF00069	0.619
MOD_GlcNHglycan	1026	1029	PF01048	0.419
MOD_GlcNHglycan	1074	1077	PF01048	0.446
MOD_GlcNHglycan	118	121	PF01048	0.455
MOD_GlcNHglycan	1196	1199	PF01048	0.506
MOD_GlcNHglycan	1202	1205	PF01048	0.499
MOD_GlcNHglycan	1206	1209	PF01048	0.496
MOD_GlcNHglycan	1229	1232	PF01048	0.548
MOD_GlcNHglycan	142	145	PF01048	0.461
MOD_GlcNHglycan	163	166	PF01048	0.557
MOD_GlcNHglycan	295	298	PF01048	0.464
MOD_GlcNHglycan	320	323	PF01048	0.500
MOD_GlcNHglycan	377	380	PF01048	0.403
MOD_GlcNHglycan	455	458	PF01048	0.490
MOD_GlcNHglycan	674	677	PF01048	0.414
MOD_GlcNHglycan	711	714	PF01048	0.461
MOD_GlcNHglycan	739	743	PF01048	0.386
MOD_GlcNHglycan	796	800	PF01048	0.561
MOD_GlcNHglycan	802	806	PF01048	0.497
MOD_GlcNHglycan	892	895	PF01048	0.497
MOD_GlcNHglycan	947	950	PF01048	0.378
MOD_GlcNHglycan	978	981	PF01048	0.538
MOD_GSK3_1	1038	1045	PF00069	0.556
MOD_GSK3_1	1200	1207	PF00069	0.760
MOD_GSK3_1	1222	1229	PF00069	0.728
MOD_GSK3_1	133	140	PF00069	0.707
MOD_GSK3_1	178	185	PF00069	0.682
MOD_GSK3_1	309	316	PF00069	0.584
MOD_GSK3_1	40	47	PF00069	0.633
MOD_GSK3_1	545	552	PF00069	0.629
MOD_GSK3_1	617	624	PF00069	0.596
MOD_GSK3_1	633	640	PF00069	0.615
MOD_GSK3_1	671	678	PF00069	0.578
MOD_GSK3_1	680	687	PF00069	0.555
MOD_GSK3_1	731	738	PF00069	0.590
MOD_GSK3_1	742	749	PF00069	0.569
MOD_GSK3_1	933	940	PF00069	0.607
MOD_GSK3_1	965	972	PF00069	0.541
MOD_N-GLC_1	888	893	PF02516	0.407
MOD_NEK2_1	1038	1043	PF00069	0.576
MOD_NEK2_1	116	121	PF00069	0.584
MOD_NEK2_1	155	160	PF00069	0.586
MOD_NEK2_1	182	187	PF00069	0.623
MOD_NEK2_1	318	323	PF00069	0.700
MOD_NEK2_1	462	467	PF00069	0.614
MOD_NEK2_1	492	497	PF00069	0.552
MOD_NEK2_1	633	638	PF00069	0.550
MOD_NEK2_1	645	650	PF00069	0.524
MOD_NEK2_1	83	88	PF00069	0.566
MOD_NEK2_1	913	918	PF00069	0.544
MOD_NEK2_1	97	102	PF00069	0.457
MOD_NEK2_1	976	981	PF00069	0.692
MOD_NEK2_1	996	1001	PF00069	0.539
MOD_PIKK_1	1160	1166	PF00454	0.692
MOD_PIKK_1	213	219	PF00454	0.680
MOD_PIKK_1	543	549	PF00454	0.668
MOD_PIKK_1	774	780	PF00454	0.604
MOD_PIKK_1	804	810	PF00454	0.735
MOD_PIKK_1	860	866	PF00454	0.519
MOD_PKA_1	127	133	PF00069	0.701
MOD_PKA_1	543	549	PF00069	0.677
MOD_PKA_2	1117	1123	PF00069	0.671
MOD_PKA_2	127	133	PF00069	0.687
MOD_PKA_2	543	549	PF00069	0.792
MOD_PKA_2	684	690	PF00069	0.626
MOD_PKA_2	83	89	PF00069	0.566
MOD_PKA_2	913	919	PF00069	0.546
MOD_PKA_2	97	103	PF00069	0.452
MOD_PKA_2	976	982	PF00069	0.673
MOD_PKB_1	1063	1071	PF00069	0.690
MOD_Plk_1	230	236	PF00069	0.671
MOD_Plk_1	549	555	PF00069	0.568
MOD_Plk_1	730	736	PF00069	0.609
MOD_Plk_1	738	744	PF00069	0.544
MOD_Plk_1	933	939	PF00069	0.627
MOD_Plk_2-3	1092	1098	PF00069	0.596
MOD_Plk_2-3	1117	1123	PF00069	0.620
MOD_Plk_2-3	573	579	PF00069	0.598
MOD_Plk_4	1042	1048	PF00069	0.540
MOD_Plk_4	110	116	PF00069	0.587
MOD_Plk_4	178	184	PF00069	0.574
MOD_Plk_4	196	202	PF00069	0.516
MOD_Plk_4	462	468	PF00069	0.570
MOD_Plk_4	603	609	PF00069	0.621
MOD_Plk_4	78	84	PF00069	0.509
MOD_Plk_4	871	877	PF00069	0.542
MOD_Plk_4	933	939	PF00069	0.607
MOD_ProDKin_1	1171	1177	PF00069	0.821
MOD_ProDKin_1	118	124	PF00069	0.708
MOD_ProDKin_1	130	136	PF00069	0.727
MOD_ProDKin_1	164	170	PF00069	0.635
MOD_ProDKin_1	256	262	PF00069	0.606
MOD_ProDKin_1	42	48	PF00069	0.676
MOD_ProDKin_1	733	739	PF00069	0.567
MOD_ProDKin_1	835	841	PF00069	0.640
MOD_SUMO_for_1	458	461	PF00179	0.586
MOD_SUMO_rev_2	108	113	PF00179	0.663
MOD_SUMO_rev_2	1216	1225	PF00179	0.685
MOD_SUMO_rev_2	340	347	PF00179	0.554
MOD_SUMO_rev_2	515	524	PF00179	0.764
MOD_SUMO_rev_2	573	583	PF00179	0.616
TRG_DiLeu_BaEn_1	764	769	PF01217	0.552
TRG_DiLeu_BaLyEn_6	1016	1021	PF01217	0.544
TRG_DiLeu_BaLyEn_6	1109	1114	PF01217	0.604
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.499
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.503
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.528
TRG_ENDOCYTIC_2	1017	1020	PF00928	0.612
TRG_ER_diArg_1	1050	1052	PF00400	0.572
TRG_ER_diArg_1	126	128	PF00400	0.635
TRG_ER_diArg_1	587	590	PF00400	0.608
TRG_ER_diArg_1	642	644	PF00400	0.545
TRG_ER_diArg_1	876	878	PF00400	0.621
TRG_ER_diArg_1	913	915	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	1040	1044	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	1051	1055	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	1112	1117	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	967	971	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J6	Leptomonas seymouri	44%	98%
A0A3Q8IBP4	Leishmania donovani	89%	100%
A0A3R7MCK0	Trypanosoma rangeli	23%	77%
A4HHR1	Leishmania braziliensis	65%	100%
A4I4T9	Leishmania infantum	90%	100%
C9ZKY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	75%
E9ALG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5C230	Trypanosoma cruzi	24%	78%