Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEC3_LEIMA

TriTrypDb:

LmjF.29.2610 , LMJLV39_290034200 , LMJSD75_290034600

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.584
CLV_NRD_NRD_1	377	379	PF00675	0.656
CLV_NRD_NRD_1	400	402	PF00675	0.618
CLV_NRD_NRD_1	656	658	PF00675	0.524
CLV_NRD_NRD_1	681	683	PF00675	0.521
CLV_PCSK_KEX2_1	28	30	PF00082	0.570
CLV_PCSK_KEX2_1	377	379	PF00082	0.656
CLV_PCSK_KEX2_1	400	402	PF00082	0.671
CLV_PCSK_KEX2_1	608	610	PF00082	0.421
CLV_PCSK_KEX2_1	656	658	PF00082	0.524
CLV_PCSK_KEX2_1	681	683	PF00082	0.521
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.570
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.421
CLV_PCSK_SKI1_1	326	330	PF00082	0.614
CLV_PCSK_SKI1_1	356	360	PF00082	0.560
CLV_PCSK_SKI1_1	362	366	PF00082	0.514
CLV_PCSK_SKI1_1	537	541	PF00082	0.525
CLV_PCSK_SKI1_1	711	715	PF00082	0.495
CLV_Separin_Metazoa	495	499	PF03568	0.494
DEG_APCC_DBOX_1	536	544	PF00400	0.528
DEG_APCC_DBOX_1	608	616	PF00400	0.421
DEG_APCC_DBOX_1	655	663	PF00400	0.586
DEG_APCC_DBOX_1	693	701	PF00400	0.586
DEG_SCF_FBW7_1	568	574	PF00400	0.694
DEG_SPOP_SBC_1	97	101	PF00917	0.581
DOC_CKS1_1	102	107	PF01111	0.519
DOC_CKS1_1	568	573	PF01111	0.691
DOC_CKS1_1	637	642	PF01111	0.542
DOC_CYCLIN_RxL_1	532	542	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.618
DOC_MAPK_gen_1	233	241	PF00069	0.487
DOC_MAPK_gen_1	353	361	PF00069	0.636
DOC_MAPK_gen_1	608	614	PF00069	0.421
DOC_MAPK_MEF2A_6	235	243	PF00069	0.646
DOC_PP2B_LxvP_1	168	171	PF13499	0.682
DOC_PP4_FxxP_1	4	7	PF00568	0.609
DOC_USP7_MATH_1	111	115	PF00917	0.686
DOC_USP7_MATH_1	183	187	PF00917	0.642
DOC_USP7_MATH_1	205	209	PF00917	0.549
DOC_USP7_MATH_1	213	217	PF00917	0.536
DOC_USP7_MATH_1	275	279	PF00917	0.562
DOC_USP7_MATH_1	285	289	PF00917	0.680
DOC_USP7_MATH_1	317	321	PF00917	0.613
DOC_USP7_MATH_1	366	370	PF00917	0.699
DOC_USP7_MATH_1	383	387	PF00917	0.561
DOC_USP7_MATH_1	581	585	PF00917	0.656
DOC_USP7_MATH_2	176	182	PF00917	0.651
DOC_WW_Pin1_4	101	106	PF00397	0.557
DOC_WW_Pin1_4	179	184	PF00397	0.655
DOC_WW_Pin1_4	278	283	PF00397	0.546
DOC_WW_Pin1_4	378	383	PF00397	0.568
DOC_WW_Pin1_4	567	572	PF00397	0.617
DOC_WW_Pin1_4	636	641	PF00397	0.535
DOC_WW_Pin1_4	91	96	PF00397	0.692
LIG_14-3-3_CanoR_1	128	136	PF00244	0.619
LIG_14-3-3_CanoR_1	240	244	PF00244	0.648
LIG_14-3-3_CanoR_1	262	269	PF00244	0.530
LIG_14-3-3_CanoR_1	505	510	PF00244	0.634
LIG_14-3-3_CanoR_1	537	546	PF00244	0.605
LIG_14-3-3_CanoR_1	657	663	PF00244	0.519
LIG_14-3-3_CanoR_1	681	689	PF00244	0.470
LIG_14-3-3_CanoR_1	70	74	PF00244	0.618
LIG_14-3-3_CanoR_1	79	85	PF00244	0.654
LIG_Actin_WH2_2	225	242	PF00022	0.581
LIG_Actin_WH2_2	347	364	PF00022	0.524
LIG_Actin_WH2_2	56	72	PF00022	0.679
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	454	458	PF00533	0.548
LIG_BRCT_BRCA1_1	463	467	PF00533	0.468
LIG_BRCT_BRCA1_2	454	460	PF00533	0.531
LIG_CSL_BTD_1	174	177	PF09270	0.663
LIG_FHA_1	240	246	PF00498	0.637
LIG_FHA_1	316	322	PF00498	0.580
LIG_FHA_1	539	545	PF00498	0.550
LIG_FHA_1	581	587	PF00498	0.636
LIG_FHA_1	592	598	PF00498	0.650
LIG_FHA_1	637	643	PF00498	0.639
LIG_FHA_1	64	70	PF00498	0.604
LIG_FHA_1	97	103	PF00498	0.677
LIG_FHA_2	122	128	PF00498	0.488
LIG_FHA_2	39	45	PF00498	0.594
LIG_FHA_2	422	428	PF00498	0.577
LIG_FHA_2	454	460	PF00498	0.531
LIG_FHA_2	53	59	PF00498	0.596
LIG_FHA_2	673	679	PF00498	0.594
LIG_FHA_2	681	687	PF00498	0.482
LIG_GBD_Chelix_1	429	437	PF00786	0.451
LIG_Integrin_isoDGR_2	305	307	PF01839	0.663
LIG_LIR_Apic_2	2	7	PF02991	0.607
LIG_LIR_Apic_2	564	568	PF02991	0.636
LIG_LIR_Gen_1	22	31	PF02991	0.633
LIG_LIR_Gen_1	32	38	PF02991	0.518
LIG_LIR_Gen_1	531	540	PF02991	0.585
LIG_LIR_Gen_1	557	566	PF02991	0.609
LIG_LIR_Gen_1	74	85	PF02991	0.558
LIG_LIR_Nem_3	22	27	PF02991	0.644
LIG_LIR_Nem_3	30	36	PF02991	0.524
LIG_LIR_Nem_3	531	536	PF02991	0.656
LIG_LIR_Nem_3	557	561	PF02991	0.596
LIG_MLH1_MIPbox_1	454	458	PF16413	0.529
LIG_NRBOX	436	442	PF00104	0.521
LIG_NRBOX	539	545	PF00104	0.528
LIG_PCNA_PIPBox_1	451	460	PF02747	0.608
LIG_PCNA_yPIPBox_3	299	312	PF02747	0.529
LIG_PDZ_Class_1	713	718	PF00595	0.458
LIG_Rb_LxCxE_1	264	281	PF01857	0.571
LIG_SH2_NCK_1	546	550	PF00017	0.548
LIG_SH2_PTP2	337	340	PF00017	0.536
LIG_SH2_SRC	565	568	PF00017	0.670
LIG_SH2_STAP1	343	347	PF00017	0.475
LIG_SH2_STAP1	546	550	PF00017	0.448
LIG_SH2_STAT3	224	227	PF00017	0.639
LIG_SH2_STAT5	337	340	PF00017	0.536
LIG_SH2_STAT5	360	363	PF00017	0.497
LIG_SH2_STAT5	457	460	PF00017	0.532
LIG_SH3_1	565	571	PF00018	0.712
LIG_SH3_3	11	17	PF00018	0.624
LIG_SH3_3	486	492	PF00018	0.585
LIG_SH3_3	565	571	PF00018	0.746
LIG_SH3_3	634	640	PF00018	0.521
LIG_SUMO_SIM_anti_2	666	673	PF11976	0.407
LIG_TRAF2_1	208	211	PF00917	0.558
LIG_TRAF2_1	247	250	PF00917	0.502
LIG_TRAF2_1	661	664	PF00917	0.583
LIG_TRAF2_1	683	686	PF00917	0.590
LIG_TRAF2_1	9	12	PF00917	0.732
LIG_TYR_ITIM	335	340	PF00017	0.536
LIG_WRC_WIRS_1	286	291	PF05994	0.485
LIG_WRC_WIRS_1	432	437	PF05994	0.580
LIG_WW_1	16	19	PF00397	0.630
MOD_CK1_1	100	106	PF00069	0.691
MOD_CK1_1	114	120	PF00069	0.459
MOD_CK1_1	146	152	PF00069	0.583
MOD_CK1_1	182	188	PF00069	0.570
MOD_CK1_1	228	234	PF00069	0.523
MOD_CK1_1	274	280	PF00069	0.642
MOD_CK1_1	386	392	PF00069	0.767
MOD_CK1_1	522	528	PF00069	0.510
MOD_CK1_1	577	583	PF00069	0.751
MOD_CK1_1	93	99	PF00069	0.689
MOD_CK2_1	121	127	PF00069	0.487
MOD_CK2_1	205	211	PF00069	0.552
MOD_CK2_1	244	250	PF00069	0.499
MOD_CK2_1	366	372	PF00069	0.707
MOD_CK2_1	38	44	PF00069	0.598
MOD_CK2_1	453	459	PF00069	0.531
MOD_CK2_1	52	58	PF00069	0.646
MOD_CK2_1	658	664	PF00069	0.592
MOD_CK2_1	672	678	PF00069	0.421
MOD_CK2_1	680	686	PF00069	0.483
MOD_GlcNHglycan	113	116	PF01048	0.677
MOD_GlcNHglycan	133	136	PF01048	0.464
MOD_GlcNHglycan	146	149	PF01048	0.611
MOD_GlcNHglycan	215	218	PF01048	0.565
MOD_GlcNHglycan	273	276	PF01048	0.675
MOD_GlcNHglycan	277	280	PF01048	0.615
MOD_GlcNHglycan	331	334	PF01048	0.554
MOD_GlcNHglycan	367	371	PF01048	0.723
MOD_GlcNHglycan	388	391	PF01048	0.602
MOD_GlcNHglycan	461	464	PF01048	0.556
MOD_GlcNHglycan	47	50	PF01048	0.646
MOD_GlcNHglycan	557	561	PF01048	0.683
MOD_GlcNHglycan	571	574	PF01048	0.731
MOD_GlcNHglycan	576	579	PF01048	0.712
MOD_GSK3_1	127	134	PF00069	0.688
MOD_GSK3_1	146	153	PF00069	0.454
MOD_GSK3_1	178	185	PF00069	0.669
MOD_GSK3_1	271	278	PF00069	0.589
MOD_GSK3_1	384	391	PF00069	0.726
MOD_GSK3_1	421	428	PF00069	0.571
MOD_GSK3_1	519	526	PF00069	0.634
MOD_GSK3_1	567	574	PF00069	0.622
MOD_GSK3_1	577	584	PF00069	0.637
MOD_GSK3_1	591	598	PF00069	0.588
MOD_GSK3_1	663	670	PF00069	0.630
MOD_GSK3_1	69	76	PF00069	0.694
MOD_GSK3_1	93	100	PF00069	0.673
MOD_N-GLC_1	425	430	PF02516	0.602
MOD_N-GLC_2	445	447	PF02516	0.627
MOD_NEK2_1	144	149	PF00069	0.685
MOD_NEK2_1	152	157	PF00069	0.615
MOD_NEK2_1	239	244	PF00069	0.508
MOD_NEK2_1	315	320	PF00069	0.651
MOD_NEK2_1	329	334	PF00069	0.556
MOD_NEK2_1	37	42	PF00069	0.577
MOD_NEK2_1	453	458	PF00069	0.522
MOD_NEK2_1	511	516	PF00069	0.652
MOD_NEK2_1	544	549	PF00069	0.544
MOD_NEK2_1	63	68	PF00069	0.639
MOD_NEK2_1	672	677	PF00069	0.563
MOD_NEK2_1	713	718	PF00069	0.482
MOD_NEK2_1	73	78	PF00069	0.559
MOD_PIKK_1	114	120	PF00454	0.619
MOD_PIKK_1	121	127	PF00454	0.550
MOD_PIKK_1	244	250	PF00454	0.599
MOD_PIKK_1	315	321	PF00454	0.677
MOD_PIKK_1	384	390	PF00454	0.715
MOD_PIKK_1	581	587	PF00454	0.714
MOD_PK_1	505	511	PF00069	0.603
MOD_PKA_1	400	406	PF00069	0.609
MOD_PKA_1	681	687	PF00069	0.522
MOD_PKA_2	127	133	PF00069	0.690
MOD_PKA_2	239	245	PF00069	0.557
MOD_PKA_2	261	267	PF00069	0.528
MOD_PKA_2	38	44	PF00069	0.586
MOD_PKA_2	400	406	PF00069	0.598
MOD_PKA_2	45	51	PF00069	0.642
MOD_PKA_2	680	686	PF00069	0.523
MOD_PKA_2	69	75	PF00069	0.666
MOD_PKA_2	78	84	PF00069	0.603
MOD_Plk_1	425	431	PF00069	0.677
MOD_Plk_1	479	485	PF00069	0.573
MOD_Plk_1	519	525	PF00069	0.629
MOD_Plk_1	556	562	PF00069	0.597
MOD_Plk_1	667	673	PF00069	0.650
MOD_Plk_1	73	79	PF00069	0.663
MOD_Plk_1	97	103	PF00069	0.614
MOD_Plk_2-3	479	485	PF00069	0.569
MOD_Plk_4	104	110	PF00069	0.563
MOD_Plk_4	160	166	PF00069	0.672
MOD_Plk_4	428	434	PF00069	0.655
MOD_Plk_4	453	459	PF00069	0.525
MOD_Plk_4	514	520	PF00069	0.580
MOD_Plk_4	667	673	PF00069	0.587
MOD_Plk_4	73	79	PF00069	0.663
MOD_ProDKin_1	101	107	PF00069	0.554
MOD_ProDKin_1	179	185	PF00069	0.647
MOD_ProDKin_1	278	284	PF00069	0.545
MOD_ProDKin_1	378	384	PF00069	0.569
MOD_ProDKin_1	567	573	PF00069	0.618
MOD_ProDKin_1	636	642	PF00069	0.538
MOD_ProDKin_1	91	97	PF00069	0.694
MOD_SUMO_for_1	27	30	PF00179	0.689
MOD_SUMO_rev_2	564	571	PF00179	0.644
MOD_SUMO_rev_2	599	604	PF00179	0.545
TRG_DiLeu_BaEn_1	557	562	PF01217	0.525
TRG_DiLeu_BaEn_4	303	309	PF01217	0.667
TRG_DiLeu_BaEn_4	349	355	PF01217	0.633
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.637
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.539
TRG_ENDOCYTIC_2	24	27	PF00928	0.704
TRG_ENDOCYTIC_2	337	340	PF00928	0.536
TRG_ER_diArg_1	400	402	PF00400	0.618
TRG_ER_diArg_1	655	657	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I841	Leptomonas seymouri	43%	97%
A0A3S7X2Z5	Leishmania donovani	90%	100%
A4HHQ9	Leishmania braziliensis	74%	100%
A4I4T7	Leishmania infantum	90%	100%
E9ALG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%