Integrin_b_cyt domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEC4_LEIMA

TriTrypDb:

LmjF.29.2620 , LMJLV39_290034300 , LMJSD75_290034700

Length:

122

Annotations

LeishMANIAdb annotations

A short, single-pass TM protein of unclear topology and function.. A highly conserved protein family in parazitic kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AEC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.506
DOC_CKS1_1	19	24	PF01111	0.394
DOC_WW_Pin1_4	102	107	PF00397	0.668
DOC_WW_Pin1_4	12	17	PF00397	0.459
DOC_WW_Pin1_4	18	23	PF00397	0.388
DOC_WW_Pin1_4	34	39	PF00397	0.233
LIG_14-3-3_CterR_2	117	122	PF00244	0.663
LIG_eIF4E_1	95	101	PF01652	0.579
LIG_FHA_1	19	25	PF00498	0.457
LIG_FHA_1	46	52	PF00498	0.371
LIG_LIR_LC3C_4	55	60	PF02991	0.337
LIG_SH2_CRK	97	101	PF00017	0.617
LIG_SH2_PTP2	19	22	PF00017	0.386
LIG_SH2_PTP2	69	72	PF00017	0.362
LIG_SH2_SRC	69	72	PF00017	0.325
LIG_SH2_STAT5	113	116	PF00017	0.685
LIG_SH2_STAT5	19	22	PF00017	0.386
LIG_SH2_STAT5	69	72	PF00017	0.337
LIG_SH3_3	103	109	PF00018	0.670
LIG_SUMO_SIM_anti_2	48	55	PF11976	0.301
LIG_SUMO_SIM_par_1	86	92	PF11976	0.648
MOD_CDK_SPxxK_3	18	25	PF00069	0.393
MOD_GlcNHglycan	54	57	PF01048	0.421
MOD_GSK3_1	27	34	PF00069	0.348
MOD_NEK2_1	100	105	PF00069	0.652
MOD_NEK2_1	47	52	PF00069	0.354
MOD_OFUCOSY	29	36	PF10250	0.535
MOD_Plk_4	108	114	PF00069	0.618
MOD_Plk_4	47	53	PF00069	0.245
MOD_ProDKin_1	102	108	PF00069	0.684
MOD_ProDKin_1	12	18	PF00069	0.451
MOD_ProDKin_1	34	40	PF00069	0.398
MOD_SUMO_rev_2	110	119	PF00179	0.617
TRG_ENDOCYTIC_2	69	72	PF00928	0.318
TRG_ENDOCYTIC_2	97	100	PF00928	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6I0	Leptomonas seymouri	67%	100%
A0A1X0P914	Trypanosomatidae	39%	100%
A0A3R7NJ38	Trypanosoma rangeli	42%	100%
A0A3S7X2V8	Leishmania donovani	93%	100%
A4HHR0	Leishmania braziliensis	82%	100%
A4I4T8	Leishmania infantum	93%	100%
C9ZKY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
E9ALG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DU61	Trypanosoma cruzi	37%	100%